scholarly journals Prospective Study of a Multimodal Convulsive Seizure Detection Wearable System on Pediatric and Adult Patients in the Epilepsy Monitoring Unit

2021 ◽  
Vol 12 ◽  
Author(s):  
Francesco Onorati ◽  
Giulia Regalia ◽  
Chiara Caborni ◽  
W. Curt LaFrance ◽  
Andrew S. Blum ◽  
...  
Keyword(s):  
Machine Learning ◽  
Prospective Study ◽  
Learning Algorithm ◽  
Electrodermal Activity ◽  
Pediatric Population ◽  
Detection Algorithm ◽  
Adult Patients ◽  
Active Mode ◽  
The Impact ◽  
Epilepsy Monitoring

Background: Using machine learning to combine wrist accelerometer (ACM) and electrodermal activity (EDA) has been shown effective to detect primarily and secondarily generalized tonic-clonic seizures, here termed as convulsive seizures (CS). A prospective study was conducted for the FDA clearance of an ACM and EDA-based CS-detection device based on a predefined machine learning algorithm. Here we present its performance on pediatric and adult patients in epilepsy monitoring units (EMUs).Methods: Patients diagnosed with epilepsy participated in a prospective multi-center clinical study. Three board-certified neurologists independently labeled CS from video-EEG. The Detection Algorithm was evaluated in terms of Sensitivity and false alarm rate per 24 h-worn (FAR) on all the data and on only periods of rest. Performance were analyzed also applying the Detection Algorithm offline, with a less sensitive but more specific parameters configuration (“Active mode”).Results: Data from 152 patients (429 days) were used for performance evaluation (85 pediatric aged 6–20 years, and 67 adult aged 21–63 years). Thirty-six patients (18 pediatric) experienced a total of 66 CS (35 pediatric). The Sensitivity (corrected for clustered data) was 0.92, with a 95% confidence interval (CI) of [0.85-1.00] for the pediatric population, not significantly different (p > 0.05) from the adult population's Sensitivity (0.94, CI: [0.89–1.00]). The FAR on the pediatric population was 1.26 (CI: [0.87–1.73]), higher (p < 0.001) than in the adult population (0.57, CI: [0.36–0.81]). Using the Active mode, the FAR decreased by 68% while reducing Sensitivity to 0.95 across the population. During rest periods, the FAR's were 0 for all patients, lower than during activity periods (p < 0.001).Conclusions: Performance complies with FDA's requirements of a lower bound of CI for Sensitivity higher than 0.7 and of a FAR lower than 2, for both age groups. The pediatric FAR was higher than the adult FAR, likely due to higher pediatric activity. The high Sensitivity and precision (having no false alarms) during sleep might help mitigate SUDEP risk by summoning caregiver intervention. The Active mode may be advantageous for some patients, reducing the impact of the FAR on daily life. Future work will examine the performance and usability outside of EMUs.

scholarly journals Pain assessment tool with Electrodermal Activity for post-operative patients: A method validation study (Preprint)

2020 ◽  
Author(s):  
Seyed Amir Hossein Aqajari ◽  
Rui Cao ◽  
Emad Kasaeyan Naeini ◽  
Michael-David Calderon ◽  
Kai Zheng ◽  
...  
Keyword(s):  
Machine Learning ◽  
Pain Assessment ◽  
Assessment Tool ◽  
Learning Algorithm ◽  
Electrodermal Activity ◽  
Machine Learning Algorithms ◽  
Adult Patients ◽  
Self Report ◽  
Physiological Data ◽  
Pain Models

BACKGROUND Accurate objective pain assessment is required in the healthcare domain and clinical settings for appropriate pain management. Automated objective pain detection from physiological data in patients provides valuable information to hospital staff and caregivers to better manage pain, in particular for those patients who are unable to self-report. Galvanic Skin Response (GSR) is one of the physiologic signals that refers to the changes in sweat gland activity, which can identify the features of emotional states and anxiety induced by varying pain levels. In this study, we used different statistical features extracted from GSR data collected from postoperative patients to detect their pain intensity. To the best of our knowledge, we are the first work building pain models using postoperative adult patients instead of healthy subjects. OBJECTIVE The goal of this paper is to present an automatic pain assessment tool using GSR signals to predict different pain intensities in non-communicative postoperative patients. METHODS The study was designed to collect biomedical data from post-operative patients reporting moderate to high pain levels. 25 subjects were recruited with the age range of 23 to 89. First, a Transcutaneous Electrical Nerve Stimulation (TENS) unit was employed to obtain patients' baselines. In the second part, the Empatica E4 wristband was attached to patients while they were performing low intensity activities. Patient self-report based on the NRS was used to record pain intensities used to correlate with the objective measured data. The labels were downsampled from 11 pain levels to 5 different pain intensities including the baseline. Two different machine learning algorithms were used to construct the models. The mean decrease impurity method was used to find the top important features for pain prediction and improve the accuracy. We compared our results with a previously published research study to estimate the true performance of our models. RESULTS Four different binary classification models were constructed using each machine learning algorithm to classify the baseline and other pain intensities (Baseline (BL) vs. Pain Level (PL) 1, BL vs. PL2, BL vs. PL3, and BL vs. PL4). Our models achieved the higher accuracy for the first three pain models in comparison with BioVid paper approach despite the challenges in analyzing real patient data. For BL vs. PL1, BL vs. PL2, and BL vs. PL4, the highest prediction accuracies were achieved when using a Random Forest classifier (86.0, 70.0, and 61.5, respectively). For BL vs. PL3, we achieved the accuracy of 72.1 using a K-nearest neighbors classifier. CONCLUSIONS We are the first to propose and validate the pain assessment tool to predict different pain levels in real postoperative adult patients using GSR signals. We also exploited feature selection algorithms to find the top important features related to different pain intensities. INTERNATIONAL REGISTERED REPORT RR2-10.2196/17783

IMPROVED TOW-END DETECTION FOR FIBER PLACEMENT INSPECTION USING MACHINE LEARNING

2021 ◽  
Author(s):  
ADRIANA W. (AGNES) BLOM-SCHIEBER ◽  
WEI GUO ◽  
EKTA SAMANI ◽  
ASHIS BANERJEE
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Image Data ◽  
Detection Algorithm ◽  
Automated Inspection ◽  
Machine Learning Algorithm ◽  
Fiber Placement ◽  
Inspection Systems ◽  
Automated Fiber Placement ◽  
The University

A machine learning approach to improve the detection of tow ends for automated inspection of fiber-placed composites is presented. Automated inspection systems for automated fiber placement processes have been introduced to reduce the time it takes to inspect plies after they are laid down. The existing system uses image data from ply boundaries and a contrast-based algorithm to locate the tow ends in these images. This system fails to recognize approximately 10% of the tow ends, which are then presented to the operator for manual review, taking up precious time in the production process. An improved tow end detection algorithm based on machine learning is developed through a research project with the Boeing Advanced Research Center (BARC) at the University of Washington. This presentation shows the preprocessing, neural network and post‐processing steps implemented in the algorithm, and the results achieved with the machine learning algorithm. The machine learning algorithm resulted in a 90% reduction in the number of undetected tows compared to the existing system.

scholarly journals Machine-learning annotation of human splicing branchpoints

2016 ◽  
Author(s):  
Bethany Signal ◽  
Brian S Gloss ◽  
Marcel E Dinger ◽  
Timothy R Mercer
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Gene Splicing ◽  
Genetic Encoding ◽  
Genome Wide ◽  
Common Genetic Variants ◽  
A Genome ◽  
Wide Scale ◽  
The Impact ◽  
Splicing Patterns

ABSTRACTBackgroundThe branchpoint element is required for the first lariat-forming reaction in splicing. However due to difficulty in experimentally mapping at a genome-wide scale, current catalogues are incomplete.ResultsWe have developed a machine-learning algorithm trained with empirical human branchpoint annotations to identify branchpoint elements from primary genome sequence alone. Using this approach, we can accurately locate branchpoints elements in 85% of introns in current gene annotations. Consistent with branchpoints as basal genetic elements, we find our annotation is unbiased towards gene type and expression levels. A major fraction of introns was found to encode multiple branchpoints raising the prospect that mutational redundancy is encoded in key genes. We also confirmed all deleterious branchpoint mutations annotated in clinical variant databases, and further identified thousands of clinical and common genetic variants with similar predicted effects.ConclusionsWe propose the broad annotation of branchpoints constitutes a valuable resource for further investigations into the genetic encoding of splicing patterns, and interpreting the impact of common- and disease-causing human genetic variation on gene splicing.

scholarly journals Analyzing the Impact of Climate Factors on GNSS-Derived Displacements by Combining the Extended Helmert Transformation and XGboost Machine Learning Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Hanlin Liu ◽  
Linqiang Yang ◽  
Linchao Li
Keyword(s):  
Machine Learning ◽  
Puerto Rico ◽  
Reference Frame ◽  
Learning Algorithm ◽  
Virgin Islands ◽  
Machine Learning Algorithm ◽  
Climate Factors ◽  
Helmert Transformation ◽  
The Impact

A variety of climate factors influence the precision of the long-term Global Navigation Satellite System (GNSS) monitoring data. To precisely analyze the effect of different climate factors on long-term GNSS monitoring records, this study combines the extended seven-parameter Helmert transformation and a machine learning algorithm named Extreme Gradient boosting (XGboost) to establish a hybrid model. We established a local-scale reference frame called stable Puerto Rico and Virgin Islands reference frame of 2019 (PRVI19) using ten continuously operating long-term GNSS sites located in the rigid portion of the Puerto Rico and Virgin Islands (PRVI) microplate. The stability of PRVI19 is approximately 0.4 mm/year and 0.5 mm/year in the horizontal and vertical directions, respectively. The stable reference frame PRVI19 can avoid the risk of bias due to long-term plate motions when studying localized ground deformation. Furthermore, we applied the XGBoost algorithm to the postprocessed long-term GNSS records and daily climate data to train the model. We quantitatively evaluated the importance of various daily climate factors on the GNSS time series. The results show that wind is the most influential factor with a unit-less index of 0.013. Notably, we used the model with climate and GNSS records to predict the GNSS-derived displacements. The results show that the predicted displacements have a slightly lower root mean square error compared to the fitted results using spline method (prediction: 0.22 versus fitted: 0.31). It indicates that the proposed model considering the climate records has the appropriate predict results for long-term GNSS monitoring.

scholarly journals Improved Antibiotic Detection in Raw Milk Using Machine Learning Tools over the Absorption Spectra of a Problem-Specific Nanobiosensor

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4552
Author(s):  
Pablo Gutiérrez ◽  
Sebastián E. Godoy ◽  
Sergio Torres ◽  
Patricio Oyarzún ◽  
Ignacio Sanhueza ◽  
...  
Keyword(s):  
Machine Learning ◽  
Milk Sample ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Raw Milk ◽  
Detection Algorithm ◽  
Learning Tools ◽  
Antibiotic Detection ◽  
Biosensor System ◽  
Spectral Detection

In this article we present the development of a biosensor system that integrates nanotechnology, optomechanics and a spectral detection algorithm for sensitive quantification of antibiotic residues in raw milk of cow. Firstly, nanobiosensors were designed and synthesized by chemically bonding gold nanoparticles (AuNPs) with aptamer bioreceptors highly selective for four widely used antibiotics in the field of veterinary medicine, namely, Kanamycin, Ampicillin, Oxytetracycline and Sulfadimethoxine. When molecules of the antibiotics are present in the milk sample, the interaction with the aptamers induces random AuNP aggregation. This phenomenon modifies the initial absorption spectrum of the milk sample without antibiotics, producing spectral features that indicate both the presence of antibiotics and, to some extent, its concentration. Secondly, we designed and constructed an electro-opto-mechanic device that performs automatic high-resolution spectral data acquisition in a wavelength range of 400 to 800 nm. Thirdly, the acquired spectra were processed by a machine-learning algorithm that is embedded into the acquisition hardware to determine the presence and concentration ranges of the antibiotics. Our approach outperformed state-of-the-art standardized techniques (based on the 520/620 nm ratio) for antibiotic detection, both in speed and in sensitivity.

Impact of Encoding of High Cardinality Categorical Data to Solve Prediction Problems

2020 ◽  
Vol 17 (9) ◽  
pp. 4197-4201
Author(s):  
Heena Gupta ◽  
V. Asha
Keyword(s):  
Machine Learning ◽  
Categorical Data ◽  
Learning Algorithm ◽  
Machine Learning Algorithm ◽  
Prediction Problem ◽  
Encoding Scheme ◽  
The Impact ◽  
Prediction Problems

The prediction problem in any domain is very important to assess the prices and preferences among people. This issue varies for different kinds of data. Data may be nominal or ordinal, it may involve more categories or less. For any category to be considered by a machine learning algorithm, it needs to be encoded before any other operation can be further performed. There are various encoding schemes available like label encoding, count encoding and one hot encoding. This paper aims to understand the impact of various encoding schemes and the accuracy among the prediction problems of high cardinality categorical data. The paper also proposes an encoding scheme based on curated strings. The domain chosen for this purpose is predicting doctors’ fees in various cities having different profiles and qualification.

scholarly journals A novel machine learning algorithm has the potential to reduce by 1/3 the quantity of ILR episodes needing review

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Rosier ◽  
E Crespin ◽  
A Lazarus ◽  
G Laurent ◽  
A Menet ◽  
...  
Keyword(s):  
Machine Learning ◽  
False Positive ◽  
Learning Algorithm ◽  
False Positive Rate ◽  
Machine Learning Algorithm ◽  
The Novel ◽  
Funding Sources ◽  
High Workload ◽  
Positive Rate ◽  
The Impact

Abstract Background Implantable Loop Recorders (ILRs) are increasingly used and generate a high workload for timely adjudication of ECG recordings. In particular, the excessive false positive rate leads to a significant review burden. Purpose A novel machine learning algorithm was developed to reclassify ILR episodes in order to decrease by 80% the False Positive rate while maintaining 99% sensitivity. This study aims to evaluate the impact of this algorithm to reduce the number of abnormal episodes reported in Medtronic ILRs. Methods Among 20 European centers, all Medtronic ILR patients were enrolled during the 2nd semester of 2020. Using a remote monitoring platform, every ILR transmitted episode was collected and anonymised. For every ILR detected episode with a transmitted ECG, the new algorithm reclassified it applying the same labels as the ILR (asystole, brady, AT/AF, VT, artifact, normal). We measured the number of episodes identified as false positive and reclassified as normal by the algorithm, and their proportion among all episodes. Results In 370 patients, ILRs recorded 3755 episodes including 305 patient-triggered and 629 with no ECG transmitted. 2821 episodes were analyzed by the novel algorithm, which reclassified 1227 episodes as normal rhythm. These reclassified episodes accounted for 43% of analyzed episodes and 32.6% of all episodes recorded. Conclusion A novel machine learning algorithm significantly reduces the quantity of episodes flagged as abnormal and typically reviewed by healthcare professionals. FUNDunding Acknowledgement Type of funding sources: None. Figure 1. ILR episodes analysis

scholarly journals A New Data-Driven Turbulence Model Framework for Unsteady Flows Applied to Wall-Jet and Wall-Wake Flows

2019 ◽  
Author(s):  
Chitrarth Lav ◽  
Jimmy Philip ◽  
Richard D. Sandberg
Keyword(s):  
Machine Learning ◽  
Mass Flow ◽  
Vortex Shedding ◽  
Learning Algorithm ◽  
Data Driven ◽  
Wall Jet ◽  
Machine Learning Algorithm ◽  
Length Scales ◽  
Wake Flows ◽  
The Impact

Abstract The unsteady flow prediction for turbomachinery applications relies heavily on unsteady RANS (URANS). For flows that exhibit vortex shedding, such as the wall-jet/wake flows considered in this study, URANS is unable to predict the correct momentum mixing with sufficient accuracy. We suggest a novel framework to improve that prediction, whereby the deterministic scales associated with vortex shedding are resolved while the stochastic scales of pure turbulence are modelled. The framework first separates the stochastic from the deterministic length scales and then develops a bespoke turbulence closure for the stochastic scales using a data-driven machine-learning algorithm. The novelty of the method lies in the use of machine-learning to develop closures tailored to URANS calculations. For the walljet/wake flow, three different mass flow ratios (0.86, 1.07 and 1.26) have been considered and a high-fidelity dataset of the idealised geometry is utilised for the sake of model development. This study serves as an a priori analysis, where the closures obtained from the machine-learning algorithm are evaluated before their implementation in URANS. The analysis looks at the impact of using all length scales versus the stochastic scales for closure development, and the impact of the extent of the spatial domain for developing the closure. It is found that a two-layer approach, using bespoke trained models for the near wall and the jet/wake regions, produce the best results. Finally, the generalisability of the developed closures is also evaluated by applying a given closure developed using a particular mass flow ratio to the other cases.

scholarly journals Harnessing Machine Learning Techniques for Mapping Aquaculture Waterbodies in Bangladesh

2021 ◽  
Vol 13 (23) ◽  
pp. 4890
Author(s):  
Hannah Ferriby ◽  
Amir Pouyan Nejadhashemi ◽  
Juan Sebastian Hernandez-Suarez ◽  
Nathan Moore ◽  
Josué Kpodo ◽  
...  
Keyword(s):  
Machine Learning ◽  
Rural Economy ◽  
Learning Algorithm ◽  
Google Earth ◽  
Machine Learning Techniques ◽  
Buffer Size ◽  
Improvement Strategy ◽  
Convolution Filter ◽  
Ground Truthing ◽  
The Impact

Aquaculture in Bangladesh has grown dramatically in an unplanned manner in the past few decades, becoming a major contributor to the rural economy in many parts of the country. National systems for the collection of statistics have been unable to keep pace with these rapid changes, and more accurate, up to date information is needed to inform policymakers. Using Sentinel-2 top of atmosphere reflectance data within Google Earth Engine, we proposed six different strategies for improving fishpond detection as the existing techniques seem unreliable. These techniques include: (1) identification of the best time period for image collection, (2) testing the buffer size for threshold optimization, (3) determining the best combination of image reducer and water-identifying indices, (4) introduction of a convolution filter to enhance edge-detection, (5) evaluating the impact of ground truthing data on machine learning algorithm training, and (6) identifying the best machine learning classifier. Each enhancement builds on the previous one to develop a comprehensive improvement strategy called the enhanced method for fishpond detection. We compared the results of each improvement strategy to known ground truthing fishponds as the metric of success. For machine learning classifiers, we compared the precision, recall, and F1 score to determine the quality of results. Among four machine learning methods studied here, the classification and regression trees performed the best with a precision of 0.738, recall of 0.827, and F1 score of 0.780. Overall, the proposed strategies enhanced fishpond area detection in all districts within the study area.

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