scholarly journals Dynamics of morphological and biochemical parameters in the blood of white mice under the action of the drug “Vitosept”

2020 ◽  
Vol 22 (99) ◽  
pp. 167-172
Author(s):  
M. P. Soltys ◽  
V. M. Gunchak ◽  
H. V. Rudyk ◽  
R. O. Vasiv
Keyword(s):  
Drug Toxicity ◽  
Biochemical Parameters ◽  
Laboratory Animals ◽  
Control Group ◽  
Hemoglobin Content ◽  
Behavioral Reactions ◽  
Compensatory Response ◽  
Test Concentration ◽  
Experimental Group ◽  
Biocidal Product

The paper presents the results of the study of the drug toxicity “Vitosept” in its preclinical studies in intact white mice. It was found that according to the assessment of toxicological parameters of the studied biocidal product is low-toxic. Oral administration of even its highest concentrations (500 mg/l) did not show a pronounced toxic effect. During the action of the drug for 20 days no deviations in the clinical condition, behavioral reactions, reflex activity did not occur. It was found that most of the values that characterize the functional state of the hematopoietic and hepatobiliary systems, against the background of different concentrations of sodium hypochlorite, did not undergo significant changes compared with the control. The hemoglobin content in the blood of white mice in the experimental groups increased compared with the control in the first three experimental groups (concentration of GHN 100–300 mg/l). With increasing concentration of the drug, when administered intraperitoneally, there was a greater number of leukocytes in the blood of laboratory animals. At the same time, a probable increase in this indicator was found only in mice of the II experimental group when administered orally to animals of the lowest test concentration (100 mg/l). The concentration of total protein, urea and glucose in the blood of white mice under the action of “Vitosept” was similar in animals of the control and experimental groups. The revealed tendency to increase the activity of certain enzymes (LF, ALT, AST) was short-lived, and is obviously a compensatory response of animals to the xenobiotic effect of the drug. On the 20th day of the experiment, the studied white mice of the experimental groups were close to those in the control group.

TOXICOLOGICAL PROFILE OF “BIOSOLBI” DRUG

1970 ◽  
pp. 67-69
Author(s):  
E. K. Rakhmatullin ◽  
O. D. Sklyarov
Keyword(s):  
Drug Toxicity ◽  
Probit Analysis ◽  
Laboratory Animals ◽  
Control Group ◽  
Hazard Class ◽  
Water Ingestion ◽  
White Rats ◽  
Poorly Soluble ◽  
And Behavior ◽  
Purebred Dogs

The article presents the results of a study of the "Bisolbi" drug toxicity (powder of light ash color, poorly soluble in water). When it is mixed with water it forms a suspension of particles that settle rapidly. Values of acute drug toxicity were determined on rats. We studied groups of six animals of the same sex, as well as similar control ones. The "Bisolbi" drug was injected to white rats intragastrically, males weighing 310 ... 320 g in doses of 2500 and 2740 mg / kg. Each dose was used in six animals; distilled water (3 ml) was used for the controls. The LD50 was calculated by the probit analysis method proposed by Litchfield and Wilcoxon modified by Z. Roth. When administered orally, an atraumatic metal probe was immersed in the stomach. Within 14 days monitored the overall health status and behavior of animals, the manifestation or absence of symptoms of intoxication; noted the features of feed and water ingestion, assessed the condition of the coat, physiological functions. Then groups of experimental rats were euthanized and pathomorphologically examined. We studied the effect of "Bisolbi" with repeated introduction and on not purebred dogs. Two groups of 3-4 years of age were completed with an average initial body weight of 13.63 ... 15.11 kg. Before use, the additive was thoroughly mixed with feed. The drug was injected during 31 days at a dose of 0.5 g / kg. Dogs of the control group (three) were fed wheat flour. After 15 and 31 days in laboratory animals in order to characterize the general condition in the blood, the amount of protein, urea, glucose, creatinine, cholesterol were determined. Based on studies it was found that the drug daily application by animals, is low toxic and safe, does not provoke the development of pathological reactions. According to the Hodge and Sterner classification "Bisolbi" can be attributed to the 6th class of toxicity - relatively harmless. Accordingto GOST 12.1.007-76 LD50 of the drug is more than 151 mg / kg, but less than 5000 mg / kg it is the 3rd hazard class (moderately hazardous).

INFLUENCE OF STOCK HOUSE LIGHT ON DAIRY PRODUCTIVITY OF COWS

2020 ◽  
Keyword(s):  
Blood Serum ◽  
Physiological State ◽  
Light Level ◽  
Inorganic Phosphorus ◽  
Control Group ◽  
Hemoglobin Content ◽  
Milk Productivity ◽  
Reproductive Ability ◽  
The Cost ◽  
Experimental Group

The article is devoted to the solution of an urgent problem- influence of different lighting modes on the dairy productivity of cows. 2 groups of cows with 20 heads each were formed. In control group, light in the cowshed was 50-75 Lux for a light period of 7.5 h in January to 16.5 h in June, and in experimental group - 150-200 Lux and 16 h, respectively. It was found that the intensity and duration of illumination affects physiological state, reproductive ability and milk productivity of cows. In the experimental group of cows, compared with the control group, hemoglobin content in blood increased by 4.6% (P < 0.01), red blood cells - by 20.6% (P < 0.05), total protein - by 11.2% (P < 0.001), glucose - by 39.1% (P < 0.05). There was a tendency to increase the total calcium and inorganic phosphorus in blood serum of cows of the experimental group. The level of alkaline phosphatase in blood serum of cows in the control group was 71.5% (P < 0.01) higher than that of cows in the experimental group. Milk yield per 1 cow in the experimental cowshed was 433 kg more than in the control. The cost of 1 kg of milk in the experimental group was 0.94 rubles lower, and the profitability of milk production and sales is 9.42% higher than in the control group. To increase the milk productivity of cows, it is recommended to increase light level in barns for tethered keeping to 150-200 Lux, with the duration of lighting in the winter and transition periods of year up to 16 hours per day.

Reproductive traits and blood biochemical parameters of sows when using a vitamin feed additive “LipoCar”

2020 ◽  
pp. 25-31
Author(s):  
I. A. Pushkaryev ◽  
N. M. Kostomakhin ◽  
S. V. Burtseva ◽  
N. A. Novikov
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Total Duration ◽  
Reproductive Traits ◽  
Feed Additive ◽  
Control Group ◽  
Large White ◽  
Basic Diet ◽  
Blood Biochemical ◽  
Experimental Group

The reproductive traits of sows are of paramount importance in the production of high-quality pork. The world experience of pig farming shows the need to solve first of all the feed problem. Diets unbalanced in the content of vitamins restrain the manifestation of genetically inherent high prolificacy of sows. The purpose of the research was to study the influence of feeding the vitamin feed additive “LipoCar” on the reproductive traits of sows and the biochemical parameters of blood serum. The results of research on the introduction of vitamin feed additive “LipoCar” into the diet of pregnant sows have been presented in the article. The experiment has been carried out in the production conditions in JSC “Linevsky pedigree farm” on sows of Large White breed. Pregnant sows have received a basic diet, balanced for all the normalized elements of nutrition. Sows of the experimental group in the composition of the basic diet fed the feed additive “LipoCar”. The dosage of the drug “Lipocar” was 2,1 g/head/day. “Lipocar” has been fed for 20 days. The total duration of the experiment was 3 months. When introducing the vitamin feed additive “LipoCar” into the main diet of sows in the second half of pregnancy the increase in the number of piglets in the litter by 1,6-6,8 % and the weight of the litter – by 5,6-56,2 % (P ≤ 0,001) have been revealed in comparison with the control group of animals. There was a higher content of carotene in the blood serum of sows of the experimental group by 50,0 % (P ≤ 0,01), vitamin A - by 48,7 % (P ≤ 0,05), and total protein – by 4,9 % (P ≤ 0,05).

scholarly journals State of metabolism of cows at dry period as the basis for reasoning of preven-tion and treatment of calves with gastrointestinal diseases

2019 ◽  
Vol 21 (93) ◽  
pp. 53-59
Author(s):  
V. Honcharenko ◽  
G. Gryshchuk ◽  
S. Sheremet
Keyword(s):  
Group Treatment ◽  
Biochemical Parameters ◽  
Metabolic Disorders ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Second Phase ◽  
Dry Period ◽  
Mineral Supplement ◽  
Treatment Regimens ◽  
Experimental Group

One of the real ways of increasing the production of livestock products is to increase the conservation of young animals, the mortality rate of which remains at this time still very high. Many calf treatment regimens have been developed, but they are not always effective, which prompts scientists and practitioners to improve already known methods of treatment, to find and justify new medical preparation. Material for research were dry-cows, healthy and sick calves. After the clinical examination of cows, the experiment was conducted in two phases: the first phase – in 3 groups of cows, the second – in clinical healthy and sick calves. Mineral supplement of Sapocorm were added to the first experimental group of cows; cows of the second experimental group – the preparation Betamint; animals of control group get basic diet. At the second phase, a group of healthy calves, as well as control and two experimental groups of patients were formed. The first group was treated with Intecol in combination with the probiotic Vetom. Calves of the second group – the preparation Intecoll, but in a complex with electrolyte solution Electrosol oral. The calves of the control group were treated with 4% solution of gentamicin sulfate and 30% solution of natrium thiosulfate. It was found out that during the dry period, cows were often subjected to metabolic disorders, and the causes of digestive disorders in calves were associated with a metabolic disorders in cows as a result of malnutrition. In the first stage of the research, the data obtained show the stimulatory effect of Betamint on the processes of hemopoiesis of the cows. In other side,  the probable magnification increase hemoglobin in the blood of cows can be explained by the influence of the components of the preparation on the metabolism of proteins. In cows of the first experimental group, which received the mineral supplement of Sapocorm, there were no probable changes in these indices. The next stage of the work was aimed at studying the effectiveness of preparation for the treatment of sick calves. In the analysis of biochemical parameters, was obtained low effectiveness of control group treatment, which was manifested by a slight increase in the biochemical parameters of the blood of diseased calves, which indicates an ineffective action of preparation. In the treatment of calves in the first group, the general condition was normal within 4–5 days of treatment. This indicates the complex effect of compounds and other elements that are components of the preparation Intecol and probiotic Vetom, on restoring the structure and functions of digestion. An analysis of the biochemical parameters of the blood of the second group when treated with the preparation Intecol and Electrosol oral plagued the normalization of the general state occurred within 2–3 days of treatment. The revealed changes indicate the complex influence of nutrients, which are components of the preparation Electrosol oral. On the basis of the conducted studies, the positive influence of the proposed treatment regimens and the effectiveness of the use of a complex of preparation with the antibiotic “Intecol” has been proved.

scholarly journals Effectiveness of Nursing Intervention Strategies on Physiological and Psychosocial Problems among Patients with Chronic Kidney Disease in Selected Hospital of Kashmir

2020 ◽  
Vol 09 (01) ◽  
pp. 1-12
Author(s):  
Dilshada Wani ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Psychosocial Problems ◽  
Nursing Intervention ◽  
Health Problems ◽  
Intervention Strategies ◽  
Physiological Parameters ◽  
Control Group ◽  
Experimental Group

Background:Chronic Kidney Disease (CKD) is a worldwide serious condition associated with increased premature mortality, decreased quality of life and increased health-care expenditures. Learning about issues such as: disease process, strict adherence to renal diet, exercises and relaxation therapies in addition to adherence the medical treatment have helped chronic kidney disease patients to self regulate and improve their physical and social functioning. With this background the investigator got strongly convinced to design some evidence based ‘Nursing intervention strategies’ for CKD patients through clinical research to alleviate their sufferings with better clinical outcomes. Methodology:A quasi-experimental study based upon two group pre-test post-test control group design was conducted on 200 adult chronic kidney disease patients (100=experimental group and 100=control group) with an aim to evaluate the effectiveness of ‘Nursing intervention strategies’ in improving their physiological and psychosocial problems in nephrology ward of a tertiary care hospital of Jammu and Kashmir i.e. Sher-i-Kashmir Institute of Medical Sciences (SKIMS) from 5th March 2012 to 31st July 2013. Result: The findings revealed that the subjects in experimental group who received the ‘Nursing Intervention Strategies’ for two weeks within hospital as well as at home till first follow up visit had shown a significant (p ≤ 0.05) improvement in 9 health problems, 11 biochemical parameters, 5 physiological parameters and 2 psychosocial parameters than the subjects in control group who reported improvement in: only 6 health problems; 5 biochemical parameters and 3 physiological parameters. Conclusion: It can be concluded that ‘Nursing Intervention Strategies’ such as: Dietary advice, progressive muscle relaxation, deep breathing, leg massaging, leg elevation and talk therapy were effective in reducing the magnitude of physiological and psychosocial problems among chronic kidney disease patients. However the long term efficacy of these strategies needs to be investigated.

Influence of the Amyrasol R-Z mineral lick briquette on biochemical parameters of blood in dairy cowsInfluence of the Amyrasol R-Z mineral lick briquette on biochemical parameters of blood in dairy cow

2020 ◽  
pp. 13-14
Author(s):  
Ayub Yu. Aliev ◽  
◽  
Karine A. Karpushchenko ◽  
Abdulgamid A. Aliev ◽  
Keyword(s):  
Dairy Cows ◽  
Milk Fat ◽  
Biochemical Parameters ◽  
Fat Content ◽  
Control Group ◽  
Milk Productivity ◽  
Basic Diet ◽  
The Republic ◽  
Experimental Group ◽  
Mineral Lick

The data obtained as a result of the use of a mineral lick briquette Amirasol R-Z in the diets of dairy cows are analyzed in the article. Authors studied the influence of the mineral lick briquette Amirasol R-Z on the biochemical parameters and milk productivity of dairy cows. The experiments were carried out on dairy cows of the red steppe breed in the conditions of the plain zone of the Republic of Dagestan. Two groups of dairy cows were formed (10 heads in each). According to the scheme of the experiment, the control group received a basic diet, the experimental group received the basic diet and the mineral lick briquette Amirasol R-Z. Each cow of the experimental group was given individually one lick briquette in a dose of 4 kg during 90 days. Researches and data processing were carried out according to generally accepted methods. Blood was taken from the experimental animals from the jugular vein for laboratory studies at the end of the experiment. The milk productivity and fat content of milk were taken into account by carrying out monthly control milk yields. At the same time, the positive effect of a lick briquette on the biochemical parameters of blood has been proven: reserve alkalinity, glucose, macro- and microelements, the activity of the copper-containing enzyme ceruloplasmin and milk productivity. A significant increase in the blood of glucose concentration by 12.93% in the cows of the experimental group, the level of reserve alkalinity by 17.66%, the concentration of macroelements and microelements, milk productivity by 5.7%, milk fat by 2.77% compared with the control group. The use of the mineral lick briquette Amirasol R-Z in the diets of dairy cows helps to prevent macro- and microelementoses, increase milk productivity, milk fat content, nonspecific immunity and obtain of healthy calves.

scholarly journals Silver (Ag) in tissues and eggshells, biochemical parameters and oxidative stress in chickens

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Anna Chmielowiec-Korzeniowska ◽  
Leszek Tymczyna ◽  
Magdalena Dobrowolska ◽  
Marcin Banach ◽  
Bożena Nowakowicz-Dębek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Biochemical Parameters ◽  
Control Group ◽  
Stress Indices ◽  
Stress Biomarkers ◽  
Antioxidative Stress ◽  
Group D ◽  
Experimental Group ◽  
And Oxidative Stress ◽  
Control Group Group

AbstractThis study aimed to assess levels of silver nanoparticle residues in eggshells and tissues as well as the levels of selected biochemical parameters and oxidative stress indices in chickens hatched from nanosilver disinfected eggs. The samples included 40 Greenleg Partridge chicks allocated into two groups. The experimental group (group D) consisted of chickens hatched from eggs disinfected with a nanosilver preparation prior to incubation, while the control group (group C) included chickens whose eggs were exposed to UV radiation for disinfection. The eggshells and kidney sections obtained from group D chickens showed a significantly higher silver level compared to group C. For the biochemical parameters, only the uric acid content was higher in group D compared to group C. Analysis of the antioxidative stress biomarkers (superoxide dismutase and catalase), showed a significant increase in group D in relation to group C.

scholarly journals INDICATORS OF BLOOD OF GALDS OF KALMYK BREED ON FEEDING WHEN INCLUDED

2020 ◽  
Vol 55 (3) ◽  
pp. 80-84
Author(s):  
I.I. Sleptsov ◽  
◽  
A.A. Martynov ◽  
Ya.S. Vasiliev ◽  
◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Sharp Decrease ◽  
High Growth ◽  
Mineral Elements ◽  
Feed Additives ◽  
Control Group ◽  
Cattle Breeding ◽  
Hematological And Biochemical Parameters ◽  
Traditional Natural ◽  
Experimental Group

Obtaining high results in the production of highquality beef in beef cattle breeding is impossible without well-organized fattening of gobies. In the conditions of Yakutia, fattening of gobies from 15 months of age can be carried out in autumn, after the summer grazing feeding. Under economic conditions of feeding, high growth rates of fattening young animals cannot be obtained. Therefore, intensive fattening with the use of mineral feeding of cattle is used. The paper presents research materials on the morphological and biochemical composition of blood and its serum in calves of the Kalmyk breed, which are on scientific and industrial fattening. In the experimental group of animals, local natural feed additives – zeolite and salt – were added to the diet, which served as adaptogens and sources of mineral elements. During the feeding period before the slaughter, the morphological composition of blood in terms of indicators has insignificant decreases, but within the physiological norm. We see these changes in the gobies of the experimental control group and associate them with a sharp decrease in atmospheric air temperature to –15 °C in the first ten days of November 2019 and a constant transition to roughage. It is also possible that the use of natural feed additives in the form of feeding zeolite and salt increases metabolic processes in the animal's body. A comparative analysis of biochemical parameters in the blood serum of gobies of the experimental group confirmed significant differences in hepatic enzymes (ALT and AST) in animals. The use of non-traditional natural feed additives with the inclusion in the diet of fattening gobies affects the hematological and biochemical parameters of blood and its serum, and, accordingly, meat quality.

scholarly journals Protective Effects of Dietary Supplement Spirulina (Spirulina platensis) against Toxically Impacts of Monosodium Glutamate in Blood and Behavior of Swiss mouse

Separations ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 218
Author(s):  
Adina Lia Longodor ◽  
Aurelia Coroian ◽  
Igori Balta ◽  
Marian Taulescu ◽  
Corina Toma ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Spirulina Platensis ◽  
Biochemical Parameters ◽  
Animal Feed ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Laboratory Animals ◽  
Control Group ◽  
Protective Effects ◽  
Swiss Mice

(1) Background: Well-known monosodium glutamate (E-621, MSG), originally used as a food flavor enhancer, was approved approximately in all countries, but the toxicity versus the safety of (MSG) are still unclear due to variable scientific toxicological reports. Moreover, it was reported to trigger elevated frequencies of nausea and headaches in humans and provide deleterious effects on laboratory animals. The objectives of the present study were to (i) estimate the possible toxic effects of the food additive MSG (ii) and the ameliorating protective effects of the dietary supplement spirulina (Spirulina platensis) on the biochemical parameters of blood and the damage produced in organs of Swiss mice after applying a supplementary daily dose of MSG for 4 weeks. (2) Methods: The present study was conducted on 20 mature Swiss mice, which were randomly organized into four groups of five Swiss mice. The treatments were (I) the control group, in which Swiss mice were fed only animal feed and drinking water; group II MSG1, which received 1 mL of MSG; group III MSG0.5, which was treated with 0.5 mL of MSG; and (IV) the group MSGS, which was treated with 1 mL of monosodium glutamate and 1 mL of spirulina (aiming to reduce the MSG toxicity). (3) Results: At the end of the experiment, Swiss mice treated with MSG demonstrated a passiveness regarding behavioral aspects. As we hypothesized, the parameters of the spirulina group reached similar values to the control group, and no histopathological observations have been found. Altogether, our findings evidenced that monosodium glutamate leads to histopathological changes in Swiss mice kidneys and caused important modifications for all biochemical parameters of the blood serum. Noticeably, the potential protective effect of Spirulina platensis was proved and was described by using the FTIR spectroscopy technique. (4) Conclusions: A diet rich in antioxidants and other plant-derived bioactive compounds may provide healthy nutrition, alleviating the potential side effects of some food additives.

scholarly journals Performance, Biochemical Profile and Antioxidant Activity of Hens Supplemented with Addition of Milk Thistle (Silybum marianum) Seed Cakes in Diet

2019 ◽  
Vol 67 (4) ◽  
pp. 993-1003 ◽  
Author(s):  
Ondřej Šťastník ◽  
Eva Mrkvicová ◽  
Leoš Pavlata ◽  
Andrea Roztočilová ◽  
Barbora Umlášková ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biochemical Parameters ◽  
Laying Hens ◽  
Control Group ◽  
Egg Mass ◽  
Milk Thistle ◽  
Feed Mixture ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Experimental Group

The aim of this study was to evaluate the effect of milk thistle seed cakes addition in laying hens diet to performance, blood biochemical parameters and antioxidant activity. A total of 30 Bovans Brown hens were included to the experiment. The trial was performed from the age of 69 weeks to 80 weeks of hens age. The experimental group received feed mixture containing 7% milk thistle seed cakes. Control group received feed mixture without milk thistle seed cakes. After the 69th week of age, the laying hens in the experimental group reached a higher number of eggs and produced more egg mass compared to the control group. In the evaluation of the egg quality parameters, higher Haugh units, a higher millimeter height of the egg and thinner eggshell in the group receiving 7% of the seed cakes were found. When evaluating health indicators, higher antioxidant activity was found in the experimental group. Blood biochemical parameters was without any differences.

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