scholarly journals Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

2016 ◽  
Vol 15 (3) ◽  
pp. 435-440
Author(s):  
Ika Setyawati ◽  
Sunarti ◽  
Pramudji Hastuti
Keyword(s):  
Family History ◽  
Medical Science ◽  
Plasma Aldosterone ◽  
Chi Square ◽  
Aldosterone Level ◽  
Aldosterone Synthase ◽  
Significance Level ◽  
History Of ◽  
Plasma Aldosterone Level ◽  
Family History Of Hypertension

Background: Genetic factors play an important role in the determination of hypertensive disease in a family. The -344T/C the aldosterone synthase gene has been reported in various populations closely related to hypertension. The aim of this study was to determine the presence of the -344T/C polymorphism of the aldosterone synthase gene and the levels of plasma aldosterone in individuals with and without a family history of hypertension.Methods: This study was a case control design, with healthy individuals with a family history of hypertension as cases (n-42) and those without a family history of hypertension as controls (n=41). The subjects’ plasma aldosterone levels were analysed by enzyme-link immunosorbent assay (ELISA) and the gene polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The data were analysed by an independent sample T-test and Chi square test, and the significance level was set at P<0.05.Result: The frequency of the TT + TC genotype was higher in cases, and this increase was significant different compared to the controls (P<0.046). The frequency of the TT + TC genotype was 2.56 higher in cases than controls. The frequency of the C allele in cases was also significantly different compared to the controls (P = 0.039) and 2.29 more frequent in cases than the controls (P = 0.039). The plasma aldosterone level was 42.35 pg/dL in cases and 34.9 pg/dL in controls (P = 0.616). Plasma aldosterone level in cases with the CC, TC and TT genotypes were 48.29, 40.8 and 35.2 pg/dL, respectively (P = 0.774). Our study concludes that individuals with a family history of hypertension are at a higher risk of developing hypertension. Follow-up studies are required to determine the incidence of hypertension in a person with a family history of hypertension and who is a carrier of genetic risk factors.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.435-440

Venous thromboembolism after ultrasound guided foam sclerotherapy

2020 ◽  
pp. 026835552095720
Author(s):  
Eduardo T de Aguiar ◽  
Jorgete B dos Santos ◽  
Danielle D Carvalho
Keyword(s):  
Venous Thromboembolism ◽  
Family History ◽  
Varicose Veins ◽  
Male Gender ◽  
Lower Limbs ◽  
Ultrasound Guided ◽  
Foam Sclerotherapy ◽  
Chi Square ◽  
Significance Level ◽  
History Of

Objective To analyze prevalence of venous thromboembolism (VTE) after ultrasound guided foam sclerotherapy. Method Clinical retrospective study with patients treated from 2004 to 2014. Charts with incomplete data and follow-up less than 60 days were excluded. Polidocanol foam (Tessari method) was used. The primary outcome was the prevalence of VTE and the secondary were possible risk factors. Chi-square test and Marascuillo prodecure were applied at a significance level of 5%. Results 2,616 patients were included with 4,712 lower limbs treated. The mean age was 50.7±0.86, in majority female, 83.7%. VTE occurred in 0.49% (pulmonary embolism 0,3%) in a mean time of 44.0±42.2 days. Male gender, personal or family history of phlebitis or DVT and high caliber varicose veins were significantly associated to VTE. Conclusion incidence of VTE is low, male gender, personal or family history of VTE and caliber of varicose veins greater than 7 mm increased the risk.

Prevalence of hypertension among school going adolescent boys in Najafgarh, Delhi, India

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Sunil Kumar Singh ◽  
Anita Verma
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Eating Habits ◽  
Medical Problem ◽  
Cross Sectional Study ◽  
Adolescent Boys ◽  
Chi Square ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension

AbstractIntroductionHypertension is a global epidemic. Hypertension has become an increasingly important medical problem in children and adolescents. Evidence shows that hypertension begins in childhood and its associated risk factors like obesity, unhealthy eating habits also emerge in children of school going age.ObjectivesTo study the prevalence of hypertension among school going adolescent boys in Najafgarh, Delhi and to find out the factors associated with hypertension among them.Materials and methodsA cross-sectional study was planned in which a self-administered questionnaire was used to collect information from the study participants. A total of 600 adolescent boys of 9th to 12th classes from four different schools in Delhi, were included in the study over a period of 12 months. Blood pressure, height, weight and waist circumference were measured for all children. Data was analyzed using SPSS software version 21.0 and for qualitative data analysis a chi-square (χ2) test was used.ResultsThe mean age of study subjects was 15.1 years. The majority of the study subjects, 372 (62%), were in the age group of 14–16 years. Among the study subjects, 44 (7.3%) had pre-hypertension and 26 (4.3%) had hypertension. Hypertension was significantly higher in those with a family history of hypertension and who were overweight/obese.ConclusionThe prevalence of hypertension was significantly high among adolescents of Delhi. Obesity and family history of hypertension were identified as important risk factors prevalent in the study population.

P1391Plasma aldosterone level in different forms of atrial fibrillation

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Shevelyok ◽  
N Vatutin
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Main Group ◽  
Plasma Aldosterone ◽  
Control Group ◽  
Aldosterone Level ◽  
Aldosterone Production ◽  
Immunoenzyme Method ◽  
History Of ◽  
Plasma Aldosterone Level

Abstract Background. Hyperactivation of the renin-angiotensin-aldosterone system plays a key role in the development of structural remodeling underlying the atrial fibrillation (AF). Nevertheless, the role of excessive aldosterone production in AF development has not been studied. Purpose. The study aims to evaluate the aldosterone levels in different forms of AF and sinus rhythm. Methods. The study included 130 patients (the main group) with non-valvular AF. Of these, 40 (30.8%) patients had permanent, 50 (38.4%) – persistent and 40 (30.8%) – paroxysmal AF. The control group consisted of 40 patients with cardiovascular pathology, who did not have a history of AF episodes. Plasma aldosterone levels were measured by immunoenzyme method. In patients with paroxysmal and persistent AF measurement was perfomed during AF episode before restoration of sinus rhythm. Aldosterone reference values was considered as 40-160 pg/ml. Results. Aldosterone levels were significantly higher in patients of the main group compared to the control (141.5 ± 41.8 pg/ml vs 105.0 ± 33.1 pg/ml, P &lt; 0.001). It was the highest in paroxysmal and persistent AF and lower – in permanent AF. Hyperaldosteronemia (&gt;160 pg/ml) prevalence was significantly higher among all patients of AF group compared to the control (32.3% vs 7.5%, respectively, P = 0.004), however multiple comparisons showed significant differences between paroxysmal AF (47.5%) and sinus rhythm only. Conclusion. Plasma aldosterone level is significantly higher in AF compared to sinus rhythm. In patients with paroxysmal and persistent AF it’s concentration is higher than in patients with permanent AF.

P480Aldosterone plasma level as risk factor of ventricular arrhythmias in heart failure with preserved ejection fraction

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Shevelyok ◽  
N Vatutin
Keyword(s):  
Plasma Level ◽  
Ventricular Arrhythmias ◽  
Left Ventricular ◽  
Plasma Aldosterone ◽  
Preserved Ejection Fraction ◽  
Qtc Prolongation ◽  
Aldosterone Level ◽  
History Of ◽  
Plasma Aldosterone Level

Abstract Background. Sudden cardiac death, one of the most common types of cardiac death, is most often triggered by ventricular arrhythmia. Plasma aldosterone level has been shown to be an independent risk factor of life-threatening ventricular arrhythmia in patients with left ventricular systolic dysfunction following acute myocardial infarction. Whether either effect also occurs in patients with heart failure and preserved ejection fraction (HFpEF) is currently unknown. Purpose. The study aims to investigate the relationship between plasma aldosterone level and ventricular arrhythmias in long-term HFpEF. Methods. The study included 158 patients (58 men and 100 women, mean age 62.3 ± 7.4 years) with HFpEF (&gt; 50%). All patients had a history of hospitalization due to HFpEF during the last 12 months, left ventricular diastolic dysfunction and / or elevated NT-proBNP level. Median confirmed HFpEF duration was 5 (range 4-8) years. Patients had no history of primary aldosteronism and did not use the mineralocorticoid receptor antagonists during the last 6 weeks. Aldosterone plasma level was measured and 24-hour electrocardiographic monitoring was performed. Results. According to laboratory results 99 patients (67.1%, 95% confidence interval (CI) 59.6-74.2%) had normal (40-160 pg/ml) aldosterone plasma level (nAld) and 59 patients (37.3%, 95% CI  30.0-45.0%) had high (&gt; 160 pg/ml) aldosterone level (hAld). hAld patients more often had QTc prolongation (44.1% versus 18.2%) and ventricular arrhythmias (83.1% vs 61.6%) compared to nAld patients (all Ps &lt; 0.001). The number of ventricular premature complexes in 24 hours was higher in hAld group (median 214, range 64-758) compared to nAld (median 52, range 16-198, P &lt; 0.003). hAld patients more often occurred bigemy, couple ventricular ectopy and nonsustained ventricular tachycardia (39.0% vs 19.0%, P = 0.01). In Cox regression models high aldosterone plasma level was the independent risk factors of QTc prolongation (odds ratio (OR) 1.6, 95% CI 1.1-5.7, P = 0.034) and prognostically unfavorable ventricular arrhythmias (OR 1.8, 95% CI 1.2-6.8, P = 0.024). Conclusion. In long-term HFpEF plasma aldosterone level is significantly related to QTc prolongation as well as ventricular arrhythmias.

scholarly journals Relation Between Hypertension Incidences with Family History of Hypertension to Summarecon Mall Serpong Visitors. Jurnal Kesehatan SCIENTIA Vol. 1 No.1, Juli 2020.

2020 ◽  
Author(s):  
Dwi Ayu Lestari ◽  
Ichsan Trisutrino ◽  
Kustia Anggereni ◽  
Resita Nurbayani
Keyword(s):  
Family History ◽  
Communicable Disease ◽  
Blood Pressure Measurement ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Family History Of Hypertension ◽  
The Relationship ◽  
Non Communicable Disease

Hypertension is a non-communicable disease which causes death in the world, including in Indonesia. Increased prevalence of hypertension can be caused by lifestyle, stress and others. The purpose of this study was to determine the relationship between the incidence of hypertension and family history of suffering from hypertension. This study used an analytical survey with aCross-Sectional Study design conducted in August 2019. The research instrument was a questionnaire and blood pressure measurement. A total of 177 Summarecon Mall Serpong visitors were respondents in the study taken by accidental sampling. Data analysis using Chi Square test. The results of this study indicate that respondents who suffer from hypertension with a family history of hypertension by 60% and respondents who do not suffer from hypertension 17.5%, the incidence of hypertension with a family history of hypertension namely (OR = 7.05; 95%; CI 3.54 -14.05; p-value = 0,000). People who have a family history of suffering from hypertension 7x more at risk of developing hypertension. The conclusion of this study is that there is a relationship between the incidence of hypertension with a family history of hypertension in Summarecon Mall Serpong Visitors

scholarly journals Socioeconomic and lifestyle determinants of the prevalence of hypertension among elderly individuals in rural southwest China: a structural equation modelling approach

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Xiao ◽  
Cai Le ◽  
Gui-Yi Wang ◽  
Lu-Ming Fan ◽  
Wen-Long Cui ◽  
...  
Keyword(s):  
Family History ◽  
Sleep Quality ◽  
Body Fat ◽  
Physical Inactivity ◽  
Structural Equation ◽  
Southwest China ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
History Of ◽  
Family History Of Hypertension

Abstract Background This study examines the association between socioeconomic and lifestyle factors and the prevalence of hypertension among elderly individuals in rural Southwest China. Methods A cross-sectional survey of 4833 consenting adults aged ≥ 60 years in rural regions of Yunnan Province, China, was conducted in 2017. Data on individual socioeconomic status, sleep quality, physical activity level, and family history of hypertension were collected with a standardized questionnaire. Blood pressure, fasting blood glucose, height, weight, and waist circumference were also measured. An individual socioeconomic position (SEP) index was constructed using principal component analysis. Structural equation modelling (SEM) was applied to analyse the association between socioeconomic and lifestyle factors and the prevalence of hypertension. Results The overall prevalence of hypertension was 50.6% in the study population. Body fat distribution, including measures of obesity and central obesity, had the greatest total effect on hypertension (0.21), followed by family history of hypertension (0.14), biological sex (0.08), sleep quality (− 0.07), SEP (− 0.06), physical inactivity (0.06), and diabetes (0.06). Body fat distribution, SEP, and family history of hypertension had both direct and indirect effects on hypertension, whereas physical inactivity, diabetes, and sleep quality were directly associated with the prevalence of hypertension. Biological sex was indirectly associated with the prevalence of hypertension. Conclusions SEP, body fat distribution, physical inactivity, diabetes, and sleep quality critically influence the prevalence of hypertension. Future interventions to prevent and control hypertension should give increased attention to individuals with low SEP and should focus on controlling diabetes and obesity, increasing physical activity levels, and improving quality of sleep among older adults aged ≥ 60 years in rural Southwest China.

scholarly journals Prevalence of Hypertension and Its Associated Factors among Indonesian Adolescents

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Andra Kurnianto ◽  
Deni Kurniadi Sunjaya ◽  
Fedri Ruluwedrata Rinawan ◽  
Dany Hilmanto
Keyword(s):  
Physical Activity ◽  
Family History ◽  
Nutritional Status ◽  
Perceived Stress ◽  
Associated Factors ◽  
Equation Model ◽  
Behavior Changes ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension

Background. Given that hypertension in adulthood has its onset in childhood, it is not surprising that the prevalence of hypertension among adolescents has also increased in recent years. However, there are limited data on the prevalence of hypertension and also the new AAP guideline has not yet been applied to the Indonesian adolescent population. Thus, this study aimed to evaluate the prevalence of hypertension using the new AAP guideline and to assess the occurrence of its associated factors among Indonesian adolescents. Methods. This was a cross-sectional study conducted at twelve senior high schools in Palembang, South Sumatera, Indonesia, from June to December 2019. The study included adolescents aged 13 to 18 years old. Anthropometric measurements were obtained. Multiple logistic regression was used to assess the risk factors most associated with hypertension among adolescents, and then an equation model was created. The prevalence of hypertension was evaluated, together with several factors such as age group, sex, ethnicity, family history of hypertension, nutritional status, physical activity, perceived stress, sleep duration, nutritional intake, and smoking. Results. In total, 1200 adolescents aged 15.9 ± 0.99 years were evaluated. The prevalence of hypertension and elevated blood pressure among adolescents was 8% and 12.2%, respectively. There were significant associations between sex, family history of hypertension, hypertensive father, nutritional status, physical activity, perceived stress, and hypertension among Indonesian adolescents (p<0.05). Stress was the most powerful risk factor of hypertension with an odds ratio of 5.83 (95% confidence interval 2.91–11.6). Conclusions. Nowadays, the prevalence of hypertension among Indonesian adolescents is quite high. This may be caused by lifestyle or behavior changes among adolescents. Sex, family history of hypertension, nutritional status, physical activity, and perceived stress influenced the 27% hypertension prevalence rate among Indonesian adolescents, particularly in Palembang, South Sumatera. In order to decrease the prevalence of hypertension in adults, concern about lifestyle or behavior changes and hypertension among adolescents should be given.

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