EVALUATION OF SIDE EFFECTS OF INFLUENZA VACCINE ON THE ORAL HEALTH AND CORRELATION WITH FLU

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Pragya Jaiswal ◽  
Raghav Agrawal
Keyword(s):  
Side Effects ◽  
Oral Cavity ◽  
Influenza Vaccine ◽  
Large Population ◽  
Pain Scale ◽  
Common Symptom ◽  
Upper Arm ◽  
The Past ◽  
Oral Symptoms ◽  
Flu Vaccine

Background: Vaccines have come a long way. They have been an important aspect of controlling and eradicating various life-threatening diseases. Vaccination is being widely used for Influenza which is one of the most common conditions affecting a large population and affects day to day activity. A vaccine being a double-edged sword, it presents various side effects as a whole and on oral cavity like ulcers, bleeding gums, white spots, sores in the oral cavity, lips, along with halitosis, etc. Objective: This prospective study was aimed to assess and understand the bad impact on by influenza vaccine on the oral cavity as well as to establish if any correlation exists between the flu vaccine and adverse oral symptoms. Methods: A total of 268 subjects studying at Government Medical College, were randomly screened for the study. Out of which only 32 received the vaccine for influenza in the past 6 months. All the subjects were given a multiple-choice questionnaire consisting of 12 short response questions related to general and oral side effects post-vaccination. The data collected was evaluated and assessed. Results: Study subjects that took the influenza vaccine within a period of the past 6 months, only ten patients suffered by side effects in which 6 suffered from flu-like symptoms and only 4 suffered orally-related symptoms simultaneously. Three manifestations that were found related to the oral cavity were white patches in the oral cavity, swelling of the lips, and atypical oral ulcers, soreness, swelling, redness, and pain in the upper arm. Other symptoms encountered in responders were fever, weakness, headache, and dizziness. The results of the present study indicated that 30% (n=3) of participants reported moderate pain (level 2). The remaining 70% reported levels 1, 3, and 5 pain with 30% reported level 1, 20% level 3 pain, and 20% level 5 pain respectively of Likert’s Pain Scale. Only 2 subjects (20%) required medical treatment for experienced symptoms. The severely unbearable pain of level 5 was reported by 2 subjects. Conclusions: No substantial relationship is observed between receiving the flu vaccine and oral symptoms. The most common symptom reported by survey participants were soreness, redness, and swelling in the upper arm with associated pain. All these systems are part of body immune defence to foreign vaccine particles and are cured naturally with immunity. Keywords:  Flu, Immune Reaction, Influenza, Oral Cavity, Vaccination.

Acceptance of SARS-CoV-2 vaccines by liver transplant recipients and candidates

2021 ◽  
Author(s):  
Philipp A. Reuken ◽  
Stefanie Albers ◽  
Falk Rauchfuss ◽  
Pavel Strnad ◽  
Utz Settmacher ◽  
...  
Keyword(s):  
Side Effects ◽  
Influenza Vaccine ◽  
Liver Transplant ◽  
Seasonal Influenza ◽  
Transplant Recipients ◽  
Household Contacts ◽  
The Past ◽  
Acceptance Rates ◽  
Liver Transplant Recipients ◽  
To Receive

AbstractGuidelines recommend vaccination against SARS-CoV-2 in transplant recipients, candidates, and their household contacts. However, little is known about the acceptance of COVID-19 vaccines in these groups.In March 2021, we surveyed 826 liver transplant recipients, candidates, and their household contacts to determine acceptance rates and factors influencing the acceptance of the COVID-19 vaccine; 341 patients (40%) and 237 household contacts (28%) returned the questionnaire. Ninety percent of patients returning the survey reported they were willing to receive the vaccine within the next 6 months or had already started vaccination. Only 2% of patients and 4% of household contacts reported refusing the vaccine, and 8% of patients and 9% of household contacts wanted to postpone vaccination because of concerns about side effects. Having received the influenza vaccine in the last 2 seasons was the strongest indicator of acceptance to receive the SARS-CoV-2 vaccine within 6 months (odds ratio 5.11; 95% confidence interval 2.43–10.74; p < 0.001). Thirty-two percent of responding patients reported fear of side effects as a reason for having refused vaccination before.Although the acceptance of the SARS-CoV-2 vaccine was particularly high among German liver transplant recipients, candidates, and household contacts in this survey, transplant physicians are encouraged to discuss safety concerns with patients who have refused the seasonal influenza vaccine in the past.

Āyuṛveda management of keratosis pilaris – a case report

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Rajasadanam Samsakumar Vipinsha ◽  
Changuli Krishna Bhat Prathibha ◽  
Puthanmadom Venkatraramana Sharma Anandaraman
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Symptomatic Relief ◽  
Complete Recovery ◽  
Upper Arm ◽  
Case Presentation ◽  
The Past ◽  
Short Period ◽  
Two Phases ◽  
Universal Treatment

AbstractObjectivesKeratosis pilaris (KP) is the condition of the skin with extensive keratin follicular plugging. It may be associated with the erythema. The upper arm extensor area, shoulders, back of neck and thighs, as well as face and the upper trunk are the areas of presentation. Available medications for KP give only symptomatic relief, while some produce serious side effects. There is no proven universal treatment for the disease that can provide complete recovery. Āyuṛveda management of KP is not yet reported.Case presentationA 26-year-old male patient, presented with main complaints started with papular lesions over his right shoulder, chest and upper back along and later with pustular lesions in the past 2 weeks. The condition was associated with redness, mild swelling and itching. The case was diagnosed as Keratosis pilaris based on its presentation, site, and pathogenesis. Also by analyzing the extent of vitiation of doṣas (morbidities), the Vata kapha pitta hara line of treatment was adopted, which was accomplished in two phases i. e. Śodhana Cikitsa and Śamana Cikitsa.ConclusionBoth internal and external treatments along with diet restrictions were found effective in arresting the pathogenesis and recovery in a short period. All the symptoms associated with the condition were completely cured with no signs of re-occurrence.

Fluorocarbon Precursor for High Aspect Ratio via Milling in Focused Ion Beam Modification of Integrated Circuits

2004 ◽  
Author(s):  
Valery Ray
Keyword(s):  
Side Effects ◽  
Aspect Ratio ◽  
Integrated Circuits ◽  
High Aspect Ratio ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
Enabling Technology ◽  
Si Substrate ◽  
Ion Beam Modification ◽  
The Past

Abstract Gas Assisted Etching (GAE) is the enabling technology for High Aspect Ratio (HAR) circuit access via milling in Focused Ion Beam (FIB) circuit modification. Metal interconnect layers of microelectronic Integrated Circuits (ICs) are separated by Inter-Layer Dielectric (ILD) materials, therefore HAR vias are typically milled in dielectrics. Most of the etching precursor gases presently available for GAE of dielectrics on commercial FIB systems, such as XeF2, Cl2, etc., are also effective etch enhancers for either Si, or/and some of the metals used in ICs. Therefore use of these precursors for via milling in dielectrics may lead to unwanted side effects, especially in a backside circuit edit approach. Making contacts to the polysilicon lines with traditional GAE precursors could also be difficult, if not impossible. Some of these precursors have a tendency to produce isotropic vias, especially in Si. It has been proposed in the past to use fluorocarbon gases as precursors for the FIB milling of dielectrics. Preliminary experimental evaluation of Trifluoroacetic (Perfluoroacetic) Acid (TFA, CF3COOH) as a possible etching precursor for the HAR via milling in the application to FIB modification of ICs demonstrated that highly enhanced anisotropic milling of SiO2 in HAR vias is possible. A via with 9:1 aspect ratio was milled with accurate endpoint on Si and without apparent damage to the underlying Si substrate.

Sending out Biased Signals: an Appropriate Proposition for Pain?

2019 ◽  
Vol 32 (2) ◽  
pp. 108-110 ◽  
Author(s):  
E. Besserer-Offroy ◽  
P. Sarret
Keyword(s):  
Side Effects ◽  
Acute Pain ◽  
Gold Standard ◽  
Pain Treatment ◽  
Opioid Analgesics ◽  
Mu Opioid Receptor ◽  
Clinical Development ◽  
Mu Opioid ◽  
Development Stages ◽  
The Past

In the past few years, several biased ligands acting at the mu-opioid receptor were reported in the literature. These agonists are aimed at reducing pain while having fewer side effects than morphine, the gold standard of opioid analgesics. In this mini-review, we describe and discuss the recent advances in mu-biased ligands actually in preclinical and clinical development stages, including the latest U.S. Food and Drug Administration review of oliceridine, a biased mu-agonist for moderate to severe acute pain treatment developed by the company Trevena.

Role of the norepinephrine transporter polymorphisms in atomoxetine treatment: From response to side effects in children with ADHD

2021 ◽  
pp. 026988112110152
Author(s):  
Melike Kevser Gul ◽  
Elif Funda Sener ◽  
Muge Gulcihan Onal ◽  
Esra Demirci
Keyword(s):  
Side Effects ◽  
Treatment Response ◽  
Large Population ◽  
Norepinephrine Transporter ◽  
Response To Treatment ◽  
Nucleotide Polymorphisms ◽  
Children With Adhd ◽  
Real Time Quantitative Pcr ◽  
Treatment Side Effects ◽  
Adhd Treatment

Objective: Atomoxetine (ATX), one of the most commonly used drugs after stimulants in attention deficit hyperactivity disorder (ADHD) treatment, is an inhibitor of the norepinephrine transporter ( NET/SLC6A2), which is also associated with the etiology of ADHD. In this study, we aimed to investigate the effect of NET gene polymorphisms on response to ATX treatment and to find the answers to the questions about whether there is a relationship between the severity of the disorder and the observed side effects in children with ADHD. Method: About 100 children with ADHD and 80 healthy controls (HCs) were included in this study. The dose of ATX was started at 0.5 mg/kg/day and titrated at 1.2 mg/kg/day. Response to treatment of 78 patients was evaluated 2 months after the beginning of the treatment. After whole blood samples were obtained, DNAs were isolated, and samples were stored at −80°C. Two single-nucleotide polymorphisms (SNPs) (rs12708954 and rs3785143) were analyzed by real-time quantitative PCR (qRT-PCR). Results: The patients with both rs12708954 and rs3785143 heterozygous genotype had better treatment response and more side effects than patients with wild type. There was not found any association between any of the investigated NET polymorphisms and ADHD severity. Conclusion: It was, however, found that the NET rs12708954 and rs3785143 genotypes affect the treatment response to ATX in our study; thus, further studies with a large population are needed to understand the effects of NET polymorphisms on treatment, side effects, and also the severity of ADHD.

THE ORIGINS OF MUSIC: INNATENESS, UNIQUENESS, AND EVOLUTION

2005 ◽  
Vol 23 (1) ◽  
pp. 29-59 ◽  
Author(s):  
JOSH McDERMOTT ◽  
MARC HAUSER
Keyword(s):  
Side Effects ◽  
Music Perception ◽  
Comparative Psychology ◽  
General Purpose ◽  
Adaptive Significance ◽  
Future Research ◽  
Relative Pitch ◽  
The Past ◽  
Evolution Of Music ◽  
Basic Features

THE ORIGINS and adaptive significance of music, long an elusive target, are now active topics of empirical study, with many interesting developments over the past few years. This article reviews research in anthropology, ethnomusicology, developmental and comparative psychology, neuropsychology, and neurophysiology that bears on questions concerning the origins and evolution of music. We focus on the hypothesis that music perception is constrained by innate, possibly human- and musicspecific principles of organization, as these are candidates for evolutionary explanations. We begin by discussing the distinct roles of different fields of inquiry in constraining claims about innateness and adaptation, and then proceed to review the available evidence. Although research on many of these topics is still in its infancy, at present there is converging evidence that a few basic features of music (relative pitch, the importance of the octave, intervals with simple ratios, tonality, and perhaps elementary musical preferences) are determined in part by innate constraints. At present, it is unclear how many of these constraints are uniquely human and specific to music. Many, however, are unlikely to be adaptations for music, but rather are probably side effects of more general-purpose mechanisms. We conclude by reiterating the significance of identifying processes that are innate, unique to humans, and specific to music, and highlight several possible directions for future research.

scholarly journals How the Lifestyle Leaders View and Manage Medications

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 611-612
Author(s):  
Taylor Patskanick ◽  
Julie Miller
Keyword(s):  
Side Effects ◽  
Medication Management ◽  
Healthcare Providers ◽  
Prescription Medication ◽  
The Internet ◽  
Prescription Medications ◽  
Over The Counter ◽  
Attitudes And Behaviors ◽  
The Past ◽  
Drug Companies

Abstract Medication management is an ongoing consideration for adults ages 85 and older, their caregivers, and healthcare providers. When asked about their attitudes and behaviors regarding medication management, over 73% of the Lifestyle Leaders reported taking 3+ prescription medications daily and managing their own medication regimes. 61.9% of participants had taken over-the-counter, non-prescription medication for pain over the past five years. When asked why some participants didn’t currently take prescription medications to manage pain, the most frequently-reported responses were: “I don’t feel that my pain warrants a prescription medication,” (19%, n=8), “I don’t want to deal with the side effects,” and “I don’t trust drug companies,” (9.5%, n=4, respectively). The Lifestyle Leaders reported they would be most likely to go to the internet (over their local pharmacist) to ask for advice about their medication(s). Meanwhile, 39% of Lifestyle Leaders would trust a robot to manage their medication(s) for them.

Fluoxetine Efficacy vs Comparative Drugs: An Overview

1988 ◽  
Vol 153 (S3) ◽  
pp. 51-58 ◽  
Author(s):  
Malcolm Lader
Keyword(s):  
Side Effects ◽  
Tricyclic Antidepressants ◽  
Antipsychotic Agents ◽  
Synaptic Cleft ◽  
Endogenous Depression ◽  
Acute Effects ◽  
Anticholinergic Effects ◽  
The Past ◽  
Chronic Effects ◽  
Clinical Action

The tricyclic antidepressants (TCAs) were discovered accidentally by pharmaceutical chemists seeking first, better antihistamines and then antipsychotic agents. Careful clinical assessment revealed the antidepressant properties and suggested that the closer the patient resembled the classical textbook description of ‘endogenous’ depression, the more likely was an adequate clinical response to occur (Kuhn, 1958). However, it was quickly realised that the TCAs possess a plethora of side-effects, particularly sedation and symptoms related to their anticholinergic effects.Despite much research over the past 25 years, it is unclear how TCAs effect clinical improvement. The two main neurotransmitters involved in some way are noradrenaline (Schildkraut, 1965) and 5-hydroxytryptamine (5-HT; serotonin; Van Praag, 1977). It was proposed that TCAs acted by blocking the reuptake of one or other or both of these neurotransmitters, thereby increasing their concentration in the synaptic cleft. However, as well as these acute effects, chronic effects, such as a decrease in the number of central beta-adrenoceptors (‘down-regulation’) occur, and these are probably more relevant to the clinical action.

scholarly journals Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

2021 ◽  
Vol 14 (9) ◽  
pp. 873
Author(s):  
Abanoub Riad ◽  
Barbora Hocková ◽  
Lucia Kantorová ◽  
Rastislav Slávik ◽  
Lucia Spurná ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Healthcare Workers ◽  
Large Scale ◽  
Large Population ◽  
Medical Attention ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Phase Iv

mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.

Understanding and Improving U.S. Financial Sanctions

2017 ◽  
Author(s):  
Jennifer M. Harris ◽  
Robert B. Kahn
Keyword(s):  
United States ◽  
Foreign Policy ◽  
Side Effects ◽  
The United States ◽  
Policy Tools ◽  
The Past

This chapter uses the Iran and Russia cases to understand how modern U.S. financial sanctions operate (including how they interact with traditional tools of foreign policy) and how to better incorporate them into the United States’ standing arsenal of foreign policy tools. It does so by considering three broad sets of questions: First, how has the use of financial sanctions evolved over the past fifteen years? Second, what are the main ways in which financial sanctions impose costs on sanctioned countries? Finally, how should U.S. policymakers alter the use of financial sanctions to maximize their impact, sustain their strength, and minimize problematic side effects?

Sign in / Sign up

Export Citation Format

Share Document