scholarly journals Dairy-Derived and Egg White Proteins in Enhancing Immune System Against COVID-19

2021 ◽  
Vol 8 ◽  
Author(s):  
Gaber El-Saber Batiha ◽  
Mohammed Alqarni ◽  
Dina A. B. Awad ◽  
Abdelazeem M. Algammal ◽  
Richard Nyamota ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Nutritional Intervention ◽  
Bioactive Components ◽  
Multiple Organs ◽  
Cell Immunity ◽  
Egg White Proteins ◽  
Pharmaceutical Industries ◽  
Dietary Components ◽  
The Impact ◽  
Global Health Challenge

Coronavirus disease (COVID-19) is a global health challenge, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) triggers a plethora of respiratory disturbances and even multiple organs failure that can be fatal. Nutritional intervention is one of the key components toward to a proper management of COVID-19 patients, especially in those requiring medication, and should thus be considered the first-line treatment. Immuno-modulation and -stimulation are currently being explored in COVID-19 management and are gaining interest by food and pharmaceutical industries. Various dietary combinations, bioactive components, nutrients and fortified foods have been reported to modulate inflammation during disease progression. Dietary combinations of dairy-derived products and eggs are gaining an increasing attention given the huge immunomodulatory and anti-inflammatory properties attributed to some of their chemical constituents. Eggs are complex dietary components containing many essential nutrients and bioactive compounds as well as a high-quality proteins. Similarly, yogurts can replenish beneficial bacteria and contains macronutrients capable of stimulating immunity by enhancing cell immunity, reducing oxidative stress, neutralizing inflammation and regulating the intestinal barriers and gut microbiome. Thus, this review highlights the impact of nutritional intervention on COVID-19 management, focusing on the immunomodulatory and inflammatory effects of immune-enhancing nutrients.

scholarly journals Impact of composted guava leaves and neem seeds on the growth and curcuminoid- and xanthorrhizol-yields of Curcuma zanthorrhiza RoxB

2020 ◽  
Vol 50 (9) ◽  
Author(s):  
Waras Nurcholis ◽  
Poppy Firzani Arifin ◽  
Taufik Ridwan ◽  
Raphael Susilowidodo ◽  
Irmanida Batubara ◽  
...  
Keyword(s):  
Leaf Length ◽  
Control Treatment ◽  
Practical Application ◽  
Bioactive Components ◽  
Treatment Results ◽  
Compost Application ◽  
Number Of Leaves ◽  
Pharmaceutical Industries ◽  
Guava Leaves ◽  
The Impact

ABSTRACT: The compost from the waste of pharmaceutical industries, such as guava leaves (GL) and neem seeds (NS) is used in organic agriculture. Curcuma zanthorrhiza RoxB. is a widely recognized herbal medicine that grows natively in Indonesia. Curcuminoids and xanthorrhizol are the primary bioactive components of C. zanthorrhiza. In this study, we aimed to evaluate the impact of GL and NS compost on the growth and bioactive yields of C. zanthorrhiza. Treatments consisted of cow manure, GL compost, NS compost, GL+NS compost, or a no compost control, at 2 and 4 kg per plant. Results demonstrated that the NS and GL+NS compost applied with 4 kg per plant had increased fresh rhizome yield compared with the other treatments. Composted NS at 2 kg per plant increased the plant height and pseudo stem diameter traits compared with the control treatment. The compost application of GL+NS at 2 and 4 kg per plant significantly increased the leaf length and number of shoots. All treatments showed unchanged the leaf width and number of leaves. The compost application of GL and NS (2 kg per plant) showed higher production of curcuminoidsthan the control. The compost consisting of GL (2 kg per plant), NS (4 kg per plant), and GL+NS also increased the production of xanthorrhizol compared with the control treatment. Results illustrated the practical application of GL and NS composts from industrial pharmaceutical extraction waste for the organic farming cultivation of C. zanthorrhiza.

Nutritional intervention promoting Mediterranean diet improves dietary intake and enhances score adherence in adolescent athletes

2020 ◽  
Vol 13 (3) ◽  
pp. 237-253
Author(s):  
Rokia Sahnoune ◽  
Malika Bouchenak
Keyword(s):  
Mediterranean Diet ◽  
Energy Intake ◽  
Nutritional Intervention ◽  
Fiber Intake ◽  
Adequate Intake ◽  
Total Proteins ◽  
Adolescent Athletes ◽  
24 Hour Recall ◽  
The Impact ◽  
Kidmed Index

BACKGROUND: Appropriate nutrition is important to maintain health, growth, and development of adolescent athlete performance. OBJECTIVE: To evaluate the impact of nutritional intervention (NI) promoting Mediterranean diet (MD), on food consumption, and adherence to MD, in scholar adolescent athletes. METHODS: Eighty athletes (Females/Males, 39/41) aged 15±1 years participated to NI. MD Adherence was assessed, using Kidmed index, at baseline, and at 6 months. Food intake was evaluated by 24-hour recall at baseline, and at four NI times. RESULTS: At baseline, 61% of athletes had poor MD adherence, and after NI, this value decreased to 10%. At 6 months of NI, 73% of males vs 46% of females had good MD adherence (≥8). Energy intake represented 2369 Kcal/d, at baseline, and was less than recommended value. After NI, significant increase was observed in energy intake (p = 0.001). Mean fiber intake (19 and 21 g/d in females and males, respectively) was less than adequate intake (26/38 g/d), but increased after NI (p = 0.000). Enhancement was noted in total, and complex carbohydrates, and total proteins, and values were increased with time (p = 0.000, p = 0.000, p = 0.003). CONCLUSION: Nutritional intervention, based on Mediterranean diet, improves total energy, and macronutrients intake, and increases MD adherence scores in adolescents athletes.

Chemical Constituents Isolated from Rhododendron ungernii with Antioxidant Profile

2019 ◽  
Vol 9 (3) ◽  
pp. 238-243 ◽  
Author(s):  
Emine Dede ◽  
Nusret Genc ◽  
Mahfuz Elmastas ◽  
Huseyin Aksit ◽  
Ramazan Erenler
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Reducing Power ◽  
Scavenging Activity ◽  
Isolation And Identification ◽  
Reduced Pressure ◽  
Scavenging Effect ◽  
Pharmaceutical Industries ◽  
Dpph Scavenging

Background: Plant in Rhododendron genus that contains phenolic compounds has been used in traditional medicine and revealed considerable biological activities. Objective: Isolation and identification of antioxidant natural products from Rhododendron ungernii. Methods: Rhododendron ungernii Trautv. flowers were collected and dried in shade. The dried flowers were extracted with methanol for 3 days. The solvent was removed by reduced pressure to yield the extract which was subjected to column chromatography (Sephadex LH-20, C18 reversed phase column) to isolate catechin-7-O-glucoside (1), quercetin-3-O-β-galactoside (2), quercetin-3-O- β-xyloside (3), farrerol (4), myricetin (5), and quercetin (6). The structures of isolated compounds were elucidated by spectroscopic methods such as 1D-NMR, 2D-NMR, and LC-TOF/MS. DPPH scavenging effect, ABTS+ scavenging activity, and reducing power (FRAP) were performed for antioxidant assays of isolated natural compounds. Results: Isolated flavonoids displayed the outstanding antioxidant activities. Catechin-7-O-glucoside (1) and quercetin-3-O-β-galactoside (2) (IC50, 3.66 µg/mL) had the most DPPH• scavenging effect among the compounds. The highest ABTS•+ scavenging activity (IC50, 1.41 µg/mL) and reducing power effect (6.05 mmol TE/g comp) were observed for myricetin (5). Conclusion: R. ungernii extract and isolated compounds could be a promising antioxidant for food and pharmaceutical industries.

scholarly journals 10.B. Workshop: Corporate influence on science – what is happening and what can be done?

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
◽  
Keyword(s):  
Fossil Fuels ◽  
Conflicts Of Interest ◽  
Research Process ◽  
Policy Outcomes ◽  
Policy And Practice ◽  
Industry Funding ◽  
Corporate Influence ◽  
Pharmaceutical Industries ◽  
The Impact ◽  
Funding Research

Abstract The role of the corporate sector in research sponsorship is growing. So too is the evidence that corporations whose products are potentially damaging to health or the environment influence science and the ways in which science is used in policy and practice. Such efforts are a key part of corporate attempts to maintain or increase the consumption or use of industry products, and to secure favourable policy outcomes. The products and practices of corporations are responsible for a growing proportion of the global disease burden. Non-communicable diseases, many driven by consumption of unhealthy commodities and exposure to chemicals, account for over 73 percent of global deaths. It is increasingly important to understand the complex and multifaceted ways corporations seek to influence science; the impact these strategies have; and the ways this influence can be addressed. This workshop brings together global experts to explore these issues. Drawing on examples from several industries (e.g. tobacco, alcohol, food, and pharmaceuticals), it aims to: Increase understanding of the ways corporations whose products are potentially damaging to health influence science. We present a newly developed, evidence-based typology which draws together the vast existing literature in this field, to present a simplified way of understanding corporate influence on science. Delegates will be provided with materials that provide a means for recognising such influence.Examine the influence that corporations have on the first stage in the research process - research agendas. We present examples from tobacco, food and pharmaceutical industries which illustrate the mechanism through which industry funding of science drives researchers to study questions that are favourable to industry. The desired outcome is to maximise research on the benefits of industry products (positioning these products as solutions to complex problems), minimise research on the harms of their products, support their policy and legal positions, and impede potential regulation of their products.Increase awareness of the involvement that corporations have had in altering the mechanisms though which science is used in policymaking. Delegates will hear how corporations promoted and embedded policymaking reforms which increase reliance on and provide a conduit for industry-favourable science.Suggest ways forward concerning management of conflicts of interest in the publication of health research. Here we will discuss the roles that journals can play in governing conflicts of interest and issues of transparency in the publication of academic research.Suggest ways forward for funding research on unhealthy commodities. We present criteria for tobacco industry-supported research funding programs, and discuss the applicability of similar programs for funding research on other unhealthy commodities, and on the practices of other industries such as the fossil fuels industry. Key messages Corporations have been seen to skew evidence bases, manipulate interpretations of science, and influence use of science in policy and practice – such influence is a major threat to public health. This workshop exposes industry tactics in this area and begins to identify ways for dealing with them.

scholarly journals Physicochemical indicators of the influence of a lined municipal landfill on groundwater quality: a case study from Poland

2021 ◽  
Vol 80 (13) ◽  
Author(s):  
Grzegorz Przydatek ◽  
Włodzimierz Kanownik
Keyword(s):  
Groundwater Quality ◽  
Chemical Constituents ◽  
The European Union ◽  
Soil Medium ◽  
Detailed Statistical Analysis ◽  
Pollutant Migration ◽  
Leachate Water ◽  
The Impact ◽  
Carbon Concentrations

AbstractThe paper aims to determine the most significant physicochemical indicators of the effects that a lined landfill in southern Poland has had on groundwater quality. The results of the tests of groundwater and leachate water from the landfill for the period 2009 to 2016 were subjected to a detailed statistical analysis based on the 10 physicochemical parameters. A factor analysis was conducted considering the European Union and national requirements for landfills using analytical and statistical tools. The leachate contamination indicators from a landfill were analysed to reveal their interaction with the groundwater. The assessment indicated that there was an elevated and statistically significantly higher electrical conductivity and copper and total organic carbon concentrations in groundwater hydraulically downgradient of the landfill. The assessment also indicated that there were significant differences in the correlations between chemical parameters downgradient of the landfill and that there was a trend of increasing concentrations of some chemical constituents in groundwater. The adverse effects of the landfill were due to the deposited amount of waste exceeding 10 Mg per day. The impact was noticeable despite low and decreasing concentrations of heavy metals (Hg, Cu, Cd, Pb and Zn) in the leachate. The deterioration of the chemical state of the groundwater in the landfill vicinity could result in the extended time of pollutant migration or mass transport in the irrigated soil medium due to the limited efficiency of the leachate intake system or sealing screen after more than 20 years of landfill operation.

SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context of the Possible Therapeutic Strategies

2021 ◽  
Vol 22 ◽  
Author(s):  
Poornima Gopi ◽  
TR Anju ◽  
Vinod Soman Pillai ◽  
Mohanan Veettil
Keyword(s):  
Virus Infection ◽  
Host Cell ◽  
Metabolic Pathways ◽  
Inflammatory Responses ◽  
Membrane Lipid ◽  
Therapeutic Strategies ◽  
Metabolic Reprogramming ◽  
Multiple Organs ◽  
The Cross ◽  
The Impact

: Novel coronavirus, SARS-CoV-2 is advancing at a staggering pace to devastate the health care system and foster the concerns over public health. In contrast to the past outbreaks, coronaviruses aren’t clinging themselves as a strict respiratory virus. Rather, becoming a multifaceted virus, it affects multiple organs by interrupting a number of metabolic pathways leading to significant rates of morbidity and mortality. Following infection they rigorously reprogram multiple metabolic pathways of glucose, lipid, protein, nucleic acid and their metabolites to extract adequate energy and carbon skeletons required for their existence and further molecular constructions inside a host cell. Although the mechanism of these alterations are yet to be known, the impact of these reprogramming is reflected in the hyper inflammatory responses, so called cytokine storm and the hindrance of host immune defence system. The metabolic reprogramming during SARS-CoV-2 infection needs to be considered while devising therapeutic strategies to combat the disease and its further complication. The inhibitors of cholesterol and phospholipids synthesis and cell membrane lipid raft of the host cell can, to a great extent, control the viral load and further infection. Depletion of energy source by inhibiting the activation of glycolytic and hexoseamine biosynthetic pathway can also augment the antiviral therapy. The cross talk between these pathways also necessitates the inhibition of amino acid catabolism and tryptophan metabolism. A combinatorial strategy which can address the cross talks between the metabolic pathways might be more effective than a single approach and the infection stage and timing of therapy will also influence the effectiveness of the antiviral approach. We herein focus on the different metabolic alterations during the course of virus infection that help to exploit the cellular machinery and devise a therapeutic strategy which promotes resistance to viral infection and can augment body’s antivirulence mechanisms. This review may cast the light into the possibilities of targeting altered metabolic pathways to defend virus infection in a new perspective.

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