scholarly journals Effect of Spirulina (Arthrospira platensis) on blood uric acid, hemoglobin and kidney histo-texture of mice treated with acetaminophen

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
M.` Zeenat ◽  
S. Sharmin ◽  
M. T. Islam ◽  
K. M. Sujan ◽  
M. I. Haque ◽  
...  
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Histopathological Examination ◽  
Research Work ◽  
Arthrospira Platensis ◽  
Renal Tissue ◽  
Diet Group ◽  
Normal Diet ◽  
Control Group

Background: Acetaminophen is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. Spirulina is a biomass of cyanobacteria that cultivated worldwide and used as a dietary supplement or whole food. It is also used as a feed supplement in the aquaculture, aquarium, and poultry industries. The present study was undertaken to determine the effect of Spirulina on blood and kidney in mice. Methods: Twenty Swiss Albino mice (Mus musculus) were randomly divided into 4 equal groups’ viz., A, B, C, and D. Group A was kept as control and fed only normal diet. Group B was supplemented with acetaminophen where as group C was supplemented with acetaminophen and Spirulina, and group D was treated with Spirulina. Results: The application of acetaminophen did not have significant effect on hemoglobin and uric acid content. But the addition of Spirulina to the diet increased significantly (P<0.05) hemoglobin and uric acid level. Histopathological examination revealed that no significant changes were found in the kidney of all of treated groups in comparison with the mice of control group. Conclusions: The research work suggests that long-term ingestion of acetaminophen does not exert a significant change in hemoglobin or uric acid level but spirulina supplemented diet may be associated with the rise in hemoglobin and uric acid level without affecting renal tissue texture in a significant manner.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

scholarly journals Evaluating serum uric acid levels in patients with acute myocardial infarction

2020 ◽  
Vol 7 (8) ◽  
pp. 1256
Author(s):  
Piyush Gosar ◽  
Ajay Pal Singh ◽  
Pravi Gosar ◽  
Bhawana Rani
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cardiovascular Morbidity And Mortality ◽  
History Of

Background: Elevated levels of serum uric acid are associated with increased cardiovascular morbidity and mortality. However, this association with cardiovascular diseases is still unclear, and perhaps controversial. The objective of study was to assess the serum uric acid level in patients with Acute Myocardial Infarction (AMI).Methods: Sixty patients with AMI were studied in Department of Medicine/ Department of Cardiology, J.A. Group of Hospitals between 2016 -2018.Details of age, sex, smoking, alcohol consumption and history of ischemic heart disease (IHD) was obtained and recorded. Serum uric acid level was estimated and compared with control group (healthy subjects).Results: Serum uric acid level was significantly higher among AMI patients (6.43±2.60) as compared to control group (4.05±0.95) (p<0.001). Majority (46.7%) of the AMI patients had uric acid level of >7.1 followed by 20% patients who had uric acid level between 4.5-5.9 (p<0.001). Uric acid level was comparable between smoker and non-smokers (p=0.803), alcoholic and non-alcoholic (p=0.086), hypertensive and non-hypertensive (p=0.668), patients with and without diabetes (p=0.278) and patients with a history of IHD and without history of IHD (p=0.403).Conclusions: Serum uric acid may be useful for prognostication among those with pre-existing AMI.

scholarly journals Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Lijuan Huang ◽  
Lihong Wu ◽  
Qiaohua Qiao ◽  
Lizheng Fang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Clinical Data ◽  
Uric Acid Level ◽  
Acid Level ◽  
Lipid Level ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Colon Polyps ◽  
Infection Status

Background. This study investigated the relationships among the characteristics of colon polyps and potential risk factors, including metabolic condition, CEA level, uric acid level, and Helicobacter pylori (Hp) infection status. Method. Clinical data from patients who received colonoscopy were collected and analyzed, including patients’ gender, age, polyp pathology, metabolic syndrome (MS) status, CEA level, uric acid level, and Hp infection status. Patients were divided into a polyp group and a control group based on whether they presented with colon polyps. Then, clinical data were compared between the two groups to identify any differences between the groups and their relationships to colon polyps. Result. Compared with the control group, the polyp group had significant differences in patient gender, body mass index (BMI), waistline, blood pressure, fasting blood glucose level, blood lipid level, and uric acid level (p<0.05), but there were no significant differences in LDL and CEA levels (p>0.05). Patients with MS or a uric acid level>340 mg/dl had a greater tendency to develop colon polyps but this was not statistically significant. Conclusion. The incidence of colon polyps may be associated with MS and uric acid levels, but further studies are warranted to confirm this conclusion.

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

scholarly journals Assessment of Serum Uric Acid Levels in Patients with Acute Myocardial Infarction

2020 ◽  
Vol 3 (2) ◽  
pp. 46-48
Author(s):  
Manjiri Ravindra Kulkarni
Keyword(s):  
Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Control Group ◽  
Study Group ◽  
Acute Mi ◽  
St Elevation

Background : Aim of the study was to discover if there is the efficacy of serum uric acid in the prognostication of myocardial infarction subjects. Subjects and Methods: A total of 200 subjects were incorporated into the research. Of them, 74 patients had ST- elevated myocardial infarction, as in 26 subjects they were diagnosed with non-ST elevation myocardial infarction. Of the total of 100 subjects in the study group, there were 70 males and 30 females. A total of 100 healthy individuals as a control group were also incorporated in the study. Serum uric acid was measured on day 0, 3, 7 as well on day 30 of MI. Results: Serum uric acid was calculated on day 0, day 3, and day 7 and on day 30 of the myocardial infarction in the case study group. The mean uric acid levels on day 0 were found to be 6.32 1.45 mg/dl, mean uric acid level on day 3 was found to be 5.98 0.98 mg/dl, mean uric acid level on day 7 was found to be 5.14 2.18 mg/dl and mean uric acid level on day 30 was found to be 4.98 0.44 mg/dl. Conclusion: Serum uric acid stages are elevated in subjects of acute MI in contrast to standard well individuals. Subjects with higher Serum uric acid levels have an elevated probability of transience and it can be measured as a marker of appalling prediction.

scholarly journals EFEK INFUSA AKAR TEMPUYUNG (SONCHUS ARVENSIS) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS PUTIH (RATTUS NORVEGICUS)

Biomedika ◽  
2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Kurnia Retnowati ◽  
EM Sutrisna ◽  
Iin Novita Nurhidayati Mahmuda
Keyword(s):  
Uric Acid ◽  
Blood Serum ◽  
Uric Acid Level ◽  
Acid Level ◽  
Negative Control ◽  
Control Group ◽  
Mouse Blood ◽  
Significant Difference ◽  
Sonchus Arvensis ◽  
Potassium Oxonate

Tempuyung (Sonchus arvensis) consisted of fiavonoid were effect as obstruct xantine oksidase enzyme, antioxidant captur superoxsidase radical. The fiavonoid total in leave of tempuyung is 0,1044%, in its root have 0,5% fiavonoid and the more is apigenin-7-O-glikosida (3,4,5). This research aim to know effect of infusa root of tempuyung (Sonchus arvensis) to lower the uric acid level at blood serum and infusa root of Tempuyung (Sonchus arvensis) to lower the uric acid level at mouse blood serum compared to allopurinol.This research is laboratory experimental method. The object were 25 Wistar male mice 2-3 months old, 150-200 gr divided into 5 groups. Negative Control group given potassium oxonate by intraperitoneal, Positive Control group given potassium oxonate by intraperitoneal, added by allopurinol 18mg/kgBB, Infusa Concentrated Group 1 given potassium oxonate by intraperitoneal added by infusa root of tempuyung 1,25g/kgBB, Infusa Concentrated Group 2 given potassium oxonate by intraperitoneal added by infusa root of tempuyung 2,5g/kgBB, Infusa Concentrated Group 3 given potassium oxonate by intraperitoneal added by infuse root of tempuyung 5g/kgBB. Executed until one day, where measurement of uric acid of mouse blood serum done before and after treatment. Measurement of uric acid level is done by using spectrophotometer. Obtained to be data to be analysed with Kolgomorov-Smirnov test, One-Way ANOVA and continued with LSD (Least Significant Difference) test with 95% confidence interval (CI). Result of statistical test of research shoe that infusa root of Tempuyung (Sonchus arvensis) dose 1,25g/kgBB, 2,5g/ kgBB, 5g/kgBB have effect to lower the uric acid level at mouse blood serum. Infusa root of Tempuyung (Sonchus arvensis) concentrated 5g/kgBB proportional wih dose allopurinol 18mg/kgBB to lower the uric acid level at mouse blood serum.Keyword: Infusa, root of Tempuyung (Sonchus arvensis), uric acid

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

scholarly journals Effect of Giving Celecoxib on Uric Acid Level on Mice

2018 ◽  
Vol 1 (2) ◽  
pp. 61-63
Author(s):  
Sara Surya
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Liver Extract ◽  
Control Group ◽  
Photometric Method ◽  
Experimental Animals ◽  
Trade Name ◽  
Blood Uric Acid ◽  
Anti Inflammatory

Celecoxib is a breakthrough for pain relievers under the trade name Celebrex�, which is a Non-Steroid Anti-Inflammatory drug with its activity as an analgesic, antipyretic and anti-inflammatory. The purpose of this study was to find out the effect of celecoxib on blood uric acid levels of female white mice was induced with fresh cow liver extract. Experimental animals were divided into five groups, namely the control group (-), the control group (+) and the three dose groups, respectively 0.26, 0.52 and 1.04 mg/20 g. Observations were made on 7, 14 and 21 days with the Enzymatic Photometric method. The results showed that administration of celecoxib suspension at a dose of 0.26, 0.52 and 1.04 mg/20 g did not affect blood uric acid levels when compared with controls (P> 0.05).

scholarly journals Jus semangka menurunkan kadar asam urat

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Wiwik Afridah ◽  
Catur ertika Sari
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Uric Acid Level ◽  
Acid Level ◽  
The Elderly ◽  
Control Group ◽  
Random Allocation ◽  
Old People ◽  
Watermelon Juice ◽  
Elderly Living

Abstract: As the population of the elderly increases, health problems such as Gout indicated by Hyperuricemia might also appear. Hyperuricemia can be prevented by increasing the intake of Vitamin C, B5, B6, and E. Therefore, the purpose of this research was to find out the effects of watermelon juice on the change in uric acid level in the elderly living in Dupak Bangunsari RT V RW 4 Surabaya. The research used quasi- experiment design. The populations involved 16 old people with Hyperuricemia, in which half of them, 8 people, were taken as the samples done by applying the random allocation technique classified as follows: 8 people in experiment group and 8 people in control group. The watermelon juice therapy was chosen as the independent variable, where as the dependent variable was the change of uric acid level. Furthermore, the uric acid level measuring tool was used to collect the data which were then recorded on the recapitulation and watermelon juice sheet. The result of analysis done by applying Fischer’s Exact test and SPSS for Windows showed that ρ = 0.001 < α = 0.05 which meant that the research hypothesis was accepted illustrating that there were some effects of watermelon juice on the change in uric acid level in the elderly living in the above mentioned region. The research has come to a conclusion that there were some effects of watermelon juice on the change in uric acid level. Hence, the old people with Hyperuricemia should consume more Vitamin C, B5, B6, and E and change their life pattern into the healthy one.

scholarly journals Pengaruh Pemberian Sari Buah Kersen terhadap Kadar Asam Urat pada Penderita Hiperurisemia

Jurnal Gizi ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Himeldah Isa Mahendra ◽  
Puspito Arum
Keyword(s):  
Uric Acid ◽  
Treatment Group ◽  
Vitamin C ◽  
Uric Acid Level ◽  
Acid Level ◽  
The Body ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Muntingia Calabura

Hyperuricemia is a health condition characterized by increasing uric acid levels in the body. Jamaican cherry (Muntingia calabura) is vitamin C containing fruit that have lowering-purine effect.The aim of this study was to determine the effect of Kersen (Muntingia calabura) extract on uric acidlevels. This was experimental study with pretest-posttest control group design. Male and female aged above 50 years and not taking vitamins were reqruites as subjects . In this study, the subjects were divided into control and treatment group with the total of 17 subjects for each group. The subjects consume 40.5 grams Kersen. The uric acid level was measured by helath professionals using Easy Touch. The diference of uric acid level were analized using Wilcoxon test  and Man-Whitney test, and the correlation and effect of Kersen were analyzed using Partial Correlation test and LinearRegression Test. The results show that uric acid levels in the treatment group were above normal as well as the control group because at the beginning of the study there were differences in the subject selection of each group. The results show that there is an effect of granting cherry juice to uric acid level ( p 0.004).Keywords: Gout, Hyperuricemia, Cherry Fruit, Vitamin C.

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