scholarly journals C-Reactive Protein, Chemerin, Fetuin-A and Osteopontin as Predictors of Cardiovascular Risks in Persons With Psoriasis Vulgaris

2021 ◽  
pp. 383-391
Author(s):  
P BORSKY ◽  
Z FIALA ◽  
C ANDRYS ◽  
M BERANEK ◽  
K HAMAKOVA ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Psoriasis Vulgaris ◽  
Serum Levels ◽  
Cardiovascular Risks ◽  
Fetuin A ◽  
Reactive Protein ◽  
Early Stages ◽  
Significant Relationships ◽  
Pasi Score

The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

scholarly journals The role of systemic inflammation in heart failure

2021 ◽  
Vol 102 (4) ◽  
pp. 510-517
Author(s):  
E V Khazova ◽  
O V Bulashova
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Systemic Inflammation ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
C Reactive Protein ◽  
Ventricular Ejection Fraction ◽  
Reactive Protein ◽  
Highly Sensitive

The discussion continues about the role of systemic inflammation in the pathogenesis of cardiovascular diseases of ischemic etiology. This article reviews the information on the role of C-reactive protein in patients with atherosclerosis and heart failure in risk stratification for adverse cardiovascular events, including assessment of factors affecting the basal level of highly sensitive C-reactive protein. Research data (MRFIT, MONICA) have demonstrated a relationship between an increased level of C-reactive protein and the development of coronary heart disease. An increase in the serum level of highly sensitive C-reactive protein is observed in arterial hypertension, dyslipidemia, type 2 diabetes mellitus and insulin resistance, which indicates the involvement of systemic inflammation in these disorders. Currently, the assessment of highly sensitive C-reactive protein is used to determine the risk of developing myocardial infarction and stroke. It has been proven that heart failure patients have a high level of highly sensitive C-reactive protein compared with patients without heart failure. The level of C-reactive protein is referred to as modifiable risk factors for cardiovascular diseases of ischemic origin, since lifestyle changes or taking drugs such as statins, non-steroidal anti-inflammatory drugs, glucocorticoids, etc. reduce the level of highly sensitive C-reactive protein. In patients with heart failure with different left ventricular ejection fraction values, it was found that the regression of the inflammatory response is accompanied by an improvement in prognosis, which confirms the hypothesis of inflammation as a response to stress, which has negative consequences for the cardiovascular system.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

Evaluation of Serum Fetuin A in Psoriatic Patients and Its Correlation to Coronary Artery Disease

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hanan M Saleh ◽  
Samah I Hassen ◽  
Aliaa S Sheha ◽  
Nardeen N Eskander
Keyword(s):  
Coronary Artery ◽  
Ct Scan ◽  
Total Cholesterol ◽  
Serum Levels ◽  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Calcium Scoring ◽  
Cardiovascular Risks ◽  
Fetuin A

Abstract Background Psoriasis is a chronic, immune-mediated, inflammatory disease of the skin. It is a multifactorial disease with genetic background triggered by environmental factors and immunological mediators. Fetuin A is considered as a marker to detect cardiac risk. Aim of the work to evaluate Fetuin A level in psoriatic patients and its correlation to coronary artery calcification and cardiovascular risks. Methods This is a case control comparative study was conducted at Dermatology outpatient clinic, during the period from January 2019 to November 2019. The Forty eight patients who were recruited in this study were classified to two groups, Group A (cases group): included twenty four patients presented clinically with chronic generalized psoriasis randomly selected from Dermatology outpatient clinics of Ain Shams University Hospital. Group B (control group): included twenty four age and sex matched healthy volunteers who were nonsmokers, non-alcoholics and don’t suffer any systemic or organic illness. Results Our results showed no significant correlation between levels of Fetuin A and age, sex, BMI or serum levels of TG or total cholesterol among psoriatic patients. In addition, negative correlation was found between Fetuin A and calcium scoring CT scan where the median serum plasma level of Fetuin A was found to be significantly decreased in cases with plaque psoriasis with increasing calcium score, with p-value &lt; 0.001 and r = -0.928. Also, there is no significant correlation was found between levels of calcium scoring and age, sex, BMI or serum levels of TG or total cholesterol nor PASI scoring among psoriatic patients. Conclusion Fetuin A and Ca scoring CT scan appear to be a useful, simple, and noninvasive examination to investigate the presence of subclinical calcification in coronary blood vessel even in psoriatic patients who seem to be otherwise healthy.

The Role of Serum Procalcitonin and Interleukin-6 in the Differentiation and Surveillance of Sepsis and Non-Infectious Systemic Inflammatory Response Syndrome.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3792-3792 ◽  
Author(s):  
Xiaoli Liu ◽  
Bin Du ◽  
Jiaqi Pan ◽  
Baolai Hua
Keyword(s):  
Length Of Stay ◽  
Inflammatory Response ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Receiver Operating Characteristic Curves ◽  
Reactive Protein ◽  
Clinical Onset ◽  
Icu Length Of Stay

Abstract To evaluate the discrimination of serum procalcitonin (PCT) and interleukin-6 (IL-6) between patients with sepsis and non-infectious inflammatory response syndrome (SIRS) and the pridicton power of clinical outcome, a perspective study was performed in 27 patients with sepsis and 30 patients with non-infectious SIRS. The serum concentrations of PCT, IL-6, and C-reactive protein (CRP), white blood cell count, percentage of neutrophil, and maximal body temperature were obtained less than 24 hours after clinical onset of SIRS. The serum levels of PCT and IL-6, and percentage of neutrophil were significantly higher in patients of sepsis than in those of SIRS (PCT 5.54 [1.20, 32.74] μg/L vs 0.77 [0.22, 3.90] μg/L, P=0.001; IL-6 163.66 [33.60, 505.26] ng/L vs 37.72 [22.52,110.78] ng/L, P=0.004; CRP 15.28±8.41 g/L vs 9.51±7.65 g/L, P=0.010; and percentage of neutrophil 91%±4% vs 88%±4%, P=0.010). Receiver operating characteristic curves showed that the power of PCT and IL-6 were the best of all above. There was significant correlation between serum concentrations of PCT or IL-6 and the APACHE II or SOFA score, so was between serum PCT concentration and the ICU length of stay. Serum concentrations of PCT and IL-6 are more reliable indicators to differentiate sepsis and non-infectious SIRS than the conventional inflammatory markers, and correlate with the disease severity. And PCT levels were significantly correlated with ICU length of stay. (Supported by research grants from PUMCH, China)

scholarly journals Pathophysiological Role of Adiponectin, Leptin and Asymmetric Dimethylarginine in the Process of Atherosclerosis

Folia Medica ◽  
2016 ◽  
Vol 58 (4) ◽  
pp. 234-240 ◽  
Author(s):  
Daniela Iv. Koleva ◽  
Maria M. Orbetzova ◽  
Julia G. Nikolova ◽  
Tanya I. Deneva
Keyword(s):  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Endothelial Dysfunction ◽  
Proinflammatory Cytokines ◽  
Asymmetric Dimethylarginine ◽  
Serum Levels ◽  
Reactive Protein ◽  
Proinflammatory Mediators ◽  
Pathophysiological Role

Abstract Adipose tissue is recognized as a rich source of proinflammatory mediators that may directly contribute to vascular injury, insulin resistance, and atherogenesis. Many studies have shown that adiponectin has antiatherogenic and anti-inflammatory properties. Adiponectin acts not only as a factor increasing insulin sensitivity, and the protective effect may result from its ability to suppress production of proinflammatory cytokines. It negatively regulates the expression of TNF-alpha and C-reactive protein (CRP) in adipose tissue; reduces expression of vascular and intracellular adhesion molecules (VCAM-1, ICAM-1), E-selectin, interleukin-8 (IL-8). Hyperleptinemia has been linked with the development of hypertension and endothelial dysfunction/atherosclerosis, two main pathophysiological conditions associated with cardiovascular disease development. Leptin-mediated increases in sympathetic nervous system activity may be among the principal mechanisms evoking obesity related hypertension. Leptin stimulates the secretion of proinflammatory cytokines, and increases the release of endothelin-1 (ET-1), which may promote hypertension. Increased serum levels of asymmetric dimethylarginine (ADMA), a physiological regulator of the biosynthesis of nitric oxide (NO), promote the process of atherosclerosis, leading to the occurrence of endothelial dysfunction and cardiovascular disease.

Serum Levels of Ficolin-3 (Hakata Antigen) in Patients with Systemic Lupus Erythematosus

2009 ◽  
Vol 36 (4) ◽  
pp. 757-759 ◽  
Author(s):  
TRINE ANDERSEN ◽  
LEA MUNTHE-FOG ◽  
PETER GARRED ◽  
SØREN JACOBSEN
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Disease Activity Index ◽  
Serum Levels ◽  
Coombs Test ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Reactive Protein

Objective.Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets.Methods.Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA.Results.Median S-ficolin-3 was 56.1 μg/ml (range 0 to ≥ 87.3) and 32.4 μg/ml (10 to ≥ 87.3) in patients and controls, respectively (p < 0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal.Conclusion.The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.

Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colon rectal cancer: Results from the ITACa trial.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 617-617 ◽  
Author(s):  
Andrea Casadei Gardini ◽  
Silvia Carloni ◽  
Emanuela Scarpi ◽  
Paolo Maltoni ◽  
Romolo Dorizzi ◽  
...  
Keyword(s):  
Surrogate Marker ◽  
High Sensitivity ◽  
Serum Levels ◽  
Phase Iii ◽  
C Reactive Protein ◽  
Prognostic Role ◽  
Carcinoma Of The Colon ◽  
Reactive Protein ◽  
Hs Crp

617 Background: Serum levels of interleukine-6 and C-reactive protein are significatively higher in patients with neoplastic conditions. Therefore, the determination of high-sensitivity C-reactive protein (hs-PCR) has been widely used as a surrogate marker for chronic elevation of circulating cytokines. Increased hs-CRP concentrations have been reported in many conditions, in particular in patients with cardiovascular diseases, obesity, diabetes, autoimmunity, inflammatory bowel diseases and cancer risk. Some authors, on the basis of these findings, have encouraged further studies to clarify the etiologic and prognostic role of the aforementioned test. Our study has been conducted in patients enrolled in the phase III prospective multicentric randomized “Italian Trial in Advanced Colorectal Cancer (ITACa),” in order to assess hs-CRP levels at diagnosis and their significance with respect to overall survival (OS) and progresion free survival. Methods: Peripheral blood samples from 133 consecutive patients were collected into EDTA tubes. The collection was obtained before the beginning of first line chemotherapy. The supernatant was immediately transfer into a cryovial and stored at –80°C. Samples were thawed and hs-CRP has been measured with Cobas c501 analyzer. Results: Levels of hs-CRP >13.1 mg/L were associated with a worse median PFS, 8.9 months (95% CI 6.8-9.6) vs. 12.1 months (95% CI 9.3-14.9) in patients with levels <13.1 mg/L (p<0.0001). Similarly, levels >13.1 mg/L were associated with worse median OS, 14.4 (95% CI 11.5-17.1) vs. 28.8 (95% CI 24.3-36.6) in patients with a concentration <13.1 mg/L (p<0.0001). In multivariate analysis, hs-PCR adjusted for baseline factors including age (<70, ≥70 years), gender, ECOG perfomance status (0,1-2), tumor localization (rectum, colon), stage at diagnosis (I-III, IV), CT regimen (Folfiri, Folfox), KRAS status (wild type, mutant), site of metastases (liver, other metastases), was found to be independently associated with PFS and OS. Conclusions: Our study demonstrates the prognostic value of hs-CRP in patients with metastatic carcinoma of the colon and rectum.

Instability mechanisms in unstable angina according to baseline serum levels of C-reactive protein: The role of thrombosis, fibrinolysis and atherosclerotic burden

2007 ◽  
Vol 122 (3) ◽  
pp. 245-247 ◽  
Author(s):  
Giampaolo Niccoli ◽  
Luigi M. Biasucci ◽  
Carmine Biscione ◽  
Antonio Buffon ◽  
Massimo Siviglia ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Baseline Serum ◽  
Reactive Protein ◽  
Atherosclerotic Burden

scholarly journals Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251819
Author(s):  
Erika Cione ◽  
Antonio Siniscalchi ◽  
Pietro Gangemi ◽  
Lucio Cosco ◽  
Manuela Colosimo ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Potential Role ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Outcome Data ◽  
Shortness Of Breath ◽  
C Reactive Protein ◽  
Clinical Marker ◽  
Reactive Protein

The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in COVID-19, we evaluated serum NSE levels in COVID-19 patients with and without dyspnea. In this study, we evaluated both SARS-CoV-2-infected and uninfected patients aged >18 years who were referred to hospitals in Catanzaro, Italy from March 30 to July 30, 2020. Epidemiological, clinical, and radiological characteristics, treatment, and outcome data were recorded and reviewed by a trained team of physicians. In total, 323 patients (178 men, 55.1% and 145 women, 44.9%) were enrolled; of these, 128 were COVID-19 patients (39.6%) and 195 were control patients (60.4%). Westergren’s method was used to determine erythroid sedimentation rate. A chemiluminescence assay was used for measurement of interleukin-6, procalcitonin, C-reactive protein, and NSE. We detected significantly higher NSE values (P<0.05) in COVID-19 patients than in controls. Interestingly, within the COVID-19 group, we also observed a further significant increase in dyspnea (Dyspnea Scale and Exercise score: 8.2 ± 0.8; scores ranging from 0 to 10, with higher numbers indicating very severe shortness of breath). These data provide the background for further investigations into the potential role of NSE as a clinical marker of COVID-19 progression.

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