scholarly journals RED GINGER (Zingiber officinale var. rubrum): ITS CHEMICAL CONSTITUENTS, PHARMACOLOGICAL ACTIVITIES AND SAFETY

2019 ◽  
Vol 8 (1) ◽  
pp. 23-29
Author(s):  
Rini Daud Supu ◽  
Ajeng Diantini ◽  
Jutti Levita
Keyword(s):  
Chemical Constituents ◽  
Zingiber Officinale ◽  
The Other ◽  
Herbal Supplements ◽  
Pharmacological Activities ◽  
Adverse Side Effects ◽  
Beneficial Effects ◽  
Medicinal Properties ◽  
Red Ginger ◽  
Anti Inflammation

Ginger (Zingiber officinale) which belongs to the Zingiberaceae family, was first cultivated in Asia (Indonesia and Malaysia). This plant is one of the most commonly used herbal supplements taken by many patients to treat various conditions. Z.officinale has three varieties based on its size, colors of rhizome and chemical constituents i.e. .Z. officinale var. officinale (big white ginger or giant ginger, badak or gajah), Z. officinale var. amarum (small white ginger, emprit), and Z. officinale var. rubrum (small red ginger, merah or beureum). These three varieties may partly be deferred from their essential oil contents and are used for different purposes. The essential oils contained in Z. officinale var. rubrum are higher than the other types of ginger, which makes stronger in its pungency smell and taste. There are many studies that confirm beneficial effects of red ginger against the symptoms of diseases, i.e. anti-inflammation, antioxidant, antiemetic, antibacterial and antidiabetics. Z.officinale var. rubrum is considered to be a safe herbal medicine with only few and insignificant adverse/side effects. Although the medicinal properties of red ginger have been known, further trials in humans are required to determine the efficacy of red ginger (or one or more of its constituents) and to establish what, if any, adverse effects are observed.

scholarly journals VALERIANA JATAMANSI: AN ETHNOBOTANICAL REVIEW

2018 ◽  
Vol 11 ◽  
Author(s):  
Afroz Patan
Keyword(s):  
Molecular Mechanism ◽  
Skin Diseases ◽  
Chemical Constituents ◽  
Modern Medicine ◽  
Therapeutic Use ◽  
Perennial Herb ◽  
Pharmacological Activities ◽  
Valeriana Jatamansi ◽  
The Family ◽  
Medicinal Properties

 Objective: The main objective of review is an effort to give detailed information on Valeriana jatamansi and its multiple medicinal properties. Methods: As per the literature, the plant V. jatamansi is a perennial herb and found at subtemperate Himalayan regions of the Kumaon and Garhwal. The plant most popularly known as “Valerian.” The plant belongs to the family Valerianaceae. The roots and rhizomes of the plants are traditionally used to treat ulcers, jaundice, dry cough, seminal weakness, skin diseases, leprosy, and for sleep enhancement due to the presence of a variety of different chemical constituents such as sesquiterpenes, coumarins, iridoids, lignanoids, alkaloids, and flavonoids. From literature, the reported methods performed for different pharmacological activities have been thoroughly discussed and complied. Results: Most of the studies compiled from literature shown that V. jatamansi possess antimicrobial, antioxidant, anti-inflammatory, cytotoxic, anxiolytic, and neuroprotective activities. Conclusion: The review reveals that continuous research on this plant is needed to know the exact molecular mechanism and further elaborative studies can lead to develop safe therapeutic use in modern medicine.

scholarly journals The Multifunctional Effects of Nobiletin and Its MetabolitesIn VivoandIn Vitro

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Hao Huang ◽  
Linfu Li ◽  
Weimei Shi ◽  
Hai Liu ◽  
Jianqiong Yang ◽  
...  
Keyword(s):  
Biological Activities ◽  
Signaling Cascades ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Promising Candidate ◽  
Beneficial Effects ◽  
Pharmaceutical Agent ◽  
Intracellular Targets ◽  
Anti Inflammation

Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found inCitrusfruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. These events may be underpinned by modulation of signaling cascades, including PKA/ERK/MEK/CREB, NF-κB, MAPK, Ca2+/CaMKII, PI3K/Akt1/2, HIF-1α, and TGFβsignaling pathways. The metabolites may exhibit stronger beneficial effects than NOB on diseases pathogenesis. The biological activities of NOB have been clarified on many systems. This review aims to discuss the pharmacological effects of NOB with specific mechanisms of actions. NOB may become a promising candidate for potential drug development. However, further investigations of NOB on specific intracellular targets and clinical trials are still needed, especially forin vivomedical applications.

scholarly journals Gmelina arborea: chemical constituents, pharmacological activities and applications

2017 ◽  
Vol 9 (4) ◽  
pp. 528 ◽  
Author(s):  
Charu Arora ◽  
Vinita Tamrakar
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Iridoid Glycoside ◽  
Immunomodulatory Activity ◽  
Gmelina Arborea ◽  
Β Cells ◽  
Pharmacological Activities ◽  
Flavone Glycoside ◽  
Ancient Times ◽  
Medicinal Properties

<p><em>Gmelina arborea </em>(<em>G. arborea</em>) is a bio-prospective plant belonging to family verbenaceae. It is widely used for it’s medicinal properties from ancient times. The present paper comprehensively reviewed the traditional uses, medicinal properties and chemical constituents isolated from <em>G. arborea</em> based on literature reported as well as critical analysis of the research. The present article is aimed to provide information on recent advances and new foundations and direction for further exploring <em>G. arborea </em>for its applications. Pharmacological research reviewed that <em>G. arborea </em>possess various medicinal properties and biological  activities including antidiuretic, antidiarrhoeal, antipyretic, antianalgesic, antioxidant, antidiabetic, antihelmintic, antibacterial, antifungal, cardiopotective, insecticidal, antiulcer, gastro-protective, anticancer, antihyperlipidemic and immunomodulatory activity. It has been reported for its applications in treatment of bone fracture, hypertension and regeneration of β-cells. The main chemical constituents of <em>G. arborea</em> include lignans, iridoid glycoside, flavonoids, flavons, flavone glycoside and sterols. The present review provides all the references and beneficial directions to explore further application of <em>G. arborea.</em></p>

scholarly journals Identification of the Chemical Constituents in Ginger (Zingiber officinale) Responsible for Thermogenesis

2018 ◽  
Vol 13 (7) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Yuto Nishidono ◽  
Azis Saifudin ◽  
Mikio Nishizawa ◽  
Takashi Fujita ◽  
Masatoshi Nakamoto ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Zingiber Officinale ◽  
Peroxisome Proliferator ◽  
Liquid Chromatography Mass Spectrometry ◽  
Peroxisome Proliferator Activated Receptor ◽  
Active Constituents ◽  
Alkyl Side Chains ◽  
Crude Drugs ◽  
Red Ginger ◽  
Related Compounds

To compare the thermogenic properties of crude drugs derived from ginger, the activities to peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) of methanol extracts of “Shokyo” (dried rhizome of Z. officinale var. rubens), “Kankyo” (steamed and dried rhizome of Z. officinale var. rubens), “Red ginger” (Indonesian dried rhizome of Z. officinale var. rubrum) and “White ginger” (Indonesian dried rhizome of Z. officinale var. amarum), were examined. The extracts of the four specimens were analyzed by liquid chromatography mass spectrometry (LC-MS). The results showed that “Shokyo” and “White ginger” strongly stimulated PGC-1α and that the amount of [10]-shogaol (6) in these was higher than in “Kankyo” and “Red ginger”. Gingerol-related compounds were isolated or prepared in order to identify the compounds responsible for stimulating PGC-1α. As a result, [10]-gingerol (3), [10]-shogaol (6), [10]-gingerdiols (11, 12) and [10]-gingerdiols 3,5-diacetate (17, 18) were identified as the active constituents, while the main constituents, [6]-gingerol (1) and [6]-shogaol (4), did not show any significant PGC-1α activity. These results suggest that gingerol-related compounds with long alkyl side chains contribute to the thermogenic properties of ginger.

scholarly journals Ethnobotanical, phytochemical and pharmacological profile of Trichosanthes tricuspidata: An updated review

2021 ◽  
Vol 6 (3) ◽  
pp. 102-107
Author(s):  
Ajay Kumar Meena ◽  
P Rekha ◽  
T Satheesh Kumar
Keyword(s):  
Bioactive Compounds ◽  
Pharmacological Activity ◽  
Chemical Constituents ◽  
Human Life ◽  
Herbal Medicines ◽  
Plant Distribution ◽  
Beneficial Effects ◽  
Therapeutic Uses ◽  
Botanical Description ◽  
Medicinal Properties

Herbal medicines, the backbone of traditional medicine in many countries have played an important role in curing the various diseases of humans and animals since ancient time. Medicinal plants are great source of bioactive compounds that have potential beneficial effects in human life. Electronic databases including PubMed, Google Scholar, books and other sources were searched using subject specific key words that were matched by Trichosanthes tricuspidata medicinal plant related useful information on botanical description, plant distribution, ethanobotanical & therapeutic uses, chemical constituents and pharmacological activity etc. Trichosanthes tricuspidata have many medicinal properties like antioxidant, anticancer, antibacterial, antifungal, Larvicidal activity, Anticonvulsant activity, Gastro protective activity and other activities. The Bioactive compounds of Trichosanthes tricuspidata responsible for its various medicinal properties and their effects at the molecular level need to be investigated in more detail. The present review summarizes the Ethnobotanical & therapeutic uses, chemical constituents and pharmacological activity information of Trichosanthes tricuspidata. The pharmacological properties of bioactive compounds in Trichosanthes tricuspidata are required to confirm the ethno medicinal or traditional claims of Trichosanthes tricuspidata for pharmaceutical therapeutic applications.

scholarly journals From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jiayu Gao ◽  
Xiao Yang ◽  
Weiping Yin
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Web Based ◽  
Scientific Databases ◽  
Pharmacological Studies ◽  
Fundamental Understanding ◽  
Medicinal Properties ◽  
Gleditsia Sinensis ◽  
Phytochemical Components

Spina Gleditsiae is an important herb with various medicinal properties in traditional and folk medicinal systems of East Asian countries. In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects. Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities. To further evidence the traditional use, phytochemicals, and pharmacological mechanisms of this herb, a systematic literature review was performed herein for Spina Gleditsiae. The review approach consisted of searching several web-based scientific databases including PubMed, Web of Science, and Elsevier using the keywords “Spina Gleditsiae”, “Zao Jiao Ci”, and “Gleditsia sinensis”. Based on the proposed criteria, 17 articles were evaluated in detail. According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities. The phytochemical and pharmacological studies reviewed herein strongly underpin a fundamental understanding of herbal Spina Gleditsiae and support its ongoing clinical uses in China. The further phytochemical evaluation, safety verification, and clinical trials are expected to progress Spina Gleditsiae-based development to finally transform the traditional TCM herb Spina Gleditsiae to the valuable authorized drug.

Antioxidant Activity of Cinnamon zeylanicum: (A Review)

2021 ◽  
pp. 106-116
Author(s):  
Muhammad Hamza Ashfaq ◽  
Amna Siddique ◽  
Sammia Shahid
Keyword(s):  
Antioxidant Activity ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Beneficial Effects ◽  
The Family ◽  
Medicinal Properties ◽  
Cinnamon Zeylanicum ◽  
Anti Fungal ◽  
Phenolic And Flavonoid ◽  
Reducing Properties

Cinnamon zeylanicum is one of the species of cinnamon plant from the family of Lauraceae. It is not only the main ingredient of spices but also exhibits many medicinal properties. Anti-microbial, anti-fungal, anti-inflammatory, anti-tyrosinase, anti-carcinogenic and anti-mutagenic are some of the activities shown by cinnamon. Radical scavenging and reducing properties of cinnamon are considered as beneficial and important in the field of medicine. Cinnamon zeylanicum consists of a variety of phenolic and flavonoid compounds in different parts of plant. These compounds play major role in antioxidant potential just because of their significant structure and moieties. Cinnamon essential oils are also used for treatment of chronic disorders and it proves to be best alternative to synthetic antioxidants. In present review article we summarized the Cinnamon zeylanicum antioxidant activity by using antioxidant assays, its chemical constituents, its beneficial effects on humans and its applications in various industries as antioxidants.

scholarly journals Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity

2019 ◽  
Vol 20 (7) ◽  
pp. 1667 ◽  
Author(s):  
Hong Li ◽  
Andrew Hung ◽  
Mingdi Li ◽  
Angela Yang
Keyword(s):  
Chemical Constituents ◽  
Blood Rheology ◽  
Chemical Compounds ◽  
Pharmacological Effects ◽  
Historical Records ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Anti Inflammation

Fritillariae Thunbergii Bulbus (FTB) has been widely used as an antitussive herb for thousands of years in China. However, FTB’s traditional uses, chemical compounds and pharmacological activities have not been systematically reviewed. This study aimed to review its traditional uses, phytochemistry, pharmacodynamics, pharmacokinetics and toxicity. We searched the Encyclopedia of Traditional Chinese Medicine to explore the historical records which indicate that it acts to clear heat, resolve phlegm, relieve cough, remove toxicity and disperse abscesses and nodules. We searched 11 databases to identify potential phytochemical or pharmacological studies. Characteristics of its chemical constituents, pharmacological effects, pharmacokinetic and toxicity were descriptively summarized. A total of 9706 studies were identified and 83 of them were included. As a result, 134 chemical constituents were identified, including 26 alkaloids, 29 compounds found in essential oils, 13 diterpenoids, two carbohydrates, two sterols, 18 amino acids, six nucleosides, four nucleobases, four fatty acids, three lignans, and 27 elements. Thirteen pharmacological effects of FTB were identified, including anti-cancer, tracheobronchial relaxation, antitussive, expectorant, anti-muscarinic, anti-inflammation, anti-thyroid, regulation of blood rheology, antiulcer, anti-diarrhea, pain suppression, antioxidation and neuroprotection. These pharmacological activities may be mainly attributed to the alkaloids in FTB. Further phytochemical, pharmacological and network pharmacological studies are recommended.

scholarly journals MESUA FERREA LINN. (NAGKESAR): A POTENT ANTIMICROBIAL PLANT SPECIES

2021 ◽  
pp. 6-13
Author(s):  
SHIFALI THAKUR ◽  
HEMLATA KAURAV ◽  
GITIKA CHAUDHARY
Keyword(s):  
Chemical Constituents ◽  
Vital Role ◽  
New Drugs ◽  
Renal Diseases ◽  
General Description ◽  
Bioactive Constituents ◽  
Pharmacological Activities ◽  
Herbal Plants ◽  
Medicinal Properties ◽  
Therapeutic Activities

Many plants have not been investigated thoroughly, which are used traditionally as a medicine to cure various diseases. Herbal plants play a vital role in the development of new drugs which can be used for various therapeutic indications. Mesua ferrea linn., commonly known as 'Nagchampa' or 'Nagkesar', is one such herbal plant having many potential therapeutic activities. It is used in diseases like rheumatism, asthma, inflammation, fever, dyspepsia, renal diseases, dysentery, bleeding piles, a bacterial and fungal infection. This plant possesses many bioactive chemical constituents like coumarins, xanthones, pyranoxanthones, flavonoids, terpenoids and steroids which can be easily isolated. It can act as precursors on many ailments. These bioactive constituents have many pharmacological activities such as anticancer, antimicrobial, antifungal, anti-inflammatory, anti-arthritis, analgesic, diuretic, anti-hemorrhoid, antiulcer and many more. Almost every part of the plant is reported to have beneficial medicinal properties. But further studies are still needed to explore the pharmacological activities of Mesua ferrea linn. plant so as to gain benefit for the treatment of various diseases. This review highlights the general description, phytochemical profiling, traditional uses and proven pharmacological attributes of Mesua ferrea linn. plant.

EFEK PENAMBAHAN EKSTRAK AIR JAHE (Zingiber officinale Roscoe) DAN PENYIMPANAN DINGIN TERHADAP MUTU SENSORI IKAN TUNA (Thunnus albacores)

2010 ◽  
Vol 6 (1) ◽  
pp. 36
Author(s):  
Silvana Dinaintang Harikedua
Keyword(s):  
Sensory Quality ◽  
Zingiber Officinale ◽  
The Other ◽  
Ginger Extract ◽  
Other Hand ◽  
Storage Treatment ◽  
Zingiber Officinale Roscoe ◽  
Hedonic Scale ◽  
And Storage

The objective of this study was to investigate the effect of ginger extract addition and refrigerate storage on sensory quality of Tuna through panelist’s perception. Panelists (n=30) evaluated samples for overall appearance and flavor attribute using hedonic scale 1–7. The sample which is more acceptable by panelists on flavor attributes having 3% gingers extract and storage for 3 days. The less acceptable sample on flavor attribute having 0% ginger extract and storage for 9 days. On the other hand, the sample which is more acceptable by panelists on overall appearance having 0% ginger extract without storage treatment. The less acceptable sample on overall appearance having 3% ginger extract and storage for 9 days.

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