scholarly journals Clinical Characteristics of Personality and Conduct Disorders in Child Patients With Vasovagal Syncope: A Clinical Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Tao Wang ◽  
Fang Wang ◽  
Yifei Li ◽  
Xiaoqing Shi ◽  
Hongyu Duan ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Child Behavior Checklist ◽  
Pediatric Patients ◽  
Vasovagal Syncope ◽  
Conduct Disorders ◽  
Control Group ◽  
Eysenck Personality Questionnaire ◽  
Healthy Children ◽  
Child Patients ◽  
Control Study

Objective: To analyze the clinical characteristics of abnormal personality and conduct disorders (CDs) in pediatric patients with vasovagal syncope (VVS).Methods: In this study, we recruited patients diagnosed with VVS at Children's Heart Center from January 2018 to December 2020. Healthy children were recruited as controls. The Eysenck Personality Questionnaire-Child edition (EPQ-C) and Achenbach Child Behavior Checklist (CBCL) were used for the assessment.Results: One hundred and fifty-one VVS patients and 151 healthy controls were included in this study. Compared with the control group, patients in the VVS group had a higher incidence of abnormal personality and were more prone to suffer from CDs. Moreover, pediatric patients with VVS suffered more events of syncope recurrence if they had CDs.Conclusion: Abnormal personality and CDs are common clinical characteristics in pediatric patients with VVS.

scholarly journals Emotional health in children and adolescents with cystic fibrosis

PRILOZI ◽  
2016 ◽  
Vol 37 (1) ◽  
pp. 65-74
Author(s):  
Nada Pop-Jordanova ◽  
Aneta Demerdzieva
Keyword(s):  
Cystic Fibrosis ◽  
Primary Schools ◽  
Child Behavior Checklist ◽  
Emotional Health ◽  
Family Members ◽  
Control Group ◽  
Eysenck Personality Questionnaire ◽  
Healthy Children ◽  
Psychometric Instruments ◽  
Gastrointestinal Problems

Abstract Although modern therapeutic procedures have considerably improved the survival and the quality of life of children with cystic fibrosis, the relevant psychological aspects have been still insufficiently considered similarly to the other chronic diseases. The aim of this research was to evaluate the emotional health: psychological characteristics and adjustment of CF children and their family coping. The study comprises 25 CF children, mean age 13.13 ± 2.29 years (23 boys and only 2 girls), selected from total 60 actually treated children for CF. Children were examined in the period of improved health conditions (without superinfection, wheezing or gastrointestinal problems). Obtained results are compared with a control group of 25 healthy children of the same age, selected by random from primary schools. The psychometric instruments used were: Kohs Design Test, Child Behavior Checklist, Eysenck Personality Questionnaire, General Anxiety Scale, Emotional Profile Index, MMPI-201 and Human Values Test, together with two projective tests of drawing (Machover and Corman). The unexpected good psychological results obtained from psychometric instruments could be explained by the fact that CF children accept the real situation and express vivacity. However, their deep feelings of fear impose on them high level of self-control and resistance. The results obtained for CBCL presented CF children as immature, with accentuated aggressiveness in interpersonal relations. The most important problem is related to the delay of puberty changes, leading to low self-esteem. Generally, family members cope relatively well with the disease in children, in spite to discrepancies in mother/child reports for child psychopathology. Divorces also occurred in some families. Psychological support for both, children and family members are necessary. The need for a holistic approach in the assessment and treatment, including biofeedback techniques was pointed out.

scholarly journals Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Melek Pehlivan ◽  
Tülay K. Ayna ◽  
Maşallah Baran ◽  
Mustafa Soyöz ◽  
Aslı Ö. Koçyiğit ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Disease Risk ◽  
Polymerase Chain Reaction Method ◽  
Control Group ◽  
Healthy Children ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Allele Specific ◽  
And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

The Diagnostic Value of Blood and Urine IP-10 Test in Children Having Active Tuberculosis or Latent Tuberculosis Infection

2021 ◽  
Author(s):  
Salim Can ◽  
Ayse Sahin ◽  
Nazan Dalgic ◽  
Deniz Aygün
Keyword(s):  
Pediatric Patients ◽  
Latent Tuberculosis ◽  
Diagnostic Value ◽  
Active Tuberculosis ◽  
Control Group ◽  
Healthy Children ◽  
Combined Use ◽  
Latent Tb ◽  
Inducible Protein ◽  
Latent Tb Infection

Abstract Objective This study aimed to investigate interferon-gamma-inducible protein-10 (IP-10) values in serum and urine in pediatric patients in the diagnosis of active tuberculosis (TB) or latent TB infection (LTBI). It also aimed to investigate whether it can be used as a biomarker to distinguish between active TB and LTBI. Methods Our study comprised active TB (25 patients), LTBI (25 patients), and the “infected” group (50 patients) formed by combining the two groups. As the control group, 37 healthy children were included in the study. TB skin test, plasma IP-10, and urine IP-10 measurements were performed in all patients included in the study. An additional QuantiFERON-TB Gold In-Tube (QFT-GIT) test was performed on patients evaluated as active TB or LTBI. Results Plasma IP-10 levels of the patients in the active TB, LTBI, and the “infected” groups were significantly higher than the control group (p = 0.022, p = 0.028, and p = 0.007, respectively). Urine IP-10 was successful in distinguishing the active TB and “infected” groups from the control group (p = 0.007 and p = 0.047, respectively). Also, in the combined use of the tests, when QFT-GIT and urine IP-10 were positive together, active TB and LTBI could be distinguished (p = 0.044). Urine IP-10 levels were found to be significantly higher in those with pulmonary TB than those with extrapulmonary TB (p = 0.012). Conclusion Our findings suggest that IP-10 can be used as a useful biomarker in the diagnosis of active TB in children.

scholarly journals Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Otchere Addai-Mensah ◽  
Daniel Gyamfi ◽  
Francis Agyei Amponsah ◽  
Max Efui Annani-Akollor ◽  
Kwabena Owusu Danquah ◽  
...  
Keyword(s):  
Antibody Production ◽  
Case Control Study ◽  
Venous Blood ◽  
Sandwich Elisa ◽  
Full Blood Count ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Malaria Microscopy ◽  
Control Study

Introduction. The pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes, as well as inadequate erythropoiesis, has been proposed. Circulating antierythropoietin (anti-EPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice. However, studies on this association have not been investigated in humans. This study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans.Methods. A total of 86 children aged 1-10 years (57 children with malaria serving as the case group and 29 healthy children serving as control), all residents of Duayaw Nkwanta, Ghana, were recruited for this case-control study. Venous blood was collected for thick and thin films for malaria microscopy, full blood count by automated haematology analyzer, and antierythropoietin antibody and erythropoietin estimation by sandwich ELISA method.Results. Out of the 86 participants recruited, only 3 (3.5%) were positive for anti-EPO antibody; 2.3% of the case group; and 1.2% of the control group. There was no association between the cases and the controls in the production of anti-EPO antibodies. Erythropoietin concentration was significantly higher in malaria-related anaemic subjects (p=0.032).Conclusion. Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia.

scholarly journals Association of Interleukin-6-174 G/C Gene Promotor Polymorphism with Rheumatoid Arthritis in Adolescence Age Group: A Case-control Study

2021 ◽  
Author(s):  
Sergei Egorovich Khalchitsky ◽  
Marina Vanikovna Sogoyan ◽  
Alexei Nicolaevich Kozhevnikov ◽  
Sergei Valentinovich Vissarionov ◽  
Alexei Georgievich Baindurashvili
Keyword(s):  
Rheumatoid Arthritis ◽  
Real Time ◽  
Case Control Study ◽  
Case Control ◽  
European Population ◽  
Control Group ◽  
Healthy Children ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Introduction: Rheumatoid Arthritis (RA) is a chronic autoimmune disease with unknown pathogenesis. The disease is multifactorial, however, the exact causes of the occurrence, as well as the targets of the autoimmune process, are unknown. Genes candidate for a predisposition to RA are cytokine genes. Of the cytokines, IL-6 is considered a key mediator of systemic and localized inflammation in RA. Aim: The comparative analysis of the frequency distribution of alleles and genotypes IL-6 -174G/C polymorphism in patients with RA and in the control group to determine the genotype most characteristic of this disease. Materials and Methods: This case-control study was conducted in a group of 136 children with RA aged 14 to 18 years. In the control group, there were 143 practically healthy children of similar age without RA and orthopedic pathology. Both groups were tested for polymorphism IL-6 -174G/C using real-time Polymerase Chain Reaction (real-time PCR). The results were statistically processed using the Pearson's Chi-square test. Results: The distribution of -174G/C genotypes in the IL-6 gene is significantly different in patients with RA when compared with the control group. In patients with RA, heterozygous carriers of -174G/C (52.94%) prevail, while in the control group the most numerous group are homozygous carriers of -174G/G (40.56%). Conclusion: As a result of this study, it was possible to identify significant differences in the distribution of the genotypes -174 G/C polymorphism in the IL-6 gene between patients with RA and subjects of the control group. In relation to the European population of the Russian Federation, this polymorphism can serve as a diagnostic marker in the study of the pathogenesis of RA.

The Effect of Ketogenic Diet on Neutrophil Count

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
May Fouad Nassar ◽  
Yasmin Gamal Abdou El Gendy ◽  
Mohamed Tarif Hamza ◽  
Marwa Nasser Mohamed ◽  
Nesrine Radwan
Keyword(s):  
Ketogenic Diet ◽  
Neutrophil Count ◽  
Case Control Study ◽  
Control Group ◽  
Healthy Children ◽  
Drug Resistant ◽  
Immunological Profile ◽  
Increased Risk ◽  
Low Carbohydrate ◽  
Control Study

Abstract Background The Ketogenic Diet (KD) is a high-fat, low-carbohydrate, and adequate-protein diet and a well-established treatment option for drug resistant childhood epilepsies. Neutrophils are important component of humans` innate phagocytic defense which usually arrive first at sites of infection and/or inflammation. Objectives The objective of this study was to assess the effect of ketosis induced by KD on neutrophils count. Methods This case control study was done in the Ketoclinic, Children’s Hospital, Ain Shams University, during the period of May 2018 till December 2019. It included 21 patients and 9 age and sex matched healthy children as a control group. Neutrophil counts were measured in both patients and controls both initially and after 6 months of KD usage. Results Although three patients reported increased incidence of infection after commencement of KD, the current study showed no significant change in the neutrophil count in studied patients compared to the controls after 6 months of KD. Conclusion KD has no effect on neutrophil number, however, further detailed studies for the full immunological profile including their function is needed to ensure that patients receiving this line of therapeutic nutrition aren`t susceptible to increased risk of infections.

Measuring the Impact of Quality of Life of Children Treated for Orofacial Clefts: A Case-Control Study

2013 ◽  
Vol 37 (4) ◽  
pp. 381-384 ◽  
Author(s):  
PN Tannure ◽  
FMM Soares ◽  
EC Küchler ◽  
LG Motta ◽  
MC Costa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Case Control ◽  
Control Group ◽  
Healthy Children ◽  
Previously Treated ◽  
Control Study

Objective: The aim of this study was to assess the quality of life (QoL) of children previously treated for cleft lip and/or palate (CL/P) and compare with non-cleft children. Method: A case-control study with 70 children between 5 and 12 years old was carried out. The case group consisted of 35 individuals previously treated for non-syndromic CL/P and presently receiving assessment at a rehabilitation hospital in Brazil. The children had received primary surgical treatment for CL/P reconstruction during early childhood. The control group consisted of 35 healthy children selected to ensure close similarity to the cleft group in age, gender and socioeconomic status. QoL was measured using the AUQEI questionnaire. Results: Cleft lip and palate had no significant influence on the QoL in children (p=0.44). A higher percentage of the cleft lip and palate group of children reported a lower QoL than the cleft lip or cleft palate groups. Gender had no significant difference on the quality of life in CL/P children (p=0.2) and in control group (p=1.0). Conclusion: The QoL in children with CL/P was found to be similar to the non-cleft group. Our results confirm that clefts repaired during earlier childhood associated with a health care program, including psychological support, is beneficial for CL/P children.

scholarly journals Influence of Organized vs Non Organized Physical Activity on School Adaptation Behavior

2020 ◽  
Vol 11 ◽  
Author(s):  
Adrian A. Mosoi ◽  
Jürgen Beckmann ◽  
Arash Mirifar ◽  
Guillaume Martinent ◽  
Lorand Balint
Keyword(s):  
Physical Activity ◽  
Conduct Disorders ◽  
Test System ◽  
Physical Activity Program ◽  
Control Group ◽  
Eysenck Personality Questionnaire ◽  
School Behavior ◽  
Sensorimotor Coordination ◽  
Positive Effects ◽  
Activity Program

It is now well-established that physical activity has positive effects on both physical and mental health. However, the influence of organized physical activity (i.e., programs controlled and supervised by a trainer) on school adaptive behavior of adolescents with disabilities and/or behavioral disorders remains unclear. School behavior adaptation involves the ability to learn, conform to school norms and manage school activities without major behavior conflicts. A cross-sectional study was conducted to test the differences between organized physical activity and non-organized physical activity in an after school program. Eighty Romanian adolescents were recruited and allocated to three groups: (a) with disabilities [Ds; N = 17, Mage = 14.55 years (SD = 1.16), 12 males and 5 females], (b) with conduct disorders [CDs, N = 21, Mage = 14.52 years (SD = 1.11) 16 males and 5 females], and (c) participants who had not shown signs of conduct disorders or disabilities [as a control group; N = 42, Mage = 14.2 years (SD = 0.46) 20 males and 22 females]. Personality traits, school behavior, and sensorimotor coordination were assessed by using the Eysenck personality questionnaire—junior scale, school in-adaptability questionnaire scale, and Vienna Test System Sport (SMK—sensorimotor coordination test) respectively. Multivariate analysis of variance MANOVA (3 × 3) and discriminant analysis were used to examine differences between the psychological and sensorimotor coordination outcomes across three groups and three types of physical activity context: (a) organized physical activity, (b) non-organized physical activity, and (c) no physical activity. The findings indicate that not participating in an organized physical activity program results in a reduced level of physical mobility and consequently is associated with maladaptive social and psychological outcomes. Thus, we argued that attending in an organized physical activity program is more beneficial for participants with disabilities and/or behavior disorders, due to an increase in the probability of school integration and development of their motor skills. Clearly more research is needed in order to investigate these effects in neurophysiological levels.

scholarly journals Six-Minute Walk Test in Pediatric Cardiac Patients

2017 ◽  
pp. 13-17
Author(s):  
Mohammed Sayed Elyan ◽  
Salah El-din Amry Ahmed ◽  
Hekma Saad Farghaly
Keyword(s):  
Functional Capacity ◽  
Chronic Conditions ◽  
Pediatric Patients ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cardiac Diseases ◽  
Healthy Children ◽  
Cross Sectional ◽  
Daily Life Activities ◽  
One Year

Background The 6MWT (6MWT) is a self-paced walking test generally used to assess the functional capacity in people with chronic conditions the main outcome is the distance that a person can walk in 6 minutes. The 6 MWT is originally developed to measure the submaximal level of functional capacity in adult patients with moderate to severe heart or lung diseases and has been extensively used in other patient populations. Because the test reflects an exercise level close to that of daily life activities, it is easy to administer, is well tolerated by patients, and is increasingly being used as a functional outcome measure for people with chronic conditions, including pediatric populations. Patients and methods Our study is a cross sectional study to discuss the effect of cardiac diseases on the functional capacity of pediatric patients suffering from cardiac diseases compared with control group via 6MWT. The study included pediatric patients admitted to pediatric cardiology unit at Assiut University children hospital from age of 5 to 18 years at duration of one year from 1/8/2016 to 31/7/2017. The Patients One hundred cases (100) cases (52 males and 48 females) were suffering from cardiac diseases (42 suffering from CHD, 38 suffering from RHD and remaining 20 cases suffering from cardiomyopathy). The Control Hundred healthy children (50 males and 50 females). From primary, preparatory and secondary schools from the same age category of the patients. Results: 34 cases of congenital adrenal hyperplasia were included, of whom 8 cases were newly diagnosed on admission while 26 cases were previously diagnosed and came for follow up, 41.2% were males, 58.8% were females.

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