scholarly journals Increased Hmgb1 Associated With Low Zinc and Symptom Severity in Children with Autism

2020 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Autoimmune Diseases ◽  
Symptom Severity ◽  
Zinc Concentration ◽  
High Mobility ◽  
Children With Autism ◽  
Immune Dysfunction ◽  
Plasma Zinc ◽  
Compelling Evidence ◽  
High Prevalence ◽  
Zinc Levels

Autistic children often have a high prevalence of immune-related pathologies, such as allergies and autoimmune diseases, and there is compelling evidence that immune dysfunction is related to the etiology of autism. High-mobility group box proteins (HMGB1) constitute a family of non-histone and ubiquitous molecules with a pro-inflammatory function. In this study, we measured HMGB1 levels in autistic individuals and compared these levels to plasma zinc concentration. We found that in individuals with autism increased levels of HMGB1 was associated with low zinc levels, as well as increased selected symptom severity. These results suggest that there is a relationship between Zinc and HMGB1levels in autistic individuals, and that low zinc levels may be exasperating inflammation in these patients.

Measurement of Hypozincaemia in Mice: A Sensitive Test for Detection of Pyrogens

1981 ◽  
Vol 61 (4) ◽  
pp. 445-449 ◽  
Author(s):  
Susan Boobis ◽  
Rose E. Hartley
Keyword(s):  
Escherichia Coli ◽  
Zinc Concentration ◽  
Shigella Dysenteriae ◽  
Metabolic Inhibitor ◽  
Repeated Treatment ◽  
Plasma Zinc ◽  
Sensitive Test ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Dose Dependent

1. The effect of bacterial pyrogens on plasma zinc concentration in mice was studied as a method of bioassay for these substances. 2. A dose-related depression of plasma zinc concentrations was observed 4 h after intravenous injection of doses of 0.05-500 ng of purified endotoxins of Salmonella abortus equi, Shigella dysenteriae and Escherichia coli. Responses were dose-dependent and reproducible for each endotoxin in five strains of mice. 3. Tolerance to endotoxin could be induced in mice by injection of doses of 500 ng but was not seen with doses of <5 ng, even after repeated treatment. 4. Dinitrophenol, a metabolic inhibitor, and amphetamine, a metabolic enhancer, did not affect plasma zinc levels, indicating that changes in basal metabolic rate do not affect the outcome of this assay. The effects of pyrogenic materials other than endotoxin on plasma zinc levels were also tested and the results suggest that measurement of hypozincaemia in mice provides the basis for a simple, practical and inexpensive test for endotoxins and other pyrogens.

scholarly journals Plasma Copper and Zinc Concentration in Individuals with Autism Correlate with Selected Symptom Severity

2012 ◽  
Vol 5 ◽  
pp. NMI.S8761 ◽  
Author(s):  
Anthony J. Russo ◽  
Andrea P. Bazin ◽  
Richard Bigega ◽  
Robert S. Carlson ◽  
Martin G. Cole ◽  
...  
Keyword(s):  
Motor Skills ◽  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Receptive Language ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Plasma Zinc ◽  
Inductively Coupled ◽  
Copper And Zinc

Aim To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. Subjects and Methods Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms. Results Autistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity. Discussion These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.

A Formula for Correcting Plasma Zinc Levels against Protein Concentration

1986 ◽  
Vol 6 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Kostas Sombolos Rudolf ◽  
Vogl Nickolas Dombros ◽  
Dimitrios Oreopoulos ◽  
Abraham Rapoport
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Total Protein ◽  
Protein Concentration ◽  
Zinc Concentration ◽  
Venous Occlusion ◽  
Plasma Zinc ◽  
Total Proteins ◽  
Before And After ◽  
Zinc Levels

Plasma zinc and total protein concentrations were measured in 13 normal volunteers, before and after a five-minute occlusion of the antecubital vein with a sphygmomanometer cuff. The percentage increment before and after five minutes of venous occlusion was 10.2 ± 4.7% for total protein and 8.8 ± 6.0% for zinc concentration. Both these differences were statistically significant (p < 0.001). We propose an equation for correction of plasma zinc levels according to concentration of total proteins. Using this equation the corrected values of plasma zinc before and after 5 minutes of venous occlusion were similar, that is, 12.33 ± 1.94 and 12.20 ± 2.05 μmol/l. In addition we found that of seven hypoproteinemic patients on continuous ambulatory peritoneal dialysis (CAPD) who had low plasma zinc levels compared to normal (uncorrected for protein concentration) controls, only two had “true” hypozincemia when their plasma zinc was corrected against protein using this formula and compared to normals (corrected for protein) controls. The paper discusses the clinical usefulness of this adjustment of measurements of plasma zinc concentration.

scholarly journals Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation

2013 ◽  
Vol 57 (3) ◽  
pp. 348-355 ◽  
Author(s):  
K. Ryan Wessells ◽  
Sonja Y. Hess ◽  
Noel Rouamba ◽  
Zinewendé P. Ouédraogo ◽  
Mark Kellogg ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Zinc Supplementation ◽  
Plasma Zinc ◽  
Plasma Zinc Concentration

High prevalence of suicidal ideation in AF: influence of psychology, AF symptom severity and AF burden

2015 ◽  
Vol 24 ◽  
pp. S382-S383
Author(s):  
T. Walters ◽  
K. Wick ◽  
A. Nisbet ◽  
G. Morris ◽  
J. Morton ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Symptom Severity ◽  
High Prevalence

scholarly journals Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Anne Masi ◽  
Edmond J. Breen ◽  
Gail A. Alvares ◽  
Nicholas Glozier ◽  
Ian B. Hickie ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Male And Female ◽  
Cytokine Levels ◽  
Female Children

scholarly journals Reduced Plasma Zinc Levels, Lipid Peroxidation, and Inflammation Biomarkers Levels in Hemodialysis Patients: Implications to Cardiovascular Mortality

Renal Failure ◽  
2013 ◽  
Vol 35 (5) ◽  
pp. 680-685 ◽  
Author(s):  
Julie calixto Lobo ◽  
Milena Barcza Stockler-Pinto ◽  
Najla Elias Farage ◽  
Tanize do Espirito Santo Faulin ◽  
Dulcinéia Saes Parra Abdalla ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Cardiovascular Mortality ◽  
Hemodialysis Patients ◽  
Plasma Zinc ◽  
Zinc Levels

Zinc Deficiency and Edema

PEDIATRICS ◽  
1986 ◽  
Vol 77 (1) ◽  
pp. 132-133
Author(s):  
MICHAEL H. N. GOLDEN ◽  
BARBARA E. GOLDEN
Keyword(s):  
Developing Countries ◽  
Zinc Deficiency ◽  
Premature Infants ◽  
Zinc Concentration ◽  
Clinical Presentation ◽  
Plasma Zinc ◽  
Plasma Zinc Concentration ◽  
Clear Association ◽  
Zinc Concentrations

To the Editor.— Kumar and Anday1 describe three premature infants presenting with edema and hypoproteinemia—the classical signs of kwashiorkor—between 5 and 9 weeks of age. Such cases are not uncommon in developing countries. Kumar and Anday's patients had low plasma zinc concentrations (43, 37, and 42 µg/dL). On this basis the authors claim that edema and hypoproteinemia is a clinical presentation of zinc deficiency not previously reported. We reported2 a clear association between "nutritional" edema and a low plasma zinc concentration in 1979; our subsequent experience has confirmed that edema of this type is always associated with a low plasma zinc concentration, as indeed Kumar and Andays' cases demonstrate.

scholarly journals Plasma Zinc Concentration Increases within 2 Weeks in Healthy Senegalese Men Given Liquid Supplemental Zinc, but Not Zinc-Fortified Wheat Bread

2011 ◽  
Vol 141 (7) ◽  
pp. 1369-1374 ◽  
Author(s):  
Grant J. Aaron ◽  
Nafissatou Ba Lo ◽  
Sonja Y. Hess ◽  
Amadou T. Guiro ◽  
Salimata Wade ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Wheat Bread ◽  
Plasma Zinc ◽  
Plasma Zinc Concentration ◽  
Supplemental Zinc
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