scholarly journals Assessment of Job Risks in the Chemical Laboratory of the Pharmacy Study Program with Job Safety Analysis (JSA) Techniques

2021 ◽  
Vol 15 (2) ◽  
pp. 125
Author(s):  
Priska Ernestina Tenda ◽  
Faizal Reza Soeharto
Keyword(s):  
Significant Risk ◽  
Pharmaceutical Chemistry ◽  
Chemistry Laboratory ◽  
Risk Level ◽  
Pharmaceutical Chemical ◽  
Occupational Illness ◽  
Descriptive Research ◽  
Calculated Risk ◽  
Titration Step ◽  
Working Procedure

Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy  with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously. Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy  with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously. 

scholarly journals Predicting Diabetic Neuropathy Risk Level Using Artificial Neural Network and Clinical Parameters of Subjects With Diabetes

2020 ◽  
pp. 193229682096558
Author(s):  
Venketesh N. Dubey ◽  
Jugal M. Dave ◽  
John Beavis ◽  
David V. Coppini
Keyword(s):  
Neural Network ◽  
Risk Factors ◽  
Diabetic Neuropathy ◽  
Assessment Tool ◽  
Classical Method ◽  
Significant Risk ◽  
Patient Data ◽  
Risk Level ◽  
Clinical Parameters ◽  
Perception Threshold

Background: A risk assessment tool has been developed for automated estimation of level of neuropathy based on the clinical characteristics of patients. The smart tool is based on risk factors for diabetic neuropathy, which utilizes vibration perception threshold (VPT) and a set of clinical variables as potential predictors. Methods: Significant risk factors included age, height, weight, urine albumin-to-creatinine ratio, glycated hemoglobin, total cholesterol, and duration of diabetes. The continuous-scale VPT was recorded using a neurothesiometer and classified into three categories based on the clinical thresholds in volts (V): low risk (0-20.99 V), medium risk (21-30.99 V), and high risk (≥31 V). Results: The initial study had shown that by just using patient data ( n = 5088) an accuracy of 54% was achievable. Having established the effectiveness of the “classical” method, a special Neural Network based on a Proportional Odds Model was developed, which provided the highest level of prediction accuracy (>70%) using the simulated patient data ( n = 4158). Conclusion: In the absence of any assessment devices or trained personnel, it is possible to establish with reasonable accuracy a diagnosis of diabetic neuropathy by means of the clinical parameters of the patient alone.

scholarly journals Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine

2016 ◽  
Vol 76 ◽  
pp. 137-151 ◽  
Author(s):  
C.R. Kirman ◽  
B. Hughes ◽  
R.A. Becker ◽  
S.M. Hays
Keyword(s):  
Significant Risk ◽  
Risk Level

scholarly journals USULAN PERBAIKAN PADA PENERAPAN SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA DI PT. SURYA TOTO INDONESIA TBK DIVISI SANITARY DENGAN METODE HIRA DAN FTA

2021 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Nur Fadilah Fatma ◽  
Dhimas Eka Mustafa Putra
Keyword(s):  
High Risk ◽  
Occupational Safety ◽  
Risk Assessments ◽  
Risk Level ◽  
Potential Hazard ◽  
Occupational Illness ◽  
Root Cause ◽  
Unsafe Behavior ◽  
Medium Level ◽  
High Level

Identification of potential hazards and risk assessments are part of the occupational safety and health program in the risk management stage, which is conducted in an effort to prevent work accidents and occupational illness. The purpose of this research is to identify the potential hazard in PT Surya Toto Indonesia Tbk Sanitary division and analyze the root cause and give suggestion of improvement. Location and time of observation is PT Surya Toto Indonesia Tbk in April until May 2017. Object of observation is potential danger in section Slip Preparing PT Surya Toto Indonesi Tbk. The methods used by the researchers are HIRARC and FTA. The identification of potential hazards and risk assessments undertaken by researchers together with experts, which in this case are OSH officers and local supervisors, resulted in 25 different risks. With the following division, 2 low risk level, 10 medium level risk, 11 high risk level and 2 extreme level risk. After handling by the management of the company against the risk of extreme and high level, there is risk to be 2 high risk and 11 medium level risks. To reduce the value of risk, companies can make safer working conditions and better supervision of employee's unsafe behavior. Keywords: Hazard Potential Identification, Risk Assessment, SMK3, HIRARC, FTA

scholarly journals Analysis of health risks associated with food safety

2021 ◽  
Vol 100 (12) ◽  
pp. 1481-1486
Author(s):  
Olga G. Bogdanova ◽  
Natalia V. Efimova ◽  
Olga A. Molchanova
Keyword(s):  
Health Risks ◽  
Dairy Products ◽  
Significant Risk ◽  
Biologically Active ◽  
Poultry Meat ◽  
Risk Level ◽  
Maximum Probability ◽  
Potential Health ◽  
Microbiological Safety ◽  
Potential Risks

Introduction. Aim. Selection of priority safety indicators and optimal research scope through analysis of potential health risks associated with chemical and microbiological safety of food products (FP). Materials and methods. Retrospectively analyzed data on chemical and microbiological safety of FP addressed on the consumer market of the Republic of Buryatia for 2016-2020. Assessment of the potential risk of harm to human health included prediction performed on linear regression models. Results. The maximum probability of violations of mandatory requirements for chemical and microbiological contamination was noted for dairy products. The minimum probability of violations was identified for the biologically active additives and industrial baby FP. The calculation of potential risks to consumer health based on the results of studies of FP revealed the categories of “high risk” - fish and seafood, “significant risk” - dairy products, confectionery, vegetables, melons, soft drinks. It was found that the supply of fish and seafood, poultry and poultry products had long supply chains, when the risks associated with non-compliance with their transportation and storage conditions were most likely Correlations were revealed between the risk level according to the microbiological criterion associated with the contamination of food, fish, culinary products, poultry meat and the incidence of acute intestinal infections. The indicated factor signs determine from 28.6% to 67.0% of the variance of the incidence. Conclusion. Identification of potential risks of harm to the public health related to FP safety indicates the need for further monitoring of the content of chemical and microbiological contaminants.

scholarly journals Les implications scientifiques et industrielles du succès de la Stovaïne®. Ernest Fourneau (1872–1949) et la chimie des médicaments en France

Gesnerus ◽  
2007 ◽  
Vol 64 (1-2) ◽  
pp. 24-53
Author(s):  
Christine Debue-Barazer
Keyword(s):  
Industrial Development ◽  
Complex Structure ◽  
Basic Research ◽  
Pharmaceutical Chemistry ◽  
Chemistry Laboratory ◽  
Pasteur Institute ◽  
Know How ◽  
International Reputation ◽  
Comparable Activity ◽  
Structure And Activity

The synthetic local anaesthetic Stovaïne® was commercialised in France in 1904. Its inventor, Ernest Fourneau, began his career as a pharmaceutical chemist in organic chemistry laboratories in Germany, where from 1899 to 1901 he discovered how basic research could benefit from the modern chemistry theories which had developed in Germany starting in the 1860s. Using the complex structure of cocaine, he invented an original molecule, with comparable activity, but less toxic. The knowledge and the know-how which he acquired in Germany nourished his reflection in the field of the chemistry of the relationships between structure and activity, and led him to the development of Stovaïne®. Emile Roux, Director of the Pasteur Institute in Paris,was interested in his work and invited him to head the first French therapeutic chemistry laboratory, in which research on medicinal chemistry was organised scientifically. The industrial development of new medicines resulting from the Pasteur Institute’s therapeutic chemistry laboratory was supported by the Etablissements Poulenc frères, France thus gaining international reputation in the domain of pharmaceutical chemistry.

scholarly journals Musculoskeletal Disorders and Its Related Factors among Workers in Circulator Loom Unit

2019 ◽  
Vol 8 (3) ◽  
pp. 265
Author(s):  
Dian Rachmawati ◽  
Sho’im Hidayat
Keyword(s):  
Body Mass Index ◽  
Physical Fitness ◽  
Musculoskeletal Disorders ◽  
Body Mass ◽  
Influential Factor ◽  
Risk Level ◽  
Related Factors ◽  
Descriptive Research ◽  
Working Posture ◽  
Medium Risk

Introduction: Musculoskeletal Disorders (MSDs) defined as a disorder of muscles, nerves, and tendons compounded by the unergonomic working posture. Workers in Circulator Loom Unit of PT. Kerta Rajasa Raya are at risk for experiencing MSDs because of their unergonomic works. The purpose of this research was to learn more about MSDs including its related factors in Circulator Loom unit of PT. Kerja Rajasa Raya workers. Methods: this was a descriptive research which conducted using the observational method. The respondents were total population workers of Circulator Loom Unit at PT Kerta Rajasa Raya which is up to 47 workers. This research used MSDs complaint, working postures, and individual factors including age, sex, working period, physical fitness, and body mass index as the variable data. Results: 91.5% respondents were experiencing MSDs with 53.5% were in moderate severity level. Using REBA method to calculate the ergonomic risk level, it can be concluded that 23.4% of respondents have low risk of experiencing MSDs, 68.1% in medium risk, and 8.5% of respondents were having high risk of experiencing MSDs. Conclusion: working posture was the most influential factor causing MSDs with correlation coefficient score 0.629, in addition, working period, age, sex, Body Mass Index, and physical fitness were existed as supporting factors. Keywords: ergonomic, musculoskeletal disorders, working posture 

scholarly journals Derivation of a no-significant-risk-level for tetrabromobisphenol A based on a threshold non-mutagenic cancer mode of action

2018 ◽  
Vol 38 (6) ◽  
pp. 862-878 ◽  
Author(s):  
Alison M. Pecquet ◽  
Jeanelle M. Martinez ◽  
Melissa Vincent ◽  
Neeraja Erraguntla ◽  
Michael Dourson
Keyword(s):  
Mode Of Action ◽  
Significant Risk ◽  
Tetrabromobisphenol A ◽  
Risk Level

scholarly journals Gambaran Keselamatan Pekerja Menggunakan Teknologi Pemantauan Drone pada Proyek Konstruksi PT. X Makassar

2020 ◽  
Vol 1 (2) ◽  
pp. 142-151
Author(s):  
Muh Fathur Rahman MT Hardjo ◽  
Andi Wahyuni ◽  
Muhammad Rum Rahim
Keyword(s):  
Sampling Technique ◽  
Worker Safety ◽  
Risk Level ◽  
Monitoring Technology ◽  
Worker Attitudes ◽  
Descriptive Research ◽  
Safety And Health ◽  
Knowledge Variable ◽  
Medium Risk ◽  
Spss Software

Safety and Health of Construction work are activities to ensure and protect the safety and health of workers through accidents in the workplace. This study is to find out the description of the safety of workers using drone monitoring technology in construction activities at PT. X. This research is a type of descriptive research in a quantitative approach aimed to determine the safety of workers using drone monitoring technology in the construction project of PT. X Makassar 2020. The research will be conducted in November with a workforce of 108 people. The sample in this study was taken by purposive sampling technique so that the sample of 55 people. Data were collected using a questionnaire, Rapid Entry Body Assessment (REBA), analysis using SPSS software and drone. Data is presented in tabular form and narrated. This study shows the Knowledge variable at PT. X that out of 55 respondents (60%) respondents said that it was good. Based on the use of PPE, most respondents were classified as not compliant, namely as many as (67.3%), while the least were classified as compliant, as many as (32.7%). The most dominant work attitude of the respondents was Very High Risk Level (as much as 80%). While the least is the Medium Risk Level (3.6%). The results of the mapping in the rector's building, library and mosque using drones. The description of worker safety based on the variables of knowledge, PPE compliance, worker attitudes and hazards can be classified in part as good, but on variables.

Elemental Composition and Associated Health Risk of Honey Obtained from Apiary Farms in Southeast Nigeria

2020 ◽  
Vol 83 (10) ◽  
pp. 1745-1756
Author(s):  
NWOGO AJUKA OBASI ◽  
CHINYERE ALOKE ◽  
STELLA EBERECHUKWU OBASI ◽  
ADEMOLA CLEMENT FAMUREWA ◽  
PATIENCE NKEMJIKA OGBU ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Health Risk ◽  
Environmental Protection Agency ◽  
Hazard Index ◽  
Significant Risk ◽  
Risk Level ◽  
Potential Health ◽  
Flame Atomic Absorption ◽  
Threshold Limit ◽  
Flame Atomic Absorption Spectrophotometer

ABSTRACT This study investigated the levels of lead, selenium, arsenic, iron, manganese, copper, zinc, chromium, cadmium, and nickel in honey and their potential health risks to consumers, using standard protocols. The honey samples were obtained from apiary farms at nine different locations in southeast Nigeria. They were digested at optimal conditions and analyzed using a flame atomic absorption spectrophotometer. Levels of the studied elements in the honey were found to vary relative to the sample source; however, all were below European Commission maximum permissible limits, with the exception of lead, whose level in some samples exceeded the recommended set limit. Estimated daily intakes of the elements via ingestion of the honey were all below the maximum permissible limit set by the European Food Safety Authority, with the exception of arsenic, whose values in some samples slightly exceeded the set limit. For all samples, estimated health risk values for the elements quantified were higher in children than in adults. The hazard quotient for arsenic, hence, the hazard index for the elements, indicated a significant risk (>1) for children for some of the honey samples studied. Arsenic was the major contributor to incremental lifetime cancer risk; its estimated value for children in all the honey samples exceeded the U.S. Environmental Protection Agency (EPA) threshold limit (>1.0 × 10−4); hence, the total cancer risk values for the carcinogenic elements indicated an absolute unacceptable risk level for children based on EPA threshold limit. HIGHLIGHTS

Derivation of a No-Significant-Risk-Level (NSRL) for diethanolamine (DEA)

2014 ◽  
Vol 68 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Bingxuan Wang ◽  
David E. Amacher ◽  
Margaret H. Whittaker
Keyword(s):  
Significant Risk ◽  
Risk Level
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