scholarly journals Cigarette Smoking, a Risk Factor for Chronic Subclinical Inflammation and a Predictor of Metabolic Syndrome in Adult Healthy Population of Bangladesh

Pulse ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 30-37
Author(s):  
Behterin Rehnuma ◽  
Sohely Najneen Eva ◽  
Mohammad Ibrahim ◽  
Tareak Al Nasir ◽  
Liaquat Ali
Keyword(s):  
Risk Factor ◽  
Subclinical Atherosclerosis ◽  
High Sensitivity ◽  
Social Program ◽  
Blood Collection ◽  
Healthy Population ◽  
Subclinical Inflammation ◽  
Reactive Protein ◽  
Hs Crp ◽  
Study Participants

Background and Aims: Smoking is a classical and major risk factor for cardiovascular disease. Inflammatory activators and metabolic disorders are the mediators of smoking-induced atherosclerotic progression. The aim of the present study was to investigate whether smoking alter inflammatory or metabolic status and affect subclinical atherosclerosis in apparently healthy persons.Methods: A total number of 149 adults, age 30-60 yrs, were recruited in the study. Participants were divided into sub-groups of smokers (76) and non-smokers (73). All participants were interviewed and underwent physical examinations and blood collection. High-sensitivity C reactive protein (Hs-CRP) was measured to assess degree of underlying inflammation. Fasting plasma glucose and lipid profile were measured to assess metabolic condition. Data were analyzed using statistical Package for Social Program (SPSS) for Windows version 17.Results: Hs-CRP (p=0.017), Fasting glucose (p=0.003), Triglyceride (p=0.005) was significantly high in smokers in comparison with nonsmokers. BMI (p=0.012) and BFM (%) (p= <0.001) showed significantly lower in comparison with the counterpart. HDL-c (p=.030) was also significantly lower in smoker group than non-smoker group. In Spearman’s correlation analyses Triglyceride (p=0.037) and smoking (p= 0.042) showed positive correlation with Hs-CRP. HDL-c is less in smoker subjects but not statistically up to the significant level.Conclusion: The rising Hs-CRP concentration reflects presence of chronic subclinical inflammation in middle aged Bangladeshi smokers and thus may have a risk for future cardiovascular disease.Pulse Vol.8 January-December 2015 p.30-37

Basal high-sensitivity-C-reactive protein levels in patients with spontaneous venous thromboembolism

2005 ◽  
Vol 93 (03) ◽  
pp. 488-493 ◽  
Author(s):  
Rainer Vormittag ◽  
Thomas Vukovich ◽  
Verena Schönauer ◽  
Stephan Lehr ◽  
Erich Minar ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Statistical Significance ◽  
Factor V Leiden ◽  
High Sensitivity ◽  
Prothrombin G20210a ◽  
Factor V ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

SummaryThe role of C-reactive protein (CRP) in venous thromboembolism (VTE) is still under discussion because of controversial results in the literature. Conflicting data may have partly been due to bias by exogenous factors altering CRP levels. We investigated CRP concentrations in patients with spontaneous VTE applying a study design that allowed the measurement of basal high sensitivity (hs)-CRP levels. Patients with a history of deep vein thrombosis (DVT, n=117) and pulmonary embolism (PE, n=97) were compared to healthy individuals (n=104). Hs-CRP levels (mg/dl) were significantly higher in patients (n=214, median/interquartile range: 0.171/0.082–0.366) than in controls (0.099/0.053–0.245, p=0.001). The unadjusted odds ratio (OR) for VTE per 1 mg/dl increase of CRP was 2.8 [95% confidence interval (CI): 1.1–6.8, p=0.03]. This association remained significant after adjustment for factor V Leiden, prothrombin G20210A and factor VIII activity above 230% (OR = 2.9, 95% CI [1.1–7.5]), but became remarkably attenuated and lost its statistical significance after adjustment for BMI alone (OR = 1.7 [0.7–4.0]). CRP was also not independently associated with VTE in subgroups of patients (those with DVT without symptomatic PE, those with PE and patients without established risk factor) in multiple regression analysis. In summary, we observed significantly higher basal hs-CRP levels in patients with spontaneous VTE compared to healthy controls. This association was independent of hereditary and laboratory risk factors for VTE, but lost its significance after adjustment for BMI. Increased basal CRP levels do not appear to represent an independent risk factor for VTE.

scholarly journals Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yasuharu Tabara ◽  
Kazuya Setoh ◽  
Takahisa Kawaguchi ◽  
Shinji Kosugi ◽  
Takeo Nakayama ◽  
...  
Keyword(s):  
Risk Factor ◽  
General Population ◽  
Confidence Interval ◽  
Cox Model ◽  
Prognostic Significance ◽  
High Sensitivity ◽  
Hazard Ratio ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
Study Participants

AbstractCirculating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is unclear. We aimed to evaluate the prognostic significance of AAT levels for all-cause mortality. Study participants comprised 9682 community residents (53.5 ± 13.3 years old). During the 9.8-year follow-up period, 313 participants died from any cause. The mortality rate increased linearly with AAT quintiles (Q1, 18.2; Q2, 24.7; Q3, 23.8; Q4, 31.9; Q5, 64.6 per 10,000 person-years). There were significant correlations between AAT and high-sensitivity C-reactive protein (hsCRP) levels (correlation coefficient, 0.331; P < 0.001). However, the Cox model analysis, when adjusted for possible covariates including hsCRP, identified the fifth AAT quintile as a risk factor for all-cause death (hazard ratio, 2.12 [95% confidence interval, 1.41–3.18]; P < 0.001). An analysis of participants older than 50 years (hazard ratio, 1.98, P < 0.001) yielded similar results. The hazard ratio increased proportionately in combination with high AAT and high hsCRP levels, and the highest hazard ratio reached 4.51 (95% confidence interval, 3.14–6.54, P < 0.001). High AAT levels were determined to be an independent risk factor for mortality in the general population.

scholarly journals Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

2021 ◽  
Vol 10 (15) ◽  
pp. 1074-1078
Author(s):  
Jayachandra Jayachandra ◽  
Arjun P. Chandrashekar ◽  
Sowrabha S. Bhat ◽  
Yoganand Yoganand ◽  
Chethan Chethan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acute Stroke ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Risk Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

C-reactive protein as a predictor of cardiovascular risk in HIV-infected individuals

Sexual Health ◽  
2014 ◽  
Vol 11 (6) ◽  
pp. 580 ◽  
Author(s):  
Clare L. V. Westhorpe ◽  
Hans G. Schneider ◽  
Mandy Dunne ◽  
Tracey Middleton ◽  
Vijaya Sundararajan ◽  
...  
Keyword(s):  
General Population ◽  
Hiv Infection ◽  
Predictive Value ◽  
High Sensitivity ◽  
Coronary Event ◽  
C Reactive Protein ◽  
Cardiac Events ◽  
Reactive Protein ◽  
Hs Crp ◽  
Study Participants

Background In some studies HIV infection confers approximately two-fold higher risk of cardiac events compared with the general population. C-reactive protein (CRP) is a well-characterised biomarker of cardiac events in the general population and is also elevated in patients with HIV infection. The aim of this study was to determine the predictive value of CRP for cardiac events in HIV-infected individuals. Methods: We retrospectively analysed CRP levels in stored plasma samples from HIV-infected patients who did or did not experience a coronary event in a case-controlled manner. All CRP measurements were performed using a high-sensitivity assay (hs-CRP). Results: Of the study participants with samples available, we found slightly elevated hs-CRP levels in the cardiac cases (median 3.5, IQR 1.6–14.4, n=23) compared with controls (median 2.6, IQR1.2–8.3, n=49) which were shown to not be statistically significant P=0.20. Analysis of CRP as a binary variable (≥5 mg L–1) was also not statistically significant (OR: 1.32, 95% CI 0.48–3.63). Conclusions: CRP levels may indicate elevated risk of future cardiac events, however this must be interpreted with caution due to the generalised elevation of CRP during HIV infection. CRP has no predictive value for atherosclerosis, and further research is required to improve early prediction of cardiovascular disease in HIV infection.

scholarly journals High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Beili Shi ◽  
Zhaohui Ni ◽  
Hong Cai ◽  
Minfang Zhang ◽  
Shan Mou ◽  
...  
Keyword(s):  
Risk Factor ◽  
Multivariate Regression ◽  
Ventricular Hypertrophy ◽  
Independent Risk Factor ◽  
High Sensitivity ◽  
Multivariate Regression Analysis ◽  
Left Ventricular ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.Methods. 287 LN patients (age: 38.54 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.Results. The prevalence of LVH in this cohort was 21.25% (). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, , and correlated with left ventricular mass index (LVMI) (, ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (, ) for LVH in patients with LN.Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.

scholarly journals Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035880 ◽  
Author(s):  
Tong Liu ◽  
Sarah Tan Siyin ◽  
Nan Yao ◽  
Ning Duan ◽  
Guoshuai Xu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Independent Risk Factor ◽  
Gallstone Disease ◽  
High Sensitivity ◽  
Secondary Outcome ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectivesGallstone disease (GSD) can be caused by various health and clinical factors such as obesity, dyslipidaemia and an unhealthy diet, all of which are associated with higher high-sensitivity C reactive protein (hs-CRP) concentrations. Whether hs-CRP represents an independent risk factor for GSD is still unclear. We prospectively investigated hs-CRP in relation to the occurrence of GSD based on the Kailuan study.Study designProspective cohort study.SettingThe Kailuan cohort study was conducted in Tangshan City in northern China.Participants95 319 participants who were free from GSD were recruited in this study. Epidemiological data, anthropometric parameters and biochemical data of participants were collected.Primary and secondary outcome measuresCox proportional hazards regression models were used to evaluate the association between hs-CRP concentrations and the risk of GSD after adjustments for potential confounders.ResultsDuring the mean 7.58 years of follow-up among 95 319 participants, 4205 participants were identified as newly diagnosed with GSD or having undergone cholecystectomy for cholelithiasis. Compared with the hs-CRP<1 mg/L group, elevated hs-CRP concentrations were significantly associated with higher risk of GSD with the corresponding HR of 1.11 (95% CI 1.03 to 1.19), 1.12 (95% CI 1.04 to 1.22) in the 1≤hs-CRP≤3 mg/L and hs-CRP>3 mg/L group, respectively. The multivariate model which included hs-CRP not only had a better line of fitness but also had better predictive values to help identify new cases of GSD during follow-up.ConclusionElevated hs-CRP concentration is an independent risk factor for new-onset GSD among the Chinese population.Trial registration numberChiCTR-TNC-11001489.

High-Sensitivity C-Reactive Protein is Not Independently Associated with Peripheral Subclinical Atherosclerosis

Angiology ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Mario Bo ◽  
Laura Corsinovi ◽  
Alessia Brescianini ◽  
Alessandro Sona ◽  
Marco Astengo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Subclinical Atherosclerosis ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lipid Clinic ◽  
Hs Crp ◽  
Cv Disease

Objective This study investigated whether high-sensitivity C-reactive protein (hs-CRP) levels are independently associated with subclinical peripheral atherosclerosis. Methods. Clinical variables, cardiovascular (CV) risk factors, 10-year CV risk, the antebrachial Index (ABI), and the carotid intima—media thickness (cIMT) were determined in a sample of consecutive subjects free from previous CV disease, admitted for a first visit at a lipid clinic. Results. In the overall sample (320 subjects, mean age 63 years, 35.8% men), hs-CRP levels were associated with major CV risk factors, 10-year CV risk, lower ABI, and higher cIMT values. In a logistic model, after adjustment for significant covariates, the associations of hs-CRP levels with ABI and cIMT were no longer statistically significant. Conclusions. Among asymptomatic, moderate- to-high CV risk subjects, hs-CRP levels were associated with severity of peripheral atherosclerosis, but these associations were not independent of traditional CV risk factors, suggesting a limited predictive role of hs-CRP for subclinical atherosclerosis.

scholarly journals Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Ana de Lurdes Agostinho Cabrita Vieira ◽  
Alexandre Baptista ◽  
Anabela Malho ◽  
Ana Pinho ◽  
Ana Paula Silva ◽  
...  
Keyword(s):  
Risk Factor ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
High Sensitivity ◽  
Reverse Epidemiology ◽  
Reactive Protein ◽  
Total Homocysteine ◽  
The Mean ◽  
Hs Crp ◽  
Necrosis Factor

The increased level of plasma total homocysteine (tHcy) in chronic kidney disease patients has been reported as a new and independent risk factor for cardiovascular disease. However, after the description of reverse epidemiology in the renal population, the association of tHcy and nutrition became less clear. We evaluated the association between homocysteine, nutritional status, and inflammation, and their impact on mortality in 95 predialysis patients. High sensitivity C-Reactive Protein (hs-CRP), interleukin 6 (IL-6), Tumor Necrosis Factor (TNF-)], and tHcy were evaluated, as was the nutritional status by the modified Subjective Global Nutritional Assessment (mSGA). We divided our population in four groups according to their tHcy and mSGA values being above or below the mean level and found the lowest survival in the group with tHcy and mSGA above the mean level, as well as higher levels of IL-6 () and TNF- (). Higher levels of homocysteine can be associated with higher mortality in predialysis patients, as long as they are associated with malnutrition and inflammation.

scholarly journals Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

2019 ◽  
Vol 7 (22) ◽  
pp. 3887-3890
Author(s):  
Dewa Ayu Swastini ◽  
Ida Ayu Dewi Wiryanthini ◽  
Ni Luh Putu Ariastuti ◽  
Agus Muliantara
Keyword(s):  
Risk Factor ◽  
Univariate Analysis ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Related Risk ◽  
Severity Prediction ◽  
Hs Crp ◽  
Atherosclerosis Severity

BACKGROUND: Inflammation plays a major role in the initiation, destabilization and the progression of atherosclerosis. High Sensitivity C-Reactive Protein (hs-CRP) reflects active systemic inflammation and have shown to be a strong predictor of future cardiovascular events. AIM: The purpose of this study was to determine the role of High Sensitivity C-Reactive Protein (hs-CRP) independent for atherosclerosis severity prediction and to find out which factors largely is affecting hs-CRP level in dyslipidemia patient. METHODS: A total of 388 patients (267 dyslipidemia, 121 controls) were enrolled in this study. We investigated whether plasma hs-CRP is associated with atherosclerosis severity that was quantified by ankle-brachial index (ABI) and Doppler ultrasound. Related risk factor that influence hs-CRP levels in patients with dyslipidemia included determination of age, gender, diabetes, smoking, hypertension, total cholesterol, TG, LDL, HDL, and fasting glucose. RESULTS: Data showed a significant association between hs-CRP concentration level and the severity of atherosclerosis (p < 0.01). Univariate analysis showed that fasting plasma glucose, triglyceride, and BMI were significantly positively correlated with hs-CRP levels. Whereas, HDL cholesterol was negatively correlated with hs-CRP levels. Multivariate regression analysis using model 1 and 2, showed that in determining hs-CRP levels, triglyceride and BMI were taking a big role. CONCLUSION: Hs-CRP correlates with extent of atherosclerosis, and high triglyceride and BMI is closely associated with high hs-CRP levels in patients with dyslipidemia.

scholarly journals Evaluation of Four Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications

2000 ◽  
Vol 46 (4) ◽  
pp. 461-468 ◽  
Author(s):  
William L Roberts ◽  
Rachel Sedrick ◽  
Linda Moulton ◽  
Anthony Spencer ◽  
Nader Rifai
Keyword(s):  
Large Scale ◽  
Clinical Laboratory ◽  
High Sensitivity ◽  
Reference Interval ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Prognostic Information ◽  
Reactive Protein ◽  
Hs Crp ◽  
Apparently Healthy

Abstract Background: C-reactive protein (CRP) can provide prognostic information about the risk of developing atherosclerotic complications in apparently healthy patients. This new clinical application requires quantification of CRP concentrations below those traditionally measured in the clinical laboratory. Methods: The Dade Behring BN II, the Abbott IMx, the Diagnostic Products Corporation IMMULITE, and the Beckman Coulter IMMAGE are four automated analyzers with high-sensitivity CRP (hs-CRP) methods. We evaluated these assays for precision, linearity, and comparability with samples from 322 apparently healthy blood donors. Results: The imprecision (CV) of the BN II, IMx, IMMULITE, and IMMAGE methods was ≤7.6%, ≤12%, ≤9.8%, and ≤9.7% at 3.5 mg/L, respectively. The BN II, IMx, IMMULITE, and IMMAGE methods were linear down to ≤0.30, ≤0.32, ≤0.85, and 2.26 mg/L, respectively. CRP concentrations demarcating each quartile in a healthy population were method dependent. The IMx method gave results comparable to the BN II method for values in the reference interval. The IMMULITE method had a positive intercept compared with the BN II method. The IMMAGE method demonstrated more scatter and a positive intercept compared with the BN II method, which may reflect the fact that it is a less sensitive assay. Conclusions: The four hs-CRP methods exhibited differences in results for a healthy population. Additional standardization efforts are required to ensure that hs-CRP results can be related to large-scale epidemiologic studies.

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