Effect of exercise duration on feed intake and body composition of Swiss albino mice

1985 ◽  
Vol 58 (2) ◽  
pp. 500-505 ◽  
Author(s):  
R. Bulbulian ◽  
K. K. Grunewald ◽  
R. R. Haack

The purpose of this study was to examine the effects of daily exercise of varying duration on the body composition, weight, and feed intake of mature Swiss albino mice. Fifty-four male mice were equally divided into a control group and five exercise groups (n = 9) performing 20, 40, 60, 120, and 240 min of daily exercise on a treadmill (7.2 m/min). Feed intake and body weight were measured weekly for 10 wk. At the completion of the study the mice were killed and the animal carcasses were chemically analyzed for fat, dry matter, and protein content. The results of this study demonstrate no differences in the body weight among groups (P less than 0.97) with all groups gaining 4.5–5.8 g during the 10-wk period. However, fat content decreased significantly from 15.7% in the control to 12.0% in the 120- and 240-min exercise groups (P less than 0.05). In contrast, protein content showed an insignificant rising trend from 13.0 to 14.6% with increasing duration of exercise. Feed intake showed a nonsignificant drop during the 20-min exercise treatment and remained unchanged among groups. These data show a slight but variable appetite-suppressing effect of light exercise in mice accompanied by favorable body composition changes even in the absence of differences in body weight. These findings suggest the mouse to be an acceptable experimental model for body composition and exercise studies.

2014 ◽  
Vol 33 (12) ◽  
pp. 1199-1208 ◽  
Author(s):  
S Saini ◽  
N Nair ◽  
MR Saini

Effects on postnatal development of Swiss albino mice exposed to nickel (Ni2+) ions as nickel chloride haxahydrate (NiCl2·6H2O) during the gestation periods were evaluated in this study. Administration of Ni to pregnant females by gavage (46.125, 92.25, and 184.5 mg Ni/kg body weight (b.w.)) at doses below median lethal dose during 0–5 (preimplantation period), 6–13 (organogenetic period), and 14–18 days (fetal period) postconception. The dams were allowed to deliver and raise their pups. Significant ( p < 0.05) decrease in litter size was observed after 184.5 mg Ni/kg b.w. during the three gestation periods particularly from preimplantation period as compared to organogenetic and fetal periods in comparison with the control group. Exposure to 184.5 mg Ni/kg b.w. during fetal period revealed higher mortality as compared to organogenetic period. Exposure to 184.5 mg Ni/kg b.w. increased the eye, limb, and tail anomalies during organogenetic period. Gestation index from preimplantation period was low at all the doses. Live birth index decreased during preimplantation and organogenetic periods after 184.5 mg Ni/kg b.w. The viability and weanling of pups decreased during all periods after 92.25 and 184.5 mg Ni/kg b.w. doses. A dose-dependent highly significant ( p < 0.01) decrease in the body weight of offspring from day 0 to 6 weeks of age at all the doses during different gestation periods were observed. Maximum body weight decrease was observed in offspring from organogenetic period. This study concludes that young ones are vulnerable during different gestational and lactation period which indicates that Ni ingested by mothers constitutes a great threat to the progeny.


Author(s):  
Shanmuga Priya ◽  
Nivedhithaa S ◽  
Huvaneswari K

  Objectives: Agomelatine is a novel melatonin (MT) receptor agonist at MT 1 and 2, serotonin receptor antagonist and an effective chronobiotic agent. The study was designed to evaluate the effects of agomelatine on body weight and food intake in restraint stress model in adult Swiss albino mice.Methods: After the approval of Institutional Animal Ethics Committee, 40 male Swiss albino mice were randomly divided into four groups of 10 animals each; two were treatment groups which received 25 mg/kg (low dose) agomelatine, 50 mg/kg (high dose) agomelatine, standard group given trazodone and the control group administered the vehicle (1% hydroxyethyl cellulose [HEC]) intraperitoneally for the last 14 days in the 3 weeks study period. Chronic restraint stress was given for 4 hrs per day for all groups starting from day 0 to 21.Results: Using paired t-test, both 12 hrs (p=0.011) and 24 hrs (p<0.001) food intake in the high dose agomelatine group were significantly increased. Between groups using ANOVA test showed a statistically significant increase in food intake for this group when compared to the control group. Unlike the low dose agomelatine group (p=0.205), the mean body weight in the group treated with high dose agomelatine revealed a statistically significant rise compared to that of the control (p=0.001) in ANOVA test.Conclusion: High dose agomelatine was effective in antagonizing the body weight lowering effect of restraint stress in addition to amelioration of reduced food intake. The study has potentially brought out the additional therapeutic benefit of agomelatine in improving the altered feeding and body weight changes when used in the treatment of the depression.


Author(s):  
Surekha D. Shetty ◽  
Laxminarayana Bairy K. ◽  
AM Prasad ◽  
Satheesha Nayak B. ◽  
Ashwini Aithal P.

Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of spermatogenesis. Semen analysis and hormone evaluation are essential parameters in the diagnosis of infertility in males. Objective: The aim of the present study is to evaluate the effect of sorafenib on FSH and intratesticular testosterone levels in male Swiss albino mice. Materials and Methods: The animals were segregated into control, positive control, and treatment groups (n=6). Treatment group received 25, 50 and 100 mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Positive control group received 100 mg/kg body weight of imatinib. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th and 10th week after the last exposure to sorafenib. Results: The intratesticular testosterone level was significantly (P<0.05) reduced in treated groups and severe effect was observed on week 4th and 5th weeks. FSH level was increased significantly (P<0.05) in sorafenib treated groups of mice. Conclusion: The administration of sorafenib does affect testosterone and FSH level significantly, but this effect is reversible once the drug is withdrawn. This finding may help the clinicians to plan and address the fertility-related issues in young patients of reproductive age who are being treated with sorafenib for advanced renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid carcinoma.


Animals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 280 ◽  
Author(s):  
Youssef A. Attia ◽  
Nicola F. Addeo ◽  
Abd Al-Hamid E. Abd Al-Hamid ◽  
Fulvia Bovera

The effect of phytase and inorganic Zn supplementation was studied in 180 male White Pekin ducks (WPD) from 1 to 56 days of age. The birds were divided into four groups fed the same basal diet (containing 26 ppm of Zn from raw materials): the control group did not receive Zn supplementation; the second group was supplemented with 30 ppm of Zn oxide; and the third and fourth groups were fed the control and the 30 ppm diets, respectively, both supplemented with 500 U of E. coli phytase. Each group contained five replicates of nine ducks. The body weight and feed intake were recorded at 1, 28 and 56 days of age. At 56 days of age, five birds/group were used to measure feed digestibility and five other birds/group were slaughtered. Zn at 30 ppm increased the body weight gain (BWG, p < 0.01) and feed intake (p < 0.05) and improved the feed conversion (FCR, p < 0.05) of the growing ducks. The Zn retention and Zn level in the excreta increased (p < 0.01) due to Zn supplementation. The addition of phytase improved BWG (p < 0.01) and FCR (p < 0.05) of growing ducks. The use of phytase reduced (p < 0.01) the level of Zn in duck excreta. Phytase supplementation to the basal diet at 30 ppm seems to be adequate to meet Zn requirements for ducks without further Zn additions.


2019 ◽  
Vol 9 (4-A) ◽  
pp. 104-107
Author(s):  
Shobhit Singh ◽  
Pushpraj Gupta ◽  
Rishikesh Gupta

Mucuna pruriens, also known as Velvet Bean, Mucuna pruriens has been used for centuries by Ayurvedic herbalists for overall wellness. Mucuna pruriens provides support for brain function, muscle health and libido. Mucuna pruriens has also been shown to have diuretic effects. It increases tissue resiliency and improves coordination. Mucuna can also increase testosterone levels, which in turn can lead to increased muscle mass and strength. It also supports the nervous and reproductive systems in the body. anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. This is an excellent natural source of L-dopa and 5-hydroxy tryptophan (5-HT) Present study was designed to evaluate the anti-anxiety activity of Mucuna pruriens extract in Swiss albino mice. Three doses of Mucuna pruriens (100, 200,400 mg/kg, p.o.) and standard dose of Buspirone (5 mg/kg, i.p.) were used for evaluation of the anti-anxiety activity. The elevated plus maze (EPM) was used to take as a measure of antianxiety effect. Mucuna pruriens at the doses of 200 mg/kg and 400 mg/kg significantly reduced the time spent and no. of entries in closed arm, increased the time spent and entries into open arm in elevated plus maze (p<0.05) as compared to control group. These results indicate that MP may be possesses antianxiety property. Keywords:  Anxiety, Elevated plus maze, Mucuna pruriens, Buspirone, Swiss Albino Mice.


2016 ◽  
Vol 3 (1) ◽  
pp. 139-144
Author(s):  
Mai Thanh Vu ◽  
Van Thanh Tran ◽  
My Thi Thuy Nguyen ◽  
Van Cao ◽  
Tuan Ngoc Minh Nguyen

Rice is a major staple food in Vietnam in which brown rice has been recognized as a potential feedstuff for poultry but data on nutritional value of this feed are lacking. In this study the using of brown rice as replacement of corn in chicken diet was evaluated. The body weight, feed intake and feed conversion ratio were recorded. In total, 192 day old chicks of country breed (Ri lai) were used in this study. Chickens were divided into four groups and reared at same conditions for 12 weeks. The first group as the control group fed on 100% corn, second group fed on 75% corn and 25% brown rice, third group fed on 50% corn and 50% brown rice and the last group fed on 25% corn and 75% brown rice. The average body weight of chickens among all the treatments was 1.7 kg per bird which was not significantly different (P=0.44). The total feed intake of chickens (4-5 kg) was recorded without significant difference (P=0.23), however the feed conversion ratio were significantly different (P<0.05) between treatments. This study considered as the first report that demonstrates the usefulness of brown rice as a potential alternative of corn for chicken diet in rural areas in Vietnam, especially on the prevailing conditions such as during high price spell of corn.Res. Agric., Livest. Fish.3(1): 139-144, April 2016


2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ahmed Abdel-Megeed ◽  
Arifa Tahir

The present study was conducted to reduce phosphorus pollution from broilers waste by supplementing phytase enzyme in broilers fee. Two hundred two-week-old broilers (Hubbard) were selected and randomly allocated to three dietary treatment groups, one control group (without phytase) and two trial groups (group A with 300 U/kg phytase and group B with 600 U/kg phytase). Each group was composed of 5 replicates with 10 chicks. Broilers fed the control diet (without phytase) gained weight slower (P< 0.05) than the other treatment groups. A significant increase in body weight gain of group A (28.00 ± 2.97) and group B (29.75 ± 3.45) was observed as compared to control group (26.75 ± 2.78). The feed intake of the birds fed the diets containing microbial phytase 600 U/kg was the highest. Phytase significantly (P> 0.05) reduces excreta P and Ca level. Phytase addition did not affect excreta pH. The presence of phytase in feed mixtures significantly (P> 0.05) improves the body weight gain and feed intake of broiler chickens.


2002 ◽  
Vol 70 (2) ◽  
pp. 135-145 ◽  
Author(s):  
◽  
Al-Shabanah OA ◽  
El-Hadiyah TM ◽  
Al-Majed AA

We have evaluated vigabatrin (γ-vinyl γ-aminobutyric acid), an irreversible inhibitor of γ-aminobutyric acid (GABA)-transaminase responsible for GABA degradation, for its effects on food consumption, body weight changes, fluid intake, changes in hematological and biochemical parameters in plasma liver and kidney of Swiss albino mice. Mice received vigabatrin 0.26% wlv chronically in drinking water for 7, 14 and 21 days. Changes in all the parameters were recorded aRer 7, 14 and 21 days respectively in different groups. Food consumption was comparable to the control group with minor fluctuations. The body weight declined significantly but only after 3-week treatment with no appreciable change in organ indices or relative organ indices. There were essentially no adverse effects on hematological parameters (RBC, WBC, HGB, neutrophils, eosinophils, monocytes, lymphocytes and basophils) with this treatment. However, there was a decrease in monocyte counts during the first week and an increase in the neutrophil counts during the third week of vigabatrin treatment. In one part plasma biochemical parameters like AST, ALT, CK-MB, creatinine, glucose and urea were also assessed with the same dose regimen. It was observed that only CK-MB and GPT activity levels were altered slightly significantly and are thought to be a result of cross enzyme inhibitions. In this experiment it was observed that lipid peroxide levels measured, as malondialdehyde did not change appreciably in both liver and kidney tissues. However, the levels of glutathione (non-protein sulfhydryl; GSH) declined significantly in comparison to control in liver and kidney. A comparison of level of GSH in liver and kidney shows that this depletion was at early time points in the former. The depletion of GSH suggests the possible involvement of GSH in detoxification process and corroborates its role in protection.


2021 ◽  
Vol 22 (2) ◽  
pp. 20-24
Author(s):  
P. G. Koynosov ◽  
◽  
L. V. Vikhareva ◽  
Al. P. Koynosov ◽  
N. Yu. Putina ◽  
...  

Aim. To identify the variability of somatometric parameters and body composition in young people of certain constitutional types and social groups. Material and methods. The survey involved 328 people (162 boys and 166 girls) who lived in different social environments. The representatives of the control group were brought up in a well-off family, and the persons of the main group lived in dysfunctional families. The measurement methods included the main indicators of total body size. Results. Data on the degree of severity of the main components of body weight in young people are presented and significant differences are established among representatives of individual constitutions and social groups. The shown relationships between the main tissue components of body weight and soma allow us to scientifically justify the development of corrective rehabilitation programs to reduce the risk of developing prenosological conditions. Conclusions. The comprehensive study of the somatic status and body composition of young people expands the understanding of the differences in the morphofunctional parameters of the human body. The obtained results of the study allow us to more objectively characterize the structural and functional organization of the soma at this stage of development and to establish the influence of social factors on the vital activity of the organism.


2020 ◽  
Vol 70 (1) ◽  
pp. 126-135
Author(s):  
Anna Szuba-Trznadel ◽  
Tomasz Hikawczuk ◽  
Małgorzata Korzeniowska ◽  
Bogusław Fuchs

AbstractWeaning is a stressful period for the piglets and the sow. Stress during weaning is related to the change of diet which can affect the physiology of the gastrointestinal tract, as well as the microbial and immunological status of the animals. In the experiment a yeast-whey preparation was used to decrease the transient growth depression related to reduction of feed intake by the piglets. The piglets were assigned to three treatments. In the control group (I) the animals obtained standard feed mixture used routinely at the farm. In the case of piglets from II and III treatment, the yeast-whey preparation was added in the quantity of 4 and 7%, respectively.Application of 7% yeast-whey preparation to the diet significantly increased the body weight of piglets (p<0.05) and in consequence the average daily body weight gain (p<0.01) in comparison with the control group of animals. Additionally, piglets which were fed the yeast-whey preparation diet had a higher feed intake (p<0.05) and better feed conversion ratio (p<0.05) than those fed a diet without the addition of this preparation. No significant differences were stated for most biological parameters (p>0.05), except for the blood urea level, which was significantly lower (p<0.05) in the treatments where the yeast-whey preparation was used. These results indicated that yeast-whey preparation efficiently suppressed post-weaning diarrhea and improved the performance of the animals.


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