scholarly journals Vitamin D supplementation –Is it the time to stop wasting money on vitamin D?

JMS SKIMS ◽  
2019 ◽  
Vol 22 (1) ◽  
Author(s):  
Shariq R Masoodi
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Respiratory Infections ◽  
Vitamin D Supplementation ◽  
Increased Risk ◽  
Wide Range ◽  
Upper Respiratory ◽  
The Relationship

In recent years, vitamin D has received increased attention, as a number of studies have shown its link to the pathogenesis of various diseases. Apart from its benefits on bone health, vitamin D supplementation has been shown beneficial in reducing risk for many chronic diseases including autoimmune diseases, type 2 diabetes, heart disease, many cancers and infectious diseases. Vitamin deficiency has been associated with increased risk of elevated blood pressure, heart attack and stroke in studies. The relationship between vitamin D deficiency and the increased incidence of upper respiratory infections, asthma and eczema, among children, has been observed in several studies. Recent meta-analyzes showed a relationship between vitamin D administration during the early months of life and a lower incidence of type 1 diabetes later in life. Therefore, it is not surprising that Vitamin D supplementation is used to prevent and treat a wide range of diseases, and the use has increased considerably in the last decade.

scholarly journals Influence of vitamin D provision on the course of acute respiratory infections in children

2021 ◽  
pp. 73-80
Author(s):  
Yu.V. Marushko ◽  
◽  
S.I. Esipova ◽  
T.V. Gishchak ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Diseases ◽  
Conflicts Of Interest ◽  
Respiratory Infections ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Skeletal System ◽  
D3 Receptors ◽  
The Relationship ◽  
Positive Effect

The review article provides data from modern studies confirming the multifaceted effect of vitamin D in the human body. Vitamin D3 receptors (VDRs) have been shown to be present in most organs and tissues of the body. This confirms the importance of vitamin D not only in the formation of the skeletal system, but also in many of its extraosseous effects. Calcitriol affects the modulation of cell growth, neuromuscular conduction, inflammation processes, and is also an important stimulator of innate immunity due to the synthesis of antimicrobial peptides that provide protection against bacteria and viruses. In recent years, the relationship between the concentration of vitamin D in the blood and the incidence of respiratory infections in children has been actively studied. Many studies have shown that low vitamin D status is characteristic of most children with respiratory infections, and an adequate level of 25(OH)D in serum has a positive effect on the frequency of these infections and the severity of their course. Most authors demonstrate the benefits of vitamin D supplementation in the prevention of respiratory diseases in children, but there is no consensus regarding the frequency and dosage of vitamin D. The authors declare that they have no conflicts of interest. Key words: vitamin D, children, deficiency, respiratory diseases, prevention.

scholarly journals Effect of Vitamin D3 Supplementation Combined with Exercise Training on Glycemic Control and Bone Health in Patients with Type 2 Diabetes: A Randomized, Placebo-Controlled Trial

2020 ◽  
Author(s):  
Xiaomin Sun ◽  
Sirui Zhou ◽  
Mengyue Dong ◽  
Wenjuan Xiao ◽  
Xin He ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glycemic Control ◽  
Bone Mass ◽  
Bone Health ◽  
Exercise Group ◽  
Vitamin D Supplementation ◽  
Oral Glucose ◽  
Mass Content

Abstract Aims This study aimed to examine the effect of a 12-week vitamin D supplementation and exercise training alone and in combination on glycemic control and bone health in Chinese type 2 diabetes patients.MethodsSixty-one type 2 diabetes patients (age, 33–65 years; 72.0% men) with non-insulin dependence were randomized into the 12-week vitamin D group (1000 IU/day), exercise group (60%–80% of maximal heart rate, 1 h/time, 2–3 times/week), vitamin D combined with exercise group, and control group. A 75-g oral glucose tolerance test was used to estimate glycemic control. Dual X-ray absorptiometry was used to examine bone health (bone mass content and bone mass density) and body fat percentage (%).Results During the 75-g oral glucose tolerance test, lower glucose and higher insulin levels were found in the vitamin D combined with exercise group, vitamin D group, and exercise group after intervention than before intervention, although the differences were not statistically significant. A significant exercise and vitamin D interaction for the insulinogenic index (P = 0.032) and a borderline interaction for the glucose disposition index (P = 0.051) were observed, while no further independent effect was observed. Compared with non-vitamin D supplementation, vitamin D supplementation significantly alleviated the loss of total bone mass content (95% CI: -29.9–19.4 vs. -74.9–-24.7), trunk bone mass content (95% CI: -24.1–19.5 vs. -56.1–-11.7), and spine bone mass density (95% CI: -0.03–0.03 vs. -0.07–-0.01).ConclusionsThe findings suggest that 12-week combined vitamin D and exercise intervention has a potentially positive effect on glycemic control, and vitamin D supplementation plays an important role in the prevention of bone loss, which was identified in the exercise alone group. Further studies are needed to elucidate the long-term effect of combined vitamin D and exercise intervention in type 2 diabetes patients.The study was registered in the Chinese Clinical Trial System (No. ChiCTR1800015383).

scholarly journals Prospective Evaluation of Vitamin D Supplementation on Peripheral Neuropathy in Type 2 Diabetes Mellitus -A Review

2021 ◽  
pp. 260-266
Author(s):  
Faisal Suliman Algaows ◽  
Fatema Abdullah Althkerallah ◽  
Norah Abdulmohsen Alsuwailem ◽  
Amnah Abdulnasser Mawlan Ahmed ◽  
Razan Fahad Alwagdani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels

Diabetic neuropathy is a long-term consequence of diabetes that can cause significant morbidity and a decline in quality of life in many individuals. Low vitamin D levels, in addition to causing rickets in infants and chondrosteoma in adults, may have a role in the development of DM and its underlying disorders, according to a growing body of evidence. Vitamin D deficiency has been linked to type 1 or type 2 diabetes, as well as the microvascular and macrovascular problems that come with it. Vitamin D insufficiency has been linked to diabetic peripheral neuropathy (DPN) as an independent risk factor. Vitamin D, both topical and oral, has been shown to considerably improve DPN symptoms and pain.

scholarly journals Vitamin D Deficiency in Patients with Type 2 Diabetes Mellitus Leads to Vascular Complications

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Salimah Navaz Gangji
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vascular Complications ◽  
Vitamin D Supplementation ◽  
Systemic Complications ◽  
Organ Systems ◽  
Increased Risk

The presence of hyperglycemia in individuals with Type 2 Diabetes Mellitus (T2DM) is associated with systemic complications within multiple organ systems. Specifically, patients with T2DM have an increased risk of developing vascular endothelial damage. Interestingly, patients with T2DM are often found to be deficient in vitamin D, a fat-soluble vitamin that not only plays a role in bone growth and gastrointestinal nutrient absorption, but insulin resistance as well. Thus, the purpose of this review is to summarize the literature that associates vitamin D deficiencies with vascular complications in both human and animal models with T2DM. This review will also summarize developments in genetic testing for VDR mutations and their potential role in diabetes progression, as well as the effects of vitamin D supplementation in patients with T2DM. Since T2DM is an increasingly prevalent disease, it is important to continue evaluating current research that investigates not only genetic causal factors for the disease, but also preventative options (such as vitamin D supplementation) that could potentially be used alongside pharmacological treatments.

scholarly journals Vitamin D and neuropathy

2013 ◽  
Vol 154 (51) ◽  
pp. 2012-2015 ◽  
Author(s):  
Zsuzsanna Putz ◽  
Tímea Martos ◽  
Nóra Németh ◽  
Anna Erzsébet Körei ◽  
Márta Szabó ◽  
...  
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Vitamin D Deficiency ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Plantar Ulcers ◽  
The Relationship

Diabetes is a widespread disease and, therefore, studies dealing with diabetes and its complications are very important for public health. Numerous reports link vitamin D deficiency to the increased risk of diabetes mellitus and complications such as neuropathy. However, there are limited and conflicting data available on vitamin D deficiency in patients with diabetic peripheral neuropathy. Studies in type 2 diabetics confirmed the relationship between vitamin D deficiency and incidence of neuropathy. Recent reports suggest a relationship between the incidence of plantar ulcers and vitamin D deficiency. Orv. Hetil., 2013, 154(51), 2012–2015.

The Relationship between Serum Vitamin D and Hemoglobin A1c Levels in Adolescents with Type 1 and Type 2 Diabetes

2011 ◽  
pp. P3-500-P3-500
Author(s):  
Benjamin U Nwosu ◽  
Louise Maranda ◽  
Zheni Stavre ◽  
Karen A Cullen ◽  
Lisa Greenman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Hemoglobin A1c ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
The Relationship

scholarly journals Diabetes Prevention: Vitamin D Supplementation May Not Provide Any Protection If There Is No Evidence of Deficiency!

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2651 ◽  
Author(s):  
Uwe Gröber ◽  
Michael F. Holick
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
The Metabolic Syndrome ◽  
Supplement Group ◽  
Increased Risk

The results of epidemiological and several interventional studies suggest an association between vitamin D deficiency and an increased risk of developing insulin resistance or type 2 diabetes. Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D < 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas. A recent study by Pittas et al. did not show a clear preventive effect of vitamin D supplementation with respect to the risk of developing type 2 diabetes. In terms of this study, it must be remembered that more than 70% of the participants in both the vitamin D supplement group and the placebo group did not have a vitamin D deficiency. In medical and pharmaceutical practice, more attention should be paid to vitamin D deficiency than has previously been accorded. Vitamin D status can be assessed objectively when necessary by laboratory testing of the serum 25(OH)D levels. Type 2 diabetes patients benefit from improving their vitamin D status with respect to their glucose metabolism and decreased mortality risk. Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40–60 ng/mL.

scholarly journals Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Pasquale Mansueto ◽  
Aurelio Seidita ◽  
Giustina Vitale ◽  
Sebastiano Gangemi ◽  
Chiara Iaria ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Hiv Infection ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
High Prevalence ◽  
Potential Benefits

Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.

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