scholarly journals Association of Interleukin-6-174 G/C Gene Promotor Polymorphism with Rheumatoid Arthritis in Adolescence Age Group: A Case-control Study

2021 ◽  
Author(s):  
Sergei Egorovich Khalchitsky ◽  
Marina Vanikovna Sogoyan ◽  
Alexei Nicolaevich Kozhevnikov ◽  
Sergei Valentinovich Vissarionov ◽  
Alexei Georgievich Baindurashvili
Keyword(s):  
Rheumatoid Arthritis ◽  
Real Time ◽  
Case Control Study ◽  
Case Control ◽  
European Population ◽  
Control Group ◽  
Healthy Children ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Introduction: Rheumatoid Arthritis (RA) is a chronic autoimmune disease with unknown pathogenesis. The disease is multifactorial, however, the exact causes of the occurrence, as well as the targets of the autoimmune process, are unknown. Genes candidate for a predisposition to RA are cytokine genes. Of the cytokines, IL-6 is considered a key mediator of systemic and localized inflammation in RA. Aim: The comparative analysis of the frequency distribution of alleles and genotypes IL-6 -174G/C polymorphism in patients with RA and in the control group to determine the genotype most characteristic of this disease. Materials and Methods: This case-control study was conducted in a group of 136 children with RA aged 14 to 18 years. In the control group, there were 143 practically healthy children of similar age without RA and orthopedic pathology. Both groups were tested for polymorphism IL-6 -174G/C using real-time Polymerase Chain Reaction (real-time PCR). The results were statistically processed using the Pearson's Chi-square test. Results: The distribution of -174G/C genotypes in the IL-6 gene is significantly different in patients with RA when compared with the control group. In patients with RA, heterozygous carriers of -174G/C (52.94%) prevail, while in the control group the most numerous group are homozygous carriers of -174G/G (40.56%). Conclusion: As a result of this study, it was possible to identify significant differences in the distribution of the genotypes -174 G/C polymorphism in the IL-6 gene between patients with RA and subjects of the control group. In relation to the European population of the Russian Federation, this polymorphism can serve as a diagnostic marker in the study of the pathogenesis of RA.

scholarly journals Anatomical Evaluation of Mandibular Bone Cortex in Patients with Mucopolysaccharidosis: A Case-Control Study

2021 ◽  
pp. 15-22
Author(s):  
Cledinaldo Lira Junior ◽  
Diego Henrique Pires Gonçalves ◽  
Kamilly de Lourdes Ramalho Frazão ◽  
Sandra Aparecida Marinho ◽  
Sérgio Henrique Gonçalves De Carvalho ◽  
...  
Keyword(s):  
Case Control Study ◽  
Panoramic Radiograph ◽  
Case Control ◽  
Control Group ◽  
Chi Square ◽  
Mandibular Bone ◽  
Exact Test ◽  
Significant Difference ◽  
Chi Square Test ◽  
Control Study

Aims: To evaluate the mandibular bone cortical of patients with mucopolysaccharidosis on panoramic radiograph, through radiomorfometric indices. Study Design: Case-control study. Place and Duration of Study: Sample: Department of Diagnostic Imaging of the Universidade Estadual da Paraíba, Campus VIII, in the city of Araruna, PB, between January and December of 2015. Methodology: Panoramic radiographs of sixteen patients with mucopolysaccharidosis and 32 controls, organized by gender and age, composed the sample. The mandibular panoramic index, gonial index, antegonial index and mental index were evaluated. Pearson's Chi-square test, Fisher's exact test and Mann-Whitney test were used to statistical analysis with a level of significance of 5.0%. Results: Mucopolysaccharidosis patients were mostly female (62.5%), with a mean age of 12.31 + 7.16 years, MPS VI (50.0%) being the most prevalent. Patients with mucopolysaccharidosis had higher values in the gonial (1.86+0.48), the antegonical (4.36+1.24) and the mental (5.24+1.21). However, only the antegoniac index presented a significant difference (P=0.047). Conclusion: The antegoniac index was higher in patients with mucopolysaccharidosis and the other radiomorphometric measures were similar to those observed in the control group. Apparently, mucopolysaccharidosis is not related to decreased bone to mandibular quality.

scholarly journals Do diabetes and family history influence the rheumatoid arthritis? - results from a case-control study

1970 ◽  
Vol 10 (4) ◽  
pp. 230-234
Author(s):  
MM Efterkharian ◽  
Z Basiri ◽  
KM Kashani
Keyword(s):  
Rheumatoid Arthritis ◽  
Family History ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Diabetes Family History ◽  
And Control ◽  
Control Study

Introduction: Up to now, several studies have been performed about the role of different factors on incidence and severity of Rheumatoid arthritis (RA) in the world. This 2009 study was carried out to investigate the association between History of diabetes and Family history of RA with RA incidence in Hamedan, a western city of Iran. Methods: As a case-control study, information from 128 cases and 130 controls, matched for age and Sex, were collected by questionnaire and analyzed using SPSS (chi-square test). Results: In case and control groups, females were 116 and 118 persons respectively and the rest were males. Statistical analysis showed that there is significant and no significant association between Family history of RA and history of diabetes with RA respectively. Conclusion: Considering previous global investigations on these topics and the results of our study, it seems that more studies will be needed to describe the association between history of diabetes and RA, but about another checked risk factor, there is a definite significant association between family history of RA and RA. Keywords: Rheumatoid arthritis; diabetes; family history; risk factors. DOI: http://dx.doi.org/10.3329/bjms.v10i4.9492 BJMS 2011; 10 (4): 230-234

scholarly journals Is There a Relation between ABO Blood Groups and Clinical Outcome in Patients with Pemphigoid? A Case-Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sedigheh Bakhtiari ◽  
Parviz Toosi ◽  
Somayyeh Azimi ◽  
Nafiseh Esmaili ◽  
Ali Montazami ◽  
...  
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Control Group ◽  
Abo Blood Groups ◽  
Chi Square ◽  
Chi Square Test ◽  
Group B ◽  
Control Study

Background.Relationship between blood groups and dermatologic diseases remains controversial and was not yet fully elucidated nor explained clearly. The aim of this study was to examine if any relation exists between different types of pemphigoid diseases and ABO blood group.Methods.In this case-control study, 159 pemphigoid patients and 152 healthy matched-controls were evaluated. All blood group (including Rh status) data for the study was obtained from the hospital medical records. Statistical comparisons were completed with chi-square test and logistic regression.Results.Blood group “O” was found in 32.9% of patients and 38.2% of control group. Blood group “A” was found among 30.8% of patients and 34.2% of control group, while group “B” was reported in 27.4% of cases and 21.1% of controls and “AB” was identified among 8.9% of patients and 6.6% of control group. 84.9% of patients were Rh positive, while in the control group 86.2% of patients were Rh positive. No significant differences were found regarding ABO blood groups (P=0.46) or Rh (P=0.76) between pemphigoid patients and control group. Also, older females had the higher risk of developing bullous pemphigoid.Conclusion.We found no relationship between ABO blood groups and pemphigoid disease.

scholarly journals PERILAKU PENCEGAHAN PENYAKIT TERHADAP KEJADIAN SKABIES PADA SANTRI DI PONDOK PESANTREN AL-FALAH PUTERA BANJARBARU

2017 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Anna Maulina Kustantie ◽  
Kurnia Rachmawati ◽  
Musafaah Musafaah
Keyword(s):  
Disease Prevention ◽  
Disease Transmission ◽  
Case Control Study ◽  
Boarding School ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

ABSTRAKSkabies adalah penyakit kulit menular yang disebabkan oleh infestasi Sarcoptes scabies. Perilaku kesehatan mencakup yang termasuk perilaku untuk tidak menularkan penyakit kepada orang lain. Tujuan penelitian adalah untuk mengetahui hubungan perilaku pencegahan penyakit terhadap kejadian skabies pada santri di pondok pesantren Al-Falah Putera Banjarbaru. Metode penelitian adalah retrospektif (case control study), pada santri berasrama di pondok pesantren Al-Falah Putera Banjarbabaru. Responden dibagi dalam 2 kelompok yakni kelompok kasus (n=36) dan kelompok kontrol (n=36). Instrumen yang digunakan berupa kueisioner perilaku pencegahan penyakit skabies. Hasil penelitian didapatkan perilaku pencegahan penyakit skabies dengan cara tidak bertukar pakaian dan alat sholat dalam kategori baik yaitu sebanyak 52 santri (72,2%), tidak bergantian handuk dalam kategori baik adalah sebanyak 59 santri (81,9%), dan menjaga kebersihan tempat tidur dalam kategori baik yaitu sebanyak 52 santri (72,2%). Hasil uji Chi Square terkait perilaku pencegahan penyakit skabies dengan cara tidak bertukar pakaian dan alat sholat, tidak bergantian handuk, dan menjaga kebersihan tempat tidur p=0,792, p=1,000, p=0,066 secara berurutan.Kata-kata kunci : perilaku pencegahan penyakit, skabies, santri. ABSTRACTScabies is a contagious skin disease caused by infestations of Sarcoptes scabies. Health promotion behavior including of disease prevention behaviors which means avoiding disease transmission. The objective of this study was to determine the relationships between disease prevention behaviors and scabies incidence on students at saAl-Falah Putera’s boarding school Banjarbaru. The methods of this study was a retrospective study (case control study), toward the boarding students at the boarding school Al-Falah Putera’s Banjarbabaru. Respondents were divided into 2 groups: the case group (n = 36) and control group (n = 36). The instrument used in the form of a questionnaire the behavior of scabies disease prevention. The result of this study showed that behavioral scabies prevention of disease by not exchanging clothes and prayer tools in both categories as many as 52 students (72.2%), not alternating towels in both categories are as many as 59 students (81.9%), and maintain the cleanliness of the beds in both categories as many as 52 students (72.2%). The Results of Chi Square test related to scabies disease prevention behaviors by not exchanging clothes and tools prayer, not alternating towel and maintain the cleanliness of the bed showed p= 0.792, p= 1.000, p= 0.066 respectively. Keywords: disease prevention behaviors, scabies, students.

scholarly journals DETERMINANTS OF DEPRESSION IN FEMALE ADOLESCENTS AND YOUTH

2008 ◽  
Vol 15 (01) ◽  
pp. 137-142
Author(s):  
SAIRA AFZAL ◽  
TASNEEM FATIMA RANA ◽  
SHAHID MEHMOOD
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Female Adolescent ◽  
Control Group ◽  
Chi Square ◽  
Psychosocial Determinants ◽  
Young Females ◽  
Child Bearing ◽  
Chi Square Test ◽  
Control Study

Introduction: Adolescents and youth are the main human resource for a nation. Depression is a grave yard for hopes and prosperity making the generation sad, inactive, and having suicidal thoughts. Thus every effort should be made to create awareness and eliminate depression from our youth. Objective: To find out the psychosocial determinants of depression in female adolescent and youth. Design: Case control study. Place and duration: Lahore cant urban area, from March, 2007 to July, 2007. Material and methods: It was a community based case control study. Total 400 young females were selected. 200 cases of depression and 200 in the control group. An interview schedule including a structured, pre-tested and bilingual questionnaire was used after taking consent. SPSS and Epi info were used for data analysis. Chi square test was applied. Results: In this study the depression in adolescent and young females had statistically significant relationship with unemployment, underage marriage, early child bearing, infertility, violence, sexual harassment(p<0.05). The family history of psychiatric ill ness in first degree relatives had no statistically significant association with depression in these females (p>0.05). Conclusion: The statistically significant psychosocial determinants of depression in young and adolescent females should be rectified by creating awareness in the society

HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Pelvic Organ Prolapse ◽  
Case Control Study ◽  
Pelvic Organ ◽  
Case Control ◽  
T Test ◽  
Pelvic Organ Prolapse Quantification ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

scholarly journals Analisis Faktor Fetus dan Tali Pusat terhadap Risiko Asphyxia Perinatal di Surakarta

2020 ◽  
Vol 3 (1) ◽  
pp. 16
Author(s):  
Siti Lestari ◽  
Dyah Dwi Astuti ◽  
Fachriza Malika Ramadhani
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Perinatal Asphyxia ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
Chi Square ◽  
Fetal Position ◽  
Control Study

Asfiksia perinatal merujuk pada kekurangan oksigen selama persalinan, sehingga berpotensi menyebabkan kematian dan kecacatan. WHO memperkirakan  4 juta anak terlahir dengan asfiksia setiap tahun, dimana 1 juta di antaranya meninggal dan 1 juta anak bertahan hidup dengan gejala sisa neurologis yang parah. Penelitian ini bertujuan untuk menganalisis faktor risiko fetal dan tali pusat pada asfiksia neonatal.Penelitian dilakukan di lakukan di RS Dr Moewardi Surakarta dengan pendekatan  quantitative retrospective case control study. Data diambil dari rekam medis antara  tahun 2013-2018. Penelitan ini melibatkan  264 neonatal yang terdiri dari 88 kelompok kasus dan 176  kelompok control. Kelompok kasus adalah bayi dengan diagnosa  asfiksia yang  dilakukan analisis terhadap faktor risiko fetal, sedangkan bayi yang tidak mengalami asfiksia dijadikan  kelompok kontrol. Hasil analisis statistik uji Chi-Square dan Fisher Exact ditemukan bahwa  kelahiran prematur (OR 2,07 CI 95% P 0,02), persalinan dengan tindakan (OR 3,61 CI 95% P 0,00), berat bayi (OR 2,85 CI 95% P 0,00), posisi janin (OR 2,37 CI 95% P 0,05), tali pusat ( QR 3,071 CI 95%  P 0,01)  berisiko terhadap insiden asfiksia perinatal. Air ketuban yang bercampur meconium (OR 1,51 CI 95% P 0,16) tidak memiliki risiko  dengan Asfiksia perinatal. Kesimpulan: Risiko terhadap insiden asfiksia perinatal  meliputi kelahiran prematur, persalinan dengan tindakan, berat bayi, posisi janin,  dan tali pusat.Perinatal asphyxia refers to a lack of oxygen during labor, which has the potential to cause death and disability. WHO estimates  4 million children born with asphyxia each year, in  which 1 million dies and 1 million survive with severe neurological sequelae. This study aims to analyze fetal and umbilical risk factors in neonatal asphyxia.This research is a quantitative retrospective case-control study, which was conducted at The Dr. Moewardi  hospital,  Surakarta. Data was taken from  medical records from 2013-2018. The case group was patients diagnosed  asphyxia, while those who did not experience asphyxia were treated as a control group.  A total of 264  samples, consisting of 88 case group respondents and 176 control group respondents. Statistical analysis Chi- Square and Fisher Exact found that preterm birth (OR 2.07 CI 95% P 0.02), labor with instrument or complication (OR 3.61 CI 95% P 0.00), infant weight (OR 2.85 CI 95% P 0, 00), fetal position (OR 2.37 CI 95% P 0.05), umbilical cord (QR 3.071 CI 95% P 0.01) are at risk for the incidence of perinatal Asphyxia. The amniotic fluid mixed with meconium (OR 1.51 CI 95% P 0.16) has no risk with perinatal asphyxia.The risk factors of incidences of perinatal asphyxia were  preterm birth, labor with instrument or complication, baby weight, fetal position and umbilical cord. 

scholarly journals The association of male infertility with telomere length: A case control study

2021 ◽  
Vol 8 (4) ◽  
pp. 325-332
Author(s):  
Kate Deepali Rajesh ◽  
Puranam Vatsalaswamy ◽  
Manvikar Purshotam Rao
Keyword(s):  
Male Infertility ◽  
Telomere Length ◽  
Real Time ◽  
Real Time Pcr ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Significant Difference ◽  
Control Study ◽  
Sperm Telomere Length

To study the relevance of sperm telomere length and infertility in men. : Our case-control study included twenty-five males in couple with sub-fertility/infertility (test group) and twenty five healthy males (control group) with proven paternity in the age group 25 to 35 years. The Absolute Sperm Telomere length (aSTL) was measured by real-time PCR. We investigated whether any significant difference in the aSTL value existed between the groups and analysed the relationship between aSTL and other sperm parameters.The mean (SE) aSTL recorded in the infertile cases was significantly shorter than for the control group being 140.60 (6.66) Kb/genome and 239.63 (12.32) Kb/genome respectively (p &#60;0.001) A weak correlation was eminent between aSTL kb/genome and the total sperm count mil/ml (rho= 0.04, p - 0.86), progressive sperm motility (rho= - 0.02, p=0.934) and sperm viability (rho= - 0.07 p=0.741) in the infertile group. The measurement of aSTL by real-time PCR is a simple and rapid method that offers further paramount information with respective to the quality of sperm. It is befitted for epidemiological studies, hence opening new perspectives in the evaluation of male infertility. Limitations - Our study was confined to men aged between 25 and 35 years. Further comparative studies are needed to explore the significance of STL and infertility in older males. Additional studies will help illumine the significance of aSTL as a prognostic biomarker in assisted reproduction.

scholarly journals QT Interval Changes in Children With Febrile Convulsion Comparing With Healthy

2021 ◽  
pp. 1-15
Author(s):  
Alireza Teimouri ◽  
◽  
Noor Mohammad Noori ◽  
Ali Khajeh ◽  
◽  
...  
Keyword(s):  
Qt Interval ◽  
Case Control Study ◽  
Age Groups ◽  
Febrile Convulsion ◽  
Case Control ◽  
Healthy Children ◽  
Age Group ◽  
Chi Square ◽  
Pediatric Cardiologist ◽  
Control Study

A temperature-related seizure is a febrile seizure that affects the QT interval. The purpose of this study was to evaluate the changes in the QT interval caused by febrile convulsion compared with healthy children. Method This case-control study considered the distribution of 180 children equally shared between patients and controls. The study was conducted at the "Ali Ebne Abi Talib" Hospital in Zahedan, Iran. The disease diagnosed and confirmed based on standard definitions of febrile convulsion. QT interval measured by ECG and interpreted by a pediatric cardiologist and collected data were analyzed with SPSS 19 considering 0.05 as significant error. Results Among the ECG parameters, HR, R in aVL, S in V3, LVM, QTd, QTc and QTcd were significantly different in children with febrile convulsion compared to the peers. From those who had abnormal QTd, FC children were more frequented but not significant (CHI SQUARE=1.053, p=0.248), when children with FC were more in abnormality regarding QTc (CHI SQUARE=13.032, p<0.001) and QTcd (CHI SQUARE=21.6, P<0.001) significantly. In children with FC, those who were aged less than 12 months, had the highest level of HR but not significant (CHI SQUARE=4.59, p=0.101). Similar trends occurred for R in aVL and S in V3 that were higher in the age group >24 months (p>0.05). LVM had the highest value in the age group of >24 months significantly (CHI SQUARE= 52.674, P<0.001) and the other QT parameters were same in Fc children with different age groups (P>0.05). Conclusion From the study concluded that dispersion corrected QT, corrected QT and dispersion QT changed significantly in children with febrile convulsion in comparing with the healthy children but with constant values in children with FC in different age groups.

scholarly journals Efficacy of Vitamin E in Methotrexate-Induced Hepatotoxicity in Rheumatoid Arthritis: An Open-Label Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Binit Vaidya ◽  
Manisha Bhochhibhoya ◽  
Shweta Nakarmi
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin E ◽  
Treatment Group ◽  
Case Control Study ◽  
Study Groups ◽  
Case Control ◽  
Control Group ◽  
Open Label ◽  
Control Study

Objective. To examine the efficacy of vitamin E in methotrexate- (MTX-) induced transaminitis in patients with rheumatoid arthritis (RA). Methods. A case-control study was conducted at a tertiary rheumatology center for 12 months. Patients with RA on MTX and deranged aminotransferases were included. Patients with previous liver diseases, baseline transaminitis before methotrexate initiation, alcohol intake, muscle diseases, under hepatotoxic drugs, and aminotransferases>3 times the upper normal limit were excluded. The patients were divided into treatment (vitamin E 400 mg bid for 3 months) and control groups (no vitamin E) using a random number table. The dose of MTX was unaltered. Follow-up was done after 3 and 6 months. Independent t-test was done to compare means of two groups. Paired t-test was done to compare differences in mean. Results. Among 230 patients, 86.5% were female with a mean BMI of 25.9±4.5 kg/m2. In the treatment group, SGPT and SGOT at baseline were 73.1±20.4 and 60.2±24.5 IU/L, respectively; at 3-month follow-up 44.6±34.2 and 38.3±20.8 IU/L, respectively; and at 6-month follow-up 40.4±35.7 and 34.2±21.9 IU/L, respectively. In the control group, SGPT and SGOT at baseline were 63.4±15.1 and 46.8±13.7 IU/L, respectively, and at 3-month follow-up 55.8±45.9 and 45.5±30.9 IU/L, respectively. Significant decrease in the level of aminotransferases was seen in the treatment group (p value < 0.001) and not in the control group (p values 0.161 and 0.728, respectively). The change in levels of SGPT and SGOT from baseline to 3 months of follow-up was statistically significant in between two study groups (p values 0.007 and <0.001, respectively). From the control group, 29 patients were crossed over to vitamin E for the next 3 months. SGPT and SGOT decreased from 97.6±44.1 to 46.1±40.9 and 69.3±34.9 to 29.1±11.6 IU/L, respectively (p values 0.031 and 0.017, respectively). Conclusion. Vitamin E significantly attenuates MTX-induced transaminitis.

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