scholarly journals Computer-aided Identification of Synergetic Wound Healing Mechanisms Exhibited by Compounds in the Bio Synthesized Wound Dressing Material

2021 ◽  
Vol 10 (4) ◽  
pp. 2831-2842
Keyword(s):  
Wound Healing ◽  
Bioactive Compounds ◽  
Wound Dressing ◽  
Biological Activities ◽  
Mangifera Indica ◽  
Beta Carotene ◽  
Fish Scale ◽  
Spider Web ◽  
Healing Wound ◽  
Pass Online

A wound dressing material synthesized from the bio-composites of chicken fibrin, fish scale collagen impregnated with the spider web, and the ethanolic leaves extract of Mangifera indica (L.). The synthesized biomaterial was analyzed by GC-MS analysis. The present study involves identifying bioactive compounds that may heal wounds from the biosynthetic wound dressing material and the biological activities determined with the help of PASS software online prediction. PASS online software is used to explore the mechanism involved in healing wound compounds. Ten bioactive compounds identified as wound healing agents 2-methyl 4-Heptanol, 3-methoxy Hexane, Stigmasterol, Z-3,17-Octadecadien-1-ol acetate, 3-Chloro-5 Cholestene, 9,12,15 Octadecatrienoic acid 2,3 –Bis(acetyloxy) propyl ester(Z, Z, Z), Trans-Z-.alpha.-bisabolene epoxide, Beta carotene, Nopyl Acetate, 9,12 Octadecadienoic acid (Z, Z)phenylmethyl ester, and their bioactivities analyzed. Analyzed bio compounds found to exhibit wound healing mechanisms.

scholarly journals Synthesis and Characterization of Wound Dressing Material from Bio-Wastes Impregnated with the Spider Web and the Ethanolic Weaves Extract of Mangifera indica (L.)

2021 ◽  
Vol 12 (2) ◽  
pp. 1998-2012
Keyword(s):  
Cost Effectiveness ◽  
Wound Dressing ◽  
Type I Collagen ◽  
Mangifera Indica ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
Type I ◽  
Fish Scale ◽  
Good Efficacy ◽  
Spider Web

Substantial progress in wound therapy has not snuffed out the passion in search of innovative wound dressing materials. This work is to analyze the physiochemical characterizations and biological evaluation of a wound dressing material. A wound dressing material had been synthesized from Physiologically Clotted Fibrin (PCF), Fish Scale Collagen (FSC). Also, the wound dressing material had impregnated with the folklore medicinal impact of the Spider Web (SW) and the Ethanolic Extract of Mangifera indica (L.)(EEMI). Infrared spectroscopic techniques confirmed the presence of Type I collagen. Surface morphology established the smooth, uniform, porous, biocompatible surface of the material. Water absorption studies, porosity measurements showed the required characteristics, the antibacterial activity favored the resistance, and the ash test supported the eco-friendly environment of the wound dressing material. Human erythrocytes had reviewed biocompatibility. The supernatant of the wound dressing material at different concentrations and incubation times had determined for percent hemolysis. Plots between percent hemolysis and concentration showed the non-hemolytic behavior of the wound dressing material. The synthesized biomaterial could propose as a wound dressing material with good efficacy, cost-effectiveness, and eco-friendly. The synthesized biomaterial could have been a better wound dressing material with good efficacy, cost-effectiveness, and eco-friendly.

A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

2020 ◽  
Vol 8 (24) ◽  
pp. 6930-6945
Author(s):  
Lingling Gao ◽  
Jingjie Chen ◽  
Wei Feng ◽  
Qing Song ◽  
Jingjing Huo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Broad Spectrum ◽  
Wound Dressing ◽  
Biological Activities ◽  
Hemorrhage Control ◽  
Injectable Hydrogel ◽  
Oxidized Dextran ◽  
Biodegradable Hydrogel

An injectable hydrogel wound dressing based on an oxidized dextran and ε-poly-l-lysine network has multiple biological activities.

A Novel Hydrocolloid Film Based on Pectin, Starch and Gunnera tinctoria and Ugni molinae Plant Extracts for Wound Dressing Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 280-292 ◽  
Author(s):  
Constanza Sabando ◽  
Walther Ide ◽  
Maité Rodríguez-Díaz ◽  
Gustavo Cabrera-Barjas ◽  
Johanna Castaño ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Bioactive Compounds ◽  
Water Uptake ◽  
Pressure Ulcer ◽  
Plant Extracts ◽  
Wound Dressing ◽  
Aqueous Media ◽  
Release Profile ◽  
Healing Property

Background: The biodegradable and biocompatible nature of pectin-based films is of particular interest in wound dressing applications, due to its non-toxicity, pH-sensitivity and gelling activity. An approach to improve the mechanical properties, the release profile of bioactive compounds as well as the performance in wet environments of pectin-based films is mixing with other biopolymers. Objective: To prepare hydrocolloid films based on crosslinked pectin / starch blend loaded with bioactive extracts from leaves of G. tinctoria and U. molinae with controlled release of bioactive compounds and healing property. Method: The hydrocolloid films were characterized by FTIR, SEM, and TGA-FTIR techniques and their tensile properties, water uptake, and polyphenolic release profile in aqueous media were evaluated. The dermal anti inflammatory activity of the hydrocolloid films was assessed by the mouse ear inflammation test. The wound healing property of the loaded hydrocolloid films was explored in a rat model and in a clinical trial (sacrum pressure ulcer). Results: The films showed an adequate water-uptake capacity between 100-160%. The release of active compounds from the hydrocolloid films followed the Korsmeyer-Peppas equation. The mechanical properties of hydrocolloid films were not affected by the plant extracts within the concentration range used. The incorporation of the bioactive extracts in the polysaccharide films inhibited the topical edematous response by about 50%. The topical application of the loaded hydrocolloid film on the pressure ulcer is completely closed after 17 days without showing any adverse reaction. Conclusion: A novel hydrocolloid matrix was produced from crosslinked starch-pectin, which exhibited suitable chemical-physical properties to be used as a carrier of plant extracts with wound healing properties.

scholarly journals EFFECT OF PRODIGIOSIN FROM SERRATIA MARCESCENS BR1 STRAIN AS AN ANTIOXIDATIVE, ANTIMICROBIAL, AND IN VIVO WOUND HEALING

2020 ◽  
pp. 175-179
Author(s):  
ELHAMEUR HACENE
Keyword(s):  
Wound Healing ◽  
Candida Albicans ◽  
Serratia Marcescens ◽  
Klebsiella Oxytoca ◽  
Beta Carotene ◽  
Antioxidant Power ◽  
Extraction And Purification ◽  
Healing Wound ◽  
Ferric Reducing Antioxidant Power

Objective: The aim of this work is to evaluate antioxidative, antimicrobial, and healing wound potential of prodigiosin extracted from Serratia marcescens strain microbiota of a traditional Algerian fermented cereal food. The goal is to develop a natural galenic formulation for external use. Methods: After extraction and purification of the red pigment, the Fourier transform infrared spectrum is determined. The antioxidative activity was performed by scavenging radical with 2-diphenyl-1-picrylhydrazyl (DPPH), bleaching of beta-carotene, and ferric reducing antioxidant power. Antimicrobial tests were assessed against bacteria and fungi pathogenic reference strains Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 10541, Klebsiella oxytoca ATCC 13182, Staphylococcus aureus CC 10541, Helicobacter pylori, and Candida albicans ATCC 10231. Healing wound activity was achieved in vivo on Wistar rats using as a reference to the commercial formulation Madécasol. Results: S. marcescens BR1 produce a prodigiosin where IR spectrum is typical. The DPPH test shows a trapping power of 80% at 1 mg/ml and an inhibitory concentration 50 equal to 0.54 mg/ml. The discoloration of β-carotene is 50% with high ferric reducing antioxidant power (FRAP). Candida albicans were the most sensitive to prodigiosin with inhibition diameters >20 mm. All strains tested are sensitive to prodigiosin. C. albicans were the most sensitive with inhibition diameters >20 mm followed by H. pylori strain (15 mm) and E. coli (13.5 mm). Prodigiosin ointment at 0.1% in Vaseline was used to achieve in vivo healing activity. Obtained results showed a fast and effective wound healing potential, better than the standard (Madécasol). The cicatrization traces totally without any of the lesions. We discovered the absence of the redness phase. This formulation, based on prodigiosin, is very promising as a natural replacement for the synthetic drug, having powerful anti-microbial, wound healing, and anti-inflammatory activities.

scholarly journals The Insight of Body’s Immune System, Inflammation and Damages in Wound Healing- The review

2021 ◽  
Vol 9 (8) ◽  
pp. 2777-2780
Author(s):  
Priyanka Patil
Keyword(s):  
Wound Healing ◽  
Immune System ◽  
Wound Dressing ◽  
Wound Dressings ◽  
Wound Infections ◽  
Wound Area ◽  
Wound Site ◽  
Healing Wound ◽  
Dressing Materials ◽  
Keywords Wound Healing

Abstract: The injuries and its infections are the most painful form of trauma. Wound infections are the growth of microorganisms within the wound area. This infection causes the body’s immune system, inflammation and damages the tissue within the wound site. Hence, there is an immense need to formulate new dressing materials for wound dressing application. To know more about new dressing material working it is need of time to study the mechanism of wound healing. Today’s review focus on mechanism of wound healing, wound dressing, new dressing material and necessity of wound dressings. Keywords: Wound healing, dressing material

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation

Burns ◽  
2020 ◽  
Vol 46 (1) ◽  
pp. 143-155 ◽  
Author(s):  
Serdar Tort ◽  
Fatmanur Tuğcu Demiröz ◽  
Şule Coşkun Cevher ◽  
Sanem Sarıbaş ◽  
Candan Özoğul ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Histopathological Evaluation
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