scholarly journals Cross-border dissemination of lumpy skin disease: risc analysis for Ukraine

2018 ◽  
Vol 20 (88) ◽  
pp. 131-135
Author(s):  
Ya. V. Kisera ◽  
Yu. G. Storchak ◽  
L. Ya. Bozhyk
Keyword(s):  
Skin Disease ◽  
Large Scale ◽  
Animal Health ◽  
Herd Immunity ◽  
Ecological Niches ◽  
Buffer Zones ◽  
European Continent ◽  
Lumpy Skin Disease ◽  
Endemic Diseases ◽  
Blood Sucking

National biosecurity is a system of organizational and technical measures that help protect humans, animals and the environment from potential and actual biological threats. That is why analysis of the main hazardous biological sources for humans and animals has been carried out. The influence of climate change on the animals’ welfare as well as their predisposition to the deferred type tendency is proved. The prevalence of vector diseases of animals, mycoses and mycotoxicoses, which can manifest themselves in the form of such emergencies as outbreaks of exotic diseases, large-scale epizootics, a sharp increase of the incidence of endemic diseases, etc., are of both ecological and biological danger. Contagious vesicular (nodular) dermatitis (Lumpy skin disease, LSD) is caused by the virus belonging to the genus Capripoxvirus, the Poxviridae family and affects mainly cattle and buffaloes. The virus is distributed mainly by means of mechanical carriers (species of Stomoxys spp. and other flies). Global warming on the European continent facilitates the migration of blood-sucking insects that are carriers of vector diseases. As a result, the insects occupy new ecological niches adapting to the new biocenoses. A poorly controlled movement of large numbers of livestock also creates a risk of disease spreading. The World Organization for Animal Health (OIE) has identified LSD as highly dangerous illnesses subject to notification. The focus is made on policies dealing with the control and eradication of contagious nodular dermatitis in case of its detection. The spread of LSD can be prevented through the introduction of biosafety measures at the farm level and the introduction of restrictions on the movement of infection-susceptible animals and goods from the infected territories. Vaccination is the most effective disease control tool in endemic areas. LSD control and elimination policy in case of disease detection includes sanitary slaughter (stamping-out) of infected animals – a complex of antiepizootic measures that carry out by direction  of the chief state inspector, including the slaughter of sick and infected animals of the herd, and if necessary, animals of another herd that could lead before the transmission of a pathogenic agent – the pathogen of contagious nodular dermatitis of cattle. All animals, that are susceptible to the disease, whether vaccinated or not, are clogged and their carcasses are destroyed by burning, burial with the guarantee of preventing the spread of infection through carcasses or other products of dead animals. Emergency control of outbreaks envisages the ring vaccination of buffer zones within 25–50 km from infected areas, as well as foundation of temporary or permanent slaughter places in the infected areas. Sufficient herd immunity must be created and maintained within large territories both around the infected area and at the borders with infected countries. Such immunity is achieved when 80% of the herd is covered by vaccination.

scholarly journals Development of a Safe and Highly Efficient Inactivated Vaccine Candidate against Lumpy Skin Disease Virus

Vaccines ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Janika Wolff ◽  
Tom Moritz ◽  
Kore Schlottau ◽  
Donata Hoffmann ◽  
Martin Beer ◽  
...  
Keyword(s):  
Skin Disease ◽  
Animal Health ◽  
Vaccine Virus ◽  
Lumpy Skin Disease ◽  
Virus Shedding ◽  
Clinical Protection ◽  
Inactivated Vaccines ◽  
Disease Free ◽  
World Organisation ◽  
Free Status

Capripox virus (CaPV)-induced diseases (lumpy skin disease, sheeppox, goatpox) are described as the most serious pox diseases of livestock animals, and therefore are listed as notifiable diseases under guidelines of the World Organisation for Animal Health (OIE). Until now, only live-attenuated vaccines are commercially available for the control of CaPV. Due to numerous potential problems after vaccination (e.g., loss of the disease-free status of the respective country, the possibility of vaccine virus shedding and transmission as well as the risk of recombination with field strains during natural outbreaks), the use of these vaccines must be considered carefully and is not recommended in CaPV-free countries. Therefore, innocuous and efficacious inactivated vaccines against CaPV would provide a great tool for control of these diseases. Unfortunately, most inactivated Capripox vaccines were reported as insufficient and protection seemed to be only short-lived. Nevertheless, a few studies dealing with inactivated vaccines against CaPV are published, giving evidence for good clinical protection against CaPV-infections. In our studies, a low molecular weight copolymer-adjuvanted vaccine formulation was able to induce sterile immunity in the respective animals after severe challenge infection. Our findings strongly support the possibility of useful inactivated vaccines against CaPV-infections, and indicate a marked impact of the chosen adjuvant for the level of protection.

scholarly journals Characterization of a Nigerian Lumpy Skin Disease Virus Isolate after Experimental Infection of Cattle

Pathogens ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 16
Author(s):  
Janika Wolff ◽  
Eeva Tuppurainen ◽  
Adeyinka Adedeji ◽  
Clement Meseko ◽  
Olayinka Asala ◽  
...  
Keyword(s):  
Disease Virus ◽  
Experimental Infection ◽  
Skin Disease ◽  
Clinical Course ◽  
Animal Health ◽  
Trade Restrictions ◽  
Skin Sample ◽  
Lumpy Skin Disease ◽  
Lumpy Skin Disease Virus ◽  
Large Ruminant

Lumpy skin disease virus (LSDV), together with sheeppox virus and goatpox virus, belong to the genus Capripoxvirus within the family Poxviridae. Collectively, they are considered the most serious poxvirus diseases of agricultural livestock. Due to their severe clinical course and consequent loss of production, as well as high mortality of naïve small and large ruminant populations, they are known to have a significant impact on the economy and global trade restrictions of affected countries. Therefore, all capripox diseases are classified as notifiable under the guidelines of the World Organization of Animal Health (OIE). Since the 1970s, several outbreaks of LSD have been recorded in Nigeria. Until now, only a little information on the virus strains leading to the reported outbreaks have been published, dealing mainly with the phylogenetic relationship of those strains and the description of field outbreaks. During the present study, we experimentally infected cattle with a low-passage Nigerian LSDV strain isolated from a skin sample of LSD positive cattle in Nigeria in 2018. Clinical, molecular and serological data indicate that this LSDV isolate is highly pathogenic in cattle since it induced a severe clinical course and approximately 33% mortality in naïve Holstein Friesian cattle after experimental infection.

scholarly journals Assessment on Economic Losses due to Animal Health and Production Constraints in Jimma Town Intensive Dairy Farms, Jimma, Ethiopia

2020 ◽  
pp. 52-60
Keyword(s):  
Skin Disease ◽  
Animal Health ◽  
Dairy Farms ◽  
Dairy Farming ◽  
Economic Losses ◽  
Financial Loss ◽  
Lumpy Skin Disease ◽  
Production Constraints ◽  
Milk Fever ◽  
Jimma Town

A single-visit-multiple subject formal survey technique was used to collect data from 75 small-scale dairy farming households which were selected at random and were interviewed using a pre-tested, semi-structured questionnaire. Seventy-three (97.3%) dairy farming was practiced under an intensive management system. Among the selected dairy farms, only (33.3%) were kept in good hygienic condition. Artificial insemination was common (69.3%) breeding system practiced in most dairy farms of studying area. This study discovered that only a few dairy farms (2.7%) undergo periodic vaccination. It appeared from the study that morbidity loss of animals was primarily caused by mastitis which calculated (42.7%), black leg (32%), lumpy skin disease (21.3%), milk fever (17.3%), heart water (10.7%) and foot rote (5.3%) in order of their decreasing order. The results of this survey revealed that mastitis was ranked as the number one disease of dairy animals while foot rote was list reported disease in the study area. Morbidity loss of production and productivity was estimated to the financial loss of (812,600 birrs) per year. Not only morbidity loss, in some farms, mortality was also common problems of the study area. Mainly common diseases such as heart water (6.7%), milk fever (5.3%), back leg (2.7%), and lumpy skin disease (1.7%) were major causes of mortality in few farms. This in turn estimated the financial loss of (625,000 birrs). Eventually, overall annual financial loss as a result of mortality and morbidity was estimated to be (1,437,600 birrs). The outbreak of lumpy skin disease and blacklegs could be controlled through improving veterinary services with respect to adequate vaccination and heart water (seasonal tick infestation) would be alleviated by spraying. The aim of the study was to assess assessment on economic losses due to animal health and production constraints in Jimma town intensive dairy farms, Jimma, Ethiopia.

Risk analysis of lumpy skin disease in Turkey

2016 ◽  
Author(s):  
Ömer Baris Ince ◽  
Serkan Çakir ◽  
Mehmet Ali Dereli
Keyword(s):  
Risk Analysis ◽  
Skin Disease ◽  
Control Strategies ◽  
Animal Health ◽  
Economic Loss ◽  
Control Measures ◽  
Lumpy Skin Disease ◽  
The World ◽  
Potential Risks ◽  
And Control

Lumpy Skin Disease (LSD) in Turkish cattle appeared suddenly two years ago. This study evaluates potential risks of LSD and recommends appropriate control measures. The World Animal Health Organization’s protocol was used for the risk analysis. Likelihoods for disease release and exposure were estimated with a qualitative scale ranging from negligible to high. Outbreaks were recorded in nine provinces in Turkey. Total economic loss due to the disease was estimated to be $241.903.500 US dollars. The risk analysis suggests a greater than negligible risk. Therefore, disease prevention and control strategies should be considered by the Turkish Veterinary Authority.

scholarly journals Epidemiological features of Lumpy skin disease of the large ruminants: Review of literature

2020 ◽  
Vol 6 (4) ◽  
pp. 9-12
Author(s):  
Sh. K. Zeynalova
Keyword(s):  
Skin Disease ◽  
Animal Health ◽  
Biological Properties ◽  
Economic Consequences ◽  
Lumpy Skin Disease ◽  
Urgent Task ◽  
The World ◽  
Spread Of Infection ◽  
Short Time ◽  
World Organisation

Lumpy skin disease (LSD) is an infectious disease in cattle, characterized by nodules on the surface of the skin and which can have serious economic consequences. Starting from 2014, new outbreaks of LSD in the world and its spread to Central Asia and the Middle East are noted. Due to the huge economic impact on the economy, the World Organisation for Animal Health (OIE) has classified LSD as a particularly dangerous disease that needs to be notified. The analysis of the literature on LSD shows that many issues remain unstudied and require appropriate research to be carried out. In connection with the difficult epizootic situation and the threat of further spread of the virus, the urgent task is the study of biological properties of the causative agent with a view of development the specific prophylactic agents that would allow to prevent the spread of infection in a short time

scholarly journals Evaluation of Serological Tests for Detection of Antibodies against Lumpy Skin Disease Virus

2020 ◽  
Vol 58 (9) ◽  
Author(s):  
Nina Krešić ◽  
Ivana Šimić ◽  
Tomislav Bedeković ◽  
Žaklin Acinger-Rogić ◽  
Ivana Lojkić
Keyword(s):  
Skin Disease ◽  
Neutralizing Antibodies ◽  
Large Scale ◽  
Neutralization Test ◽  
Virus Neutralization Test ◽  
Virus Neutralization ◽  
Enzyme Linked Immunosorbent Assay ◽  
Surveillance Program ◽  
Kappa Index ◽  
Lumpy Skin Disease

ABSTRACT Lumpy skin disease (LSD) is an emerging, transboundary viral pox disease affecting cattle of all ages and breeds. The serological assay for monitoring immunity following vaccination is a virus neutralization test (VNT/OIE) that determines the neutralization index (NI). The first validated enzyme-linked immunosorbent assay (ELISA; IDVet) has become commercially available, facilitating large-scale serosurveillance for LSD. Although the VNT is labor intensive and time consuming, it is still the recommended test by the OIE. Thus, in this study, we modified the virus neutralization test by employing Madin-Darby bovine kidney (MDBK) cells. The qualitative results obtained with the modified method were compared to the qualitative results obtained by VNT/OIE and ELISA. We used blood sera received within a surveillance program for LSD in 2018. In total, 291 serum samples were tested using VNT/MDBK and ELISA. Of 291 samples, 80 samples were tested by VNT/OIE and used for comparison of the performances between VNT/MDBK and VNT/OIE. The compatibility of results obtained by VNT/MDBK and VNT/OIE resulted in a kappa index of 0.9 with overall proportion agreement of 0.96. Agreement between VNT/MDBK and VNT/OIE was achieved in 56 positive and 21 negative samples. The compatibility of results obtained by ELISA and VNT/MDBK were compared on 291 samples in total and resulted in a kappa index 0.834 with overall proportion agreement of 0.955. Agreement between ELISA and VNT/MDBK was achieved in 238 positive and 40 negative samples. The results obtained demonstrated a strong correlation between VNT/MDBK and the other two methods, indicating the suitability of VNT/MDBK for the detection of the LSD virus-specific neutralizing antibodies.

scholarly journals Entomological and Virological Methods for the Identification of Potential Vectors of Lumpy Skin Disease Virus in the South-Eastern Part of Northern Caucasus, Russia

2020 ◽  
Vol 70 (3) ◽  
pp. 296-304
Author(s):  
Anastasija Aleksandrovna Glazunova ◽  
Timofey Aleksandrovich Sevskikh ◽  
Olga Viktorovna Kustikova ◽  
Svetlana Georgievna Dresvjannikova ◽  
Timur Ravilevich Usadov ◽  
...  
Keyword(s):  
Disease Virus ◽  
Skin Disease ◽  
Large Scale ◽  
Insect Population ◽  
Northern Caucasus ◽  
Web Based ◽  
Lumpy Skin Disease ◽  
Lumpy Skin Disease Virus ◽  
Potential Risk Factors ◽  
Flight Season

AbstractThe article provides assessment of field and laboratory methods for the collection and evaluation of potential vectors of lumpy skin disease virus (LSDV) in one of the districts of Krasnodarskiy Kray in southern Russia. In this study, we tested several methods of vector collection and a PCR protocol for the detection of the LSDV genome in insects. Descriptive data on samples were collected using a free web-based application Epicollect5.Potential LSDV vectors are quite widely spread insects in this region. We identified 15 insect species, including Musca domestica, Musca autumnalis and Stomoxys calcitrans. Analysis of the insect population showed an increase in species diversity and a decrease in abundance of the insect population by the end of the flight season.PCR tests did not detect LSDV genome in the collected samples. All the methods tested were found suitable for large-scale monitoring of lumpy skin disease (LSD). Further studies on potential risk factors of LSD spread are necessary to improve measures on preventing and eliminating the disease.

scholarly journals Complete Genome Sequences of the Neethling-Like Lumpy Skin Disease Virus Strains Obtained Directly from Three Commercial Live Attenuated Vaccines

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Elisabeth Mathijs ◽  
Frank Vandenbussche ◽  
Andy Haegeman ◽  
Alasdair King ◽  
Bethuel Nthangeni ◽  
...  
Keyword(s):  
Disease Virus ◽  
Skin Disease ◽  
Complete Genome ◽  
Animal Health ◽  
Genome Sequences ◽  
Lumpy Skin Disease ◽  
Lumpy Skin Disease Virus ◽  
Live Attenuated Vaccines ◽  
Virus Strains ◽  
Important Disease

Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. Here, we report the complete genome sequences of three LSDV strains obtained directly from the live attenuated vaccines: Lumpyvax (MSD Animal Health), Herbivac LS (Deltamune) and Lumpy Skin Disease Vaccine (Onderstepoort Biological Products).

Veterinary and legislative aspects relating to the feeding of by-products and waste

1980 ◽  
Vol 3 ◽  
pp. 19-24
Author(s):  
W. A. Watson
Keyword(s):  
Animal Health ◽  
Foot And Mouth Disease ◽  
Contagious Bovine Pleuropneumonia ◽  
Buffer Zones ◽  
Member States ◽  
Animal Products ◽  
Endemic Diseases ◽  
Number Of Factors ◽  
Vesicular Disease ◽  
Epidemic Diseases

The livestock population of Great Britain has been free from several of the most serious epidemic diseases since the late 19th century (rinder-pest, contagious bovine pleuropneumonia); others occur infrequently following introduction from abroad (foot-and-mouth disease (FMD), swine fever, swine vesicular disease (SVD); and the endemic diseases such as bovine tuberculosis and brucellosis are subject to successful eradication programmes.On first examination the risk from exotic disease appears to lessen from year to year. The incidence of FMD has declined dramatically in Europe with the introduction of effective vaccination and slaughter policies and FAO/OIE programmes creating protective vaccination buffer zones in the east. Again within the European Community consideration is being given to a common policy to eradicate swine fever from all member States. However, a number of factors operate against these encouraging trends.a. The relaxation of international trade barriers to the movement of live animals and animal products. It is essential within this framework to ensure that our animal health safeguards are preserved as far as possible against the introduction of disease from either member States or into the Community from third countries.b. Pressures from the industry increase for the importation of livestock, semen or embryos to expand the gene pool within breeds.c. The pyramidal structure of the industry — particularly the pig and poultry industry — increases the risk of dissemination of any disease agents introduced.d. Larger, more intensive units reduce individual animal observation allowing symptoms of disease to remain undetected for longer periods and hence outbreaks to be more explosive when they occur.

scholarly journals The efficiency of methods for catching insects - vectors of vector-borne diseases of animals and their species composition

2021 ◽  
Vol 22 (5) ◽  
pp. 761-769
Author(s):  
O. A. Burova ◽  
O. I. Zakharova ◽  
N. N. Toropova ◽  
N. A. Gladkova ◽  
A. A. Blokhin
Keyword(s):  
Skin Disease ◽  
Temporal Dynamics ◽  
Developmental Cycle ◽  
Insect Vectors ◽  
Black Flies ◽  
Biting Midges ◽  
Lumpy Skin Disease ◽  
Saratov Region ◽  
Blood Sucking ◽  
Nizhny Novgorod Region

The article provides the results of study of the effectiveness of collection methods and the taxonomic identification of insects in the regions of Russia. During the research three methods of collecting insects were used: a UV trap, fly strips and a liquid gadfly trap (“death puddle”). The following blood-sucking insects play a key role in the epizootology of transmissible infections - houseflies (Muscidae), black flies (Simuliidae), mosquitoes (Culicidae), biting midges (Ceratopogonidae), gadflies (Tabanidae). There has been obtained new information on the species, territorial and temporal dynamics of the distribution of vectors of lumpy skin disease in cattle in the subjects of the Russian Federation. Data collection of the spatial and temporal spread of the disease visualized using GIS-technologies have been generated on the basis of the statistical reports. As the result of the research, it has been established that in the Nizhny Novgorod region representatives of the Psychodidae family, the percentage of which was 40.9 %, predominate in the nocturnal entomological complex. They are followed by mosquitoes (genus Culex) - 21.6 %, biting midges - 16.4 % manure flies - 7.0 % and black flies - 3.0 %, respectively. In the Saratov region, the nocturnal entomological complex was represented by manure flies (family Sphaeroceridae), black flies (family Simuliidae) and mosquitoes (genus Culex), the percentages were 56,0, 32,0 and 12,0 %, respectively. At the same time, in the Saratov region there were collected 239 times less mosquitoes than in the Nizhny Novgorod region, which was due to an increase in temperature in the conditions of the southern regions. This caused the water bodies to dry out and reduced the pool of insects whose developmental cycle is related to water. It has been established that all-year keeping of cattle in winter cow yards provides the diversity and rise in the number of insect vectors, which increases the risk of lumpy skin disease as compared to the grazing system of cattle keeping. For collection daytime insect vectors, it is recommended to use fly strips covered with rosin and mineral oil. For collection insects of the nocturnal entomocomplex, which are the main transmitters of the lumpy skin disease virus, one should use ultraviolet traps.

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