scholarly journals Preserving the Flame in the Mental Life of Premature Babies

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Clinical Research ◽  
Emotional Intensity ◽  
Mental Life ◽  
Observational Method ◽  
Early Deprivation ◽  
Premature Newborns ◽  
Clinical Vignettes ◽  
Premature Babies ◽  
Emotional Model ◽  
One Year

The aim of this article is to emphasize the necessity to protect the early psyche in premature newborns, separated from their mothers since birth. These babies survived and stayed alive thanks to a “complex life saver incubator”, handled by a professional team. We will present clinical vignettes that show some of the delicate mental mechanisms that are observable, and the emotional intensity that these babies are able to proyect in the observer. We will show how early deprivation of a maternal object can affect the incipient mind of a child. In January 2017 it started a one year experience using the Esther Bick’s Observational method in a multi professional team in a neonatology Unit. This team takes care of the babies and the idea is to help them internalize an emotional model in order to contain and work through the intense emotions that are awaken while taking care of the babies, without acting or be overwhelmed. This experience will open a road through which we are going to be able to hold alive the flame of the mental life in these little patients, as well build a road to widen clinical research in this field.

Features of modern clinical research blood analysis in the assessment of erythropoiesis in deep-premature newborns

2021 ◽  
Vol 66 (1) ◽  
pp. 26-34
Author(s):  
Galina Nikolaevna Kuzmenko ◽  
N. V. Kharlamova ◽  
S. B. Nazarov ◽  
E. A. Matveeva ◽  
Yu. A. Ivanenkova
Keyword(s):  
Neonatal Period ◽  
Venous Blood ◽  
Diagnostic Procedures ◽  
Blood Parameters ◽  
Blood Analysis ◽  
Iron Availability ◽  
Average Amount ◽  
Premature Newborns ◽  
Early Neonatal Period ◽  
Premature Babies

One of the urgent problems of nursing premature babies is the timely prediction, diagnosis and treatment of anemia, the frequency of which reaches 90%. Of particular importance is the study of reticulocytic blood parameters in deep-premature newborns, since the correct assessment of hemograms is crucial in the management of this category of children. To determine the characteristics of red blood cells and reticulocyte parameters of venous blood hemogram in premature newborns 24-32 weeks of gestation in the dynamics of the neonatal period. 111 newborns were examined at 24-32 weeks of gestation in the early neonatal period (on day 3-7) and at the age of 1 month of life. Along with standard diagnostic procedures, in accordance with current clinical recommendations and standards, 28 parameters of erythrocyte and reticulocyte hemogram parameters were determined for children. Venous blood was examined using an automatic hematological analyzer ADVIA 2120i, Siemens, USA. In deep-premature newborns in the early neonatal period, there is a high activity of erythropoiesis, respectively, the severity of respiratory and metabolic disorders with rejuvenation of reticulocytic subpopulations. Negative values of Delta hemoglobin were found against the background of a decrease in the average amount of hemoglobin in reticulocytes in children 24-27 weeks of gestation, which characterizes the lowest values of iron availability for erythropoiesis in this category of newborns. It is shown that a decrease in reticulocyte counts and normochromia in all examined newborns by the age of one month are accompanied by high levels of immature reticulocyte fraction, while a third of children still have limited iron availability for erythropoiesis.

ENTRE ENCUENTRO Y DESENCUENTRO: TEMPORALIDAD EN TERAPIA DE PAREJA

2020 ◽  
Vol 1 (49) ◽  
pp. 69-89
Author(s):  
sofía De la Puerta ◽  
Carolina Correa
Keyword(s):  
Clinical Practice ◽  
Systemic Therapy ◽  
Couple Therapy ◽  
Clinical Case ◽  
Subjective Time ◽  
Present Moment ◽  
Clinical Process ◽  
Heterosexual Couple ◽  
Clinical Vignettes ◽  
One Year

The objective of this work is to understand a clinical process of systemic orientation from the perspective of subjective temporality. The work is based on the theory of subjective time and considers its historical and sociocultural dimension, reviewing its main theoretical constructs that will understand couple relationships and therapeutic processes. A clinical case was analyzed a from the perspective of subjective temporality, based on the main antecedents of the case and using clinical vignettes. Participants were a 36- and 37-year-old heterosexual couple who participated in a couple therapy with two therapists trained in systemic therapy for approximately one year. The sessions were videotaped and analyzed through the theory of subjective temporality. The analysis of the subjective temporality constitutes a contribution to the clinical practice, since it allows to understand and to develop an approach centered in the present moment and that allows analyzing the synchrony and encounter of the members of the system.

scholarly journals The Relationship Between Social Support and Postpartum Depression in Mothers with Premature Babies

2018 ◽  
Author(s):  
Mohammad Shafie ◽  
Hamideh Davoodizadeh Jolgeh ◽  
Maryam Dabirifard ◽  
Sara Dabirifard ◽  
Milad Shafiee
Keyword(s):  
Social Support ◽  
Postpartum Depression ◽  
Neonatal Intensive Care ◽  
Economic Status ◽  
Educational Status ◽  
P Value ◽  
Significance Level ◽  
Premature Newborns ◽  
Premature Babies ◽  
The Social

Introduction: Failure in social support is one of the important factors in developing postpartum depression. Since mothers with premature or sick babies have higher levels of anxiety during postpartum period in comparison with other members, they need more social support. So, in this study we decided to evaluate the relation between postpartum depression and the level of social support in mothers who have premature newborns. Methods: This descriptive-correlative study was conducted on 100 mothers who had premature newborns and were  discharged from the Neonatal Intensive Care Unit of Shahid Sadoughi Hospital in 2016. The sampling was conducted using the available sampling method. Mothers were asked to complete the social support and postpartum depression questionnaire. . All collected data were entered to the SPSS v.17 and analyzed by the analytic and descriptive statistical indices. The significance level was set at p-value<0.05. Results: The final results revealed that social support had a significant association (p-value<0.05) with the number of mother’s child, her husband’s job,  and family economic status . Furthermore, the findings revealed that postpartum depression had a significant association with the father's job, the educational status of father, and the economic status of family. Conclusion: It can be concluded that the more social support leds to the less incidence of postpartum depression.

scholarly journals 3446 The OHSU Physician-Scientist Experience: Integrating intensive translational research training for medical students into a competency-based educational framework

2019 ◽  
Vol 3 (s1) ◽  
pp. 74-75
Author(s):  
Karen W. McCracken ◽  
Peter Mayinger ◽  
Cynthia Morris
Keyword(s):  
Medical Student ◽  
Medical Students ◽  
Clinical Research ◽  
Translational Research ◽  
Research Experience ◽  
Research Opportunities ◽  
Competency Based ◽  
Physician Scientist ◽  
One Year ◽  
The One

OBJECTIVES/SPECIFIC AIMS: The aim of this program is to provide early support to motivated medical students interested in a career as a physician-scientist in a framework of competency-based medical education. The CTSA creates an opportunity to provide clinical research education and protected time for research for medical students in clinical and translational research. METHODS/STUDY POPULATION: This physician-scientist experience offers research opportunities in a wide variety of research disciplines, focused on clinical and translational investigations. The program offers both five-month and one-year blocks of protected research time. The five-month option is integrated into the four- year medical curriculum. The one-year option requires enrollment in an established Master of Clinical Research degree. Both options provide research experience under the mentorship of a physician-scientist. The five-month option aligns with UME competencies categorized under the six ACGME Domains of Competence. The one-year option includes coursework in research design, biostatistics, research ethics, data management, scientific communication, and proposal development within the CTSA-based education program. All students in the program attend a bimonthly journal club and seminar series starting in year one and extending through the research experience. This includes discussion of the importance of mentorship, selecting a residency, scientific writing and presentation, and personal narratives of physician-scientists and their pathways to this career. All students will be followed to determine career outcome. RESULTS/ANTICIPATED RESULTS: Between 2015 and 2018, 67 students entered the program 46% selected the year out, and 56% selected the 5-month option. Students selecting this program constitute about 10% of the medical student population overall. We have had 17 graduates of the program to date. 55% of the cohort is women which parallels the OHSU medical student population. Long-term follow-up of at least 10 years will be needed to determine career outcomes. We assess student productivity by traditional measures of submitted abstracts, manuscripts, and presentations as well as longer term outcomes such as career orientation in medicine such as entry into a research-oriented residency and ultimately into an academic medicine or research. DISCUSSION/SIGNIFICANCE OF IMPACT: The OHSU physician-scientist experience successfully matches medical students with a diverse set of research mentors focused on the CTSA. Although institutional structures determine the variety of specific research opportunities, the integration of physician-scientist training into a CTSA-based training program expands the reach of training programs such as the TL1.

scholarly journals The Rationale, Feasibility, and Optimal Training of the Non-Physician Medical Nutrition Scientist

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Susan E. Ettinger ◽  
Jennifer A. Nasser ◽  
Ellen S. Engelson ◽  
Jeanine B. Albu ◽  
Sami Hashim ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Clinical Research ◽  
Formative Evaluation ◽  
Medical Science ◽  
Train The Trainer ◽  
Nutrition Science ◽  
Learning Barriers ◽  
Practice Of Medicine ◽  
One Year

Dietary components have potential to arrest or modify chronic disease processes including obesity, cancer, and comorbidities. However, clinical research to translate mechanistic nutrition data into clinical interventions is needed. We have developed a one-year transitional postdoctoral curriculum to prepare nutrition scientists in the language and practice of medicine and in clinical research methodology before undertaking independent research. Candidates with an earned doctorate in nutrition science receive intensive, didactic training at the interface of nutrition and medicine, participate in supervised medical observerships, and join ongoing clinical research. To date, we have trained four postdoctoral fellows. Formative evaluation revealed several learning barriers to this training, including deficits in prior medical science knowledge and diverse perceptions of the role of the translational nutrition scientist. Several innovative techniques to address these barriers are discussed. We propose the fact that this “train the trainer” approach has potential to create a new translational nutrition researcher competent to identify clinical problems, collaborate with clinicians and researchers, and incorporate nutrition science across disciplines from “bench to bedside.” We also expect the translational nutrition scientist to serve as an expert resource to the medical team in use of nutrition as adjuvant therapy for the prevention and management of chronic disease.

scholarly journals COVID-19 challenges in clinical trials

2021 ◽  
Vol 10 (6) ◽  
pp. 769
Author(s):  
Murugan Panchatcharam ◽  
Sravanthi Lakshmi Mukku
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Human Subjects ◽  
Well Being ◽  
The Past ◽  
The Face ◽  
Current Scenario ◽  
One Year ◽  
Research Organisations ◽  
Contract Research Organisations

Clinical research involves working with human subjects to answer questions relevant to their well-being in an ethical manner. The current scenario from the past one year has drastically changed the face of the clinical trials. The present COVID prevalence and simultaneously conducting the research with all the regulations and the precautions has been the difficult task for the contract research organisations (CRO).

Autologous Stem Cell Transplantation Is Feasible and of Potential Benefit In Very Elderly Patients with Lymphoma and Limited Comorbidities

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3561-3561
Author(s):  
Rebecca Elstrom ◽  
Peter Martin ◽  
Tsiporah B. Shore ◽  
Richard R. Furman ◽  
Jia Ruan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Elderly Patients ◽  
Clinical Research ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Research Funding ◽  
Medium Risk ◽  
One Year

Abstract Abstract 3561 Introduction: In patients with Hodgkin lymphoma (HL) and non-Hodgkin's lymphoma (NHL) for whom initial therapy is not curative, high dose chemotherapy followed by autologous stem cell transplantation (AutoSCT) may offer a second chance for cure or long term remission. Because of the potential toxicities of this therapy, elderly patients are usually not considered candidates for this approach. Although recent publications have suggested that AutoSCT may benefit some patients over 65 years of age, data regarding feasibility in older patients (69 or greater) are lacking. Patients and Methods: The stem cell transplant database at Weill Cornell Medical College was reviewed to identify patients with a diagnosis of lymphoma (HL or NHL) age 69 or greater who had undergone AutoSCT. Patients were included if age, date of transplant, response and survival data were available. Baseline Charlson comorbidity risk index (CCI) was calculated and correlated with outcome. Results: Twenty-one patients aged 69 or greater (range 69–86, median 71) with adequate records were identified who underwent autologous stem cell transplantation for treatment of lymphoma. Thirteen patients had diffuse large B cell lymphoma, 3 had transformed indolent lymphoma, 2 had Burkitt lymphoma, one had peripheral T cell lymphoma, one had follicular lymphoma, and one had HL. Sixteen patients underwent AutoSCT in first relapse with chemotherapy sensitive disease, 2 patients had primary refractory lymphoma, 2 were in 2nd or greater relapse, and one patient was in first complete remission (CR). Two patients underwent total body irradiation (TBI) as part of conditioning, while the other 19 patients underwent conditioning with chemotherapy alone. Sixteen patients (76%) achieved CR following autoSCT, while 3 patients did not achieve CR; 2 patients died before response assessment could be undertaken. With median follow up of 20 months, the median progression-free survival following autoSCT was 10 months and median overall survival was 18 months. Age was associated with PFS (HR 1.18, p=0.05, 95% C.I. 1.05–1.33) but not OS (HR 1.11, p=0.09, 95% C.I. 0.98–1.25). Eight of 18 patients with adequate follow up (44%) remained in remission for at least 18 months post-transplant. CCI data were available for 19 patients. Four patients (19%) died within or shortly after 100 days, all of transplant-related toxicity. Two of these 4 patients were high risk by CCI, one was medium risk, and CCI data were not available for the fourth patient. Three other patients were of medium risk; 2 are alive in CR and one died of progressive lymphoma 19 months after transplantation. Thirteen patients were of low risk by CCI. Of these patients, 9 (69%) are either alive at time of follow up or survived for greater than one year after transplant, while 4 (31%) died within one year of progressive lymphoma. Conclusion: Autologous stem cell transplantation is feasible and of potential benefit in selected elderly patients with lymphoma. Age alone need not exclude patients with good functional status and limited comorbidity from this therapeutic approach. Consideration of comorbidities may allow selection of patients most likely to tolerate and benefit from AutoSCT. Disclosures: Furman: GlaxoSmithKline: Clinical research funding, Consultancy, Research Funding, Speakers Bureau; Genentech: Clinical Research Funding, Consultancy, Research Funding, Speakers Bureau; Cephalon: Speakers Bureau, Speakers bureau; Calistoga: Consultancy, Honoraria; Celgene: Clinical Research, Consultancy, Research Funding. Leonard:Hospira: Consultancy, Honoraria; Cell Therapeutics: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; GlaxoSmithKline: Consultancy, Honoraria; Biogen IDEC: Consultancy, Honoraria; Calistoga: Consultancy, Honoraria; Johnson and Johnson: Consultancy, Honoraria; EMD Serono: Consultancy, Honoraria; Sanofi Aventis: Consultancy, Honoraria; Millenium: Consultancy, Honoraria; Biotest: Consultancy, Honoraria; Cephalon: Consultancy, Honoraria; Pharmion: Consultancy, Honoraria; Eisai: Consultancy, Honoraria; Cougar Biotechnology: Consultancy, Honoraria; Immunomedics: Honoraria; Genentech: Consultancy, Honoraria; Novartis: Consultancy, Honoraria.

scholarly journals One year on: The impact of COVID-19 on clinical research

2021 ◽  
Vol 92 ◽  
pp. 24-27
Author(s):  
Luigi Tavazzi ◽  
Aldo P. Maggioni ◽  
Claudio Rapezzi ◽  
Roberto Ferrari
Keyword(s):  
Clinical Research ◽  
One Year ◽  
The Impact

scholarly journals COLOSTROTERAPIA E OS SEUS BENEFÍCIOS PARA RECÉM-NASCIDOS PREMATUROS: UMA REVISÃO DE LITERATURA

2021 ◽  
Vol 9 (210) ◽  
pp. 1-16
Author(s):  
Mariana Gonçalves de Oliveira ◽  
Sabrina Alapenha Ferro Chaves Costa Lima
Keyword(s):  
Scientific Literature ◽  
Qualitative Approach ◽  
Narrative Review ◽  
Fundamental Importance ◽  
Review Of Literature ◽  
Premature Newborns ◽  
Premature Babies ◽  
Promising Treatment ◽  
Immunological Factors ◽  
Very High

Breastfeeding is a food of fundamental importance for newborns, especially for those who are born prematurely. In premature babies, due to the interruption in the adequate time for a pregnancy, the incidence of complications in their body is very high. The administration of colostrotherapy, a treatment based on maternal colostrum, has been speculated as a way of promoting immunological factors in premature children. This research aims to investigate from the scientific literature the benefits that the treatment of colostrotherapy can provide to premature newborns. It is a narrative review of literature with a qualitative approach and exploratory character. The study revealed as results that through the oropharyngeal ingestion of colostrum, a potential increase in the level of immunological factors acting in the newborn's body was observed. Thus, strengthening the understanding that the administration of colostrotherapy in newborns can be considered an effective, safe and promising treatment.

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