scholarly journals Toward a Universal Theoretical Framework to Understand Robustness and Resilience: From Cells to Systems

2021 ◽  
Vol 8 ◽  
Author(s):  
Jason E. Davis ◽  
Mary Beth Kolozsvary ◽  
Karolina M. Pajerowska-Mukhtar ◽  
Bo Zhang
Keyword(s):  
Theoretical Framework ◽  
Living Systems ◽  
Changing Environment ◽  
Ample Evidence ◽  
The Face ◽  
Common Framework ◽  
Limiting Resources ◽  
And Function

Research across a range of biological subdisciplines and scales, ranging from molecular to ecosystemic, provides ample evidence that living systems generally exhibit both a degree of resistance to disruption and an ability to recover following disturbance. Not only do mechanisms of robustness and resilience exist across and between systems, but those mechanisms exhibit ubiquitous and scalable commonalities in pattern and function. Mechanisms such as redundancy, plasticity, interconnectivity, and coordination of subunits appear to be crucial internal players in the determination of stability. Similarly, factors external to the system such as the amplitude, frequency, and predictability of disruptors, or the prevalence of key limiting resources, may constrain pathways of response. In the face of a rapidly changing environment, there is a pressing need to develop a common framework for describing, assessing, and predicting robustness and resilience within and across living systems.

Conformation of Ribosomes from Escherichia Coli

1974 ◽  
Vol 32 ◽  
pp. 210-211
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Binding Sites ◽  
Ribosomal Proteins ◽  
Fluorescent Dyes ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Dimensional Structure ◽  
Complete Understanding ◽  
And Function

The present knowledge of the three-dimensional structure of ribosomes is far too limited to enable a complete understanding of the various roles which ribosomes play in protein biosynthesis. The spatial arrangement of proteins and ribonuclec acids in ribosomes can be analysed in many ways. Determination of binding sites for individual proteins on ribonuclec acid and locations of the mutual positions of proteins on the ribosome using labeling with fluorescent dyes, cross-linking reagents, neutron-diffraction or antibodies against ribosomal proteins seem to be most successful approaches. Structure and function of ribosomes can be correlated be depleting the complete ribosomes of some proteins to the functionally inactive core and by subsequent partial reconstitution in order to regain active ribosomal particles.

Fractal analysis in biology and medicine

2020 ◽  
pp. 85-92
Keyword(s):  
Fractal Analysis ◽  
A Priori ◽  
Research Work ◽  
Structure And Function ◽  
Review Article ◽  
Living Systems ◽  
Modern Biology ◽  
Additional Information ◽  
Important Additional Information ◽  
And Function

The review article discusses the possibilities of using fractal mathematical analysis to solve scientific and applied problems of modern biology and medicine. The authors show that only such an approach, related to the section of nonlinear mechanics, allows quantifying the chaotic component of the structure and function of living systems, that is a priori important additional information and expands, in particular, the possibilities of diagnostics, differential diagnosis and prediction of the course of physiological and pathological processes. A number of examples demonstrate the specific advantages of using fractal analysis for these purposes. The conclusion can be made that the expanded use of fractal analysis methods in the research work of medical and biological specialists is promising.

scholarly journals Determination of the Vertical Dimension and the Position of the Occlusal Plane in a Removable Prosthesis Using Cephalometric Analysis and Golden Proportion

2021 ◽  
Vol 11 (15) ◽  
pp. 6948
Author(s):  
Gabriele Cervino ◽  
Sergio Sambataro ◽  
Chiara Stumpo ◽  
Salvatore Bocchieri ◽  
Fausto Murabito ◽  
...  
Keyword(s):  
Vertical Dimension ◽  
Occlusal Plane ◽  
X Rays ◽  
Common Procedure ◽  
Lower Incisor ◽  
Golden Proportion ◽  
The Face ◽  
Removable Prosthesis ◽  
Edentulous Patients

The aim of this study is to demonstrate the use and the effectiveness of cephalometry and golden proportions analysis of the face in planning prosthetic treatments in totally edentulous patients. In order to apply this method, latero-lateral and posterior-anterior X-rays must be performed in addition to the common procedure. Two main concerns for totally edentulous patients are the establishment of the vertical dimension and the new position of the occlusal plane. The divine proportion analysis was carried out by the use of a golden divider. The prosthetic protocol was divided into three steps and a case was selected for better understanding. Referring to the golden relations, if the distance from the chin to the wing of the nose is 1.0, the distance from the nose to eye is 0.618. This proportion is useful and effective in determining the correct prosthetic vertical dimension. The incisal margin of the lower incisor must be positioned between Point A (A) and protuberance menti (Pm) according to the gold ratio 0.618 of the total height A-Pm. Posteriorly the occlusal plane must be placed 2 mm below the divine occlusal plane (traced from the incisal margin of lower incisors to Xi point). A prosthesis made in accordance with cephalometric parameters and divine proportions of the face helps to improve the patient’s aesthetics, function and social personality.

Myth and Ethics in Business

2001 ◽  
Vol 11 (4) ◽  
pp. 575-597 ◽  
Author(s):  
Aviva Geva
Keyword(s):  
Social Sciences ◽  
Business Ethics ◽  
Theoretical Framework ◽  
Analytical Tool ◽  
Revolving Door ◽  
Real Case ◽  
Ethical Aspect ◽  
Rational Thinking ◽  
Humanities And Social Sciences ◽  
And Function

Abstract:Business myth is generally treated in business ethics literature as a mental obstacle that must be removed in order to prepare the ground for rational thinking on the ethical aspect of business conduct. This approach, which focuses on the content of myth, does not explicate the nature and function of myth. Based on the study of myth in the fields of humanities and social sciences, this paper develops a theoretical framework and analytical tool—the revolving-door model—for researching myth in business. The proposed framework (1) offers new perspectives on myth: the consumer’s, the producer’s, the mythologist’s, and the ethicist’s; (2) explicates various distortion mechanisms of the myth; and (3) enables a redefinition of the relation of business myth to business ethics. The applicability of this framework is demonstrated by means of a real case which sets the stage for examining a set of common myths.

Assessment of the impact of nanoparticles on the activity of biomimetic membrane

2021 ◽  
Vol XXXVII (1) ◽  
pp. 89-100
Author(s):  
Dorota Kondej
Keyword(s):  
Occupational Safety ◽  
Biological Membranes ◽  
Structure And Function ◽  
Lipid Monolayer ◽  
Biomimetic Membranes ◽  
Safety And Health ◽  
Biomimetic Membrane ◽  
And Function ◽  
The Impact

This paper presents basic information on a structure and function of biological membranes. Types of biomimetic membranes modelling properties of biological membranes were introduced. The method of testing surface properties of a lipid monolayer, which is the basic type of biomimetic membranes, was described. The presented method makes it possible to evaluate the effect of nanoparticles on the surface activity of biomimetic membranes based on the determination of the surface index MA. This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering.

Kinematic Design of Functional Nanoscale Mechanisms From Molecular Primitives

2021 ◽  
Author(s):  
Meysam T. Chorsi ◽  
Pouya Tavousi ◽  
Caitlyn Mundrane ◽  
Vitaliy Gorbatyuk ◽  
Kazem Kazerounian ◽  
...  
Keyword(s):  
Ion Channels ◽  
Range Of Motion ◽  
Systematic Approach ◽  
Design Space ◽  
Vital Role ◽  
Degree Of Freedom ◽  
Living Systems ◽  
Kinematic Design ◽  
Systematic Exploration ◽  
And Function

Abstract Natural nanomechanisms such as capillaries, neurotransmitters, and ion channels play a vital role in the living systems. But the design principles developed by nature through evolution are not well understood and, hence, not applicable to engineered nanomachines. Thus, the design of nanoscale mechanisms with prescribed functions remains a challenge. Here, we present a systematic approach based on established kinematics techniques to designing, analyzing, and controlling manufacturable nanomachines with prescribed mobility and function built from a finite but extendable number of available "molecular primitives." Our framework allows the systematic exploration of the design space of irreducibly simple nanomachines, built with prescribed motion specification by combining available nanocomponents into systems having constrained, and consequently controllable motions. We show that the proposed framework has allowed us to discover and verify a molecule in the form of a seven link, seven revolute (7R) close loop spatial linkage with mobility (degree of freedom) of one. Furthermore, our experiments exhibit the type and range of motion predicted by our simulations. Enhancing such a structure into functional nanomechanisms by exploiting and controlling their motions individually or as part of an ensemble could galvanize development of the multitude of engineering, scientific, medical, and consumer applications that can benefit from engineered nanomachines.

scholarly journals El post-cognitivismo en cuestión: extensión, corporización y enactivismo

2016 ◽  
Vol 19 (3) ◽  
pp. 475
Author(s):  
Federico Gabriel Burdman
Keyword(s):  
Extended Mind ◽  
Theoretical Framework ◽  
Original Formulation ◽  
Embodied Mind ◽  
The Face

http://dx.doi.org/10.5007/1808-1711.2015v19n3p475In this paper I look into a problem concerning the characterization of the main conceptual commitments of the ‘post-cognitivist’ theoretical framework. I will firs consider critically a proposal put forth by Rowlands (2010), which identifie the theoretical nucleus of post-cognitivism with a convergence of the theses of the extended and the embodied mind. The shortcomings I fin in this proposal will lead me to an indepedent and wider issue concerning the apparent tensions between functionalism and the embodied and enactive approaches. I will then discuss the standing of embodied, enactive and extended approaches in the face of the dividing issue concerning functionalism, with an eye on the possibility of divorcing the thesis of the extended mind of its original formulation in functionalist terms. In this way, I shall consider the outlook of overcoming some of the conceptual tensions in post-cognitivism by thinking its theoretical framework as non-functionalist.

scholarly journals The Impact of Arthroscopic Capsular Release in Patients with Primary Frozen Shoulder on Shoulder Muscular Strength

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Michał Waszczykowski ◽  
Michał Polguj ◽  
Jarosław Fabiś
Keyword(s):  
Muscular Strength ◽  
Frozen Shoulder ◽  
Active Motion ◽  
Capsular Release ◽  
Arthroscopic Capsular Release ◽  
Limited Function ◽  
And Function ◽  
The Impact

The aim of this study was to evaluate the impact of arthroscopic capsular release in patients with primary frozen shoulder on muscular strength of nonaffected and treated shoulder after at least two-year follow-up after the surgery. The assessment included twenty-seven patients, who underwent arthroscopic capsular release due to persistent limitation of range of passive and active motion, shoulder pain, and limited function of upper limb despite 6-month conservative treatment. All the patients underwent arthroscopic superior, anteroinferior, and posterior capsular release. After at least two-year follow-up, measurement of muscular strength of abductors, flexors, and external and internal rotators of the operated and nonaffected shoulder, as well as determination of range of motion (ROM) and function (ASES) in the operated and nonaffected shoulder, was performed. Measurement of muscular strength in the patient group did not reveal statistically significant differences between operated and nonaffected shoulder. The arthroscopic capsular release does not have significant impact on the decrease in the muscular strength of the operated shoulder.

scholarly journals Theoretical framework for estimating snow distribution through point measurements

2015 ◽  
Vol 9 (1) ◽  
pp. 1-44
Author(s):  
E. Trujillo ◽  
M. Lehning
Keyword(s):  
Snow Depth ◽  
Survey Design ◽  
Spatial Location ◽  
Theoretical Framework ◽  
Statistical Properties ◽  
Spatial Covariance ◽  
Sample Mean ◽  
Snow Properties ◽  
Survey Designs

Abstract. In recent years, marked improvements in our knowledge of the statistical properties of the spatial distribution of snow properties have been achieved thanks to improvements in measuring technologies (e.g. LIDAR, TLS, and GPR). Despite of this, objective and quantitative frameworks for the evaluation of errors and extrapolations in snow measurements have been lacking. Here, we present a theoretical framework for quantitative evaluations of the uncertainty of point measurements of snow depth when used to represent the average depth over a profile section or an area. The error is defined as the expected value of the squared difference between the real mean of the profile/field and the sample mean from a limited number of measurements. The model is tested for one and two dimensional survey designs that range from a single measurement to an increasing number of regularly-spaced measurements. Using high-resolution (~1 m) LIDAR snow depths at two locations in Colorado, we show that the sample errors follow the theoretical behavior. Furthermore, we show how the determination of the spatial location of the measurements can be reduced to an optimization problem for the case of the predefined number of measurements, or to the designation of an acceptable uncertainty level to determine the total number of regularly-spaced measurements required to achieve such error. On this basis, a series of figures are presented that can be used to aid in the determination of the survey design under the conditions described, and under the assumption of prior knowledge of the spatial covariance/correlation properties. With this methodology, better objective survey designs can be accomplished, tailored to the specific applications for which the measurements are going to be used. The theoretical framework can be extended to other spatially distributed snow variables (e.g. SWE) whose statistical properties are comparable to those of snow depth.

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