scholarly journals Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Ebtihal Kamal ◽  
Lamis AbdelGadir Kaddam ◽  
Alnour Alagib ◽  
Amal Saeed
Keyword(s):  
Rheumatoid Arthritis ◽  
Alkaline Phosphatase ◽  
Serum Albumin ◽  
Total Protein ◽  
Liver Enzymes ◽  
Gum Arabic ◽  
Protective Effects ◽  
Soluble Fiber ◽  
Serum Globulin ◽  
Globulin Level

Background: Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the synovial joints with systemic manifestations. RA has a major impact on liver and kidney functions as part of the disease pathogenesis or as a sequel of disease medications or, mostly, both of them. The kidney and liver involvement increases the RA morbidity and mortality. Nowadays, dietary interventions are proposed as potential modifiers for disease severity. Gum Arabic (GA) is acacia senegal exudates; it is soluble fiber with prebiotic properties. GA has been discovered to be protective against experimental nephrotoxicity and hepatotoxicity, with comparable findings in human studies. This article addresses the effect of GA on hepatic and renal profile among RA patients.Methods: Forty patients aged 18–70 received GA daily for 12 weeks as a single dose of 30 g. The liver enzymes, total protein level, serum albumin, serum globulin level, urea, creatinine, and serum electrolytes have been measured as a baseline after 4 weeks and by the end of the study. Cobas C311 (Roche, Germany) automated chemistry analyzer directly determined the values for total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine. The study ethically has been approved by the Ethical Committee of the National Medicines and Poisons Board. Trial Registration Identifier: NCT02804581.Results: Regarding the liver enzymes, GA has significantly decreased the liver enzymes apart from alkaline phosphatase, which showed no significant change. In contrast, GA has increased the serum albumin level with a minor impact on the serum globulin level. Furthermore, GA has also significantly decreased the level of urea (P = 0.0001) and level of Sodium (P = 0.002) with nonsignificant change on creatinine and potassium concentrations.Conclusion: GA presents hepatic and renal protective effects among RA patients, evidenced by the significant reduction of urea and liver enzymes. Thus, it can be recommended as a dietary supplement for RA patients. Nonetheless, we recommend further investigation to support our findings.

A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy

2019 ◽  
Vol 29 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Yasunori Yoshino ◽  
Ayumi Taguchi ◽  
Takuya Shimizuguchi ◽  
Yujiro Nakajima ◽  
Maki Takao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Overall Survival ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
High Serum ◽  
Serum Globulin ◽  
Globulin Level ◽  
Albumin To Globulin Ratio

ObjectiveWe investigated whether the pretreatment albumin to globulin ratio, serum albumin level, and serum globulin level can be used to predict survival among cervical cancer patients treated with radiation based therapy and assessed globulin fractions.MethodsWe retrospectively enrolled 128 patients with cervical cancer treated with radiation based therapy at our institution between 2010 and 2015. The associations of the pretreatment albumin to globulin ratio, and serum albumin and globulin levels with overall survival were assessed. Additionally, the associations of the globulin fractions with the serum globulin levels and overall survival were evaluated.ResultsMedian follow-up duration was 30 months (IQR 16–44 months). A low albumin to globulin ratio (< 1.53) was found to be an independent prognostic factor for overall survival (HR= 3.07; 95% CI, 1.03 to 13.3; P=0.044). On evaluating serum globulin and albumin separately, a high serum globulin level was significantly associated with overall survival (cut-off value 2.9 g/dL; HR=3.74; 95% CI 1.08 to 23.6; P=0.036) whereas a low serum albumin level was not associated with overall survival (cut-off value 3.6 g/dL; HR=1.77; 95% CI 0.57 to 4.54; P=0.29). Electrophoresis data of the serum proteins revealed that the γ-globulin fraction was most strongly correlated with the globulin levels (P<0.001). Furthermore, a high γ-globulin level (≥1.28 g/dL) was significantly associated with poor overall survival (log rank test, P=0.034).ConclusionsA pretreatment low albumin to globulin ratio, which might be attributable to a high serum globulin level, can be used to predict poor prognosis in cervical cancer patients treated with radiation based therapy.

scholarly journals Serum Total Protein, Albumin, Globulin, and Prealbumin in Acne Patients

2020 ◽  
Author(s):  
Hao Jiang ◽  
Changyi Li ◽  
bin wei ◽  
Qiang Wang ◽  
Qinggao Wang ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Serum Levels ◽  
Control Group ◽  
Healthy Controls ◽  
Serum Globulin ◽  
Serum Total Protein ◽  
Protein Levels ◽  
Healthy Control ◽  
Age And Sex

Abstract Background/Objectives: This study was designed to investigate serum protein levels in acne patients.Method: Acne patients (n=362) and healthy volunteers (n=272) were matched in terms of both age and sex. Serum levels were measured.Results: Among the 362 acne patients and 272 age- and sex-matched healthy controls, serum albumin levels in female acne patients were lower than in the healthy controls (P < 0.05), serum albumin levels in male acne patients were lower than in the healthy controls (P < 0.01). Additionally, serum globulin and total protein levels were significantly lower in acne patients than in the healthy control group (P < 0.01). Serum levels of prealbumin were significantly lower in female acne patients than in the control group (P < 0.05). Finally, the severity of female and male acne patients was negatively correlated with serum total protein, albumin, globulin, and prealbumin levels. Conclusions: The results of this study suggested that acne patients are potentially accompanied with protein malnutrition.

scholarly journals Hepatic Injury in Neonates with Perinatal Asphyxia

2021 ◽  
Vol 8 ◽  
pp. 2333794X2098778
Author(s):  
Akram Elshafey Elsadek ◽  
Naglaa FathyBarseem ◽  
Hany Abdelaziz Suliman ◽  
Hatem Hamed Elshorbagy ◽  
Naglaa M. Kamal ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Albumin ◽  
Apgar Score ◽  
Total Protein ◽  
Liver Enzymes ◽  
Perinatal Asphyxia ◽  
International Normalized Ratio ◽  
Impaired Liver Function ◽  
Group I ◽  
Group Ii

Background: Perinatal asphyxia (PA) is a major cause of morbidity and mortality in which dramatic transient impairment in liver functions occurs in some patients. Objectives: We aimed to evaluate the state of the liver in cases of Perinatal asphyxia and to assess the severity of hepatic impairment in relation to different grades of HIE. Patients and Methods: This case-control study was conducted on 100 full-term newborns with perinatal asphyxia (Group I) and 50 healthy neonates served as controls (Group II). All biochemical parameters of liver function were measured on the 1st, 3rd, and 10th day after birth. These parameters include serum alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, serum albumin, serum bilirubin (total and direct), and international normalized ratio (INR), in both cases and controls. Results: Among babies with PA, 25 (25%) had an Apgar score of 0 to 3 (severe PA), 43 (43%) had an Apgar score of 4 to 5 (moderate PA) and 32 (32%) had an Apgar score of 6 to 7 (mild PA) at 5 minutes of life. HIE was found in 39% among cases of PA and the remaining 61% were normal. Among babies with PA and HIE; 25.7% had stage I, 41% had stage II and 33.3% had stage III. Impaired liver function was reported in 48% of asphyxiated babies. On the first day of life, ALT, AST, ALP, LDH, PT, and INR were significantly higher in Group I compared to Group II. However, total protein and serum albumin were significantly lower in Group I compared to Group II. ALT and AST showed a positive correlation with the severity of HIE. On the third day of life, LDH rises as the stage of HIE progressed from stage 0 to stage 3. The difference in LDH among most stages of HIE was statistically significant. Conclusion: Liver enzymes can be used as an easy early diagnostic marker to differentiate between babies with asphyxia and those without asphyxia. Also, liver enzymes can be used for the detection of the severity of PA.

scholarly journals Hepatoprotective Effect of Chenopodium Album Linn. Whole Plant on Biochemical Parameters Against Paracetamol Induced Hepatotoxicity in Rats

2015 ◽  
Vol 14 (2) ◽  
pp. 1-4
Author(s):  
Maliha Ata ◽  
Selim Md Jahangir ◽  
Md Mahbubul Islam ◽  
Rasheda Akter ◽  
Md Tofayel Hossain Sarkar ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Chenopodium Album ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Active Principle ◽  
Acute Administration ◽  
Protective Effects ◽  
Whole Plant

Chenopodium album Linn (Called Bathua in Bengali) is a plant which has a long history of uses in liver disorders in this subcontinent. This study was done to evaluate the hepatoprotective effects of ethanol extract of this plant on paracetamol induced hepatotoxicity in albino rats. The total experiments were designed as follows (I) Experiment (part I):- Induction of hepatotoxicity by single administration of paracetamol at a dose of 2 gm/kg body weight. (2) Experiment (part II) : Effects of ethanol extract of Chenopodium album Linn. on paracetamol induced hepatotoxicity in albino rats. The biochemical reports suggested that acute administration of paracetamol produced significant hepatotoxicity in experimental rats which was evidenced by significant increase in Serum Bilirubin, Serum Alanine Aminotransferase (ALT) Serum Aspartate Aminotransferase (AST) Serum Alkaline Phosphatese (ALP) level, decrease in serum albumin and serum total protein level. When rats were treated with extracts of C. album plant in paracetamol induced hepatotoxic albino rats, the results showed marked reduction in serum bilirubin, serum ALT, serum AST and serum ALP level and increase of serum albumin level but not sigificant increase of total protein as compared with paracetamol treated group. The results of the present study revealed that ethanol extract of Chenopodium album Linn. whole plant has got protective effects against paracetamol induced hepatotoxicity. Further study is needed to find out the curative effect and to isolate the active principle and to explore out the exact hepatoprotective mechanism of this plant extract.Chatt Maa Shi Hosp Med Coll J; Vol.14 (2); Jul 2015; Page 1-4

scholarly journals Alterations in Serum Protein Levels in Patients with Cushing’s Syndrome before and after Successful Treatment

2000 ◽  
Vol 85 (9) ◽  
pp. 3309-3312
Author(s):  
P. Putignano ◽  
G. A. Kaltsas ◽  
M. Korbonits ◽  
P. J. Jenkins ◽  
J. P. Monson ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Serum Protein ◽  
Cushing’S Syndrome ◽  
Successful Treatment ◽  
Total Protein ◽  
Cushing's Syndrome ◽  
Reference Ranges ◽  
Serum Globulin ◽  
Protein Levels ◽  
Albumin To Globulin Ratio

Abstract Alteration in serum protein concentration is used commonly in clinical practice as a nonspecific indicator of underlying disease or to monitor disease activity. Although hypercortisolemia may affect protein metabolism directly or indirectly, data regarding alterations of levels of serum protein in a large series of patients with Cushing’s syndrome (CS) have been lacking. We have now evaluated, retrospectively, the levels of circulating serum albumin, globulins, total proteins, and the albumin to globulin ratio in 99 patients with endogenous CS before, immediately after, and 3, 6, and 12 months following successful treatment. Subjects with concomitant infections or other chronic diseases were excluded from the analysis. Although mean serum albumin and total protein levels were within the normal reference ranges, in general, they gradually increased after treatment with maximal values being reached at 12 months after normalization of hypercortisolemia (P &lt; 0.0001 for both); there were no significant changes in serum globulin levels or in the albumin to globulin ratio. Patients with CS as a whole showed a weak but significant negative correlation between serum albumin and 0900 h cortisol level (r = −0.303; P = 0.0035). In conclusion, our data suggest that CS is associated with a small but significant reduction in circulating serum protein levels, which are restored following treatment of hypercortisolemia, although these changes occur within the reference range. Thus, extreme alterations in serum total protein or albumin levels in patients with CS should alert physicians to the presence of concomitant pathology, and additional specific investigation should be undertaken to elucidate the cause.

scholarly journals Plasma Proteins in Enterica Serovar Typhi patients in Northern Sudan

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Nagah A.A.Mohamed ◽  
Mohieldin Omer
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Plasma Proteins ◽  
Albumin Level ◽  
P Value ◽  
Serum Globulin ◽  
Serum Total Protein ◽  
Significant Difference ◽  
G Ratio ◽  
Protein Serum

Background: The study entailed a quantitative assessment of serum total protein, albumin, globulin, and albumin.Method: globulin ratio in individuals who diagnosed positively with typhoid fever and detection any alteration in plasma protein in receptiveness to typhoid titers. One hundred positively diagnosed with typhoid infection mean age (41.5 ± 2.1) years on zero day treatments. In addition to healthy one hundred individuals mean age (42.9 ± 1.9) years were recruited in this study.Results: There were significant difference  P. value = 0.000   in total protein, serum albumin, serum globulin and A/G ratio for typhoid positive and negative,  mean (8.4±0.01,6.8±0.06), (3.5±0.01, 4.1±0.03), (4.9±0.01, 2.8±0.06), (0.7 ± 0.003, 1.5 ± 0.02) respectively. No significant difference, P. value was 0.632, 0.832 and 0.760 serum total protein (7.5 ± 0.92, 7.6 ± 0.79) serum albumin (3.8 ± 0.38, 3.8 ± 0.37) and serum globulin (3.8 ± 0.16, 3.9 ± 0.16) for males and females respectively. Also no significant difference, P. value was 0.11, 0.60, and 0.06 serum total protein (8.4 ± 0.01, 8.4± 0.02) serum albumin (3.5 ± 0.01, 3.5 ± 0.01) and serum globulin (5.0 ± 0.01, 4.9 ± 0.01) for titer 1/160 and titer 1/320.Conclusion: Low albumin level and hypoglycemia should be surveillant when anti typhoid pharmaceutical commenced.Key words: Plasma Proteins, Enterica Serovar Typhi, Sudan

Haemato-Biochemical Alterations After Epidural Administration of Dexmedetomidine Alone and in Combination with Bupivacaine in Buffalo Calves

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
A. Jaiswal ◽  
S. S. Pandey ◽  
A. S. Parihar ◽  
N. Rajput ◽  
R. Jain
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Glucose ◽  
Serum Creatinine ◽  
Total Protein ◽  
Epidural Injection ◽  
Epidural Administration ◽  
Healthy Male ◽  
Buffalo Calves ◽  
Biochemical Alterations ◽  
Biochemical Examination

The study was conducted on 12 healthy male buffalo calves weighing between 50 to 60 Kg to evaluate haemato-biochemical alterations after epidural injection of dexmedetomidine alone and in combination with bupivacaine. Haematological examination showed nonsignificant alterations. Biochemical examination showed significant increase in blood glucose, blood urea nitrogen and serum creatinine while there was nonsignificant alterations in total protein and alkaline phosphatase. All haemato-biochemical changes were transient and compensatory.

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

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