scholarly journals The concentration of insuline-like growth factor in colostrum, milk and plasma of cows

2019 ◽  
Vol 21 (93) ◽  
pp. 121-124
Author(s):  
D. V. Hrudetska ◽  
M. R. Simonov ◽  
O. O. Dashkovskyy
Keyword(s):  
Growth Factor ◽  
Plasma Level ◽  
Clinical Status ◽  
Postnatal Period ◽  
Energy Deficit ◽  
Black And White ◽  
Oncological Diseases ◽  
High Level ◽  
The Given ◽  
Dairy Breed

Recently, a significant amount of data has been reported indicating on the link between consumption of dairy products and development of oncological diseases. This could be explained by the presence in milk of various hormones, particularly insulin-like growth factor (IGF). This hormone is a mediator between somatotropin and tissues. In response to the increase of the blood level of growth hormone, hepatocytes begin actively synthesize the IGF, which accelerates the rate of the metabolism, including those of onco-cells. The majority of studies relate to humane medicine, and data on the dependence of IGF milk levels on breed, period of lactation, diet, physiological, and clinical status of an animal are lacking. Taking this into consideration, the purpose of this study was to analyze the concentration of insulin-like factor in colostrum, milk of cows and blood plasma at various stages of lactation. Study was performed on cows of Ukrainian black-and-white dairy breed in their from second to fifth lactation with milk yield 5100–5700 kg per previous lactation. Concentration of IGF was detected in colostrum, milk and plasma of cows, using enzyme immunoassay. Obtained material gives evidence that the highest IGF level is present in colostrum. After that hormone concentration decreases up to 10–14 day of lactation. High level of IGF in colostrum might be associated with necessity to stimulate metabolism of calves in early postnatal period of ontogenesis. Immediately after calving plasma level of IGF decreases. The highest level was observed on 10–14th days of lactation. Taking into consideration physiological function of the given hormone, there is no univocal explanation of the decrease of its plasma level in cows at the beginning of lactation. This could be associated with energy deficit, physiological condition of animals or with developing of lactation dominant and levels of other hormones. Potential of further research lies in investigation of the dependence of the IGF level in the secretion of the mammary gland on productivity, breed, age and diet of animals.

scholarly journals EFFICIENCY OF THE USE THE CROSSBREEDING OF UKRAINIAN BLACK-AND-WHITE DAIRY AND SWISS CATTLE IN THE STATE STUD FARM "PASICHNA"

2021 ◽  
Vol 61 ◽  
pp. 35-48
Author(s):  
I. V. Verbych ◽  
O. V. Medvid
Keyword(s):  
Functional Properties ◽  
The Body ◽  
Natural Resistance ◽  
Adaptation Capacity ◽  
Black And White ◽  
Dairy Fat ◽  
Service Period ◽  
Effective Selection ◽  
High Level ◽  
Dairy Breed

Goal. To study the influence of intermediate crossing on the level of dairy productivity, qualitative milk indicators, exterior features and resistance of the body of pureorgain and local animals. Methods. Selection and genetic analysis, comparative, statistical. The results. Scientific and production studies were conducted on the basis of a tribal factory of the State Enterprise "Pasichnya" IKSGP NAAN "of the StarosinyaVsky district of the Khmelnytsky region in the chains of distinct animals of the Podilsky factory type of Ukrainian Black-and-White dairy (UCHRMP) and local animals derived from the crossing of the BPRMP cows with Bojabs of the Shvitsky breed. According to the results of experimental studies, it has been found that local cows-first-bristles are somewhat inferior to the purest animals of the Ukrainian Black-and-White dairy breed by the magnitude of the NADA (93.8 kg), but it is compensated by milk quality (fat +0.26%, protein +0.19%), where in the general yield of dairy fat (+9.5 kg) and protein (+6.4 kg), they are favorably different from its purgatory rior. The analysis of the results of the reproductive capacity of cows shows that local animals were first fruitfully inseminated at the age of 545 days and the duration of fertility was 283 days, at that time, purely meters were inserted at the age of 567 days, and the duration of the sharing was 281.5 days. Service-period in the cows-first-born of genotypes, respectively, amounted to 97 and 112 days. The obtained data for the morphological and functional properties of the cow-first-prints show that the assessed number of both groups meets the needs of target standards on technological features and have high indicators of the studied functional properties. Comparative analysis of exterior valuation indicators between the studied groups shows that local cows have higher rates over latitudinal gates, in particular, by breast width and width in the ice, at that time inferior to the children's rior in the rectors of height in the racing, in the area of the torso. and hammer. In the study of natural resistance in the studied cows it has been established that the estimated animal groups are characterized by a sufficiently high level of protective functions of the body and adaptation capacity to technological conditions, which creates good opportunities for further effective selection. The general assessment of the natural resistance of cows-firstbody by morphological and biochemical parameters of blood, phagocytic, bactericidal and lysozymic activity showed that local cows according to Method VE Chumachenko and others. (1990) have a natural resistance to 3 points (61) higher than in their pure-breeding rior (58 points). Conclusions. Results of analysis of dairy performance of local cows-first-birthsters derived from the crossing of Ukrainian Black-and-White breeds with bulls of the Shvitskaya breed showed that the data of the animal though inferior to the christening rior of the Ukrainian Black-and-White dairy breed by the magnitude of the NADA but this difference is compensated by the quality of milk, where The total output of dairy fat and protein, they are favorably different from pureoral analogues. By indicators of reproducible ability, it has been found that local animals were first crazy at the age of 823 days that on 21 days earlier than puredom and 15 days they have a smaller service period. An analysis of the results of the estimation of morphological and physiological properties of the elder showed that there are no significant differences in the investigated groups of primary differences. All animals correspond to technological requirements. The exterior evaluation of the investigated groups of the firstborn showed that purely cows, having higher rates in the elevation in the roll, in the height in the ice and a contrary length of the trunk and the intensity, but inferior to the latitude gauge: the width of the breast, width in the machaches and width in the machaches and width in the machach. Animal estimation according to natural resistance indicators found that animals of both groups have a sufficiently high level of protective functions of the body and adaptation capacity to technological conditions that creates good opportunities for further effective selection.

scholarly journals D-vitamin status of cattle depending on the conditions of detention and physiological state

2018 ◽  
Vol 20 (88) ◽  
pp. 141-146
Author(s):  
L. L. Yuskiv ◽  
V. Vlizlo
Keyword(s):  
Alkaline Phosphatase ◽  
Physiological State ◽  
Inorganic Phosphorus ◽  
Postnatal Period ◽  
Winter Period ◽  
Dry Period ◽  
Black And White ◽  
Vitamin Status ◽  
Calcium Phosphorus ◽  
Dairy Breed

The article contains data on the content of active metabolite of vitamin D3 – 25OHD3, calcium, phosphorus, magnesium and activity of alkaline phosphatase in the blood of cows and their calves in the early postnatal period. The experiment was conducted on cows-analogues of the Ukrainian Black-and-White dairy breed during the dry period and after calving and on calves received from them. The experiment was performed during the winter period of the stall at the Lviv region farm. The blood for tests was collected from the jugular vein before morning feeding at 3–5 days before calving and in the 5th–7th and 55th–60th days after calving. The blood from the calves was collected in the following dates: on the first day and at 5th–7th days old and at 55–60th days old.  It was established that, the content of 25-hydroxycolecalciferol in blood calves on the first day after birth was 18.90 ± 2.08 nmol/l. In subsequent periods of study, its level decreased, in particular, at 5th−7th days old it was 1.52 times lower (P < 0.05), and in the at 55–60th days old – 2.07 times (P < 0.01) than on the first day old age during the winter period of the stall. Changes in the content of 25OHD3, total calcium and its fractions, inorganic phosphorus, magnesium and activity of alkaline phosphatase and its isoenzymes in the blood of cows in the prenatal and lactation periods have been determined. In particular, the content of 25OHD3 was 18.7 ± 2.27 nmol/l at 3–5 days before calving in the blood of cows, on the 5–7th day after calving continued to decrease and amounted to 15.8 ± 0.83 nmol/l, and on the 55–60th day of the postpartum period it increased to 20.5 ± 2.08 nmol/l.

scholarly journals VARIABILITY OF LONGEVITY TRAITS OF COWS OF UKRAINIAN BLACK-AND-WHITE DAIRY BREED IN VARIOUS VARIANTS OF SELECTION

2019 ◽  
Vol 57 ◽  
pp. 143-151 ◽  
Author(s):  
L. M. Khmelnychyi ◽  
A. V. Loboda
Keyword(s):  
High Reliability ◽  
Statistical Significance ◽  
Black And White ◽  
Genetic Potential ◽  
Breeding Selection ◽  
The Difference ◽  
High Level ◽  
Dairy Breed ◽  
Selection Of

In modern conditions of intensive dairy farming, the first and most important task was to ensure a high level of productivity of cows with simultaneous long-term use. Taking into account the important breeding aspect of the measure for intra-and interlinear breeding, it was considered appropriate to study the efficiency of combining the lines at the breeding of animals of the Sumy intra-breed type of Ukrainian Black-and-White diary breed by traits of longevity. The research on determining the effectiveness of combining the lines at breeding of cows on grounds of duration of use and lifetime productivity was carried out in the herd of pedigree plant PE "Burynske" of Pidlisnivskyi department in Sumy district. According to the results of evaluation of cows obtained by intrabreeding selection of eight genealogical formations of the experimental herd, was found significant effect of heredity lines on indicators of longevity. According to the estimation of longevity, the offspring of four lines were the best: Valiant, Sjuprim, Starbuck and O. Aivengo. Advantage of daughter progeny of sires Valiants line with the highest longevity over the animals of lines of Montfrech, Matt, M. Chiftein and S. T. Rokita on this basis amounted to 252–526 days (P < 0.01–0.001). The next by lifetime rating was the offspring of O. Aivengo's line sires had an advantage over cows of the above lines with variability of 220–393 days (P < 0.05–0.001). The same lines (Valianta, Sjuprim, Starbuck and Aivengo) almost did not differ among themselves by the number of used lactations (4.6–4.8) and exceeded cows of remaining lines by 0.6–1.4 lactation. The difference between the maximum and minimum values was reliable at P < 0.001. The highest yield for a productive life was obtained from cows belonging to the Aivengo line 1189870, which with a high reliability of difference predominated the offspring of all estimated lines with variability from 3532 (P < 0.001; Syuprim line) to 13617 kg of milk (P < 0.001; line Montfrech). High lifetime milk yields differed also descendants of sires lines Sjuprim (29684 kg), Starbuck (26811 kg) and M. Chiftein (26516 kg). Among the crossed variants with the minimum longevity indicators, offspring derived from bulls-sires of interlinear selection ♂Montfrech × ♀Mett and the reverse cross – (♂Mett × ♀Montfrech) are distinguished. This was explained to a certain extent by the fact that continuators of these lines were only crossbred sires of Ukrainian Black-and-White diary breed. In variants using the parent lines of Monfrech and Matt with maternal lines, the successors of which are Holstein sires, longevity indicators in the offspring obtained from these crosses are improving. According to the lifetime yield of dairy fat, the highest rates were obtained from offspring with interlinear selection of those sires who have the highest lifetime yield of milk. These daughters are from the crosses ♂Starbuck × ♀Sjuprim (1197.4 kg) and ♂S. T. Rokita × ♀Aivengo (1189.6 kg). An indicator of the effectiveness of longevity was also milk yield per day of life of dairy cows. Variability in interline selection varied from 8.7 (♂Metta × ♀Monfrech) to 12.0 kg (♂S. T. Rokita × ♀Aivengo). The difference between these variants was 3.3 kg with high reliability (P < 0.001; td = 5.95). Conclusions. Identified and confirmed statistical significance regularities concerning to influence the level of traits duration of use and lifetime productivity of an alternative selection system of linear breeding convinced about feasibility of regular monitoring to assess the combination of lines in the further breeding selection cows of Sumy intrabreed type of Ukrainian Black-and-White dairy cattle. Re-selection of the best options and rejection of ineffective ones will help to increase the genetic potential of longevity traits.

Linear type trait evaluation of firstborns of Ukrainian Black-and-White Dairy breed depending on the body build

2019 ◽  
pp. 24-34
Author(s):  
R. Stavetska ◽  
Y. Dynko ◽  
M. Bushtruk ◽  
I. Starostenko ◽  
O. Babenko ◽  
...  
Keyword(s):  
Body Condition Score ◽  
High Capacity ◽  
The Body ◽  
Body Depth ◽  
Linear Type ◽  
Body Build ◽  
Black And White ◽  
Condition Score ◽  
Type Traits ◽  
Dairy Breed

It has been experimentally proven that the strength and direction of the connection between the linear type traits evaluation of the Ukrainian black-and-white dairy breed cows and their body build depends on the type of the build and the sign of the exterior. The study was conducted in 2018 on a breeding plant of the Ukrainian Black-and-White Dairy breed SPC named Shchorsa in Kiev region (n=89). Differentiation of cows on types of their body build was conducted by the method proposed by Chernenko (low-capacity, mid-capacity and high-capacity types) and Kolesnik (by the massiveness index – on the friable and dense, the bone index – delicate and rough, the wide-breast and wide-rump indices – on narrow-body and wide-body types). It was found that the cow-heiferswere well-developed, had intermediate stature and optimum body condition score, deep body, and wide, slight slope rump. They alsohad desirable rear legs, set and foot angle but some toe-out, the udder was well-balanced. Under the good total score of the exterior of studied cows there were some animals with short stature (134– 136 cm), very wide rump, straight rear legs side view and toe-out, extremely steep foot angle, loose fore udder attachment, deep udder below hocks and front teat placement inside of quarter. The degree of development of the studied linear traits of cow-heifers confirms their in-herd variability. The variability of the exterior traits varies from 10,7 % (body depth) to 38,6 % (stature). In addition to the stature of a significant variability was characterized of angularity (22,4 %), rear legs set (22,5 %), body condition score (21,8 %), as well as traits that describe udder: rear udder attachment (31,4 %), udder depth (32,6 %) and front and rear teat position (31,3 % and 25,1 %, respectively). The high variability of linear traits indicates the possibility of effective their selection. As a result of the research, it has been established that the strength and direction of the correlations between the linear type traits evaluation of Ukrainian Black-and-White Dairy breed cows and the type of their body build depends on the type of the body build and the linear trait. The low-, mid- and high-capacity bodies build types (according to Chernenko) reliably correlate with chest width (r=0,58) and body depth (r=0,48), rear legs rear view (r=0,30), the central ligament (r=0,28), udder depth (r =-0,22) and teat length (r=0,25), P˂0,01–0,001. Friable and dense bodies build (according to Kolesnik) were most strongly associated with stature (r=-0,28), chest width (r =-0,70), and body depth (r=-0,38), as well as with rear legs rear view (r=-0,23), P˂0,05...0,001; delicate and rough bodies build – with stature (r=-0,51), angularity (r=-0,22),rump width (r=-0,35), udder depth (r=-0,27) and rear udder attachment (r =0,20), P ˂ 0,05–0,001; narrow-body and wide-body types – with chest width (r=0,30) and rump width (r=0,23), P˂0,05–0,01. Linear type trait evaluation of cows depends on the body build. The strength and direction of the correlations between types of body build and linear traits showed that the most informative is the classification of the body build by low-, mid- and high-capacity according to Chernenko – on the average η2x=17,5 %. The less informative – by narrow-body and wide-body types according to Kolesnik – η2x=7,6 %. The classification of cows on delicate-rough, narrow-body and wide-body types (according to Kolesnik) according to informativeness and reliability can have the intermediate position – η2x=10,0–11,5 %. The strongest influence on the body build has the cows’ height (η2x=27,9 % on average for all studied types of body build), chest width (η2x=33,5 %), body depth (η2x=21,8 %), rump width (η2x=24,1 %) and rear legs (η2x=18,7 %). Key words: cows, linear type trait evaluation, body build, correlation, power of influence.

FEATURES OF THE EXTERIOR TYPE OF UKRAINIAN BLACK-AND-WHITE DAIRY BREED OF THE CHERKASSY REGION, ESTIMATED BY THE LINEAR CLASSIFICATION METHOD

2017 ◽  
Vol 54 ◽  
pp. 112-119
Author(s):  
L. M. Khmelnychy
Keyword(s):  
Local Population ◽  
The Body ◽  
Breeding Value ◽  
Linear Classification ◽  
Body Structure ◽  
Linear Type ◽  
Maternal Line ◽  
Black And White ◽  
Type Traits ◽  
Dairy Breed

The estimation of the first-born cows of Ukrainian Black-and-White dairy breed by the exterior type in the leading breeding herds of Cherkassy region by the method of linear classification (n = 566) has been carried out. The results of the evaluated animals by the 100-score system indicate that within the group of traits, the average level of assessment is "good with the plus". The animals have been differed by the good development of group features characterizing the dairy type (82.4 score), body condition (83.5 score), limbs (82.8 score), udder (82.7 score) and overall score (82.8 score). The degree of development 18 descriptive traits of the exterior of cows, has been predicted by the method of linear classification, indicates their significant intraherd variability. Animals have the moderate height, deep body and angularity. The rump angle, the angle of hock joint and the teats length, according to the variability of scores in the range of 17.8–22.4%, have an average optimal development. The level of scores for the rear width (5.9 score), attachment of the fore (6.3 score) and the rear parts (6.0 score) of the udder testifies to their good development. The body structure of the cows-firstborn has a sufficient description of the type traits that determine their milk yield. At the present stage of selection and breeding work due to the use of bull-sires different origins and breeding value on the local population livestock with significant genotype diversity, the degree of influence each of the hereditary factors in the overall variability of linear features has a scientific and practical significance. In our studies, the force of influence conditional bloodiness of the Holstein mother's breed in the overall fraction of variability of linear type traits within the exterior complexes and the overall assessment takes a significant percentage - from 24.9 to 31.5 with a high degree of reliability according to Fischer's criterion. Among the descriptive traits, the proportion of influence the conditional bloodiness of mother, which is confirmed by high statistical confidence, ranges from 14.4 to 19.8%, and refers to the traits important for breeding. The level of coefficients of influence the father's breeding value in the total phenotypic variability for some of the linear traits is high and reliable. First of all it concerns group traits of the exterior, the development of which is determined by the pedigree value of father by 37.1–41.8%, and the overall assessment of type – by 46.6%. The coefficients of influence father's breeding value in most of the descriptive traits have high reliability (P < 0,001). The coefficients of the force of influence father, depending on the heredity of Holstein for the linear traits of almost the same level as his pedigree value. Since in this case the organized factor is purebreed Holstein and crossbreed bulls-sires of domestic selection, the positive role of Holstein heredity in improving the exterior type of cows has been traced realistically. The necessity of linear breeding, as an effective method in the system of dairy cattle breeding, has been substantiated by reliable values of the coefficients of the force of influence of father's line on the linear traits of offspring (3.4–29.5%). Despite the significant variability of coefficients of the force of influence on the linear traits, most of them have a high level of reliability within the evaluated body parts important for selection. The effect of cows belonging to the maternal line on the development of features of the body structure is insignificant and unreliable (5.3–9.2%). In the process of breeding aimed at improving cows of dairy herd by the exterior type, the pedigree value of parents has been assessed according to the method of linear classification of their daughters and their belonging to perspective genealogical formations.

INFLUENCE OF LIVE WEIGHT IN CULTIVATION ON THE DURATION OF PRODUCTIVE USE OF COWS OF UKRAINIAN BLACK-AND-WHITE DAIRY BREED OF DIFFERENT BLOODLINE ON THE HOLSTEIN BREED

2020 ◽  
Vol 11 (2) ◽  
pp. 16-27
Author(s):  
L. M. Danets ◽  
I. V. Tkachova ◽  
V. P. Shablia
Keyword(s):  
Average Duration ◽  
Live Weight ◽  
Black And White ◽  
Holstein Breed ◽  
Complex Integral ◽  
The Cost ◽  
State Enterprises ◽  
Dairy Breed ◽  
Integral Feature ◽  
A Share

The duration of productive use is a complex integral feature and is determined by both genetic and paratypical factors. This feature should ensure maximum milk productivity of animals, economic efficiency of dairy farms and generally limit the cost of raising and keeping cows. Research conducted in the experimental farms of state enterprises "Kutuzovka", Kharkov district of Kharkov region using cow’s Ukrainian black-and-white dairy breed (4038 cows). We studied the duration of productive use of cows divided into gradations according to the conditional bloodline for the Holstein breed, depending on the weight in the control age periods of cultivation (at birth, at 6, 12 and 18 months). The maximum value of the duration of productive use was recorded in the group of cows with a share of conditional blood for the Holstein breed up to 30% inclusive (the average duration of productive use is 2.77 lactations). The highest indicator of the duration of productive use of the studied animals was 4.09 lactations. Among cows with a share of conditional blood for the Holstein breed up to 30% longer produced those born with a weight of more than 40 kg (4.09 lactations), at 6 months of age weighed 100-149 kg, at 12 months – 200-249 kg, at 18 months of age – 350-399 kg. Among animals with a share of bloodline of 31-60 %, those that had a weight at the age of 6 months produced the longest: 155-190 kg (3.17 lactations), at 12 months – 250-299 kg (2.98 lactations), at 18 months – 350-399 kg (3.06 lactations). In the most numerous gradation with the share of bloodline for the Holstein breed 61-90 %, the longest productive use was characterized by animals born with a weight of 30-39 kg (2.12 lactation), at 6 months of age they weighed more than 200 kg (3.29 lactation), at 12 months-300-349 kg (3.40 lactation), at 18 months – 400-449 kg (2.82 lactation). The average duration of productive use of cows of this grade is quite low – in the range of 2.82-3.29 lactations. The highest degree of influence on the duration of productive use in this gradation of animals was recorded by the live weight factor at 6 months of age (η2 = 10.8). Сcomparative assessment of the cows gradation with a share of conditional blood for the Holstein breed of 91 % or more found that the longest productive use was characterized by cows that had a live weight at birth of 30-39 kg (1.93 lactation), in 6 months – 155-199 kg (2.73 lactation), in 12 months – 250-299 kg (2.87 lactation) and in 18 months – 350-399 kg (2.62 lactation). The degree of influence of live weight at this age on the duration of productive use of cows is insignificant, except for live weight at 6 months of age (η2 = 11.8).

scholarly journals Epidermal growth factor alleviates the negative impact of urea on frozen-thawed bovine sperm, but the subsequent developmental competence is compromised

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rasoul Kowsar ◽  
Shahrzad Ronasi ◽  
Nima Sadeghi ◽  
Khaled Sadeghi ◽  
Akio Miyamoto
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Dna Fragmentation ◽  
Acrosome Reaction ◽  
Developmental Competence ◽  
Ros Production ◽  
Sperm Capacitation ◽  
Bovine Sperm ◽  
Epidermal Growth ◽  
High Level

AbstractUpon insemination, sperm cells are exposed to components of the female reproductive tract (FRT) fluids, such as urea and epidermal growth factor (EGF). It has been shown that both urea and EGF use EGF receptor signaling and produce reactive oxygen species (ROS) that are required at certain levels for sperm capacitation and acrosome reaction. We therefore hypothesized that during bovine sperm capacitation, a high level of urea and EGF could interfere with sperm function through overproduction of ROS. High-level urea (40 mg/dl urea is equal to 18.8 mg/dl of blood urea nitrogen) significantly increased ROS production and TUNEL-positive sperm (sperm DNA fragmentation, sDF) percentage, but decreased HOS test score, progressive motility, acrosome reaction and capacitation. The EGF reversed the negative effects of urea on all sperm parameters, with the exception of ROS production and DNA fragmentation, which were higher in urea-EGF-incubated sperm than in control-sperm. The developmental competence of oocytes inseminated with urea-EGF-incubated sperm was significantly reduced compared to the control. A close association of ROS production or sDF with 0-pronuclear and sperm non-capacitation rates was found in the network analysis. In conclusion, EGF enhanced urea-reduced sperm motility; however, it failed to reduce urea-increased sperm ROS or sDF levels and to enhance subsequent oocyte competence. The data suggests that any study to improve sperm quality should be followed by a follow-up assessment of the fertilization outcome.

Flattening of Affect and Personal Constructs

1970 ◽  
Vol 116 (530) ◽  
pp. 39-43 ◽  
Author(s):  
F. M. McPherson ◽  
Valerie Barden ◽  
A. Joan Hay ◽  
D. W. Johnstone ◽  
A. W. Kushner
Keyword(s):  
Emotional Expression ◽  
Emotional Response ◽  
Rater Agreement ◽  
Personal Constructs ◽  
Good Definition ◽  
Organic Psychoses ◽  
Tone Of Voice ◽  
High Level ◽  
The Given ◽  
Affective Flattening

Affective flattening is a disorder of emotional expression, of which a good definition is ‘a gross lack of emotional response to the given situation’ (Fish, 1962). It is a clinical sign whose assessment depends upon the clinician's intepretation of the patient's facial expression, tone of voice and content of talk (Harris ' Metcalfe, 1956). Although these are subtle cues, it has been shown that experienced clinicians can assess the severity of affective flattening with a high level of inter-rater agreement (Miller et al., 1953; Harris ' Metcaife, 1956; Wing, 1961; Dixon, 1968). The disorder is usually associated with a diagnosis of schizophrenia, although it may occur in other conditions, such as the organic psychoses (Bullock et al., 1951).

Consensus document on radiotherapy in patients with implantable pacemakers and cardioverter – defibrilators

2018 ◽  
Vol 2 (47) ◽  
pp. 27-31
Author(s):  
Lidia Chmielewska-Michalak ◽  
Ewelina Konstanty ◽  
Przemysław Mitkowski
Keyword(s):  
Current Knowledge ◽  
Clinical Status ◽  
Electronic Devices ◽  
Heart Rhythm ◽  
Complex Care ◽  
Consensus Document ◽  
Cardiac Implantable Electronic Devices ◽  
Number Of Patients ◽  
High Level ◽  
Emergency Mode

The number of patients with cardiac implantable electronic devices (CIED), who require oncological management including radiotherapy (RT) is still increasing. According to current knowledge the most frequent device dysfunction related to exposition to ionizing radiation is reprogramming to emergency mode (soft reset). There are uncommon cases of complete, irreversible device damage. CIED dysfunction during RT can be observed in approximately 3% of patients. In majority of cases they are asymptomatic, although in literature there are descriptions of deterioration of clinical status due to bradycardia or exacerbation of heart failure. The most important factor of device malfunction is radiotherapy with photons of energy >10 MV or protons despite energy used. So far there were no cases published with inadequate ICD therapies due to the presence of electromagnetic field interference during RT. Because patients with CIED undergoing RT need complex care to achieve high level of safety, experts of Heart Rhythm Society establish document, published in 2017 which summarized current knowledge about this group of patients. The document contains guidelines on peri-radiotherapy care of patients with CIED.

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