scholarly journals The Role of Red Blood Cell Deformability and Na,K-ATPase Function in Selected Risk Factors of Cardiovascular Diseases in Humans: Focus on Hypertension, Diabetes Mellitus and Hypercholesterolemia

2016 ◽  
pp. S43-S54 ◽  
Author(s):  
J. RADOSINSKA ◽  
N. VRBJAR
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Adverse Outcomes ◽  
Erythrocyte Membranes ◽  
Cell Deformability ◽  
Triggering Factor ◽  
Pass Through ◽  
Rbc Deformability

Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformability. The triggering factor for changes of RBC deformability during hypercholesterolemia seems to be the increased content of cholesterol in erythrocyte membranes.

scholarly journals Cardiovascular diseases in diabetic patients

2010 ◽  
Vol 1 (1) ◽  
pp. 46-50
Author(s):  
I. Y Yarek-Martynova ◽  
M. V Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Cerebrovascular Diseases ◽  
Diabetic Patients ◽  
Metabolic Disturbances ◽  
Lower Extremity Ischemia ◽  
Traditional Risk Factors ◽  
Extremity Ischemia

The review pays attention to a considerable rise in the incidence of diabetes mellitus (DM) and to its association with cardiovascular diseases (CVD) and events. It is noted that these events may be present much earlier than DM is diagnosed. The paper also discusses in detail a role of hyperglycemia, postprandial one in particular, hyperinsulinemia, insulin resistance, endothelial dysfunction, impaired blood rheological properties, lipid metabolic disturbances, and genetic and traditional risk factors in the development of atherosclerosis, coronary heart disease, chronic heart failure, cerebrovascular diseases, and lower extremity ischemia in DM.

scholarly journals Current understanding of the role of age-related hypogonadism in the development of cardiovascular diseases

2021 ◽  
Vol 93 (1) ◽  
pp. 79-83
Author(s):  
Natalia B. Lebedeva ◽  
Vladimir V. Hoffman
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Vascular Tone ◽  
Hormone Replacement ◽  
Circulatory System ◽  
Age Related

The literature review presents novel data on the prevalence of age-related hypogonadism and its relationship with aging, its impact on the circulatory system and cardiovascular diseases. This review summarizes the methods for diagnosing age-related hypogonadism, its association with traditional cardiovascular risk factors such as dyslipidemia, insulin resistance and diabetes mellitus, obesity, arterial hypertension. The mechanisms of the possible direct effect of testosterone on endothelium and vascular tone, the role of hormone replacement therapy as a way of preventing cardiovascular diseases are discussed.

The Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary Tract

2020 ◽  
Vol 16 (9) ◽  
pp. 931-948
Author(s):  
Benjamin Rahmani ◽  
Jason Gandhi ◽  
Gunjan Joshi ◽  
Noel L. Smith ◽  
Inefta Reid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Neuropathy ◽  
Gallbladder Cancer ◽  
Biliary Tract ◽  
Treatment Approach ◽  
Database Search ◽  
Heavy Burden ◽  
Prevalence Of Diabetes Mellitus

Background: The increasing prevalence of diabetes mellitus worldwide continues to pose a heavy burden. Though its gastrointestinal impact is appropriately recognized, the lesser known associations may be overlooked. Objective: We aim to review the negative implications of diabetes on the gallbladder and the biliary tract. Methods: A MEDLINE® database search of literature was conducted with emphasis on the previous five years, combining keywords such as "diabetes," "gallbladder," and "biliary". Results: The association of diabetes to the formation of gallstones, gallbladder cancer, and cancer of the biliary tract are discussed along with diagnosis and treatment. Conclusion: Though we uncover the role of diabetic neuropathy in gallbladder and biliary complications, the specific individual diabetic risk factors behind these developments is unclear. Also, in addition to diabetes control and surgical gallbladder management, the treatment approach also requires further focus.

Role of vitamin D in risk factors of patients with type 2 diabetes mellitus

2020 ◽  
Vol 154 (5) ◽  
pp. 151-156 ◽  
Author(s):  
Qingqing Zhang ◽  
Yucheng Wu ◽  
Yu Lu ◽  
Xiaoqiang Fei
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus

Features of the course of coronavirus infection in patients with diabetes mellitus

2022 ◽  
pp. 18-21
Author(s):  
Vladimir Anatolievich Klimov ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Human Population ◽  
Fatal Outcome ◽  
Significant Risk ◽  
Adverse Outcomes ◽  
Concomitant Disease ◽  
Patients With Diabetes ◽  
Coronavirus Infection ◽  
Population Mortality

Diabetesmellitus, overweight and the age of a patient over 65 years old are identified by clinicians as themain factors that can complicate the course of the coronavirus infection and increase the likelihood of fatal outcome. Although in the general human population mortality from coronavirus fluctuateswithin 3–5 %, sometimes very significantly differing in individual countries, this level can reach 15–25 % among patientswith diabetes, especially for those receiving insulin therapy. Diabetes mellitus as a concomitant disease in COVID-19 is considered one of the most significant risk factors for the development of adverse outcomes due to a more severe course of infection in conditions of hyperglycemia and other aggravating factors.

THE ROLE OF COMPREHENSIVE GERIATRIC ASSESSMENT IN THE TREATMENT OF CANCER PATIENTS IN ELDERLY AND SENILE AGE

2020 ◽  
pp. 65-73
Author(s):  
Ю. В. Алексеева ◽  
Т. Ю. Семиглазова ◽  
Б. С. Каспаров ◽  
Е. В. Ткаченко ◽  
К. И. Прощаев ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Malignant Tumors ◽  
Adverse Outcomes ◽  
Geriatric Syndromes ◽  
Complex Treatment ◽  
Increase Life Expectancy ◽  
Specialized Treatment

Современные подходы к организации диагностики и лечения больных пожилого и старческого возраста со злокачественными новообразованиями позволяют улучшать качество жизни и увеличивать продолжительность жизни. Оценка гериатрического статуса в онкологии позволяет прогнозировать осложнения в процессе комплексного лечения, в том числе лекарственного, модифицировать терапию для уменьшения факторов риска неблагоприятных исходов, осуществлять отбор пациентов на специализированное лечение с использованием стандартных схем. Таким образом, своевременная оценка гериатрических синдромов и их коррекция способна расширить показания к специализированному лечению больных пожилого и старческого возраста. Modern approaches to the organization of diagnosis and treatment of elderly and senile patients with malignant tumors allow to maintain the necessary level of health, improve the quality of life and increase life expectancy. Assessment of geriatric status in Oncology allows: to predict complications during the complex treatment, including drug treatment; to modify treatment to reduce the risk factors of adverse outcomes; to select patients for specialized treatment using standard schemes. So, timely assessment of geriatric syndromes and their correction can expand the indications for specialized treatment of elderly and senile patients.

scholarly journals A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases

2010 ◽  
Vol 91 (5) ◽  
pp. 1220-1226 ◽  
Author(s):  
Inès Birlouez-Aragon ◽  
Giselle Saavedra ◽  
Frédéric J Tessier ◽  
Anne Galinier ◽  
Lamia Ait-Ameur ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
High Heat ◽  
Heat Treated

scholarly journals ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASES

2013 ◽  
Vol 4 (5) ◽  
pp. 44-50
Author(s):  
Pranay Wal ◽  
Ankita Wal ◽  
Nikita Saraswat ◽  
Shalini Singh ◽  
Shikha Bajpai
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Factors Associated

Ambient air pollution and cardiovascular diseases: From bench to bedside

2018 ◽  
Vol 25 (8) ◽  
pp. 818-825 ◽  
Author(s):  
Simone Vidale ◽  
Carlo Campana
Keyword(s):  
Risk Factors ◽  
Air Pollution ◽  
Cardiovascular Diseases ◽  
Air Pollutants ◽  
Causes Of Death ◽  
Ambient Air ◽  
Epidemiological Studies ◽  
Ambient Air Pollution ◽  
Particulate Matter Exposure

Air pollution has a great impact on health, representing one of the leading causes of death worldwide. Previous experimental and epidemiological studies suggested the role of pollutants as risk factors for cardiovascular diseases. For this reason, international guidelines included specific statements regarding the contribution of particulate matter exposure to increase the risk of these events. In this review, we summarise the main evidence concerning the mechanisms involved in the processes linking air pollutants to the development of cardiovascular diseases.

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