scholarly journals Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications

2022 ◽  
Vol 12 ◽  
Author(s):  
Wanyue Dan ◽  
Lihua Peng ◽  
Bin Yan ◽  
Zhengpeng Li ◽  
Fei Pan
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Genetic Factors ◽  
Survival Rates ◽  
Relative Survival ◽  
Therapeutic Implications ◽  
The Past ◽  
Human Microbiota ◽  
Current State ◽  
Esophageal Carcinogenesis ◽  
The Relationship

Esophageal adenocarcinoma (EAC) is one of the main subtypes of esophageal cancer. The incidence rate of EAC increased progressively while the 5-year relative survival rates were poor in the past two decades. The mechanism of EAC has been studied extensively in relation to genetic factors, but less so with respect to human microbiota. Currently, researches about the relationship between EAC and the human microbiota is a newly emerging field of study. Herein, we present the current state of knowledge linking human microbiota to esophageal adenocarcinoma and its precursor lesion—gastroesophageal reflux disease and Barrett’s esophagus. There are specific human bacterial alternations in the process of esophageal carcinogenesis. And bacterial dysbiosis plays an important role in the process of esophageal carcinogenesis via inflammation, microbial metabolism and genotoxicity. Based on the human microbiota alternation in the EAC cascade, it provides potential microbiome-based clinical application. This review is focused on novel targets in prevention, diagnosis, prognosis, and therapy for esophageal adenocarcinoma.

Movie Envy

2019 ◽  
pp. 70-80
Author(s):  
Olivier Asselin
Keyword(s):  
Point Of View ◽  
Digital Revolution ◽  
The Past ◽  
Current State ◽  
Movie Theatre ◽  
The Relationship

“Canadian cinema.” The term may appear self-evident but is problematic. First, one may question the value of national approaches to culture, especially here, in Quebec and Canada, where the debates over the Nation seem interminable, and especially now, in an era of globalization. Next, one may question the value of media-centered approaches to culture, especially when the successive waves of the “digital revolution” have blurred the boundaries between technologies and among artistic practices. Rather than try to survey “important” fiction films for theatres in Quebec or Canada, this essay adopts another point of view to examine the presence of cinema in Montreal museums over the past few years by focusing on three singular exhibitions. It may well be symptomatic of the current state of film in Quebec and Canada—but also, paradoxically, everywhere else—and says much about the relationship between medium and nation, the expansion of cinema beyond the movie theatre, and the internationalization of culture.

scholarly journals On Directional Dendritic Growth and Primary Spacing—A Review

Crystals ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 627 ◽  
Author(s):  
Joel Strickland ◽  
Bogdan Nenchev ◽  
Hongbiao Dong
Keyword(s):  
Experimental Research ◽  
Dendritic Growth ◽  
Primary Spacing ◽  
Process Variables ◽  
Directionally Solidified ◽  
The Past ◽  
Current State ◽  
Growth Problem ◽  
Solidification Parameters ◽  
The Relationship

The primary spacing is intrinsically linked with the mechanical behavior of directionally solidified materials. Because of this relationship, a significant amount of solidification work is reported in the literature, which relates the primary spacing to the process variables. This review provides a comprehensive chronological narrative on the development of the directional dendritic growth problem over the past 85 years. A key focus within this review is detailing the relationship between key solidification parameters, the operating point of the dendrite tip, and the primary spacing. This review critiques the current state of directional dendritic growth and primary spacing modelling, briefly discusses dendritic growth computational and experimental research, and suggests areas for future investigation.

scholarly journals Insight and psychosis: the next 30 years

2019 ◽  
Vol 217 (3) ◽  
pp. 521-523 ◽  
Author(s):  
Anthony S. David
Keyword(s):  
Conceptual Development ◽  
State Of The Art ◽  
Involuntary Treatment ◽  
The Past ◽  
Current State ◽  
Decision Making Capacity ◽  
Cognitive Neurosciences ◽  
Clinical Associations ◽  
The Relationship ◽  
Made In

Academic interest in the concept of insight in psychosis has increased markedly over the past 30 years, prompting this selective appraisal of the current state of the art. Considerable progress has been made in terms of measurement and confirming a number of clinical associations. More recently, the relationship between insight and involuntary treatment has been scrutinised more closely alongside the link between decision-making capacity and insight. Advances in the clinical and cognitive neurosciences have influenced conceptual development, particularly the field of ‘metacognition’. New therapies, including those that are psychologically and neurophysiologically based, are being tested as ways to enhance insight.

scholarly journals Esophageal Cancer in Canada: Trends according to Morphology and Anatomical Location

2012 ◽  
Vol 26 (10) ◽  
pp. 723-727 ◽  
Author(s):  
Michael C Otterstatter ◽  
James D Brierley ◽  
Prithwish De ◽  
Larry F Ellison ◽  
Maureen MacIntyre ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Esophageal Adenocarcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Relative Survival ◽  
Incidence Rates ◽  
Anatomical Location ◽  
Males And Females

BACKGROUND: Esophageal adenocarcinoma has one of the fastest rising incidence rates and one of the lowest survival rates of any cancer type in the Western world. However, in many countries, trends in esophageal cancer differ according to tumour morphology and anatomical location. In Canada, incidence and survival trends for esophageal cancer subtypes are poorly known.METHODS: Cancer incidence and mortality rates were obtained from the Canadian Cancer Registry, the National Cancer Incidence Reporting System and the Canadian Vital Statistics Death databases for the period from 1986 to 2006. Observed trends (annual per cent change) and five-year relative survival ratios were estimated separately for esophageal adenocarcinoma and squamous cell carcinoma, and according to location (upper, middle, or lower one-third of the esophagus). Incidence rates were projected up to the year 2026.RESULTS: Annual age-standardized incidence rates for esophageal cancer in 2004 to 2006 were 6.1 and 1.7 per 100,000 for males and females, respectively. Esophageal adenocarcinoma incidence rose by 3.9% (males) and 3.6% (females) per year for the period 1986 to 2006, with the steepest increase in the lower one-third of the esophagus (4.8% and 5.0% per year among males and females, respectively). In contrast, squamous cell carcinoma incidence declined by 3.3% (males) and 3.2% (females) per year since the early 1990s. The five-year relative survival ratio for esophageal cancer was 13% between 2004 and 2006, approximately a 3% increase since the period from 1992 to 1994. Projected incidence rates showed increases of 40% to 50% for esophageal adenocarcinoma and decreases of 30% for squamous cell carcinoma by 2026.DISCUSSION: Although esophageal cancer is rare in Canada, the incidence of esophageal adenocarcinoma has doubled in the past 20 years, which may reflect the increasing prevalence of obesity and gastroesophageal reflux disease. Declines in squamous cell carcinoma may be the result of the decreases in the prevalence of smoking in Canada. Given the low survival rates and the potential for further increases in incidence, esophageal adenocarcinoma warrants close attention.

Does crime affect entrepreneurship? A discussion of the current literature

2016 ◽  
Vol 5 (3) ◽  
pp. 254-272 ◽  
Author(s):  
Josh Matti ◽  
Amanda Ross
Keyword(s):  
Current Literature ◽  
Design Methodology ◽  
Agglomeration Economies ◽  
Economic Conditions ◽  
Location Decision ◽  
Content Type ◽  
The Past ◽  
Current State ◽  
The Impact ◽  
The Relationship

Purpose There are countless factors that affect where an entrepreneur chooses to open a business that have been studied in the literature, including local socio-economic conditions, government policy, and agglomeration economies. One important aspect to the location decision that has not received as much attention from researchers thus far is the impact of crime on entrepreneurship. The purpose of this paper is to discuss the current literature on this topic, with a particular emphasis on the empirical issues present that have likely caused the research in this area to be scarce. Design/methodology/approach The authors conduct an analysis of the current state of the literature examining the relationship between crime and entrepreneurship. Looking at what has been done in the past, as well as improvements in the data, the authors discuss what has been done and what can be done in the future. Findings The authors discuss areas related to entrepreneurship and crime that the authors see as an emerging literature, based largely on the improvements in data and identification strategies that allow the authors to answer questions that the authors previously could not. Originality/value This paper is a review of the current literature, which also discusses areas that future researchers should consider and analyze further.

A multistate additive relative survival semi-Markov model

2015 ◽  
Vol 26 (4) ◽  
pp. 1700-1711 ◽  
Author(s):  
Florence Gillaizeau ◽  
Etienne Dantan ◽  
Magali Giral ◽  
Yohann Foucher
Keyword(s):  
Cause Of Death ◽  
Simulated Data ◽  
Relative Survival ◽  
Transplant Recipients ◽  
Multistate Models ◽  
Kidney Transplant Recipients ◽  
Current State ◽  
The Relationship ◽  
French Cohort ◽  
Chronological Time

Medical researchers are often interested to investigate the relationship between explicative variables and times-to-events such as disease progression or death. Such multiple times-to-events can be studied using multistate models. For chronic diseases, it may be relevant to consider semi-Markov multistate models because the transition intensities between two clinical states more likely depend on the time already spent in the current state than on the chronological time. When the cause of death for a patient is unavailable or not totally attributable to the disease, it is not possible to specifically study the associations with the excess mortality related to the disease. Relative survival analysis allows an estimate of the net survival in the hypothetical situation where the disease would be the only possible cause of death. In this paper, we propose a semi-Markov additive relative survival (SMRS) model that combines the multistate and the relative survival approaches. The usefulness of the SMRS model is illustrated by two applications with data from a French cohort of kidney transplant recipients. Using simulated data, we also highlight the effectiveness of the SMRS model: the results tend to those obtained if the different causes of death are known.

scholarly journals Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer

2021 ◽  
Vol 11 (7) ◽  
pp. 659
Author(s):  
Soukaina Boutriq ◽  
Alicia González-González ◽  
Isaac Plaza-Andrades ◽  
Aurora Laborda-Illanes ◽  
Lidia Sánchez-Alcoholado ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Estrogen Metabolism ◽  
Type I ◽  
Cancer Therapies ◽  
Type Ii ◽  
Therapeutic Implications ◽  
Current State ◽  
Scant Attention ◽  
Gynaecological Malignancies ◽  
The Relationship

Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies.

scholarly journals Molecular Basis of Atrial Fibrillation Initiation and Maintenance

Hearts ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 170-187
Author(s):  
Kira Beneke ◽  
Cristina E. Molina
Keyword(s):  
Atrial Fibrillation ◽  
Molecular Basis ◽  
Genetic Factors ◽  
Transcriptional Regulators ◽  
Genetic Changes ◽  
Therapeutic Implications ◽  
The Past ◽  
Risk Variants ◽  
Underlying Mechanisms ◽  
And Oxidative Stress

Atrial fibrillation (AF) is the most common cardiac arrhythmia, largely associated to morbidity and mortality. Over the past decades, research in appearance and progression of this arrhythmia have turned into significant advances in its management. However, the incidence of AF continues to increase with the aging of the population and many important fundamental and translational underlaying mechanisms remain elusive. Here, we review recent advances in molecular and cellular basis for AF initiation, maintenance and progression. We first provide an overview of the basic molecular and electrophysiological mechanisms that lead and characterize AF. Next, we discuss the upstream regulatory factors conducting the underlying mechanisms which drive electrical and structural AF-associated remodeling, including genetic factors (risk variants associated to AF as transcriptional regulators and genetic changes associated to AF), neurohormonal regulation (i.e., cAMP) and oxidative stress imbalance (cGMP and mitochondrial dysfunction). Finally, we discuss the potential therapeutic implications of those findings, the knowledge gaps and consider future approaches to improve clinical management.

scholarly journals Eco-critical Elements in the Selected Poems of Jayanta Mahapatra

2020 ◽  
Vol 8 (5) ◽  
pp. 1
Author(s):  
Ranjit G. ◽  
Dr. K. Rajkumar
Keyword(s):  
Environmental Crisis ◽  
Indian English ◽  
Critical Elements ◽  
The Past ◽  
Current State ◽  
Work Relationship ◽  
Human And Nature ◽  
Native Place ◽  
The Relationship

Jayanta Mahapatra is a well-known, distinguished, Indo-Anglican writer whose poems and short stories are acknowledged worldwide. He was awarded the Sahithya Akademi Award for his work Relationship in 1981, which enabled him to gain the name of one of the doyens of Indian English Poetry. His major themes are all linked with his native place Orissa. His poems mentions Puri, Konarka, Chilika lake, Bhubaneswar recurrently and each of them are pictured in detail. An Ecocritical study on his poems is worth probing as it deserves more attention and consideration in the current state of environmental crisis. His sole inspiration is his interaction with the nature and his intimate relationship to it. As ecocriticism rightly perceives it as the study of the relationship between human and nature, deserves a detailed study with his poems. River daya in his poem takes the role of a bearer of history and is the memory of the past valor and glory of Orissa. The study here focuses on the elements of ecocriticism in his selected poems.

Toward a Biregional Agenda for the Twenty-first Century

2000 ◽  
Vol 42 (2) ◽  
pp. 9-34 ◽  
Author(s):  
Andrew Crawley
Keyword(s):  
Latin American ◽  
First Century ◽  
The Political ◽  
The West ◽  
The Past ◽  
Economic Context ◽  
Current State ◽  
The Relationship ◽  
The Eu

In the wake of the 1999 Rio Summit and its focus on biregional cooperation, this article reviews the background and development of European-Latin American relations over the past two decades, the political and economic context, the current state of transatlantic links, and the shortterm prospects for the relationship. Among its several premises is that the EU and Latin America constitute the bulk of the West, and the ways they work together will therefore condition the role of each of them on the international stage.

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