scholarly journals An analysis of NESTROFT and Red cell indices in evaluating antenatal mothers for Beta Thalassemia trait

2018 ◽  
Vol 17 (3) ◽  
pp. 411-416
Author(s):  
Rana Safia ◽  
Zeeba S Jairajpuri ◽  
Shaan Khetrapal ◽  
MJ Hassan ◽  
Monika Gupta ◽  
...  
Keyword(s):  
Health Care ◽  
Low Cost ◽  
Care Center ◽  
Medical Science ◽  
Osmotic Fragility ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Health Care Center ◽  
Red Cell Indices ◽  
Thalassemia Trait

Background: The frequency of thalassemia trait is about 3% worldwide, while in developing countries like India, it is a major cause of burden on the health care system. Naked eye single tube red cell osmotic fragility test (NESTROFT) used in population screening for beta thalassemia trait. It is a simple, low cost, reliable and most suitable screening test for β BTT, with a sensitivity of 99.8% in regions with high prevalence rates.Material &Methods: The present study was conducted in the Department of Pathology and included a total of 174 antenatal cases, attending the Out Patient Department of Obstetrics and Gynecology of a tertiary health care center in New Delhi between June 2011 to January 2012. The aim of the study was to screen mothers antenatally for early detection of BTT and to test the validity of NESTROFT in detection of thalassemic carriers of this area.Results: 174 pregnant women attending antenatal clinics were screened for detecting hemoglobinopathy with the help of NESTROFT, red cell indices, haemoglobin electrophoresis and HPLC It was seen that only four cases were BTT while ten were of microcytic anaemia and two had normal red cell indices.Conclusion: antenatal diagnosis of BTT is an important screening programme to reduce the burden of birth of children suffering from thalassemia and other hemoglobinopathies.Bangladesh Journal of Medical Science Vol.17(3) 2018 p.411-416

scholarly journals Role of Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) in Detecting Beta-Thalassemia Trait

2018 ◽  
Vol 36 (4) ◽  
pp. 145-152 ◽  
Author(s):  
Asma Ferdousi ◽  
Mainuddin Ahmad ◽  
Jhulan Das Sharma ◽  
Rasheda Samad ◽  
AKM Zafar Ullah
Keyword(s):  
Predictive Value ◽  
Disease Incidence ◽  
Osmotic Fragility ◽  
Beta Thalassemia ◽  
Red Cell ◽  
College Hospital ◽  
Single Tube ◽  
Naked Eye ◽  
Thalassemia Trait

Thalassemia is one of the commonest inherited diseases in Bangladesh. The birth of a thalassemic child places considerable strain, not only on the affected child and its family but also on the community and the nation at large. To reduce the burden of the society and to reduce the disease incidence by providing genetic counseling, detection of carrier is important. The present study evaluates the role of ‘Naked Eye Single Tube Red Cell Osmotic Fragility Test’ (NESTROFT) in detecting ß-thalassemia trait. The current study is a cross sectional study done during the period of September 2008 to August 2009. The study subjects were sibs, parents and relatives of thalassemia patients of age more than 1 year attending Pediatric department of Chittagong Medical College Hospital. Sample size was 50. Here subjects with lowered osmotic fragility test were detected and later on Hb- electrophoresis was done. All the data were recorded and analyzed by SPSS programme. The Sensitivity, Specificity and predictive value of positive and negative tests were computed and they were 92.6%, 80%, 92.6% and 80% respectively. False positive cases were found. The present study found NESTROFT to be both sensitive and reasonably specific and of high negative predictive value. However, multicenter study with large sample is needed to recommend NESTROFT as a single screening test for detection of ß-thalassemia trait.J Bangladesh Coll Phys Surg 2018; 36(4): 145-152

scholarly journals Experience with NESTROFT for screening for thalassemia trait/ minor: evaluation against CBC and HPLC in a high prevalence region in Saurashtra, Gujarat, India

2020 ◽  
Vol 8 (3) ◽  
pp. 1108
Author(s):  
Varsha P. Sorathiya ◽  
Nishith A. Vachhani ◽  
Sanjeev L. Nandani ◽  
Daya J. Vekariya ◽  
Heena N. Kashiyani ◽  
...  
Keyword(s):  
High Performance ◽  
Complete Blood Count ◽  
Osmotic Fragility ◽  
Cost Effective ◽  
Red Cell ◽  
Simple Method ◽  
High Prevalence ◽  
Prevention Programmes ◽  
Red Cell Indices ◽  
Thalassemia Trait

Background: Hemoglobinopathies pose a significant health burden in India. Prevention programmes can significantly reduce this burden. Although sophisticated methods of screening for β thalassemia trait are available, a cheap and simple method is beneficial for population screening. Although the Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) has been evaluated in many studies, sample sizes were small in some and many earlier studies have not done complete blood count (CBC) and High-Performance Liquid Chromatography (HPLC) in all the cases. We evaluate the suitability of NESTROFT for detection of β-thalassemia trait in a high prevalence region in Saurashtra, Gujarat.Methods: Here, 1000 unrelated individuals were studied. NESTROFT, CBC and estimation of HbA2 and HbF or other hemoglobin variants were done by HPLC.Results: Prevalence of β thalassemia trait was 7.8% in this population. NESTROFT showed an overall sensitivity and specificity of 94.87 and 85.38 respectively for the detection of β thalassaemia trait. Using red cell indices (MCH <27 pg and MCV <80 fl), One β thalassemia trait with normal indices would have been missed. Among twelve individuals with other hemoglobinopathies (HbS, HbD, HbE, δβ thalassemia trait or HPFH), seven had a positive NESTROFT while three had normal MCV & MCH values.Conclusions: NESTROFT is a cost-effective sensitive test which does not require any equipment and can be done in remote areas. It remains a useful first line screening test when large populations have to be screened. 

EVALUATION OF DIAGNOSTIC ACCURACY OF HEMATOLOGICAL INDICES IN THE DIFFERENTIATION OF BETA THALASSEMIA TRAIT FROM IRON DEFICIENCY ANEMIA

2021 ◽  
pp. 24-26
Author(s):  
Kavita Choudhary ◽  
M. L Gupta ◽  
Monika Hemin Shroff ◽  
Abhishek Rajawat
Keyword(s):  
Predictive Value ◽  
Hypochromic Anemia ◽  
Deficiency Anemia ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Hematological Indices ◽  
Medical College ◽  
Red Cell Indices ◽  
Thalassemia Trait ◽  
Youden’S Index

Background: 2 most frequent type of microcytic hypochromic anemias are Iron deciency anemia (IDA) and beta thalassemia trait (β-TT) continue to be a cause of signicant burden to the society, particularly in developing countries like INDIA, where there is limitation of resources. The objective of the present study was to evaluate the validity of different discrimination indices to differentiate β-TTfromIDA. Methods:All diagnosed patients of microcytic hypochromic anemia admitted in Geetanjali Medical College and Hospital, Udaipur (Raj) between Jan 2018 to June 2020, were included in this study. Sensitivity, specicity, positive predictive value (PPV), negative predictive value (NPV) and Youden's index (YI) were calculated. Result: According to our study following rankings of various discrimination indices were obtained for BTT patients, RDW Index > Mentzer's Index = Ehsani Index > Sirdah Index > MDHLIndex > MCHD Index. Conclusion: According to our results and observations, the percentage of correctly diagnosed patients are the highest with RDW Index and Mentzer's Index. It should be kept in mind that several studies have shown that none of the red cell indices carry 100% sensitivity and specicity in diagnosing BTT.

Non-Fatal Deliberate Self-Harm in Three Remote Indigenous Communities in Far North Queensland, Australia

Crisis ◽  
2019 ◽  
Vol 40 (6) ◽  
pp. 422-428 ◽  
Author(s):  
Chris Rouen ◽  
Alan R. Clough ◽  
Caryn West
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Care Center ◽  
Indigenous Communities ◽  
Indigenous Australians ◽  
Deliberate Self Harm ◽  
Health Care Center ◽  
Far North ◽  
Primary Health ◽  
Self Harm

Abstract. Background: Indigenous Australians experience a suicide rate over twice that of the general population. With nonfatal deliberate self-harm (DSH) being the single most important risk factor for suicide, characterizing the incidence and repetition of DSH in this population is essential. Aims: To investigate the incidence and repetition of DSH in three remote Indigenous communities in Far North Queensland, Australia. Method: DSH presentation data at a primary health-care center in each community were analyzed over a 6-year period from January 1, 2006 to December 31, 2011. Results: A DSH presentation rate of 1,638 per 100,000 population was found within the communities. Rates were higher in age groups 15–24 and 25–34, varied between communities, and were not significantly different between genders; 60% of DSH repetitions occurred within 6 months of an earlier episode. Of the 227 DSH presentations, 32% involved hanging. Limitations: This study was based on a subset of a larger dataset not specifically designed for DSH data collection and assesses the subset of the communities that presented to the primary health-care centers. Conclusion: A dedicated DSH monitoring study is required to provide a better understanding of DSH in these communities and to inform early intervention strategies.

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