scholarly journals Two-Year Follow-Up Study of the Relationship Between Brain Structure and Cognitive Control Function Across the Adult Lifespan

2021 ◽  
Vol 13 ◽  
Author(s):  
Shulan Hsieh ◽  
Meng-Heng Yang
Keyword(s):  
Cognitive Function ◽  
Cognitive Control ◽  
Brain Structure ◽  
Control Function ◽  
Age Difference ◽  
Cross Sectional ◽  
Average Interval ◽  
Age Related ◽  
Short Period ◽  
The Relationship

Age-related decline in cognitive control and general slowing are prominent phenomena in aging research. These declines in cognitive functions have been shown to also involve age-related decline in brain structure. However, most evidence in support of these associations is based on cross-sectional data. Therefore, the aim of this study is to contrast cross-sectional and longitudinal analyses to re-examine if the relationship between age-related brain structure and cognitive function are similar between the two approaches. One hundred and two participants completed two sessions with an average interval of 2 years. All participants were assessed by questionnaires, a series of cognitive tasks, and they all underwent neuroimaging acquisition. The main results of this study show that the majority of the conclusions regarding age effect in cognitive control function and processing speed in the literature can be replicated based on the cross-sectional data. Conversely, when we followed up individuals over an average interval of 2 years, then we found much fewer significant relationships between age-related change in gray matter structure of the cognitive control network and age-related change in cognitive control function. Furthermore, there was no “initial age” effect in the relationships between age-related changes in brain structure and cognitive function. This finding suggests that the “aging” relationship between brain structure and cognitive function over a short period of time are independent of “initial age” difference at time point 1. The result of this study warrants the importance of longitudinal research for aging studies to elucidate actual aging processes on cognitive control function.

scholarly journals Age-Related Difference in the Relationship Between Age Stereotypes and Health Behavior in Midlife Koreans

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 447-448
Author(s):  
Hyun-E Yeom ◽  
Eunyoung Park ◽  
Misook Jung
Keyword(s):  
Health Status ◽  
Health Behavior ◽  
Stress Index ◽  
Age Difference ◽  
Middle Aged ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Age Related ◽  
Related Stress ◽  
The Relationship

Abstract Aging stereotypes about health may affect the interpretation of health-related changes in midlife. The purposes of this study were to examine the influence of age-related stereotypic beliefs on health behavior linked to health status and stress and to investigate whether the relationship differs by age. This is a cross-sectional study using a convenience sample of 446 Korean middle-aged adults (mean age=50.7). Data were analyzed using the PROCESS macro approach of SPSS. Age-related stereotypic beliefs affected health behavior through the evaluation of health status (Index=-.006, 95% CI [-.002, -.001]) and related stress (Index=-.002, 95% CI [-.004, -.001]). The relationship between age-related stereotypic beliefs and health status significantly differed by age (β= -.02, p=.004), indicating that individuals with stronger age-related stereotypic beliefs tended to report poorer health status as they aged. With regard to the age difference, the influence of age-related stereotypic beliefs affecting health behavior through health status and related stress became relatively stronger when midlife individuals became older. The findings of this study highlight the importance of carefully assessing age-related beliefs based on consideration of age-related differences in middle-aged individuals. Developing psychoeducational strategies to modify the negative and erroneous aging-related beliefs and to improve health behavior is warranted.

scholarly journals Auditory word recognition across the lifespan

2016 ◽  
Vol 6 (1-2) ◽  
pp. 119-146 ◽  
Author(s):  
Henrike K. Blumenfeld ◽  
Scott R. Schroeder ◽  
Susan C. Bobb ◽  
Max R. Freeman ◽  
Viorica Marian
Keyword(s):  
Older Adults ◽  
Cognitive Control ◽  
Cognitive Processes ◽  
Processing Speed ◽  
Word Identification ◽  
Age Related ◽  
Auditory Word ◽  
Auditory Word Recognition ◽  
The Relationship ◽  
Age Related Changes

Abstract Recent research suggests that bilingual experience reconfigures linguistic and nonlinguistic cognitive processes. We examined the relationship between linguistic competition resolution and nonlinguistic cognitive control in younger and older adults who were either bilingual or monolingual. Participants heard words in English and identified the referent among four pictures while eye-movements were recorded. Target pictures (e.g., cab) appeared with a phonological competitor picture (e.g., cat) and two filler pictures. After each eye-tracking trial, priming probes assessed residual activation and inhibition of target and competitor words. When accounting for processing speed, results revealed that age-related changes in activation and inhibition are smaller in bilinguals than in monolinguals. Moreover, younger and older bilinguals, but not monolinguals, recruited similar inhibition mechanisms during word identification and during a nonlinguistic Stroop task. Results suggest that, during lexical access, bilinguals show more consistent competition resolution and recruitment of cognitive control across the lifespan than monolinguals.

scholarly journals Behavioral interventions to benefit cognition (Intervenciones cognitivas para beneficiar la cognición)

Retos ◽  
2015 ◽  
pp. 197-202
Author(s):  
Jennifer L. Etnier ◽  
Chia-Hao Shih ◽  
Aaron Piepmeier
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Behavioral Interventions ◽  
Animal Studies ◽  
Exercise Intervention ◽  
Treatment Strategies ◽  
Future Research ◽  
Dietary Interventions ◽  
Cross Sectional ◽  
Age Related

With the growing population of older adults, the identification of treatment strategies to prevent or ameliorate age-related cognitive decline has been an important topic in recent years. After reviewing cross-sectional, longitudinal, and experimentally designed studies, as well as evidence from narrative and meta-analytic reviews, the authors concluded that behavioral approaches such as physical activity, cognitive training, and dietary interventions show promising results. In addition, given the likelihood that multiple underlying mechanisms support cognitive function, research is currently focusing on how to combine lifestyle factors into multi-component interventions to generate greater and more meaningful effects. Though evidence for these enhanced benefits exists from animal studies, few multi-component studies have been performed with humans. However, the findings from these studies are promising and a continued pursuit of multi-component behavioral interventions to benefit cognitive performance is warranted. Given the world’s aging population and accompanying age-related health issues such as cognitive decline and dementia, future research should focus on understanding the biological mechanisms responsible for these effects in order to allow for the development of behavioral lifestyle prescriptions to benefit cognitive performance.Keywords. aging, cognitive function, exercise intervention, oxidative stress, cognitive engagement.Resumen. Con la creciente población de adultos mayores, la identificación de las estrategias de tratamiento para prevenir o mejorar el deterioro cognitivo relacionado con la edad ha sido un tema importante en los últimos años. Después de revisar estudios con diseños transversales, longitudinales y experimentales, así como la evidencia de revisiones de literatura narrativa y meta-analítica, los autores concluyen que los enfoques conductuales como la actividad física, el entrenamiento cognitivo y las intervenciones dietéticas muestran resultados prometedores. Además, dada la probabilidad de que múltiples mecanismos subyacentes apoyan la función cognitiva, las investigaciones se enfocan actualmente en la manera de cómo combinar factores del estilo de vida en las intervenciones con múltiples componentes para generar efectos mayores y más significativos. Aunque existe evidencia de estos beneficios a partir de estudios en animales, se han realizado pocos estudios de componentes múltiples en humanos. Sin embargo, los resultados de estos estudios son prometedores y se garantiza un seguimiento continuo de las intervenciones conductuales de componentes múltiples para beneficiar el rendimiento cognitivo. Teniendo en cuenta el envejecimiento de la población mundial y los problemas de salud relacionados con la edad que la acompañan, tales como el deterioro cognitivo y la demencia, la investigación futura debería centrarse en la comprensión de los mecanismos biológicos responsables de estos efectos con el fin de permitir el desarrollo de las prescripciones de comportamiento de estilo de vida para beneficiar el rendimiento cognitivo.Palabras claves. envejecimiento, funcionamiento cognitivo, intervención con ejercicio, estrés oxidativo, participación cognitiva.

scholarly journals Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Megan C. Bakeberg ◽  
Anastazja M. Gorecki ◽  
Jade E. Kenna ◽  
Alexa Jefferson ◽  
Michelle Byrnes ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Linear Models ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cognitive Status ◽  
Cross Sectional ◽  
Age Related

IntroductionCholesterol levels have been associated with age-related cognitive decline, however, such an association has not been comprehensively explored in people with Parkinson’s disease (PD). To address this uncertainty, the current cross-sectional study examined the cholesterol profile and cognitive performance in a cohort of PD patients.MethodsCognitive function was evaluated using two validated assessments (ACE-R and SCOPA-COG) in 182 people with PD from the Australian Parkinson’s Disease Registry. Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Triglyceride (TRG) levels were examined within this cohort. The influence of individual lipid subfractions on domain-specific cognitive performance was investigated using covariate-adjusted generalised linear models.ResultsFemales with PD exhibited significantly higher lipid subfraction levels (TC, HDL, and LDL) when compared to male counterparts. While accounting for covariates, HDL levels were strongly associated with poorer performance across multiple cognitive domains in females but not males. Conversely, TC and LDL levels were not associated with cognitive status in people with PD.ConclusionHigher serum HDL associates with poorer cognitive function in females with PD and presents a sex-specific biomarker for cognitive impairment in PD.

Power Vector Analysis of Corneal Astigmatism among Chinese over Fifty Years Old: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Yilin Pang ◽  
Xiaoguang Cao ◽  
Xianru Hou ◽  
Li Yuan ◽  
Yongzhen Bao
Keyword(s):  
Axial Length ◽  
Linear Trend ◽  
Linear Regression Analysis ◽  
Corneal Astigmatism ◽  
Vector Analysis ◽  
Cross Sectional ◽  
Age Related ◽  
Relationship Of ◽  
The Relationship ◽  
Cataract Patients

Abstract Background: To investigate the relationship between corneal astigmatism and age, axial length (AL) among Chinese over fifty years old. Methods: This study enrolled 1,082 right eyes of age-related cataract patients over 50 years old in the clinic of Peking University People’s Hospital, Beijing, China. Axial length, magnitude and meridian of anterior corneal astigmatism were measured by IOLMaster. Restricted cubic splines and Spearman rank correlation coefficients were used to investigate the relationship of the magnitude of cornea astigmatism to age and AL. Power vector analysis method and linear regression analysis were used to assess the relationship of the meridian of astigmatism to age and AL. Results: For this study , mean age, AL, and corneal astigmatism value were 72.45 ±9.28 years, 23.90±1.93mm, and 1.12±0.74D, respectively. The magnitude of corneal astigmatism was 0.75D or higher in 63.8% eyes. The magnitude of corneal astigmatism increased with age after 65 years old. This correlation was statistically significant when AL was between 22.00mm and 26.00mm. The vector value in J 0 was inversely correlated with age. The mean vector value change from with-the-rule (WTR) to against-the-rule (ATR) corneal astigmatism was 0.22D/10 years during 50-65 years old and 0.15D/10 years during 65-85 years old, and was 0.22D/10 years in male and 0.12D/10 years in female, respectively. Conclusions: A large proportion of elderly Chinese cataract patients over 50 years old have corneal astigmatism more than 0.75D . There was a non-linear trend from WTR astigmatism towards ATR astigmatism with age, which was more obvious in elder age and in male. When AL is between 22.00mm and 26.00mm, the magnitude of corneal astigmatism increases with age after 65 years old.

Effect of Subcutaneous Tissue on Changes in Thigh Circumference Following Anterior Cruciate Ligament Reconstruction

2019 ◽  
Vol 40 (08) ◽  
pp. 544-550
Author(s):  
Ryo Yoshii ◽  
Yu Konishi ◽  
Daisuke Ando ◽  
Satoshi Ochiai ◽  
Tetsuo Hagino ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Cruciate Ligament ◽  
Subcutaneous Fat ◽  
Quadriceps Muscle ◽  
Thigh Circumference ◽  
Cross Sectional ◽  
Short Period ◽  
Anterior Cruciate ◽  
Muscle Cross Sectional Area ◽  
The Relationship

AbstractCircumference measurements have been used to estimate muscle cross-sectional area (CSA) in clinical settings. Measurements of thigh circumference are affected by muscle and subcutaneous fat (SF). In fact, SF could increase over a short period. Therefore, clarifying the relationship between thigh circumference and muscle and SF following ACL reconstruction is important. This study’s primary purpose was to examine pre- and post-operative changes in thigh circumference, thigh muscles and SF CSAs in both legs. Secondary, the relationship between thigh circumference and muscle and SF CSAs was examined to demonstrate that circumference measurements could be used to detect atrophy. Quadriceps, hamstrings, and SF CSAs at 15, 10, and 5 cm proximal to the patella were measured by MRI pre- and 4 weeks postoperatively to examine how reconstruction affected those tissues in the thighs. The results showed increases in SF CSA (r=0.72 at 10 cm, r=0.67 at 15 cm) greatly affected thigh circumference in females on the surgical side. In males, increases in SF CSA (r=0.83) at 15- and 5-cm and decreases in quadriceps muscle CSA (r=0.73) at 5 cm affected thigh circumference on the surgical side. Thigh circumference measurements might not reflect actual muscle CSA in ACL patients.

scholarly journals Hubungan Gangguan Fungsi Kognitif dengan Kejadian Depresi pada Lansia di Posyandu Lansia Ikur Koto Wilayah Kerja Puskesmas Ikur Koto Kota Padang

2019 ◽  
Vol 1 (1) ◽  
pp. 30-37
Author(s):  
Indri Zaliavani ◽  
Mutiara Anissa ◽  
Fidiariani Sjaaf
Keyword(s):  
Cognitive Function ◽  
The Elderly ◽  
Negative Influence ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
A Value ◽  
Relationship Of ◽  
Spearman Test ◽  
The Relationship

In the elderly, environmental stress and decreased cognitive function often cause depression. Depression that is not treated properly can cause an increase in the use of health facilities, a negative influence on the quality of life elderly, and can even cause death. Purpose of this research to know the relationship of cognitive function disorders with depression in the elderly at Posyandu Lansia Ikur Koto working area of the Puskesmas Ikur Koto, Padang. This type of research is correlative analytic with cross-sectional approach. Research has been conducted at posyandu lansia Ikur Koto in February 2019. The samples in this research was elderly who were recorded at the posyandu lansia Ikur Koto there were 51 elderly. Data analysis univariate presented in the form of a frequency distribution table and bivariate analysis using the spearman test using the SPSS program. Result of the 51 respondents, the majority of age was 60-74 years old (70,6%), the highest sex were women (94,1%), the highest education was elementary school (56,9%) ), the most marital status was married (52,9%), the highest health status (58,8%) did not suffer chronic diseases and most medical history does not use drugs (98%),most (72,5%) did not experiencing depression, most (37,3%) had mild cognitive function disorders and there were relationship between cognitive function disorders and depression in the elderly with a value p=0,007<0,05 and r=-0,373. Conclusion is there were significant relationship between cognitive function disorders and depression in the elderly at Posyandu Lansia Ikur Koto working area of the Puskesmas Ikur Koto, Padang.

scholarly journals Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder from the Scottish Bipolar Family Study

2020 ◽  
Vol 4 ◽  
pp. 206
Author(s):  
Laura de Nooij ◽  
Mathew A. Harris ◽  
Emma L. Hawkins ◽  
Toni-Kim Clarke ◽  
Xueyi Shen ◽  
...  
Keyword(s):  
Mood Disorder ◽  
Brain Structure ◽  
Family Study ◽  
Familial Risk ◽  
Age Difference ◽  
Age Related ◽  
Brain Ageing ◽  
Prospective Longitudinal ◽  
Brain Age

Background: Within young individuals, mood disorder onset may be related to changes in trajectory of brain structure development. To date, however, longitudinal prospective studies remain scarce and show partly contradictory findings, with a lack of emphasis on changes at the level of global brain patterns. Cross-sectional adult studies have applied such methods and show that mood disorders are associated with accelerated brain ageing. Currently, it remains unclear whether young individuals show differential brain structure aging trajectories associated with onset of mood disorder and/or presence of familial risk. Methods: Participants included young individuals (15-30 years, 53%F) from the prospective longitudinal Scottish Bipolar Family Study with and without close family history of mood disorder. All were well at time of recruitment. Implementing a structural MRI-based brain age prediction model, we globally assessed individual trajectories of age-related structural change using the difference between predicted brain age and chronological age (brain-predicted age difference (brain-PAD)) at baseline and at 2-year follow-up. Based on follow-up clinical assessment, individuals were categorised into three groups: (i) controls who remained well (C-well, n = 93), (ii) high familial risk who remained well (HR-well, n = 74) and (iii) high familial risk who developed a mood disorder (HR-MD, n = 35). Results: At baseline, brain-PAD was comparable between groups. Results showed statistically significant negative trajectories of brain-PAD between baseline and follow-up for HR-MD versus C-well (β = -0.60, pcorrected < 0.001) and HR-well (β = -0.36, pcorrected = 0.02), with a potential intermediate trajectory for HR-well (β = -0.24 years, pcorrected = 0.06).   Conclusions: These preliminary findings suggest that within young individuals, onset of mood disorder and familial risk may be associated with a deceleration in brain structure aging trajectories. Extended longitudinal research will need to corroborate findings of emerging maturational lags in relation to mood disorder risk and onset.

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