scholarly journals Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment

2021 ◽  
Vol 8 ◽  
Author(s):  
Jean-Christophe Bélanger ◽  
Véronique Bouchard ◽  
Jessica Le Blanc ◽  
Louisia Starnino ◽  
Mélanie Welman ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Platelet Activation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Cognitive Outcomes ◽  
Activity Levels ◽  
Platelet Activity ◽  
Cross Sectional ◽  
The Relationship

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decline. Given these apparently opposing effects of platelet activation on cognitive health, we investigated whether BDNF levels intercede in the relationship between platelet activation and cognitive function; and whether this relationship is moderated by the presence of CAD.Methods: In this cross-sectional study, 1,280 participants with (n = 673) and without CAD (n = 607) completed the Montreal Cognitive Assessment (MoCA). Plasma BDNF and soluble P-selectin (a marker of platelet activity) levels were assessed using multiplex flow cytometry.Results: In a mediation model, platelet activity was correlated with higher plasma BDNF concentrations (b = 0.53, p < 0.0001). The relationship between sP-selectin and BDNF concentrations was stronger for individuals without CAD (b = 0.71, p < 0.0001) than for CAD participants (b = 0.43, p < 0.0001; pinteraction <0.0001). Higher BDNF concentrations were associated with higher MoCA scores (b = 0.26, p = 0.03). The overall effect of platelet activity on cognitive performance was non-significant (total effect: b = −0.12, p = 0.13), and became significant when accounting for BDNF as a mediating factor (direct effect: b = −0.26, p = 0.01). This resulted in a positive indirect effect of platelet activity (via BDNF) on MoCA scores (b = 0.14, CI 95% 0.02–0.30), that was smaller in CAD participants than in non-CAD participants [Δ −0.07 (95% CI −0.14 to −0.01)].Conclusions: BDNF released from activated platelets could be a mitigating factor in a negative association between platelet activity and cognitive function.

Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study

2021 ◽  
pp. 1-10
Author(s):  
Nicole L. Spartano ◽  
Jayandra J. Himali ◽  
Ludovic Trinquart ◽  
Qiong Yang ◽  
Galit Weinstein ◽  
...  
Keyword(s):  
Physical Activity ◽  
Neurotrophic Factor ◽  
Smoking Status ◽  
Linear Trend ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Activity Levels ◽  
Vigorous Activity ◽  
Middle Aged ◽  
Cross Sectional

Background: One of the mechanisms suggested to link physical activity (PA) to favorable brain health is through stimulation of neural growth factors such as brain-derived neurotrophic factor (BDNF). Acute bouts of PA stimulate circulating BDNF levels. Objective: In this investigation, we assessed whether habitual, accelerometer-measured PA levels were related to circulating BDNF levels in a middle-aged cohort. Methods: In the Framingham Heart Study Third Generation cohort, 1,769 participants provided reliable accelerometry data and were not missing BDNF measurement and platelet counts. In a cross-sectional analysis, using multivariable regression, we related PA measures to serum BDNF levels, adjusting for age, sex, smoking status, platelet count, depression status, and accelerometer wear time. Results: Our study participants (mean age 47±9 years, 50.8% women) spent an average of 22.3 mins/day moderate-to-vigorous (MV)PA. Most PA variables (steps, MVPA, light activity, and sedentary time) were not related to BDNF levels (p > 0.05). We observed a non-linear trend, where 15–50 mins/week vigorous activity was associated with lower BDNF compared to those with 0 min vigorous activity (β= –0.049±0.024, p = 0.05), but with no significant associations at lower or higher vigorous activity levels. In smokers, MVPA was also associated with lower BDNF levels (β= –0.216±0.079, p = 0.01). Conclusion: Our study reveals that circulating BDNF is not chronically elevated in individuals with higher levels of habitual PA in middle-aged adults from the community and may even be chronically suppressed with higher PA in subgroups, including current smokers. These results do not contradict previous studies demonstrating that circulating BDNF rises acutely after PA.

scholarly journals Relationship between exclusive breastfeeding and brain-derived neurotrophic factor in children

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248023
Author(s):  
Carlos Berlanga-Macías ◽  
Mairena Sánchez-López ◽  
Montserrat Solera-Martínez ◽  
Ana Díez-Fernández ◽  
Inmaculada Ballesteros-Yáñez ◽  
...  
Keyword(s):  
Exclusive Breastfeeding ◽  
Sexual Maturation ◽  
Neurotrophic Factor ◽  
Developmental Stages ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Future Research ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
The Relationship

Objective A positive relationship between breastfeeding and brain-derived neurotrophic factor (BDNF) in infants has been suggested due to the presence of BDNF in human milk. This study aimed to determine the relationship between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren. Methods A cross-sectional analysis including 202 schoolchildren, aged eight to 11 years, from Cuenca, Spain, was conducted. Information on sociodemographic and anthropometric variables, sexual maturation, birth weight and exclusive breastfeeding (‘no exclusive breastfeeding’, and exclusive breastfeeding for ≤6 and >6 months), and BDNF serum levels using an ELISA method were obtained. Covariance analyses (ANCOVA) were conducted to examine the relationship between serological BDNF and exclusive breastfeeding after controlling for potential confounders. Results ANCOVA models showed no significant differences in BDNF levels between children who were exclusively breastfed for more than six months versus those who were not (p > 0.05). No significant differences were observed by age group (eight to nine years versus 10 to 11 years; p > 0.05). Additionally, no clear negative trend in BDNF serum levels according to sexual maturation categories was found (p > 0.05). Conclusion These findings suggest that exclusive breastfeeding does not have a significant positive association on BDNF from eight to 11 years, since children who were exclusively breastfed did not have significantly higher BDNF levels than those who were not exclusively breastfed. Likewise, BDNF levels were not found to be negatively affected by hormonal development. Future research should examine the influence of exclusive breastfeeding on BDNF over the different developmental stages.

scholarly journals Peripheral Brain-Derived Neurotrophic Factor and Contactin-1 Levels in Patients with Attention-Deficit/Hyperactivity Disorder

2019 ◽  
Vol 8 (9) ◽  
pp. 1366 ◽  
Author(s):  
Liang-Jen Wang ◽  
Chih-Ching Wu ◽  
Min-Jing Lee ◽  
Miao-Chun Chou ◽  
Sheng-Yu Lee ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Neurotrophic Factor ◽  
Performance Test ◽  
Continuous Performance Test ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hyperactivity Disorder ◽  
Drug Naïve

Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study investigates whether BDNF and CNTN1 affect susceptibility to attention deficit/hyperactivity disorder (ADHD). A total of 136 drug-naïve patients with ADHD (108 boys and 28 girls) and 71 healthy controls (45 boys and 26 girls) were recruited. Blood samples were obtained to measure the plasma levels of BDNF and CNTN1 in each child. We found that BDNF levels in the ADHD boys exceeded those in the control boys, but BDNF levels in the ADHD girls were lower than those in the control girls. Boys who had higher BDNF levels performed worse on the Wechsler Intelligence Scale for Children—Fourth Edition, but girls who had higher BDNF levels made fewer omission errors in the Conners’ Continuous Performance Test. However, CNTN1 level did not differ significantly between patients and controls, and were not correlated to ADHD characteristics, regardless of gender. The findings suggest BDNF may influence sex-specific susceptibility to ADHD, but CNTN1 was not associated with ADHD pathophysiology.

Evaluation of cytokines, oxidative stress markers and brain-derived neurotrophic factor in patients with fibromyalgia – A controlled cross-sectional study

Cytokine ◽  
2016 ◽  
Vol 84 ◽  
pp. 25-28 ◽  
Author(s):  
Aline Ranzolin ◽  
Angela Luzia Branco Pinto Duarte ◽  
Markus Bredemeier ◽  
Cláudio Antônio da Costa Neto ◽  
Bruna Maria Ascoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Oxidative Stress Markers ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stress Markers

scholarly journals The Mediating Effect of Depression on the Relationship between Cognitive Function and the Activities of Daily Living in Post-stroke Patient

2021 ◽  
Vol 30 (4) ◽  
pp. 309-317
Author(s):  
Ji Eun Kim ◽  
Hwee Wee
Keyword(s):  
Cognitive Function ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Cross Sectional Study ◽  
Mediating Effect ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Post Stroke ◽  
Demographic Covariates ◽  
The Relationship

Purpose: This study aimed to identify the relationship between cognitive function and activities of daily living (ADL) in addition to the mediating effect exerted by depression on this relationship in post-stroke patients.Methods: A cross-sectional study was performed. A total of 182 patients were recruited from two general and three geriatric hospitals in South Korea between July 2017 and June 2018. Cognitive function, depression, and ADL measures were assessed after informed consent was obtained. Data obtained were analyzed using multiple regression and a simple mediation model that applies the PROCESS macro with a 95% bias-corrected bootstrap confidence interval (5,000 bootstrap resampling).Results: The covariates were sex, age, educational level, types of paralysis, and type of hospital. After controlling for the demographic covariates, cognitive function significantly accounted for the variance of ADL. It was also demonstrated that depression partially mediated the relationship between cognitive function and ADL in post-stroke patients.Conclusion: Cognitive function directly influences the ADL in post-stroke patients and indirectly influences it through depression. This suggests that strategies for improving depression in post-stroke patients should be considered while managing cognitive functioning for improving the ADL.

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