scholarly journals The efficiency of the drug based on butaphosphane, B vitamins and L-carnitine in the treatment of horses

2021 ◽  
Vol 23 (101) ◽  
pp. 31-37
Author(s):  
O. M. Pyatnychko ◽  
M. I. Zhyla ◽  
N. V. Shkodyak ◽  
O. O. Saliy ◽  
M. V. Derkach ◽  
...  

An important feature of living organisms, acquired in the process of evolution, is the ability to adapt to various external influences and changes in the environment, to maintain homeostasis and regulatory processes in organs, systems and the body as a whole. However, with modern breeding technologies, the physiological capabilities of the animal's body are often unable to change as quickly as required by the conditions of industrial maintenance, which leads to stress. Vitamin preparations and biologically active feed additives are widely used by veterinary medicine specialists to increase resistance to stressful situations, disease prevention, increase resistance, safety and productivity of farm animals. Preparation L-tsyn, solution for injection (manufactured by BIOTESTLAB LLC), is a drug, the action of which is due to the prescription combination of active substances, namely: butaphosphane, B vitamins (vitamin B12, vitamin B3) and L-carnitine. The aim of the study was to investigate the effectiveness of the drug L-tsyn on horses under the influence of stressors of various natures. Two experiments on working horses with constant, excessive physical activity with chronic exercises and with complex therapy of intoxication with signs of acute renal failure in horse were conducted. Clinical trials of the drug were performed on working horses aged 5–15 years, of different sexes. The drug was administered in a dose of 20–25 ml per animal, 1 time per day for 5 consecutive days. The clinical condition of the experimental animals was observed for 21 days from the start of the drug. The morpho-functional state of the animal's body before and after the drug was established according to the indicators of the clinical condition, morphological and biochemical parameters of the blood, which were determined according to generally accepted methods. In working horses under excessive load the drug L-tsyn activated the processes of hematopoiesis, improved the physiological state of the body and contributed to the increase the general tone of the body. The drug as part of complex therapy in the treatment of intoxication, showed hepato- and nephroprotective properties, reduced the manifestations of intoxication, helped to restoration of the animal’s normal physiological state. According to the results of clinical, hematological and biochemical studies, it can be concluded that the drug L-tsyn has a stimulating effect on metabolic processes in the animals’ body, shows tonic properties, increases the body's resistance to toxins and adverse environmental factors and can be used as monotherapy and for the complex treatment of diseases of various etiologies in horses.

Author(s):  
V.G. Stoyanovskyy ◽  
O.I. Kamratska ◽  
I.A. Kolomiіets ◽  
O.I. Slepokura

The article is devoted to increasing the preserving and survival of piglets in conditions of industrial cultivation, where their organism is exposed to constant effects of adverse technological factors. The state of stress that occurs in this case leads to a decrease in the rate of growth and resistance of the young to a variety of diseases and can ultimately cause death of animals. One of the most promising directions for preventing the negative effects of stress and increasing the overall resistance of the piglet organism is the search, development and introduction of dietary supplements that increase physiological processes in the body, improve metabolism, increase the energy of growth, increase the yield of meat products. The purpose of the work was to find out the physiological state of a piglet organism during the period of weaning at the influence of the biologically active feed supplement «Praimiks Bionorm K» in the conditions of the SEPC «Komarnivsky». The research was carried out on piglets of 5 – 60-day-old age of the Poltava beef breed. Technological stress was the weaning of piglets at 40 days of age and the group maintenance of them with a change in the structure of the ration during the growing season. Piglets of the experimental group, together with the main feed, were additionally fed with «Praimiks Bionorm K» in the amount of 9.0 g/100 kg of feed (manufacturer – biotechnology company «Ariadna» Odessa). According to the results of the conducted research, it was found that the process of adaptation of the organism of the piglets of the control group to the stress isolation after 5 days was accompanied by an increase in blood hemoglobin concentration in 1.35 times (P < 0.01), the number of leukocytes – by 1.21 times (P < 0.05) at the expense of rodent and segmental neutrophils and monocytes – 1.54 times (P < 0.01), with a decrease in the number of eosinophils – 3.0 times (P < 0.001) and lymphocytes – 1.15 times (P < 0.01), compared with the period before weaning. 20 days after weaning in the K group, there was a decrease in the number of eosinophils in the blood by 2.25 times in the blood and lymphocytes by 1.25 times (P < 0.01), in the increase in the cellular and segmental neutrophils by 2.15 and 1.90 times, monocytes – by 1.85 times (P < 0.01) in comparison with the period before weaning. Neutrophilia, lymphopenia and eosinopenia were the most pronounced and persistent signs of stress in the piglets of the K group that arose out of the regulatory influence of glucocorticoids. While using biologically active feed supplement «Praimiks-Bionorm K» 5 days after weaning in the blood of piglets, the content of hemoglobin increased by 1.26 times; after 20 days its concentration increased by 1.22 times, as well as the increase in the number of leukocytes in 1.22 times (P < 0.01), neutrophils of rod-nuclei – 2.0 times, segmental ones – 1.37 times (P < 0.01), compared to control. The obtained results indicate that the use of BAFA «Praimiks Bionorm-K» allows to prevent the development of stressful events in the piglet organism, improve the status of the cellular level of nonspecific resistance and the level of productivity during the period of weaning and at different stages of development of the stress reaction after weaning.


Vestnik ◽  
2021 ◽  
pp. 190-195
Author(s):  
М.С. Кулбаева ◽  
А.Н. Курал ◽  
Л.Б. Умбетьярова ◽  
Н.Т. Аблайханова ◽  
Г.К. Атанбаева ◽  
...  

Человека давно интересует вопрос о том, как умственная нагрузка влияет на организм. Известно, что при длительной умственной работе преобразуется сила процессов возбуждения и торможения, изменяется соотношение между ними. С возникновением утомления в головном мозгу нарушаются взаимосвязи между корой больших полушарий и подкорковыми образованиями. При этом наблюдается снижение регулирующего влияния больших полушарий на все функции организма и уменьшение активизирующих воздействий подкорковых отделов мозга. Кроме того, длительное сидячие положение, состояние низкой двигательной активности ведут к значительному уменьшению центростремительных импульсов с рецепторов мышц, сухожилий, суставов. В исследовании приняли участие 17 относительно здоровые, имеющие стабильное физиологическое состояние девушек-студенток в возрасте от 21 до 25 лет. Для исследования были взяты 16 биологически активных точек на стандартных меридианах, связаных с определенным органом. Для оценки физиологического состояния органов до и после умственной нагрузки были исследованы показатели ЭП БАТ на коже. Выявлено снижение показателей каждого органа после умственной нагрузки по сравнению с показателями до ее выполнения со статистической достоверностью во всех исследуемых органах (р<0,05). Особенно низкие значения показателей ЭП БАТ после умственной нагрузки были выявлены в биоактивных точках меридиана печени F.3 Тай-Чун, меридиана толстой кишки GI.5 Ян-Си и GI.4 Хэ-Гу, меридиана сердца С.7 Шэнь-Мэнь, меридиана тонкой кишки IG.1 Шао-Цзе и IG.2 Цянь-Гу, меридиана почек R.1 Юн-Цюань и Р.2 Жань-Гу. Humans has long been interested in the question of how mental activity affects the body It is known that with prolonged mental work, the strength of the processes of excitation and inhibition is transformed, the ratio between them changes. With the onset of fatigue in the brain, the relationship between the cerebral cortex and subcortical formations is disrupted. At the same time, there is a decrease in the regulatory influence of the large hemispheres on all body functions and a decrease in the activating effects of the subcortical parts of the brain. In addition, prolonged sitting, a state of low motor activity leads to a significant decrease in centripetal impulses from the receptors of muscles, tendons, and joints. The study involved 17 relatively healthy, stable physiological condition of female students aged 21 to 25 years. For the study, 16 biologically active points were taken from standard meridians associated with a specific organ. To assess the physiological state of the organs before and after the load of mental labor, the indicators of EC BAP on the skin. A decrease in the indicators of each organ after mental labor was revealed in comparison with the indicators before mental labor with statistical reliability in all the studied organs (p˂0.05). Especially low values of the EC BAP values after a load of mental labor were found in the bioactive points of the liver meridian F. 3 Tai-Chun, the colon meridian GI.5 Yang-Si and GI. 4 He-Gu, the heart meridian C. 7 Shen-Men, the small intestine meridian IG.1 Shao-tse and IG.2 Qian-Gu, the meridian of the kidneys R. 1 Yun-Chuan and R. 2 Zhan-Gu.


2021 ◽  
pp. 8-14
Author(s):  
Светлана Тарасовна Быкова ◽  
Тамара Григорьевна Калинина ◽  
Ирина Макаровна Московская

Полноценное, сбалансированное питание - основной фактор в формировании здоровья детей, когда в организме наиболее интенсивно протекают процессы роста и развития, формируются и созревают многие органы и системы, совершенствуются их функции. В статье приведены основные направления исследований зарубежных и отечественных ученых по лечению генетических заболеваний, таких как фенилкетонурия. Одним из приоритетных направлений в области здорового питания населения России в соответствии со Стратегией научно-технологического развития РФ до 2030 г. является развитие производства пищевых продуктов, обогащенных незаменимыми ингредиентами, специализированных продуктов детского питания, продуктов функционального назначения, диетических пищевых продуктов и биологически активных добавок. По данным ВОЗ от структуры питания на 70 % зависят здоровье и физическое развитие детей и подростков. Фенилкетонурия (ФКУ) - наследственное заболевание, вызывающее нарушение метаболизма аминокислоты фенилаланина у ребенка, одно из первых, рекомендованных ВОЗ для ранней диагностики у новорожденных. Отсутствие лечения вызывают серьезное поражение центральной нервной системы, отставание в умственном и физическом развитии. Особенностью современного этапа развития диетотерапии для детей, страдающих различными заболеваниями, в том числе наследственными, является разработка качественных функциональных продуктов питания, способствующих сохранению и улучшению здоровья ребенка за счет регулирующего и нормализующего воздействия на организм с учетом его физиологического состояния и возраста. Данные продукты можно широко использовать в практике лечебного питания не только в составе гипофенилаланиновой диеты, но и при любых заболеваниях, требующих ее соблюдения. В настоящее время единственным методом лечения ФКУ является диетотерапия, организованная с первых дней жизни с использованием специализированных смесей без фенилаланина. Из питания исключаются высокобелковые продукты растительного и животного происхождения. Целью лечебного воздействия диеты на ребенка является поддержка концентрации фенилаланина (ФА) в крови в пределах 2-12 мг на 100 мл в зависимости от возраста ребенка. Full-fledged balanced nutrition is the main factor in the formation of children's health, when the processes of growth and development are most intense in the body, many organs and systems are formed and mature, and their functions are improved. The article presents the main research areas of foreign and domestic scientists on the treatment of genetic diseases, such as phenylketonuria. One of the priority areas in the field of healthy nutrition of the Russian population in accordance with the Strategy for Scientific and Technological Development of the Russian Federation until 2030 is the development of the production of food products enriched with essential ingredients, specialized children's food products, functional products, dietary food products and biologically active additives. According to WHO, the health and physical development of children and adolescents depends on the nutritional structure by 70%. Phenylketonuria (PKN) - an inherited disease that causes impaired metabolism of the amino acid phenylalanine in a child - is one of the first recommended by WHO for early diagnosis in newborns. Lack of treatment causes serious damage to the central nervous system, a lag in mental and physical development. A feature of the modern stage of development of dietary therapy for children suffering from various diseases, including hereditary ones, is the development of quality functional food products that contribute to the preservation and improvement of the health of the child, due to the regulatory and normalizing effect on the body, taking into account its physiological state and age. These products can be widely used in the practice of therapeutic nutrition not only in the sastava of the hypophenylalanine diet, but also for any diseases requiring its observance. Currently, the only method of treating PKN is diet therapy, organized from the first days of life using specialized mixtures without phenylalanine. High-protein products of vegetable and animal origin are excluded from nutrition. The goal of the therapeutic effect of the diet on the child is to maintain the concentration of phenylalanine (FA) in the blood in the range of 2-12 mg per 100 ml, depending on the age of the child.


2021 ◽  
Vol 23 (104) ◽  
pp. 10-17
Author(s):  
L. V. Vyslotska ◽  
B. V. Gutyj ◽  
O. V. Kozenko ◽  
V. I. Khalak ◽  
M. V. Chornyj ◽  
...  

One of the conditions for obtaining high-quality pig products is the use of feed additives, which contain all the necessary biologically active substances, eliminating their deficiency in feed and acting as catalysts for metabolic processes in pigs. That is why the aim of the study was to study the effect of feed additive “Sylimevit” on the enzymatic and non-enzymatic parts of the antioxidant system of piglets after weaning. Two groups of piglets were formed – control and experimental, in the amount of 10 individuals in each group, selected on the principle of analogues – age, breed and body weight. During the weaning period, the piglets were kept under the sow in special machines, had constant access to the mother, and from the age of 5 days – free access to concentrated feed. Feeding of animals was carried out in accordance with the norms for a given age of pigs. Prior to the study, a clinical and physiological examination of the piglets was performed. Their general condition and activity when eating food were taken into account. On the 28th day of life, the piglets were weaned from the sow and regrouped from different nests in order to be further maintained during the period of fattening and rearing with a change in the structure of the diet, which served as technological stress for the animals. From the age of 5 days, piglets of all groups were fed pre-starter feed. Piglets of the experimental group, from 21 to 40 days of age, were additionally fed the feed supplement “Sylimevit” at a dose of 100 mg/kg body weight per day. Feeding piglets Silimevit feed enhances their antioxidant status. The use of this feed additive in piglets contributed to the activation of both enzymatic and non-enzymatic parts of the antioxidant defense system of piglets after weaning, as indicated by an increase in blood 35-day-old piglets superoxide dismutase activity by 26.9 % (P < 0.001), catalase – 41.1 % (P < 0.001), glutathione peroxidase – by 52.7 % (P < 0.05), glutathione reductase – by 53.5 % (P < 0.05), the content of reduced glutathione – by 75 % (P < 0.001). This is due to the fact that silimevit contains active substances such as milk thistle and vitamins, which are strong direct-acting antioxidants and directly interact with free radicals and reactive oxygen species.


Author(s):  
S. S. Mirgalimova ◽  
A. O. Trufanova ◽  
R. R. Fatkullin

The physiological state of animals is to a certain extent characterized by hematological indicators, since blood occupies a special place in the body. By transferring nutrients and biologically active substances, the blood performs the general regulation of vital functions of the body. The use of Vitartil as a feed additive in the diets of animals leads to an increase in glycolytic processes and a decrease in the body’s need for oxygen delivery, which contributes to the growth of the animal body. The purpose of the research was to study the changes in blood parameters taking into account the age of Hereford steers against the background of the use of Vitartil feed additive to the main diet and its effect on the productive traits of animals. In order to carry out the experiment two groups of steers-analogs of Hereford breed have been formed at the age of 6 months per 10 heads in each. The difference between the groups was that the steers of the experimental group have been received the feed additive Vitartil in addition to the main diet. The greater yield of the meat part was in the steers of the experimental group in comparison with the herdmates of the control group. This indicator in the experimental group was 78,9 %, while in the control group it was lower by 1,6 %. The animals of the experimental group were superior to their herdmates in terms of meat weight by 1,4 kg or by 8,8 %. The relative number of bones was lower in the experimental group and amounted to 18,4 %, and in the control group 19,2 %. The meat content index was high in the steer have been received the biologically active additive Vitartil and was 4,3, and in the control group 4,0. It has been found that the use of Vitartil feed additive to the main diet of Hereford steers increases the blood content of hemoglobin and glucose, which has a certain effect on the morphological and chemical composition of meat, as well as increases its energy value.


Author(s):  
L. P. Yarmots ◽  
G. A. Yarmots ◽  
A. E. Belenkaya ◽  
M. O. Smyshlyaeva

Unbalanced mineral and vitamin nutrition of lactating cows can be a critical factor in the realization of their productive potential. The development and introduction into production of inexpensive, but effective feed additives is the main trend of improving the feeding of modern animal husbandry. Under the conditions of the Tyumen region such natural raw materials can be sapropels, which successfully combine a variety of biologically active substances. The purpose of the research was to study the digestibility of nutrients and energy metabolism in lactating cows when sapropel is included in the ration. Scientifi c and economic experiment in the study of the effectiveness of feeding sapropel lake Nepryak has been carried out in the training and experimental farm of the State Northern Trans-Urals Agrarian University. The animals of the control group have been fed the main diet. Cows of the 1st and 2nd experimental groups have been fed 300 and 500 g of sapropel per head/day, respectively, in addition to the main ration. It has been found as a result of research that the introduction of sapropel into the ration of cows has a positive effect on the digestibility of nutrients. The digestibility coefficients were higher in the animals of the 1st and 2nd experimental groups compared with the cows of the control group. Cows from the experimental groups digested all the organic substances of the ration better. During the experiment period cows of the 1st and 2nd experimental groups in contrast to the control group had higher milk yield by 11,31 and 10,38 %, respectively, milk protein yield by 10,56 and 5,95 %, milk fat yield by 17,18 and 12,99 %. It has been established that the introduction of sapropel into the ration of cows has the positive effect on the digestibility of nutrients, contributes to the increase of milk productivity, normalizes the metabolism in the body.


2018 ◽  
Vol 20 (92) ◽  
pp. 137-141
Author(s):  
B. Kyryliv

We have studied the dynamics of growth and development of chicken egg production of line cross “Hayseks brown” from day age to the age of peak performance. During the experiment, the study of the intensity of metabolic processes in the body of 6, 35, 90, 120, and 150 day-olds, i.e., in critical periods when there is intense growth of feathers and juvenile molten (30–60 days), the beginning of the oviposition (120 days) and the beginning of an intensive oviposition (150 days). In these age periods, the level of soluble proteins, amine nitrogen, and the activity of alanine and aspartate aminotransferases were determined in liver tissues, cuticles of the muscular stomach, gastrointestinal mucosa, gastrointestinal mucosa, duodenum and pancreas. As a result of the research, it was found that the intensity of the growth of chickens is different from the recommendation for the “Hayseks Brown” cross. Only at the age of 119–126 days growing the body weight of the reared chickens coincides with the recommended technology for hens of the cross “Hayseks Brown”. The results of biochemical studies are related to changes in the physiological state and magnitude of gains. During the growth of repair young poultry, in the critical periods of growth and development, it is necessary to deliberately affect the processes of protein metabolism by enhancing the processes of digestion and assimilation of nutrients and biologically active substances of fodder and the sufficient introduction of free amino acids by the use of exogenous enzyme preparations.


2021 ◽  
pp. 56-71
Author(s):  
N. Polischuk ◽  
◽  
B. Коvаlеnkо ◽  
V. Коvаlеnkо ◽  
◽  
...  

Purpose. To prepare a justification for the use of sodium and potassium salts of humic and fulvic acids (humates) as substances with biologically active properties in fish feeds based on the analysis of sources of scientific and technical information and own experimental materials, Findings. A complex general characteristic of humic substances was provided, the mechanism of biologically active action of humates on living organisms was described. Examples of the use of humates in crop production, medicine, animal husbandry and aquaculture were given. The results of our own studies on the use of humates as a feed additive for valuable objects of aquaculture were presented. Prospects for the inclusion of micro-additives of sodium and potassium humates in the composition of fish feed in order to increase fish survival and digestibility of feed were outlined. Originality. To date, the introduction of humates into fish feed as micronutrients was experimental. The analysis of scientific sources and materials of own studies gave the basis for the conclusion about the need of complex detailed studying of mechanisms of effects of humates on fish. In particular, it is of interest to study the protective properties of humates from the accumulation of heavy metals in the body of fish for the use of micronutrients of these substances in fish feeds. Practical value. The use of humate feed additives in aquaculture will help to solve such urgent problems as the prevention of excessive losses of biological material of cultivated objects, reduction of feed costs, improvement of consumer characteristics of food products. Humates, as substances of natural origin with protective and immunomodulatory action, can become substitutes for some synthetic therapeutic and prophylactic drugs. Key words: aquaculture, humates, compound feed, feed additive, growth rate, survival, feed assimilation.


Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 230
Author(s):  
Mendel Friedman ◽  
Christina C. Tam ◽  
Jong H. Kim ◽  
Sydney Escobar ◽  
Steven Gong ◽  
...  

Trichomoniasis in humans, caused by the protozoal parasite Trichomonas vaginalis, is the most common non-viral sexually transmitted disease, while Tritrichomonas foetus causes trichomonosis, an infection of the gastrointestinal tract and diarrhea in farm animals and domesticated cats. As part of an effort to determine the inhibitory effects of plant-based extracts and pure compounds, seven commercially available cherry tomato varieties were hand-peeled, freeze-dried, and pounded into powders. The anti-trichomonad inhibitory activities of these peel powders at 0.02% concentration determined using an in vitro cell assay varied widely from 0.0% to 66.7% against T. vaginalis G3 (human); from 0.9% to 66.8% for T. foetus C1 (feline); and from 0.0% to 81.3% for T. foetus D1 (bovine). The organic Solanum lycopersicum var. cerasiforme (D) peels were the most active against all three trichomonads, inhibiting 52.2% (G3), 66.8% (C1), and 81.3% (D1). Additional assays showed that none of the powders inhibited the growth of foodborne pathogenic bacteria, pathogenic fungi, or non-pathogenic lactobacilli. Tomato peel and pomace powders with high content of described biologically active compounds could serve as functional food and feed additives that might help overcome adverse effects of wide-ranging diseases and complement the treatment of parasites with the anti-trichomonad drug metronidazole.


Author(s):  
S. V. Ponomarev ◽  
Y. V. Fedorovykh ◽  
A. B. Akhmedzhanova ◽  
O. A. Levina ◽  
V. A. Pospelov ◽  
...  

Modern technologies of industrial fish farming allow getting high-quality products. However, stressful conditions of an artificial ecosystem (high planting density, violation of optimal hydrochemical conditions) can negatively affect food activity, growth rate, lead to the development of alimentary diseases and depletion of the antioxidant potential In conditions when fish is deprived of natural food, and the metabolism is completely under human control, the use of balanced feeds enriched with macro — and microelements, as well as biologically active substances, maximizes metabolic processes and helps to increase the growth rate and obtain physiologically complete juveniles. The use of antioxidant feed additives allows not only to carry out timely therapy, but also to provide a preventive effect to prevent the negative consequences of an artificial ecosystem. Currently, there are a number of antioxidant feed additives, among which are of particular interest to natural bioantioxidant of flavonoid nature, such as catechins, dihydrochalcones, flavonols, leukocyanins, dihydroquercetin. The article discusses the experience of using a new generation antioxidant — dihydroquercetin and an immunostimulator — arabinogalactan in feeding a tilapia hybrid (Oreochromis mossambicus × Oreochromis niloticus). It was found that the addition of dihydroquercetin (25,0– 50,0 mg/kg) and arabinogalactan (50,0 mg/kg) to the production feed allowed to increase productivity by 26,0%, as well as to show a positive effect on the physiological state of fish. The results obtained complement the existing ideas about the fields of application of antioxidants, and also prove the prospects of using plant-based products as antioxidant feed additives.


Sign in / Sign up

Export Citation Format

Share Document