scholarly journals The problem of control of zeranol – a growth promoter of ruminant in beef

2018 ◽  
Vol 20 (88) ◽  
pp. 53-55
Author(s):  
V. Salata
Keyword(s):  
Endocrine System ◽  
Test System ◽  
Feed Additives ◽  
The Body ◽  
Farm Animals ◽  
Growth Promoter ◽  
Metabolic Processes ◽  
Growth Promoters ◽  
Livestock Breeding ◽  
Processing Plants

With the intensification of livestock breeding and the growing demand for meat in the population, producers in order to increase the productivity of farm animals widely apply various feed additives: amino acids, minerals, enzymes, hormones, tranquilizers, antibacterial substances, antioxidants, flavors, dyes, etc. Hormonal supplements or growth promoters used in feeding farm animals, leads to a violation of metabolic processes in the body of animals and poultry, while there are changes in the structure and chemical composition of the biological value of meat. The consumption of such products by a person affects metabolic processes of the organism, hormonal background, endocrine system, breaking the work of the organism as a whole. The purpose of the work was to conduct a search to determine the presence of zeranol, a growth stimulator for ruminants in beef, which arrives at the slaughter shops of the Ternopil and Lviv regions. The determination of zeranol in meat was carried out using a test system for the enzyme immunoassay of RIDASCRIN® Zeranol (manufactured by Ar-Biopharm / R-Biopharm, Darmstadt, Germany). It was found that on average 36% of the samples of beef carcasses entering for processing contained a stimulant for the growth of the mass of ruminant synthetic stimulant-anabolic zeranol, that is below the detection limit of zeranol 0.062 μg/kg. Detected samples, in which the content of zeranol was lower than the limit of this method, indicates that, according to the sensitivity of this method, these tests were attributed to negative ones, that is, zeranol is absent. Two companies with the highest levels of zeranol were also found: it is a beef of MP “Plai”, and PE “Fedoriv”. Consequently, it is recommended that monitoring, sampling and selection of beef meat at meat processing plants be carried out in order to establish safety indicators, in particular, the content of zeranol. Planned monitoring will monitor and analyze the situation with regard to zeranol in Ukraine. The problem of food safety and the assessment of potential risks of meat is extremely complicated and requires the introduction of requirements for the control of this synthetic drug in the normative legal acts of Ukraine. It is also proposed to conduct research on the development of methods for reducing the quantitative content of zeranol in beefmeat during its refrigeration.

scholarly journals Perspectives for rare earth elements as feed additive in livestock — A review

2020 ◽  
Vol 33 (3) ◽  
pp. 373-381 ◽  
Author(s):  
Hujaz Tariq ◽  
Amit Sharma ◽  
Srobana Sarkar ◽  
Lamella Ojha ◽  
Ravi Prakash Pal ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Feed Additives ◽  
Egg Laying ◽  
Farm Animals ◽  
Feed Additive ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Potential Growth ◽  
Safe Alternative

There is a need for newer feed additives due to legal prohibition on inclusion of growth promoting antibiotics in livestock diets in several countries due to antimicrobial resistance. In this context, rare earth elements (REE) have gained attention among animal nutritionists as potential growth promoters. Currently, several studies have reported better weight gain, milk production, egg laying capacity and feed conversion efficiency among different breeds of farm animals following supplementation with REE, with however largely inconsistent results. Furthermore, REE supplementation has also shown to improve ruminal fibrolytic and proteolytic activities as well as flavor of meat with negligible residues in edible tissue, however the mechanism behind this action is still unclear. According to existing research, due to their poor absorption and similarity with calcium REE might exert their action locally on gut microbial populations within the gastrointestinal tract (GIT). Moreover, REE have also shown anti-inflammatory, anti-oxidative as well as immune stimulating effects. The present review aims to broaden the knowledge about use of REE as feed additives for livestock and sum up efficacy of REE supplementation on performance and health of animals by comparing the findings. Till date, researches with REE have shown properties that make them a promising, new and safe alternative feed additive but further exploration is recommended to optimize effects and clarify discrepancy of various results before practical proposals can be drafted.

Growth promoters: reassessing the risk

1991 ◽  
Vol 1991 ◽  
pp. 43-43
Author(s):  
A.R. Peters
Keyword(s):  
Antimicrobial Activity ◽  
Feed Additives ◽  
Growth Promoter ◽  
Therapeutic Action ◽  
Medicinal Products ◽  
Growth Promoters ◽  
Consumer Concerns ◽  
Binding Agents ◽  
Veterinary Medicinal Products

Legislation to control veterinary medicinal products is undergoing continual development in the EEC and UK and therefore the risks are continually reassessed. In the present paper current and future legislation together with consumer concerns both real and imaginary are reviewed.Since the EEC ban on hormonal growth promoter implants in 1986 the remaining legal products are all feed additives. Registration of feed additives in the EEC is controlled under Directive 70/524 and its various amending directives. this directive is concerned with all products added to feed and mainly includes substances used to affect the quality of the feedstuff i.e., emulsifiers, stabilisers, antioxidants, colorants and binding agents and also vitamins and micronutrients. The majority of growth promoters exert their affects by antimicrobial activity and these and certain prophylactic medicinal products such as coccidiostats are also included. All products with a therapeutic action are controlled under the Veterinary Medicine Directives 81/851 and 81/852, quite separate legislation and under the responsibility of a different department within the EEC Coimdssion. However, there is provision under Directive 84/587 amending 70/524 to transfer the medicinal feed additives to 81/851 and 81/852.

Features response and course of typical pathological processes in burn disease in puberty

2015 ◽  
Vol 6 (4) ◽  
pp. 69-74
Author(s):  
Anastasia Grigorievna Vasilyeva ◽  
Evgeny Vladimirovich Zinoviev ◽  
Denis Valerievich Kostyakov
Keyword(s):  
Burn Injury ◽  
Endocrine System ◽  
Qualitative Change ◽  
The Body ◽  
External Shocks ◽  
Metabolic Processes ◽  
Burn Victims ◽  
Adaptive Capabilities ◽  
Burn Disease ◽  
Almost All

In response to burn injury in the body of the child in puberty naturally develop typical pathological processes, which include almost all organs and systems, leads to severe disruption of homeostasis failure of adaptive mechanisms. Burn is the most powerful stress factor that causes changes in the body that are typical of the general adaptation syndrome. The main pathogenesis and peculiarities of typical pathological processes in burn disease significantly affected are determined by the endocrine system. Produce hormones are involved not only in the starting mechanism, but also in the development of compensatory-adaptive reactions, mobilizing the body's protective properties. Thus, a feature of adolescence is that at this age the body undergoes a qualitative change to the restructuring of all systems. There are significant morphological and functional restructuring of important metabolic processes in the body organs like the pituitary gland, adrenal glands, thyroid and pancreas, characterized by high activity of metabolic processes, strengthening of cell and tissue differentiation, intensification of regenerative processes. The consequence is excessive functional activity of organs and systems at rest, associated with low and often paradoxical reactivity to external shocks, including a burn injury, which leads to a decrease in functional and adaptive capabilities of the organism adolescents. All these features to consider when choosing the strategy of surgical treatment of persons puberty, burn victims.

scholarly journals The effect of different doses of probiotic feed additives on hematologic indices and morphological structure of individual pig internal organs

2020 ◽  
Vol 3 (1) ◽  
pp. 13-20
Author(s):  
M. Zhyla ◽  
N. Shkodyak ◽  
G. Kotsyumbas ◽  
Y. Stronskyi ◽  
O. Sobodosh ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Histological Structure ◽  
Metabolic Processes ◽  
Morphological Studies ◽  
Significant Difference ◽  
White Breed

In order to improve the digestibility and absorption of feed, metabolic processes, growth and development of animals, increase the resistance of the body immunomodulatory agents, probiotics, prebiotics, combined enzyme-probiotic feed additives are widely used. The purpose of our work was to conduct comparative clinical trials of the effectiveness of the probiotic feed additive Probion-forte in terms of productivity, blood indices and histological structure of individual internal  pigs organs during fattening. The researches were carried out on 120 piglets of big white breed at the age of 28 days, which were divided into 4 groups with 30 units in each one. The probiotics were added to feed in different concentrations in order to determine their efficiency and examine influence on piglets organism: the first group was given probiotic Probion-forte in dose of 1.0 g/kg (10 weeks); the second one – Probion in dose of 1.0 g/kg (6 weeks) and 0.5 g/kg (4 weeks); the third one was given probiotic Bio Plus 2B in dose of 0.4 g/kg for 10 weeks; and the fourth one was a control group. The compound feed was provided according to norms recommended for big white breed taking into account age. On the 42nd day (6 weeks) and on the 70th day of test 10 units were selected for haematological, pathomorphological and microbiological tests. The productivity of animals of all studied groups was evaluated by the average daily gains, safety, feed conversion and slaughter output. The stabilized with EDTA piglets’ blood was used for morphological studies, and blood serum – for biochemical studies. The clinical trials have shown that the application of Probion-forte, as a feed additive for fattening of piglets within 10 weeks after weaning, did not cause adverse reactions, was well tolerated by animals and contributed to the improvement of the processes of erythropoiesis and leucopoiesis, increased of serum total protein content. The increasing activity of serum transaminases indicated more intense metabolic processes in experimental animals’ organism, which was confirmed by increase in average daily weight gains and slaughter output compared to control. In the microscopic examination of the thymus, spleen, lymph nodes, intestines, liver, the characteristic histological structure of the organs was preserved and indicated their active morphofunctional state throughout the study period. Morphometrically the increase in the height of the villi in the duodenum and the size of the thymus lobes in piglets, which were fed with probiotic feed additives was established. The efficiency and appropriateness of the application of these products was confirmed in the first and second experimental groups. However, the most significant difference was observed in piglets fed with Probion-forte for 10 weeks at a dose of 1.0 g/kg of feed.

scholarly journals The efficiency of the drug based on butaphosphane, B vitamins and L-carnitine in the treatment of horses

2021 ◽  
Vol 23 (101) ◽  
pp. 31-37
Author(s):  
O. M. Pyatnychko ◽  
M. I. Zhyla ◽  
N. V. Shkodyak ◽  
O. O. Saliy ◽  
M. V. Derkach ◽  
...  
Keyword(s):  
Clinical Condition ◽  
Physiological State ◽  
Feed Additives ◽  
The Body ◽  
B Vitamins ◽  
Biologically Active ◽  
Farm Animals ◽  
Vitamin B3 ◽  
Regulatory Processes ◽  
Complex Therapy

An important feature of living organisms, acquired in the process of evolution, is the ability to adapt to various external influences and changes in the environment, to maintain homeostasis and regulatory processes in organs, systems and the body as a whole. However, with modern breeding technologies, the physiological capabilities of the animal's body are often unable to change as quickly as required by the conditions of industrial maintenance, which leads to stress. Vitamin preparations and biologically active feed additives are widely used by veterinary medicine specialists to increase resistance to stressful situations, disease prevention, increase resistance, safety and productivity of farm animals. Preparation L-tsyn, solution for injection (manufactured by BIOTESTLAB LLC), is a drug, the action of which is due to the prescription combination of active substances, namely: butaphosphane, B vitamins (vitamin B12, vitamin B3) and L-carnitine. The aim of the study was to investigate the effectiveness of the drug L-tsyn on horses under the influence of stressors of various natures. Two experiments on working horses with constant, excessive physical activity with chronic exercises and with complex therapy of intoxication with signs of acute renal failure in horse were conducted. Clinical trials of the drug were performed on working horses aged 5–15 years, of different sexes. The drug was administered in a dose of 20–25 ml per animal, 1 time per day for 5 consecutive days. The clinical condition of the experimental animals was observed for 21 days from the start of the drug. The morpho-functional state of the animal's body before and after the drug was established according to the indicators of the clinical condition, morphological and biochemical parameters of the blood, which were determined according to generally accepted methods. In working horses under excessive load the drug L-tsyn activated the processes of hematopoiesis, improved the physiological state of the body and contributed to the increase the general tone of the body. The drug as part of complex therapy in the treatment of intoxication, showed hepato- and nephroprotective properties, reduced the manifestations of intoxication, helped to restoration of the animal’s normal physiological state. According to the results of clinical, hematological and biochemical studies, it can be concluded that the drug L-tsyn has a stimulating effect on metabolic processes in the animals’ body, shows tonic properties, increases the body's resistance to toxins and adverse environmental factors and can be used as monotherapy and for the complex treatment of diseases of various etiologies in horses.

scholarly journals Effects of a blend of chestnut and quebracho tannins on gut health and performance of broiler chickens

2021 ◽  
Author(s):  
Enzo A Redondo ◽  
Leandro M Redondo ◽  
Octavio A Bruzzone ◽  
Juan M Diaz-Carrasco ◽  
Claudio Cabral ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Health Indicators ◽  
Feed Additives ◽  
Farm Animals ◽  
In Vivo Model ◽  
Necrotic Enteritis ◽  
Gut Health ◽  
Growth Promoters ◽  
Gross Lesions

Consumer demands and increased regulations on the use of antimicrobials in farm animals accentuated the need to develop strategies to replace antimicrobial growth promoters (AGPs) in food-producing animals. The present study evaluates the productive and gut health outcomes during the implementation of AGPs free programs based on the inclusion of a tannin blend compared with AGPs based program under commercial conditions. In the first trial, 6 farms were randomly assigned to AGP or tannin-based programs. In a second trial, both programs were applied simultaneously in one farm and the results were studied over 1 year. Although productive results from both trials were similar among treatments, evaluations of gut health indicators show improvements in the tannins treated flocks. Frequency and severity of intestinal gross lesions were reduced in jejunum (42% vs 23%; p<0.05 – 1.37 vs. 0.73; p<0.01, respectively) and ileum (25% vs. 10%; p<0.0.5 – 1.05 vs. 0.58; p<0.01) in tannins treated birds. Results from 16S studies, show that cecal microbiota diversity was not differentially affected by AGPs or tannins, but changes in the relative abundance of certain taxa were described, including Lactobacillus and Bifidobacterium groups. Additional evaluations using an in vivo model for C. perfringens necrotic enteritis showed that tannins treated birds had reduced incidence of gross lesions in jejunum (43.75 vs. 74.19%; p<0.01) and ileum (18.75% vs. 45.16%; p<0.05) compared with control. These results suggest that AGPs can be replaced by tannins feed additives, and contribute in the implementation of antimicrobial-free programs in broilers without affecting health or performance.

scholarly journals Feed additives to enhance productivity and natural agricultural resistance of animals

2019 ◽  
Vol 80 (4) ◽  
pp. 292-297
Author(s):  
I. V. Cheryomushkina ◽  
A. E. Chernitsky ◽  
N. N. Manilevich
Keyword(s):  
Clinical Status ◽  
Adaptive Immune Response ◽  
Stress Sensitivity ◽  
Feed Additives ◽  
The Body ◽  
Natural Resistance ◽  
Farm Animals ◽  
Feed Additive ◽  
Control Drug ◽  
Gastrointestinal Pathology

The use of intensive technologies in industrial livestock leads to an increase in the stress sensitivity of animals, a decrease in their immune status and the development of pathological conditions. To increase the safety of young stock, including by reducing its incidence and death from diseases, feed additives are being developed, including probiotics, prebiotics and (or) other components that stimulate the immunological resistance of animals, their growth and productivity. This article examines the effectiveness of the use of a complex feed additive containing a multienzyme enzyme preparation, the probiotic preparation Prolam and amaranth oilcake to increase the efficiency of growing calves. The studies were performed on calves of the red-motley breed from 10 days of age in Voronezhpishcheprodukt LLC. The study of the effect of the feed additive on the immune and clinical status was carried out on 40 calves, which were divided into 4 groups. The calves of the three experimental groups used the feed additive at a dosage of 5, 10 and 15 g per day from day 10, the control drug was not used. The use of a complex feed additive to calves in the neonatal period helps to optimize the process of formation of intestinal microbiocenosis, increase the body's natural resistance and adaptive immune response to antigenic effects, accompanied by a decrease in the incidence of animals, the duration and severity of gastrointestinal pathology. The use of the feed additive in the dosage of 10–15 g / head per day favorably affected the growth rate and the natural resistance of the body of calves. The data obtained are the basis for the inclusion of feed additives in the diet of young farm animals.

Development and study of the effectiveness of a biologically active drug in the diet of sows

2021 ◽  
pp. 36-45
Author(s):  
N. I. Kulmakova ◽  
N.M. Kostomakhin ◽  
V. G. Semenov ◽  
R.M. Mudarisov ◽  
I.N. Khakimov ◽  
...  
Keyword(s):  
Active Drug ◽  
Live Weight ◽  
Essential Amino Acids ◽  
Feed Additives ◽  
The Body ◽  
Biologically Active ◽  
Daily Weight Gain ◽  
Metabolic Processes ◽  
Pregnancy And Lactation ◽  
Positive Effect

Many researchers note the need to improve feed additives and the search for new promising drugs for the intensification of the pig industry. We have developed a biologically active complex drug Microlact. It is used by animals as a means aimed at correcting the disturbed metabolism of sows associated with pregnancy and lactation, to activate the growth and development of piglets as well as their viability. The purpose of the work was to develop and study the effectiveness of the biologically active drug in the diet of lactating sows. The use of the drug led to the improvement of biochemical parameters of blood of pregnant sows, indicating the activation of metabolic processes in their body, which provided the increase in milk yield of sows, average daily weight gain of piglets and their livability. The live weight of piglets for weaning increased by 8,0% (P < 0,01), the livability of suckling piglets increased to 93,1%, which is a consequence of improving the quality of colostrum and milk, and consequently the positive effect of the biologically active drug containing an optimal complex of minerals, vitamin E in the composition of malt sprouts, essential amino acids and organic form of selenium. More nutritious colostrum and milk contributed to the better development of the piglets’ body and resistance to adverse factors. Immunoglobulins have been obtained by piglets with colostrum and milk increase their resistance and contribute to higher livability. The increase in the weight of suckling pigs has a positive effect on the further development and growth of animals on fattening. Thus, the administration of the biologically active drug Microlact to sows during pregnancy leads to the activation of metabolic processes, which can only be provided by a high level of functioning of the organs and systems of the body.

Influence of feed additives on the hematological and biochemical parameters of the blood of lactating cows

2022 ◽  
pp. 27-33
Author(s):  
R. A. Maksimova ◽  
◽  
E. M. Ermolova ◽  
V. I. Kosilov ◽  
Yu. A. Karmatskikh ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Live Weight ◽  
Blood Parameters ◽  
Feed Additives ◽  
The Body ◽  
Farm Animals ◽  
Feed Additive ◽  
Main Task ◽  
Lactating Cows ◽  
Hematological And Biochemical Parameters

Increasing the milk productivity of cows is the main task facing the livestock industry of our country. The study of some hematological and biochemical blood parameters in dairy cows when different feed additives are included in their rations is an urgent research task. The purpose of the investigations was to study the hematological and biochemical parameters of the blood of lactating cows when using different feed additives in the ration. During the investigations, the influence of feed additives such as Zaslon 2+ (at a dose of 20 g/head/day to the main ration), Diatomite (100 g/head/day to the main ration) and Monosporin (70 g/head/day to the main ration) on the hematological and biochemical blood parameters of lactating cows has been observed. The studied feed additives are used for the adsorption of mycotoxins in feed, normalization of digestive processes, and improvement of the livability and productivity of farm animals. In order to study the influence of the tested feed additives on the hematological parameters of the blood of lactating cows under the conditions of the Troitsky area in the Chelyabinsk region, on four groups of cows selected according to the principle of analogues (age, live weight, productivity, breed, physiological condition) the scientific and economic experiment has been carried out. As the result of the investigations, data have been obtained indicating that the feed additive Zaslon 2+ at the dose of 20 g/head/day has the greatest effect on the metabolism in the body of lactating cows.

Effect of Vasectomy and / or Adding Cuminum cyminum Seeds in the diet of Awassi Ram Lambs on their Carcasses Traits

2014 ◽  
Vol 38 (2) ◽  
pp. 79-86
Author(s):  
Tamara N. Dawood
Keyword(s):  
Body Weight ◽  
Carcass Traits ◽  
Feed Additives ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Muscle Area ◽  
Eye Muscle ◽  
The Third ◽  
Ram Lambs

     This experiment was carried out at Animal Farm, College of Veterinary Medicine, Baghdad University, from Mar. up to Sept. 2010. Twenty eight Awassi ram lambs of 4-5 months old were equally divided into four groups of similar body weight and fed 2% of concentrate diet of body weight with grazing for 3-4 hours a day. The first group (C) and the third group (V) were fed concentrate diet free of cumin seeds; while the second group (CU) and the fourth group (CV) were fed the same amount of concentrate diet contain 3% of cumin seeds. All animals were grazed daily for 3-4 hours as one group. The third and the fourth groups were vasectomized by close vasectomy operation at the beginning of the experiment.  The results revealed that cumin seeds used as feed additives for Awassi ram lambs caused significant (P<0.05) increase in live animal body weight, fasting and empty body weight, hot and cold carcass weights also it had an effect on carcass measurements, empty digestive and stomach weight, most carcass joints weight, rib eye muscle area, Longismus dorsi weight, lean and fat weight in the rack joint compare with the control group. However vasectomy had significant (P<0.05) increase in the body weight, fasting, empty and hot and cold carcass weight, the weight of pelt, full and empty digestive system, most of joint weights, fat tail, fat weight of the rack joint, while the 4th group showed higher values than the most carcass traits compared with the 2nd and 3rd groups and significantly (P<0.05) higher than the control group (1st group). It is concluded that vasectomy and cumin seeds have positive effect on lamb performance and carcass traits. Cumin seeds can be used as effective and cheep feed additives. Further studied are required to prove the suitable ratio of cumin seeds addition alongside with castration in other farm animals.

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