scholarly journals Algorithm prediction of cognitive impairment

2015 ◽  
pp. 28-38
Author(s):  
N.K. Svyrydova ◽  
T.P. Parnikoza ◽  
G.M. Chupryna ◽  
R.V. Sulikom ◽  
G.S. Lubenets ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Independent Risk Factor ◽  
Neuropsychological Testing ◽  
Cerebral Arteries ◽  
Cognitive Disorders ◽  
Hypertensive Patients ◽  
Rate Of Progression ◽  
The Brain ◽  
Therapeutic Profile

The most strong and independent risk factor for cognitive disorders are age because the brain undergoes a series of regular changes that make it more vulnerable to various pathological effects. Diagnosis of cognitive impairment in patients with atherosclerosis of coronary and cerebral arteries in the early stages of development (for example, at the stage of mild cognitive disorders) hard due to ignorance of doctors therapeutic profile of peculiarities and rate of progression of cognitive impairment in hypertensive patients, especially their maintenance and necessary neuropsychological testing.

scholarly journals Bacterial overgrowth syndrome with hyperammonemia as a cause of cognitive disorders

2021 ◽  
pp. 79-87
Author(s):  
L. G. Vologzhanina ◽  
E. N. Borodina ◽  
O. A. Igumnova ◽  
A. A. Trapeznikova
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Clinical Practice ◽  
Statistical Analysis ◽  
Intestinal Microbiota ◽  
Clinical Observation ◽  
Bacterial Overgrowth ◽  
Cognitive Disorders ◽  
Capillary Blood ◽  
The Brain

The growth of cognitive impairment (CI) in clinical practice makes us search for their new pathogenetic mechanisms, among which the effect of intestinal microbiota on the brain is currently being actively studied. The mechanisms of interaction of the axis “brain - microbiota” have not been completely studied. The aim of this study was to confirm the possible effect on the brain of the neurotoxin ammonia, which rises in the blood due to the syndrome of excessive bacterial growth (SIBO). Materials and methods: The article presents data from a clinical observation, which included an examination of 70 patients of the gastrocenter in Perm with dyspepsia syndrome, who studied changes in the intestinal microbiota, the level of ammonia of capillary blood, and cognitive impairment, and conducted a correlation analysis. Results: According to the results of a statistical analysis of the obtained data, we did not find any significant changes or significant correlations between the studied parameters. However, the identified tendency in the connection “SIBO - hyperammonemia - cognitive impairment” suggests that the presence of SIBO can aggravate the severity of not only existing gastroenterological manifestations, but also be a risk factor for hyperammonemia, as well as contribute to the formation of impaired human cognitive functions.

scholarly journals Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

2012 ◽  
Vol 35 (11) ◽  
pp. 1087-1092 ◽  
Author(s):  
Tatsuo Kawai ◽  
Mitsuru Ohishi ◽  
Yasushi Takeya ◽  
Miyuki Onishi ◽  
Norihisa Ito ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Hypertensive Patients

scholarly journals Features of diagnosis of cognitive disorders in patients with chronic brain ischemia

2016 ◽  
pp. 8-11
Author(s):  
N.P. Pavliuk
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Cognitive Impairment ◽  
Cognitive Disorders ◽  
Chronic Ischemia ◽  
Modern Health Care ◽  
Chronic Brain Ischemia ◽  
The Many ◽  
The Brain

One of the major problems in modern health care are cerebrovascular disease, which occupy a leading place in the structure of mortality and disability in the population. Among the many clinical features of chronic ischemia of the brain is a key manifestation of cognitive impairment that often determine the severity of condition and quality of life of the patient and his relatives. Diagnosis of cognitive impairment is very important, as the timely appointment of therapy may prevent or at least delay the development of dementia.

scholarly journals Association between serum lipid and ischaemic stroke in a tertiary hospital in Northern Andhra Pradesh, India

2020 ◽  
Vol 7 (7) ◽  
pp. 1078
Author(s):  
Tamminana Venugopala Rao ◽  
Budumuru Annaji Rao ◽  
Sreedevi Panchadi ◽  
K. Sudheer
Keyword(s):  
Risk Factor ◽  
Ischaemic Stroke ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Independent Risk Factor ◽  
Ldl Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Stroke Patients ◽  
The Brain

Background: The incidence of cerebrovascular disease increases with age and the number of strokes is projected to increase as the elderly population grows. A stroke occurs when blood vessels that carry blood to the brain suddenly blocked or burst, preventing blood flow to the brain. The most common cause of blood vessel blockages is thrombosis (a blood clot) or an embolism (floating clot). Blood clots may form in the arteries that are damaged by atherosclerosis. Atherosclerosis is an aging process but some factors (risk factor) precipitate it to occur earlier. To find out the risk factors properly are of tremendous importance as risk factor change could directly influence or indirectly affect case fatality by altering the natural history of the disease. Serum lipids are thought to interact with the pathogenesis of stroke through the atherosclerotic mechanism. Objective was to identify the high serum lipid as an independent risk factor of stroke.Methods: This is a hospital-based case-control study. Seventy cases of stroke patients and age, sex-matched 70 healthy control subjects were enrolled by non-random sampling. 12 hours of fasting plasma lipids were estimated in both cases and control subjects. Then it was compared between cases and controls.Results: Hypercholesterolemia was higher in the case group than control but not statistically significant. Mean LDL- cholesterol, and triglycerides were significantly higher in the case group than the control group. The mean value of serum HDL-cholesterol was not significantly lower in the case group than the control group.Conclusions: Serum lipids are significantly higher in ischaemic stroke patients than the control group (LDL cholesterol and triglyceride). So, it may be an independent risk factor of ischemic stroke.

The problem of cognitive impairment in neurological practice (reference review)

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
T. I. Purdenko
Keyword(s):  
Cognitive Impairment ◽  
Early Diagnosis ◽  
Neurodegenerative Diseases ◽  
Old Age ◽  
Cognitive Disorders ◽  
Cerebral Diseases ◽  
Success Of Treatment ◽  
The Brain

The article presents an analysis of the literature on the problem of cognitive disorders. It is in old age, when vascular and neurodegenerative diseases of the brain are most frequently diagnosed, leading to cognitive disorders of varying severity: from mild to severe. Early diagnosis of cerebral diseases increases significantly the chances of success of treatment to the problem.

Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot study

2005 ◽  
Vol 23 (6) ◽  
pp. 1211-1216 ◽  
Author(s):  
Angelo Scuteri ◽  
Anna Maria Brancati ◽  
Walter Gianni ◽  
Antonio Assisi ◽  
Massimo Volpe
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Pilot Study ◽  
Arterial Stiffness ◽  
Independent Risk Factor ◽  
The Elderly

scholarly journals Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment

2019 ◽  
Vol 316 (5) ◽  
pp. H1124-H1140 ◽  
Author(s):  
Gabor A. Fulop ◽  
Stefano Tarantini ◽  
Andriy Yabluchanskiy ◽  
Andrea Molnar ◽  
Calin I. Prodan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Arteries ◽  
Vascular Cognitive Impairment ◽  
Cerebral Veins ◽  
Older Individuals ◽  
Low Velocity ◽  
Venous Circulation ◽  
Age Related ◽  
The Brain

There has been an increasing appreciation of the role of vascular contributions to cognitive impairment and dementia (VCID) associated with old age. Strong preclinical and translational evidence links age-related dysfunction and structural alterations of the cerebral arteries, arterioles, and capillaries to the pathogenesis of many types of dementia in the elderly, including Alzheimer’s disease. The low-pressure, low-velocity, and large-volume venous circulation of the brain also plays critical roles in the maintenance of homeostasis in the central nervous system. Despite its physiological importance, the role of age-related alterations of the brain venous circulation in the pathogenesis of vascular cognitive impairment and dementia is much less understood. This overview discusses the role of cerebral veins in the pathogenesis of VCID. Pathophysiological consequences of age-related dysregulation of the cerebral venous circulation are explored, including blood-brain barrier disruption, neuroinflammation, exacerbation of neurodegeneration, development of cerebral microhemorrhages of venous origin, altered production of cerebrospinal fluid, impaired function of the glymphatics system, dysregulation of cerebral blood flow, and ischemic neuronal dysfunction and damage. Understanding the age-related functional and phenotypic alterations of the cerebral venous circulation is critical for developing new preventive, diagnostic, and therapeutic approaches to preserve brain health in older individuals.

scholarly journals Brain Protection in the Endo-Management of Proximal Aortic Aneurysms

Hearts ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 25-37
Author(s):  
Lydia Hanna ◽  
Richard Gibbs
Keyword(s):  
Neuropsychological Testing ◽  
Cerebral Arteries ◽  
Thoracic Endovascular Aortic Repair ◽  
Aortic Aneurysms ◽  
Brain Protection ◽  
Resonance Imaging ◽  
High Prevalence ◽  
Neuroprotective Strategies ◽  
Weighted Magnetic Resonance Imaging ◽  
The Brain

Neurological brain injury (NBI) remains the most feared complication following thoracic endovascular aortic repair (TEVAR), and can manifest as clinically overt stroke and/or more covert injury, detected only on explicit neuropsychological testing. Microembolic signals (MES) detected on transcranial Doppler (TCD) monitoring of the cerebral arteries during TEVAR and the high prevalence and incidence of new ischaemic infarcts on diffusion-weighted magnetic resonance imaging (DW-MRI) suggests procedure-related solid and gaseous cerebral microembolisation to be an important cause of NBI. Any intervention that can reduce the embolic burden during TEVAR may, therefore, help mitigate the risk of stroke and the covert impact of ischaemic infarcts to the function of the brain. This perspective article provides an understanding of the mechanism of stroke and reviews the available evidence regarding potential neuroprotective strategies that target high-risk procedural steps of TEVAR to reduce periprocedural cerebral embolisation.

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