scholarly journals The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence

2021 ◽  
Vol 14 ◽  
Author(s):  
Omid Miry ◽  
Jie Li ◽  
Lu Chen
Keyword(s):  
Experimental Evidence ◽  
Memory Formation ◽  
Cognitive Map ◽  
Comprehensive Understanding ◽  
Experimental Support ◽  
Recent Advances ◽  
Memory Engram ◽  
And Function ◽  
Memory Indexing ◽  
Theoretical Proposal

More than a century after Richard Semon's theoretical proposal of the memory engram, technological advancements have finally enabled experimental access to engram cells and their functional contents. In this review, we summarize theories and their experimental support regarding hippocampal memory engram formation and function. Specifically, we discuss recent advances in the engram field which help to reconcile two main theories for how the hippocampus supports memory formation: The Memory Indexing and Cognitive Map theories. We also highlight the latest evidence for engram allocation mechanisms through which memories can be linked or separately encoded. Finally, we identify unanswered questions for future investigations, through which a more comprehensive understanding of memory formation and retrieval may be achieved.

scholarly journals Neurons interact with the microbiome: an evolutionary-informed perspective

Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Christoph Giez ◽  
Alexander Klimovich ◽  
Thomas C. G. Bosch
Keyword(s):  
Nervous System ◽  
Neural Circuits ◽  
Current Knowledge ◽  
System Development ◽  
Nervous System Development ◽  
Comprehensive Understanding ◽  
Strategic Model ◽  
Microbe Interactions ◽  
Host Microbe Interactions ◽  
And Function

Abstract Animals have evolved within the framework of microbes and are constantly exposed to diverse microbiota. Microbes colonize most, if not all, animal epithelia and influence the activity of many organs, including the nervous system. Therefore, any consideration on nervous system development and function in the absence of the recognition of microbes will be incomplete. Here, we review the current knowledge on the nervous systems of Hydra and its role in the host–microbiome communication. We show that recent advances in molecular and imaging methods are allowing a comprehensive understanding of the capacity of such a seemingly simple nervous system in the context of the metaorganism. We propose that the development, function and evolution of neural circuits must be considered in the context of host–microbe interactions and present Hydra as a strategic model system with great basic and translational relevance for neuroscience.

scholarly journals Recent advances in understanding and managing psoriatic arthritis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2670 ◽  
Author(s):  
Dafna D. Gladman
Keyword(s):  
Psoriatic Arthritis ◽  
Early Diagnosis ◽  
Clinical Laboratory ◽  
Joint Damage ◽  
Screening Tools ◽  
Therapeutic Interventions ◽  
Joint Disease ◽  
New Therapeutic Approaches ◽  
Recent Advances ◽  
And Function

This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who present late do not fare as well. There are a number of clinical, laboratory, and ultrasound features that can help identify patients destined to develop PsA, and several screening tools have been developed. It is recognized that genetic and epigenetic factors, as well as T cells and cytokines, play a role in the pathogenesis of PsA, and several targets have been identified for therapeutic interventions. New therapies have been developed and tested in PsA and have been found to be highly effective for both skin and joint manifestations of the disease. The expectation is that, in the future, PsA patients will be treated early and more aggressively and that there will not be significant progression of joint damage. Moreover, with effective treatment of the skin and joint disease and management of risk factors for the comorbidities, we can expect to reduce their occurrence and further reduce the excess mortality and reduced quality of life and function in these patients.

scholarly journals KONTRIBUSI POSITIF ORIENTALISME: KAJIAN ATAS REINHART DOZY (1820-1883 M)

2020 ◽  
Vol 20 (1) ◽  
pp. 85
Author(s):  
Ghulam Falach
Keyword(s):  
Qualitative Research ◽  
Islamic Law ◽  
Great Influence ◽  
Literary Work ◽  
Comprehensive Understanding ◽  
Islamic History ◽  
Library Research ◽  
History Of ◽  
And Function ◽  
Islamic Civilization

The main focus of Orientalist thought is nothing but to reconstruct and influence Islamic civilization. Their enthusiasm to activate orientalism is increasingly challenged by the presence of Islam as a religion that has followers of most of the world's population. One of the actions of orientalism towards the Islamic world is to start a research movement on the Qur'an and al-Hadith which are the basis of the law and guidelines of Muslims. Not far from the critics of the Qur'an and al-Hadith, they also deconstructed aspects of the development of science, Islamic law, and even the originality of Islamic history. Some famous orientalism figures, one of them is Reinhart Dozy, a famous orientelism from the Netherlands with the concept of literacy in the history of Islamic civilization in Spain. Even though he received a lot of criticism and appreciation from both orientalists and Muslim thinkers, his literary work has had a great influence on Islamic civilization. The discussion steps of this study are entirely carried out using qualitative research that is library research. To be more useful and function properly, this paper is equipped with an explanation using the method of description, interpretation and analysis of data in each discussion. This is done, none other than to focus the discussion to produce a consistent and comprehensive understanding.

scholarly journals Organic Cocrystals: Recent Advances and Perspectives for Electronic and Magnetic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Mengjia Jiang ◽  
Chun Zhen ◽  
Shuyu Li ◽  
Xiaotao Zhang ◽  
Wenping Hu
Keyword(s):  
Magnetic Properties ◽  
Magnetic Fields ◽  
Research Interest ◽  
Comprehensive Understanding ◽  
Electronic And Magnetic Properties ◽  
Recent Advances ◽  
Magnetic Applications ◽  
Application Fields ◽  
Growth Methods

Cocrystal engineering is an advanced supramolecular strategy that has attracted a lot of research interest. Many studies on cocrystals in various application fields have been reported, with a particular focus on the optoelectronics field. However, few articles have combined and summarized the electronic and magnetic properties of cocrystals. In this review, we first introduce the growth methods that serve as the basis for realizing the different properties of cocrystals. Thereafter, we present an overview of cocrystal applications in electronic and magnetic fields. Some functional devices based on cocrystals are also introduced. We hope that this review will provide researchers with a more comprehensive understanding of the latest progress and prospects of cocrystals in electronic and magnetic fields.

scholarly journals Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

2021 ◽  
Vol 22 (17) ◽  
pp. 9317
Author(s):  
Konstantinos Zifkos ◽  
Christophe Dubois ◽  
Katrin Schäfer
Keyword(s):  
Experimental Evidence ◽  
Extracellular Vesicles ◽  
Thrombus Formation ◽  
Experimental Studies ◽  
Cell Types ◽  
Heterogenous Group ◽  
Clearance Mechanism ◽  
And Function ◽  
Role And Function

Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles, including exosomes, microvesicles and apoptotic bodies, which are released into the extracellular environment in response to proinflammatory or proapoptotic stimuli. From earlier studies suggesting that EV shedding constitutes a cellular clearance mechanism, it has become evident that EV formation, secretion and uptake represent important mechanisms of intercellular communication and exchange of a wide variety of molecules, with relevance in both physiological and pathological situations. The putative role of EVs in hemostasis and thrombosis is supported by clinical and experimental studies unraveling how these cell-derived structures affect clot formation (and resolution). From those studies, it has become clear that the prothrombotic effects of EVs are not restricted to the exposure of tissue factor (TF) and phosphatidylserines (PS), but also involve multiplication of procoagulant surfaces, cross-linking of different cellular players at the site of injury and transfer of activation signals to other cell types. Here, we summarize the existing and novel clinical and experimental evidence on the role and function of EVs during arterial and venous thrombus formation and how they may be used as biomarkers as well as therapeutic vectors.

scholarly journals Recent advances in alveolar biology: Evolution and function of alveolar proteins

2010 ◽  
Vol 173 ◽  
pp. S43-S54 ◽  
Author(s):  
Sandra Orgeig ◽  
Pieter S. Hiemstra ◽  
Edwin J.A. Veldhuizen ◽  
Cristina Casals ◽  
Howard W. Clark ◽  
...  
Keyword(s):  
Recent Advances ◽  
And Function

Bone Grafts: An Overview of Bone Remodeling, Types and Recent Advances

2021 ◽  
pp. 6101-6105
Author(s):  
Gopala Krishna Ganta ◽  
Rama Krishna Alla ◽  
Kamala Cheruvu ◽  
Bharathi Ram Guduri
Keyword(s):  
Bone Graft ◽  
Bone Remodeling ◽  
Gold Standard ◽  
Bone Grafts ◽  
Form And Function ◽  
Recent Advances ◽  
And Function ◽  
Insight Into

Bone grafts are often used to retrieve the lost bone in the most acceptable, technical and skilful manner that enables to restore the form and function of the bone. Numerous bone graft materials have been developed to fill and/or remodel the bony defects. Though, autografts were considered to be the gold standard among the grafts available; they have got some inherent disadvantages. The current research is more focused on allografts, which addressed the problems associated with autografts. This article provides an insight into the remodeling process, and various types of bone grafts currently available. Also, the emphasis was given on the recent advances of the bone grafts.

Evidence for bicomponent fibers: A review

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 636-653
Author(s):  
Shufang Zhu ◽  
Xin Meng ◽  
Xu Yan ◽  
Shaojuan Chen
Keyword(s):  
Experimental Evidence ◽  
Structural Characteristics ◽  
Future Perspectives ◽  
Comprehensive Understanding ◽  
Preparation Methods ◽  
Bicomponent Fibers ◽  
Common Concern ◽  
Bicomponent Fiber

Abstract Recently, bicomponent fibers have been attracting much attention due to their unique structural characteristics and properties. A common concern was how to characterize a bicomponent fiber. In this review, we generally summarized the classification, structural characteristics, preparation methods of the bicomponent fibers, and focused on the experimental evidence for the identification of bicomponent fibers. Finally, the main challenges and future perspectives of bicomponent fibers and their characterization are provided. We hope that this review will provide readers with a comprehensive understanding of the design and characterization of bicomponent fibers.

scholarly journals Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 38 ◽  
Author(s):  
Azza Abdel-Gadir ◽  
Amir H. Massoud ◽  
Talal A. Chatila
Keyword(s):  
Immune Responses ◽  
Treg Cell ◽  
Allergic Diseases ◽  
Treg Cells ◽  
Immunological Tolerance ◽  
Inflammatory Disorders ◽  
Cell Responses ◽  
Recent Advances ◽  
And Function ◽  
Is Failure

Allergic diseases are chronic inflammatory disorders in which there is failure to mount effective tolerogenic immune responses to inciting allergens. The alarming rise in the prevalence of allergic diseases in recent decades has spurred investigations to elucidate the mechanisms of breakdown in tolerance in these disorders and means of restoring it. Tolerance to allergens is critically dependent on the generation of allergen-specific regulatory T (Treg) cells, which mediate a state of sustained non-responsiveness to the offending allergen. In this review, we summarize recent advances in our understanding of mechanisms governing the generation and function of allergen-specific Treg cells and their subversion in allergic diseases. We will also outline approaches to harness allergen-specific Treg cell responses to restore tolerance in these disorders.

scholarly journals Mechanical Chirality of Rotaxanes: Synthesis and Function

Symmetry ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 144 ◽  
Author(s):  
Kazuko Nakazono ◽  
Toshikazu Takata
Keyword(s):  
Helical Structure ◽  
Chiral Molecules ◽  
Polymer Systems ◽  
Property Change ◽  
Recent Advances ◽  
Potential Applicability ◽  
And Function

Mechanically chiral molecules have attracted considerable attention due to their property and function based on its unique interlocked structure. This review covers the recent advances in the synthesis and function of interlocked rotaxanes with mechanical chirality along with their dynamic and complex stereochemistry. The application of mechanically chiral rotaxanes to control the polymer helical structure is also introduced, where amplification of mechanical chirality appears to cause the macroscopic polymer property change, suggesting the potential applicability of mechanical chirality in polymer systems.

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