scholarly journals Evaluation of some prescribed and over-the-counter drugs induced hemato-biochemical changes in mice

2020 ◽  
Vol 5 (4) ◽  
pp. 297-302
Author(s):  
Mohammad Rohul Amin ◽  
Shukhi Khanam ◽  
Lalin Mazumder ◽  
ABM Zunayeed Rahman ◽  
AKM Mostafa Anower ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Leukocyte Count ◽  
Male Mice ◽  
Hemoglobin Content ◽  
Animal Science ◽  
Differential Leukocyte Count ◽  
Over The Counter ◽  
Group A ◽  
Group B ◽  
Structured Questionnaire

The present study was performed in the Department of Physiology and Pharmacology, Faculty of Animal science and Veterinary Medicine, PSTU, Bangladesh. Data were collected using a semi-structured questionnaire from 125 people in Babugonj upazilla, Barishal for using drugs without prescription or at prescription. The experiment was conducted to evaluate the effects of prescribed and over-the-counter drugs on hematological (TEC, Hb and DLC) and biochemical (blood glucose) parameters in mice during the period March to April, 2019. 140 male mice were randomly divided into seven groups (A, B, C, D, E, F and G), each consisting of 20 mice. Group A was kept as control. Paracetamol, diclofenac, pantoprazole, ranitidine, diazepam and clonazepam were administered orally to mice of group B, C, D, E, F and G, respectively for 28 days. Paracetamol and ranitidine were used by 100% people followed by peantoprazole (80.80%), diclofenac-60%, diazepam-42.40% and clonazepam-24%, respectively without prescription. Paracetamol were used by 100% people followed by peantoprazole (84%), ranitidine-76%, diclofenac-66.40%, clonazepam-53.60% and diazepam 32.80%, respectively at prescription. Paracetamol and diazepam decreased significantly (p<0.05) total erythrocyte count (TEC) at 28th day. Paracetamol, diclofenac and diazepam decreased significantly (p<0.01 and p<0.05) hemoglobin content (Hb) at 28th day. The Differential leukocyte count (DLC) was not significantly changed at 28th day in mice. Paracetamol, diclofenac, pantoprazole, ranitidine, diazepam and clonazepam increased significantly (p<0.01 and p<0.05) blood glucose level in mice. It may be concluded that paracetamol is one of the most frequently used and self prescribing drugs in Bangladesh. Asian J. Med. Biol. Res. June 2019, 5(4): 297-302

scholarly journals Evaluation of Effect of Melatonin on Hematological Parameters in Patients of Periodontitis

2019 ◽  
pp. 46-49
Author(s):  
Anagha Marawar ◽  
Pramod Marawar ◽  
Nandal D H ◽  
Rahul Kunkulol ◽  
Sandeep Narwane
Keyword(s):  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Differential Leukocyte Count ◽  
Erythrocyte Sedimentation ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Root Planning ◽  
Scaling And Root Planning

Introduction: Considering the immunity enhancing property of melatonin, a study on the evaluation of the effect of melatonin on the hematological parameters in patients suffering from Periodontitis.  Methods: This study was conducted in the Department of Periodontics, Rural Dental College, Loni. Patients of chronic Periodontitis, of age between 18 to 65 years of either gender ready to give informed consent to participate in the study were included. Postoperative patients, patients having night duties, drivers and those using heavy machinery, pregnant women, lactating mothers, patients with any clinically significant systemic disease and patients on any other drugs were excluded from the study. Patients were divided into two Groups. Group B received scaling and root planning (SRP) and melatonin 3 mg per day were compared to Group A which received SRP only. The Total Leukocyte count, Differential Leukocyte count and Erythrocyte sedimentation rate of each patient was studied at a baseline, 1st (30 days) visit, 2nd (60 days) visit and 3rd (90 days) visit. Results: Both the groups consisted of 80 subjects each. Group A consisted of 71.25% male and 28.75% female patients. There were 56.25% male and 43.75% female patients in Group B. With respect to visit 3, the TLC was statistically lower in Group B. The neutrophil count of Group B was significantly lower during visit 3 as compared to Group A. The lymphocyte count of Group B was significantly lower than that of Group A during the visit 1, and also significantly higher during visit 3 on comparison with Group A. There was no statistically significant difference in the groups with respect to eosinophil and basophil count. The Monocyte count of Group B was statistically lower when compared to that of Group A. There was no statistically significant difference between ESR of Group A & Group B.  Conclusions: It can be concluded that melatonin has a positive effect on TLC and differential count of patients of periodontitis, conferring a new facet to the management of periodontitis and an attempt to impede the disease progression. Keywords: Melatonin; Hematological parameters; Periodontitis; Total Leukocyte count; Differential Leukocyte count; Erythrocyte sedimentation rate; Scaling and Root Planning.

scholarly journals Systemic inflammatory response indicators in rabbits (Oryctolagus cuniculus) experimentally infected with sporulated oocysts of Eimeria stiedai (Apicomplexa: Eimeriidae)

2011 ◽  
Vol 20 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Fagner Luiz da Costa Freitas ◽  
Beatriz Lie Yamamoto ◽  
Wagner Luiz da Costa Freitas ◽  
Jose Jurandir Fagliari ◽  
Katyane de Sousa Almeida ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Leukocyte Count ◽  
Experimental Period ◽  
Infection Level ◽  
Molecular Weights ◽  
New Zealand White Rabbits ◽  
Group A ◽  
Eimeria Stiedai ◽  
Group B

Hemograms and acute-phase proteins in adult male New Zealand White rabbits that had been experimentally infected orally with sporulated oocysts of Eimeria stiedai were evaluated over a 28-day period. Fifty animals were used, divided into two groups: group A infected with 1 × 10(4) sporulated oocysts of E. stiedai and group B inoculated with distilled water. On the seventh day after infection, the infected animals presented anemia and leukocytosis with neutrophilia and monocytosis. Protein fractionation by means of electrophoresis identified 19 acute-phase proteins with molecular weights ranging from 24 to 238 kD. Ceruloplasmin, transferrin and haptoglobin showed high levels on the seventh day after infection, with gradual increases in their concentrations until the end of the experimental period. Thus, from the data of the present study, E. stiedai is considered to be a pyogenic etiological agent for which the infection level can be monitored through the leukocyte count and serum concentrations of ceruloplasmin, transferrin and haptoglobin, and these can be recommended as complementary tests.

scholarly journals Efficacy of Telmisartan in Pristane Induced Arthritis Rat Model

2021 ◽  
Vol 35 (3) ◽  
pp. 6-11
Author(s):  
Quratulain Mehdi
Keyword(s):  
Rheumatoid Arthritis ◽  
Rat Model ◽  
Leukocyte Count ◽  
Female Rats ◽  
Total Leukocyte Count ◽  
Standard Diet ◽  
Entire Study ◽  
Intergroup Comparison ◽  
Group A ◽  
Group B

Introduction: Rheumatoid arthritis is one of the most common systemic inflammatory diseases characterized by progressive damage to the joints. There is rising evidence that Renin Angiotensin Aldosterone System signaling is also involved in the inflammatory response in rheumatoid arthritis and its blockers possess anti-arthritic properties. Telmisartan is an angiotensin receptor blocker and PPAR-? agonist and its anti-arthritic effects were evaluated. Aims & Objectives: This experimental study was designed to evaluate the anti-arthritic efficacy of telmisartan in pristane induced rat model of arthritis in adult female rats. Place and duration of study: The study was conducted in the Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health and Armed Forces Institute of Pathology from July 2020 to August 2020. Material & Methods: Twenty four (24) adult non-pregnant female Sprague Dawley rats were divided in three groups (n=8) designated as Group A (normal control), Group B (arthritic control) and Group C (telmisartan group) & maintained on standard diet and water adlibitum. Rheumatoid arthritis was induced in each rat of Groups B &C by a single intradermal injection of 0.5ml pristane at the base of its tail on day 0 and the disease developed in two weeks. All 3 groups were given distilled water 2.5 ml/kg from 2-4 weeks and Group C was additionally given dissolved telmisartan orally at 2 mg/kg/day. Anti-arthritic efficacy was determined by assessing arthrogram score and total leukocyte count on day 0, 14 and 28 along with histological examination done at the end of the study. Data analysis was done using SPSS version 25. Results: Healthy rats in group A maintained a unremarkable arthogram & histogram score & TLC count of 6675±350/?l during the entire study period. Telmisartan administration in Group C for two weeks after pristane induction resulted in significant reduction in arthrogram score (AS) 9.5±3.66, total leukocyte count (TLC) 7350±550/?l and histological score (HS) to 6.88±1.24 as compared to (AS) 14.50±2.07, WBC 10150±350/?L & (HS) 10.75±2.05 in Group B, left untreated with pristane alone. The intergroup comparison showed significant p value < 0.05 respectively. Conclusion: Anti-arthritic effect was shown by telmisartan as it was able to ameliorate the changes induced by pristane.

Evaluation of β-Tricalcium Phosphate Biomaterial in Femur Fracture Repair in Dogs

2021 ◽  
Author(s):  
D.K. Dwivedi ◽  
R.B. Kushwaha ◽  
M.S. Bhadwal ◽  
A.K. Gupta ◽  
J.S. Soodan ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Tricalcium Phosphate ◽  
Femur Fracture ◽  
Leukocyte Count ◽  
Weight Bearing ◽  
Fracture Repair ◽  
Total Leukocyte Count ◽  
Intramedullary Pinning ◽  
Group A ◽  
Group B

Background: Fracture repair is one of most common procedure carried out by veterinary clinicians. Fracture healing most of the time associated with delayed union, non-union and mal-uinon. Therefore, the objective of this study was to evaluate the clinical, haemato-biochemical and radiological outcome in patients after implantation of β-tricalcium phosphate as a bone graft substitute to promote the fracture healing.Methods: Eight clinical cases brought to the clinics with femur fracture were divided into two groups viz. A and B, with four animals in each group. Femur fractures were stabilized with intramedullary pinning and β-TCP biomaterial and intramedullary pinning and β-TCP plus autologous bone marrow aspirate (BMA) composite in group A and B respectively. The efficacy of fixation was studied on the basis of clinical evaluation, haemato-biochemical and radiographical parameters on day 0 and on 7th, 15th, 30th, 45th and 60th post-operative day. Result: Excellent weight bearing was noticed in group B. The overall functional outcome in group B was better in comparison to group A animals. Haematological parameters viz. haemoglobin, packed cell volume, total leukocyte count and differential leukocyte count did not differ significantly within and between the groups. The biochemical parameters viz. serum calcium increased significantly (P less than 0.05) on 7th and 15th post-operative day. A significant reduction in serum alkaline phosphatase level observed on successive post-operative days in both groups. Radiographs of fractures treated in both the groups showed good reduction and fracture fixation, early signs of fracture healing in group B than group A animals. The size of callus formation was more in group A than group B. No any graft related complications observed during the study period. The β-tricalcium phosphate facilitated fracture healing and early ambulation of affected limb.

scholarly journals Effect of dietary concentrate level on body immune response in calves fed a wheat straw-based diet : short communication

2000 ◽  
Vol 71 (4) ◽  
Author(s):  
A. Santra ◽  
N.N. Pathak
Keyword(s):  
Immune Response ◽  
Wheat Straw ◽  
Body Weight Gain ◽  
Total Body Weight ◽  
Differential Leukocyte Count ◽  
Concentrate Supplementation ◽  
Group A ◽  
Group Protein ◽  
Total Body ◽  
Group B

Twenty 9-month-old crossbred calves were divided into 2 equal groups (A and B; n = 10). The feeding trial was conducted for 119 days to study the effect of concentrate supplementation on body immune response and blood metabolites in calves. The concentrate and roughage (wheat straw) ratio in the diet of Groups A and B was 60:40 and 30:70, respectively. Daily dry matter intake was significantly (P < 0.01) higher in Group A than in Group B, which also resulted in significantly higher (P < 0.01) total body weight gain in the former group. Protein, albumin, globulin, total and differential leukocyte count in blood were similar in the 2 groups but blood glucose level was higher (P < 0.05) in the calves of Group A. There was no difference in body immune response between the groups, which indicated that body immune response of animals is not significantly influenced by restricted concentrate feeding.

Effects of exogenous growth hormone pretreatment on the pituitary growth hormone response to growth hormone-releasing hormone alone or in combination with pyridostigmine in Type I diabetic patients

1991 ◽  
Vol 125 (5) ◽  
pp. 510-517 ◽  
Author(s):  
Andrea Giustina ◽  
Simonetta Bossoni ◽  
Corrado Bodini ◽  
Antonino Cimino ◽  
Giuseppe Pizzocolo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Type I ◽  
Gh Secretion ◽  
Glucose Levels ◽  
Group A ◽  
Group B ◽  
And Control

Abstract. We evaluated the effects of iv pretreatment with exogenous GH on the GH response to GHRH either alone or in combination with pyridostigmine in 14 Type I diabetic patients and 6 normal subjects. All the subjects received an iv bolus injection of biosynthetic human GH, 2 IU; 2 h later they received either a. pyridostigmine, 120 mg orally, or b. placebo, 2 tablets orally, followed 1 h later by iv injection of GHRH(1-29) NH2, 100 μg. In normal subjects the median GH peak after GH+GHRH was 1.8, range 1.2-6.9 μg/l. Pyridostigmine enhanced the GH response to GHRH in all subjects. The median GH peak after pyridostigmine+ GH+GHRH was 32.7, range 19.8-42.1 μg/l (p<0.001 vs GHRH alone). Seven diabetic subjects had median GH peaks after GH+GHRH >6.9 μg/l (the maximum GH peak after GH+GHRH in normal subjects) (group A: median GH peak 35.7, range 21.7-55 μg/l). The other diabetic subjects had GH peak lower than 6.9 μg/l (group B: median GH peak 4.4, range 2.1-6.5 μg/l). Pyridostigmine significantly increased the GH response to GHRH in group B patients (median GH peak 29.3, range 15.7-93.4 μg/l, p<0.001 vs GH+GHRH alone), but not in group A patients (median GH peak 39.9, range 21.9-64.9 μg/l). Group A diabetic patients were younger and had higher HbA1c and blood glucose levels than group B patients. In those diabetic patients with an exaggerated GH response to GH+GHRH, pyridostigmine failed to cause the increase in GH secretion observed in diabetic and control subjects with no responses to GH+GHRH. It can be suggested that elevated 24-h GH levels in some Type I diabetic patients may be due to decreased somatostatinergic tone which in turn causes altered autoregulation of GH secretion. We hypothesize that this finding is a consequence of a reset of the hypothalamic control of GH secretion caused by a chronically elevated blood glucose level in this subpopulation.

scholarly journals Effects of Crude Extract of Neem Bark on the Pancreas of Streptozotocin Induced Diabetic Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
A. J. Ajibade ◽  
E. O. James ◽  
B. D. Kehinde
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Crude Extract ◽  
Wistar Rats ◽  
Enzymatic Activities ◽  
Diabetic Group ◽  
Bark Extract ◽  
Group A ◽  
Group B

This study investigated the histological and serum enzymatic activities of Azadirachta indica, an Indian medicinal plant, on the pancreas in streptozotocin induced diabetic adult wstar rats. Forty six adult wistar rats weighing 100 g to 220 g were randomly separated into four groups; Group A was regarded as the control , while group B was the diabetic group, C and diabetic – extract treated group. The control group received distilled water throughout the experiment; the remaining three groups were induced with streptozotocin intra-peritoneally to induced diabetes in the wistar rats. After some days, the animals were confirmed diabetic with the help of a measuring glucometer. Thereafter, group B diabetic rats remained untreated while Group C and D were treated with a low dose (250 mg/kg) of the crude neem bark extract and a high dose (500 mg/kg) of the extract respectively for 42 days. The aqueous neem bark extract was suspended in the drinking water of the treated animals for the period of 42 days. The body weights of the animals were weighed weekly and likewise the measurement of the blood glucose level was taken. The animals were sacrificed at the end of 42 days by cervical dislocation and the pancreas was removed and weighed immediately using sensitive weighing balance. The blood samples were collected from the sacrificed animals into EDTA bottle for serum enzymatic analysis. The organ pancreas was fixed in a 10% formol saline, processed and stained with Heamatoxylin and Eosin for general histological study. The microscopic examination of diabetic group showed some degenerative and necrotic cells which made the pancreatic tissue distorted compared with the control that appeared normal. The diabetic group C and D rats treated with the extract showed ameliorative potentials of the extract with improvement in histo-architecture of the pancreatic tissue following recovery from damage. Analysis of the blood serum level showed that the aqueous neem bark extract has ameliorative effect on the enzymatic activities in serum of the treated rats. The alanine amino transferase, aspartate amino transferase and alkaline phosphatase levels were significantly reduced (P<0.05) in the crude extract- treated animals compared with the untreated group B and control group A with significantly increased ( P<0.05 ) enzymatic activities in wistar rats in these groups. The antioxidant status was compromised in diabetic group B with significantly increased (P<0.05) LPO, reduced SOD and GSH compared with significantly reduced (P<0.05) LPO, increased (P<0.05) SOD and GSH in group A- control and Group C and D diabetic-extract treated Wistar rats. Similarly, the blood glucose level increased significantly (P<0.05) in group B diabetic group compared with significantly reduced (P<0.05) blood glucose level in group A control as well as C and D extract-treated rats. The study concluded that crude extract of neem has ameliorative potentials on streptozotocin-induced diabetic wistar rats characterized by oxidative damage which reveals improvement in tissue morphology.

scholarly journals Clinical appraisal of Lodhradi Kashaya on type 2 diabetes mellitus patients

2017 ◽  
Vol 4 (1) ◽  
pp. 58
Author(s):  
Varun K. Singh ◽  
K. R. C. Reddy
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Dosage Form ◽  
Dose Group ◽  
Group A ◽  
Group B

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Lodhradi Kashaya (LKSD) is basically ayurvedic kwath dosage form, described as Madhumehajeet (winner of diabetes mellitus) in ayurvedic classics Basavarajeeyam and the same formulation in Vaidya Chintamani and Charaka Samhita too. The aim of this study was to assess prospectively the drug’s ability in management of type 2 diabetes. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Total 31 patients were taken following the guideline mention in CCRAS protocol for diabetes mellitus research. They are divided into two groups, group A and B, given LKSD 4 g &amp; 2 g TDS respectively for three-month follow up. They are investigated against their blood glucose, HbA1C and liver profile tests. Patients were also investigated for subjective parameters viz polyurea, polyphagia, exhaustion and constipation and their response has also been noted regarding palatability acceptance and ease of administration.</span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Patients has responded positively for formulation. Decrease in FBS and PPBS were found highly significant (P ˂ 0.001) in both groups but more in higher dose (group A). Decrease in HbA1C is also found highly significant in both groups. In LFT, SGOT level were also decreased more in group B in comparison to group A, and it is significant (P = 0.017 and 0.002). SGPT level were also decreased more in group B in comparison to group A, and it is significant in group B (P= 0.085 and 0.002).  </span></p><p class="abstract"><strong>Conclusions:</strong> LKSD is having astringent taste due to tannins and phenols in it. It was found significant not only in controlling blood sugar but also in management of other factors related to diabetes mellitus.</p>

scholarly journals Effect of zinc on some selected blood parameters and reproductive performance of male mice

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
M. G. Morshed ◽  
M. S. Hossain ◽  
Mst. G. Pervin ◽  
M. S. Haque ◽  
M. K. Islam
Keyword(s):  
Birth Weight ◽  
Litter Size ◽  
Zinc Supplementation ◽  
Leukocyte Count ◽  
Sperm Count ◽  
Treated Group ◽  
Total Leukocyte Count ◽  
Male Mice ◽  
Abnormal Sperm ◽  
Group B

Background: The effect of zinc supplementation on birth weight, litter size, total erythrocyte count (TEC), hemoglobin estimation, total leukocyte count (TLC), blood glucose level, abnormal sperm count and histopathology of testis in mice was evaluated. Methods: 45 albino mice were randomly divided into 3 equal groups viz. control group, A; 10 mg zinc/kg feed treated group, B; 20 mg zinc/kg feed treated group, C. Each group was comprised of 10 male mice and 5 female mice. Then they are allowed to breed for about 25 days. After breeding males were withdrawn from each group and treated with zinc for 30 days. Then male mice were transferred back to female cage and were allowed to breed for 25 days. Results: Mice of group B and C showed a significant increase (p<0.01) in total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content, litter size and decreased abnormal sperm count. No significant increase in body weight, even a decrease in glucose content was recorded in group B and birth weight was found increased in group C. In the histopathological study, no significant change found with different doses of zinc supplementation except reactive cell infiltration and slight tissue degeneration in the mice fed with 20 mg zinc supplement/kg feed was recorded. Conclusion: Supplementing zinc @ 10-20 mg/kg feed was found to enhance hematological parameters, increase litter size and decrease abnormal sperm count in mice.

scholarly journals Effectiveness of the Family Portal Function on the Lilly Connected Care Program (LCCP) for Patients With Type 2 Diabetes: Retrospective Cohort Study With Propensity Score Matching

10.2196/25122 ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. e25122
Author(s):  
Yiyu Zhang ◽  
Chaoyuan Liu ◽  
Shuoming Luo ◽  
Jin Huang ◽  
Yuxin Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Self Monitoring ◽  
The Family ◽  
Group A ◽  
Group B ◽  
Education Courses

Background Diabetes is a major health concern worldwide. Family member engagement in diabetes self-management education programs can improve patients’ diabetes management. However, there is limited evidence that the family portal on diabetes management apps is effective in the glycemic control of patients with diabetes. Objective We aimed to evaluate the effectiveness of family support through the family portal function on Lilly Connected Care Program (LCCP) platform. Methods This retrospective cohort study included patients with type 2 diabetes recruited to the LCCP platform from September 1, 2018, to August 31, 2019. Propensity score matching was used to match family (group A) and non–family (group B) portal use groups with similar baseline characteristics. The patients were followed up with for 12 weeks. The main objectives were differences in mean fasting blood glucose, proportion of patients achieving fasting blood glucose target <7mmol/L, mean postprandial blood glucose, proportion of patients achieving postprandial blood glucose target <10mmol/L, proportion of patients achieving both fasting blood glucose <7mmol/L and postprandial blood glucose <10mmol/L, self-monitoring of blood glucose frequency at week 12 and the number of diabetes education courses patients completed during the 12 weeks. Moreover, logistic regression analysis was used to explore the baseline factors which may be associated with the use of family portal, and odds ratios with 95% confidence intervals were calculated. Results A total of 6582 adult patients (aged ≥18 years) with type 2 diabetes who were receiving insulin therapy were enrolled in the study. Overall, 6.1% (402/6582) of the patients chose to engage their family members to use the family portal. Two groups of 394 patients were well-matched regarding baseline characteristics. After matching, mean fasting blood glucose and postprandial blood glucose at week 12 were significantly lower in group A than in group B (fasting blood glucose: 7.12 mmol/L, SD 1.70 vs 7.42 mmol/L, SD 1.88, respectively, P=.02; postprandial blood glucose: 8.56 mmol/L, SD 2.51 vs 9.10 mmol/L, SD 2.69, respectively, P=.002). When comparing group A to group B, the proportion of patients achieving both fasting blood glucose <7mmol and postprandial blood glucose <10mmol/L at week 12 (46.8% vs 39.4%, respectively, P=.04), self-monitoring of blood glucose frequency at week 12 (8.92 times per week, SD 6.77 vs 8.02 times per week, SD 5.97, respectively, P=.05) and number of diabetes education courses completed in 12 weeks (23.00, IQR9.00-38.00 vs 15.00, IQR 4.00-36.00, respectively, P<.001) was higher. Additionally, multivariate logistic regression analysis showed that higher age (OR=0.987, 95% CI 0.978-0.996, P=.006) and higher baseline fasting blood glucose (OR=0.914, 95% CI 0.859-0.972, P=.004) were correlated with less use of the family portal function, while increased baseline self-monitoring of blood glucose frequency (OR=1.022, 95% CI 1.012-1.032], P<.001) as well as increased education courses (OR=1.026, 95% CI 1.015-1.036, P<.001) were associated with more use of the family portal function. Conclusions Family support through the LCCP family portal is effective for glycemic control and self-management behavior improvement in type 2 diabetes patients.

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