scholarly journals Hepatoprotective Effect of Chenopodium Album Linn. Whole Plant on Biochemical Parameters Against Paracetamol Induced Hepatotoxicity in Rats

2015 ◽  
Vol 14 (2) ◽  
pp. 1-4
Author(s):  
Maliha Ata ◽  
Selim Md Jahangir ◽  
Md Mahbubul Islam ◽  
Rasheda Akter ◽  
Md Tofayel Hossain Sarkar ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Chenopodium Album ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Active Principle ◽  
Acute Administration ◽  
Protective Effects ◽  
Whole Plant

Chenopodium album Linn (Called Bathua in Bengali) is a plant which has a long history of uses in liver disorders in this subcontinent. This study was done to evaluate the hepatoprotective effects of ethanol extract of this plant on paracetamol induced hepatotoxicity in albino rats. The total experiments were designed as follows (I) Experiment (part I):- Induction of hepatotoxicity by single administration of paracetamol at a dose of 2 gm/kg body weight. (2) Experiment (part II) : Effects of ethanol extract of Chenopodium album Linn. on paracetamol induced hepatotoxicity in albino rats. The biochemical reports suggested that acute administration of paracetamol produced significant hepatotoxicity in experimental rats which was evidenced by significant increase in Serum Bilirubin, Serum Alanine Aminotransferase (ALT) Serum Aspartate Aminotransferase (AST) Serum Alkaline Phosphatese (ALP) level, decrease in serum albumin and serum total protein level. When rats were treated with extracts of C. album plant in paracetamol induced hepatotoxic albino rats, the results showed marked reduction in serum bilirubin, serum ALT, serum AST and serum ALP level and increase of serum albumin level but not sigificant increase of total protein as compared with paracetamol treated group. The results of the present study revealed that ethanol extract of Chenopodium album Linn. whole plant has got protective effects against paracetamol induced hepatotoxicity. Further study is needed to find out the curative effect and to isolate the active principle and to explore out the exact hepatoprotective mechanism of this plant extract.Chatt Maa Shi Hosp Med Coll J; Vol.14 (2); Jul 2015; Page 1-4

scholarly journals AMELIORATION OF GENTAMICIN-INDUCED RENAL DAMAGE IN RATS BY ETHANOL EXTRACT OF THE WHOLE PLANT BIOPHYTUM SENSITIVUM (LINN.) DC

2018 ◽  
Vol 10 (5) ◽  
pp. 130
Author(s):  
Abhirama B. R. ◽  
Shanmuga Sundaram R ◽  
Raju A
Keyword(s):  
Body Weight ◽  
Water Intake ◽  
Total Protein ◽  
Urine Volume ◽  
Ethanol Extract ◽  
Group Iv ◽  
Control Group ◽  
Group I ◽  
Whole Plant ◽  
Group Ii

Objective: Present study was undertaken to investigate the nephroprotective activity of whole plant ethanol extract of Biophytum sensitivum Linn. DC (B. sensitivum; EEBS) on gentamicin induced-nephrotoxicity in Wistar albino rats.Methods: Animals were divided into five groups, containing six animals in each. Gentamicin (GM) 100 mg/kg/d; i. p., was given to all groups except normal control to induce nephrotoxicity for a period of 8 d in rats. Animals in Group I served as control and Group II as GM-treated or nephrotoxic control. Group III received standard quercetin (50 mg/kg; p. o.); group IV received EEBS (250 mg/kg; p. o.) and group V received EEBS (500 mg/kg; p. o.), for 8 d. Several renal functional tests and injury markers such as a change in body weight, water intake, urine volume and pH, urinary levels of total protein, albumin, sodium, potassium, calcium and magnesium were measured. Different hematological parameters including, red blood cells (RBC), hemoglobin (Hb), packed cell volume (PCV), mean corpuscular haemoglobin (MCH), white blood corpuscles (WBC), lymphocyte, monocyte, polymorphs and eosinophil were also analyzed.Results: The results revealed that co-administration of EEBS at 250 and 500 mg/kg significantly reduced the urinary excretion of total protein (4.05±0.04, 3.53±0.05 g/dl), albumin (0.81±0.08, 0.71±0.00 g/dl), calcium (8.05±0.05, 7.81±0.06 mg/dl) and magnesium (0.79±0.05, 0.77±0.06 mg/dl) respectively. EEBS treatment in group IV and V animals produced a significant increase in body weight (2.58±0.17, 2.52±0.22 g), water intake (17.35±0.82, 17.87±0.86 ml/24 h) urine output (7.24±0.15, 7.88±0.08 ml/24 h), compared to animals in group II. Co-therapy with both doses of extracts also showed significant increase in RBC (6.85±0.31, 7.10±0.43 million/mm3) Hb (13.96±0.21, 13.83±0.31 g/dl), MCH (20.45±0.49, 20.67±0.51 pg) and PCV (38.29±0.42, 38.53±0.20%) levels, whereas WBC (8.24±0.21, 8.15±0.10 1X103/mm3) and polymorphs (14.19±0.20, 14.05±0.11%) levels were found to be significantly reduced respectively in animals than those in toxic control group.Conclusion: This study substantiated and confirmed the ethnomedical usefulness of B. sensitivum as a nephroprotective and antioxidant agent.

Evaluation of antifertility activity of the ethanol extract of Ammania baccifera (L) whole plant in male albino rats

2007 ◽  
Vol 3 (2) ◽  
Author(s):  
R Dhanapal ◽  
G S Kumar ◽  
V L Bubu ◽  
K Chandramohan ◽  
R A Kumar ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Albino Rats ◽  
Whole Plant

scholarly journals Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats

2021 ◽  
Author(s):  
Peter Folorunsho Ayodele ◽  
Dorcas Ibukun Akinloye ◽  
Adio Jaimiu Akamo ◽  
David Adejare Agboola ◽  
Oluseyi Adeboye Akinloye
Keyword(s):  
Tumor Necrosis ◽  
Ethanol Extract ◽  
Interleukin 10 ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Inflammatory Changes ◽  
Cd Exposure ◽  
Xylopia Aethiopica ◽  
Necrosis Factor

The wide use of cadmium (Cd) in industry causes great environmental health problems to humans and animals. The aim of this study was to investigate the protective effects of Xylopia aethiopica fruit ethanol extract (XAFEE) on cadmium-induced inflammation and dyslipidemia in male albino rats. Thirty albino rats weighing 120–180 g were randomly selected into six groups (n = 5): control rats (administered distilled water only), Cd alone group (10 mg/ kg bw), Cd + 150 mg/kgbw XAFEE, Cd + 300 mg/kgbw XAFEE, 150 mg/kgbw XAFEE and 300 mg /kgbw XAFEE groups after 2-week acclimatization. The experiment lasted for 21 days, after which blood sample was collected by cardiac puncture. Changes in tumor necrosis factor (TNF-α), interleukin 10 (IL-10), total cholesterol (TC), triacylglycerol (TAG), phospholipids and free fatty acids (FFAs) concentrations in serum were determined. The results of the present study indicated that Cd exposure remarkably increased (p < 0.05) the TC, TAG, phospholipids, FFAs and TNF-α concentrations, and significantly decreased IL-10 concentration (p < 0.05). These findings suggest that inflammatory changes and alterations in lipid metabolism might be one of the mechanisms underlying the subtle effects of Cd toxicity, “dyslipidemia.” XAFEE expressed protective role against toxic influence of Cd on affected parameters in rats. The results raised the possibility of Xylopia aethiopica fruit being considered as a condiment in soup, local drinks, supplements or herbs preparations in areas where there are chances of Cd exposure, occupationally or environmentally.

scholarly journals EFFECT OF SHARAPUNKHA (TEPHROSIA PURPUREA) ON GASTROINTESTINAL SYSTEM

2020 ◽  
Vol 11 (5) ◽  
pp. 60-63
Author(s):  
Manojkumar . ◽  
Sangeeta Gehlot
Keyword(s):  
Serum Bilirubin ◽  
Smooth Muscles ◽  
Treated Group ◽  
Serum Bilirubin Level ◽  
Gastrointestinal System ◽  
Albino Rats ◽  
Active Principle ◽  
Healthy Human ◽  
Tephrosia Purpurea ◽  
Human Volunteers

Sharapunkha (Tephrosia purpurea) is one of the important drugs in Ayurvedic system of medicine. The present study was undertaken to find out the action of Sharapunkha (Tephrosia purpurea) on Gastrointestinal System. During the passage of drug through oral route, it is probable that the active principle present in Sharapunkha, might act on gastrointestinal System. Albino rats were used in this study and divided into control and drug treated group. Drug treated group rats were feed with intragastric drug decoction, along with their normal water and food. Water intake, diet intake, weight of rats, gastrointestinal motility and serum bilirubin level were compared. Healthy human volunteers were selected, and prepared drug decoction was given for 7 days. Observations were done based on self-assessment of the volunteers about any significant physiological variation specially related to the G.I. System. After study, it was found that Sharapunkha enhances intestinal motility, decreases serum bilirubin in albino rats. Human volunteers had feeling of increase appetite, easy bowel motion and increase urge for micturition. These facts suggest that some ingredients of Sharapunkha are acting on the smooth muscles of the bowel and urinary bladder. So, it may be presumed that Sharapunkha influences the feeding and satiety center located in hypothalamus. Sharapunkha decoction preparation does influence the activity of the autonomic nervous system with consequent alterations in the functions of gastrointestinal tract and possibly the urinary system.

scholarly journals Protective Effects of Xylopia aethiopica Fruit Ethanol Extract (XAFEE) on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats

2021 ◽  
Author(s):  
Peter Folorunsho Ayodele ◽  
Dorcas Ibukun Akinloye ◽  
Adio Jaimiu Akamo ◽  
David Adejare Agboola ◽  
Oluseyi Adeboye Akinloye
Keyword(s):  
Tumor Necrosis ◽  
Ethanol Extract ◽  
Interleukin 10 ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Inflammatory Changes ◽  
Cd Exposure ◽  
Xylopia Aethiopica ◽  
Necrosis Factor

The wide use of cadmium (Cd) in industry causes great environmental health problems to humans and animals. The aim of this study was to investigate the protective effects of Xylopia aethiopica fruit ethanol extract (XAFEE) on cadmium-induced inflammation and dyslipidemia in male albino rats. Thirty albino rats weighing 120–180 g were randomly selected into six groups (n = 5): control rats (administered distilled water only), Cd alone group (10 mg/ kg bw), Cd + 150 mg/kgbw XAFEE, Cd + 300 mg/kgbw XAFEE, 150 mg/kgbw XAFEE and 300 mg /kgbw XAFEE groups after 2-week acclimatization. The experiment lasted for 21 days, after which blood sample was collected by cardiac puncture. Changes in tumor necrosis factor (TNF-α), interleukin 10 (IL-10), total cholesterol (TC), triacylglycerol (TAG), phospholipids, free fatty acids (FFAs) and HDL-TAG concentrations in serum were determined. The results of the present study indicated that Cd exposure remarkably increased (p < 0.05) the TC, TAG, phospholipids, FFAs, HDL-TAG, TNF-α concentrations, and significantly decreased IL-10 concentration (p < 0.05). These findings suggest that inflammatory changes and alterations n lipid metabolism might be one of the mechanisms underlying the subtle effects of Cd toxicity, “dyslipidemia.” XAFEE expressed protective role against toxic influence of Cd on affected parameters in rats. The results raised the possibility of Xylopia aethiopica fruit being considered as a condiment in soup, local drinks, supplements or herbs preparations in areas where there are chances ofCd exposure, occupationally or environmentally.

scholarly journals Melatonin and alpha lipoic acid restore electrolytes and kidney morphology of lopinavir/ritonavir-treated rats

2019 ◽  
Vol 9 (1) ◽  
pp. e06-e06 ◽  
Author(s):  
Elias Adikwu ◽  
Nelson Brambaifa ◽  
Wolfe Atuboyedia Obianime
Keyword(s):  
Renal Dysfunction ◽  
Lipoic Acid ◽  
Total Protein ◽  
Morphological Changes ◽  
Albino Rats ◽  
Protective Effects ◽  
Alpha Lipoic Acid ◽  
Serum Electrolytes ◽  
Kidney Morphology ◽  
Dose Dependent

Introduction: Lopinavir/ritonavir (LPV/r) may cause renal dysfunction such as electrolyte and acid base disorders and alteration in kidney morphology. Drug–induced renal dysfunction can occur through multiple mechanisms including oxidative stress and inflammation. Objectives: The current study aimed at evaluating the protective effects of melatonin (MT) and alpha lipoic acid (ALA) against serum electrolytes and kidney histology of LPV/r-treated rats. Adult albino rats were randomized into six groups (A to F). Rats in the control groups were treated orally with normal saline and 1% ethanol as placebo and solvent control for 90 days respectively. Rats in the experimental groups were pre-treated orally with 10 mg/kg of MT, 10 mg/kg of ALA, and MT+ ALA daily before treatment with 22.9/5.71, 45.6/11.4 94 and 91.4/22.9 mg/kg/d of LPV/r for 90 days respectively. Materials and Methods: At the end of treatment, rats were euthanized. Blood samples were collected and serum samples were extracted and evaluated for electrolytes, total protein, and albumin. Additionally, kidneys were excised via dissection and evaluated for morphological changes. Results: Significant (P<0.001) decreases in serum sodium, potassium, chloride, bicarbonate, total protein and albumin in a dose-dependent fashion were obtained in LPV/r-treated rats when compared to control. Dose-dependent kidney morphological changes characterised by tubular necroses were obtained in LPV/r-treated rats. The observations in LPV/r-treated rats were significantly reversed in MT (P<0.01), ALA (P<0.01) and MT+ALA (P<0.001) pre-treated rats when compared to LPV/r-treated rats. Conclusion: MT and ALA can serve as adjuvant therapies for LPV/r-associated alterations in serum electrolytes and kidney histology.

scholarly journals Evaluation of Antidiarrheal properties of ethanol extract of Brassica juncea in experimental animals

2021 ◽  
Vol 11 (2-S) ◽  
pp. 19-23
Author(s):  
Aslam P Muhammad ◽  
Rawal Pinkey ◽  
C Ramesh ◽  
G Chaitra
Keyword(s):  
Brassica Juncea ◽  
Castor Oil ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Oral Toxicity ◽  
Whole Plant ◽  
Soxhlet Apparatus ◽  
Ethanol Extracts ◽  
Antidiarrheal Agent

Objective: The present study was designed to evaluate the anti-diarrheal potentials of ethanol extract of Brassica juncea in albino rats.  Materials and methods: The defatted powder of whole plant of Brassica juncea subjected to extraction using ethanol in soxhlet apparatus.  The acute oral toxicity was studied for ethanol extract according to OECD guidelines 425. The antidiarrheal properties of ethanol extracts was assessed against castor oil induced diarrhea, magnesium sulfate induced diarrhea and charcoal passage test in albino wistar rats. Results: The ethanol extract of Brassica juncea has effectively reversed diarrhea. The extract at higher dose 400mg/kg shows significant reduction the number of feces against castor oil induced and MgSO4 induced diarrhea. In charcoal passage test, higher dose of ethanol extract also shown significant reduction in the distance travelled. Conclusion: The result obtained establish the efficiency of ethanol extract of Brassica juncea as antidiarrheal agent Keywords: Brassica juncea, castor oil, magnesium sulphate, charcoal passage test.

scholarly journals Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Ebtihal Kamal ◽  
Lamis AbdelGadir Kaddam ◽  
Alnour Alagib ◽  
Amal Saeed
Keyword(s):  
Rheumatoid Arthritis ◽  
Alkaline Phosphatase ◽  
Serum Albumin ◽  
Total Protein ◽  
Liver Enzymes ◽  
Gum Arabic ◽  
Protective Effects ◽  
Soluble Fiber ◽  
Serum Globulin ◽  
Globulin Level

Background: Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the synovial joints with systemic manifestations. RA has a major impact on liver and kidney functions as part of the disease pathogenesis or as a sequel of disease medications or, mostly, both of them. The kidney and liver involvement increases the RA morbidity and mortality. Nowadays, dietary interventions are proposed as potential modifiers for disease severity. Gum Arabic (GA) is acacia senegal exudates; it is soluble fiber with prebiotic properties. GA has been discovered to be protective against experimental nephrotoxicity and hepatotoxicity, with comparable findings in human studies. This article addresses the effect of GA on hepatic and renal profile among RA patients.Methods: Forty patients aged 18–70 received GA daily for 12 weeks as a single dose of 30 g. The liver enzymes, total protein level, serum albumin, serum globulin level, urea, creatinine, and serum electrolytes have been measured as a baseline after 4 weeks and by the end of the study. Cobas C311 (Roche, Germany) automated chemistry analyzer directly determined the values for total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine. The study ethically has been approved by the Ethical Committee of the National Medicines and Poisons Board. Trial Registration Identifier: NCT02804581.Results: Regarding the liver enzymes, GA has significantly decreased the liver enzymes apart from alkaline phosphatase, which showed no significant change. In contrast, GA has increased the serum albumin level with a minor impact on the serum globulin level. Furthermore, GA has also significantly decreased the level of urea (P = 0.0001) and level of Sodium (P = 0.002) with nonsignificant change on creatinine and potassium concentrations.Conclusion: GA presents hepatic and renal protective effects among RA patients, evidenced by the significant reduction of urea and liver enzymes. Thus, it can be recommended as a dietary supplement for RA patients. Nonetheless, we recommend further investigation to support our findings.

scholarly journals Hepatoprotective potential of Indigofera tirunelvelica Sanjappa: in vitro and in vivo studies on CCl4 induced wistar albino rats

2020 ◽  
Vol 11 (4) ◽  
pp. 6404-6410
Author(s):  
Subburayalu S ◽  
Asha KRT ◽  
Deepa Somanath ◽  
Palavesam A
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Free Radical Scavenging ◽  
Albino Rats ◽  
Whole Plant ◽  
Wistar Albino Rats

The hepatoprotective efficiency of Indigofera tirunelvelica Sanjappa whole plant against CCl4 induced hepatotoxicity was examined. Rat hepatocyte monolayer culture and wistar albino rats were exercised as in vitro and in vivo screening models of protective agent for liver. In in vitro analyses, the whole plant ethanolic extract of Indigofera tirunelvelica Sanjappa were inspected. Silymarin was chosen as a standard treatement drug. In vitro, free radical scavenging property was also evaluated. In animal studies, hepatotoxicity was produced in Wistar albino rats by dispensing CCl4. The degree of hepatotoxicity was examined by determining the ranges of serum enzyme. The antioxidant parameters such as superoxide dismutase, catalase, reduced glutathione, and malondialdehyde of the hepatocytes were also evaluated. In in vitro studies, ethanol extract of I. tirunelvelica whole plant was identified to be the most active than other assessed extracts. Besides, whole plant ethanol extract of I. tirunelvelica was noticed to be rich in phenolic and flavonoids. It exhibited expressive free radical scavenging property versus diphenylpicryl hydrazyl (DPPH) and superoxide ion radicals. In the animals studies, whole plant ethanolic extract of I. tirunelvelica at a ranges of doses (100, 200 and 400 mg/kg body weight) revealed considerable amount of protection against CCl4 induced hepatotoxicity as evident by the protection of CCl4 induced changes biochemical parameters. The results of the present study suggested that the significant hepatoprotective property of whole plant ethanol extract of I. tirunelvelica against CCl4 induced hepatotoxicity and intimates its use as a potential medicinal drug for liver diseases.

Sign in / Sign up

Export Citation Format

Share Document