scholarly journals Chinese Herbal Medicine for the Treatment of Children and Adolescents With Refractory Mycoplasma Pneumoniae Pneumonia: A Systematic Review and a Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoying Ling ◽  
Xun Sun ◽  
Huimin Kong ◽  
Shanshan Peng ◽  
Zheng Yu ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Mycoplasma Pneumoniae ◽  
Meta Analysis ◽  
Chinese Herb ◽  
Trial Sequential Analysis ◽  
Efficacy Rate ◽  
X Ray ◽  
Tnf Α ◽  
Disappearance Time ◽  
Α Level

Objectives: Chinese herb medicine (CHM) is one of the most popular complementary and alternative therapies, which has been widely used to treat Refractory Mycoplasma Pneumoniae Pneumonia (RMPP). However, the effect and safety of CHM remain controversial. Hence, we conducted this meta-analysis to evaluate whether CHM combination therapy could bring benefits to children and adolescents with RMPP.Methods: Seven databases were used for data searching through November 11, 2020 following the PRISMA checklist generally. Review Manager 5.3, Trial sequential analysis 0.9.5.10 Beta software and Stata16.0 were applied to perform data analyses. Mean difference or risk ratio was adopted to express the results, where a 95% confidence interval (CI) was applied.Results: In general, this research enrolled 17 trials with 1,451 participants. The overall pooled results indicated that CHM was beneficial for children and adolescents with RMPP by improving the clinical efficacy rate [RR = 1.20, 95% CI (1.15, 1.25), p < 0.00001], shortening antipyretic time [MD = −2.60, 95% CI (−3.06, −2.13), p < 0.00001], cough disappearance time [MD = −2.77, 95% CI (−3.12, −2.42), p < 0.00001], lung rale disappearance time [MD = −2.65, 95% CI (−3.15, −2.15), p < 0.00001], lung X-ray infiltrates disappearance time [MD = −2.75, 95% CI (−3.33, −2.17), p < 0.00001], reducing TNF-α level [MD = −5.49, 95% CI (−7.21, −3.77), p < 0.00001]. Moreover, subgroup results suggested that removing heat-phlegm and toxicity therapy had more advantages in shortening antipyretic time, cough disappearance time, lung X-ray infiltrates disappearance time and reducing TNF-α level. Meanwhile promoting blood circulation therapy seemed to be better at relieving lung rale. However, regarding adverse events, the two groups displayed no statistical difference [RR = 0.97, 95% CI (0.60, 1.57), p = 0.91].Conclusion: Despite of the apparently positive results in relieving clinical symptoms, physical signs and reducing inflammation, it is premature to confirm the efficacy of CHM in treating RMPP because of the limitation of quality and the number of the included studies. More large-scale, double-blind, well-designed, randomized controlled trials are needed in future research.

scholarly journals Xiao’er Xiaoji Zhike Oral Liquid Combined with Azithromycin for Mycoplasma pneumoniae Pneumonia in Children: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Gui-Min Zhang ◽  
Zhi-Yan Huang ◽  
Rong Sun ◽  
Shi-Li Ye ◽  
Qun Feng
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Meta Analysis ◽  
Scientific Journal ◽  
Effective Rate ◽  
Biomedical Literature ◽  
Cochrane Library ◽  
Control Group ◽  
X Ray ◽  
Disappearance Time ◽  
Oral Liquid

Background. This study was aimed at systematically evaluating the clinical effect and safety of Xiao’er Xiaoji Zhike oral liquid in the treatment of Mycoplasma pneumoniae pneumonia (MPP) in children and providing evidence-based references for clinical application. Methods. The databases like Chinese Biomedical Literature Database, China Network Knowledge Infrastructure, Wan Fang Database, Chinese Scientific Journal Database, PubMed, EmBase, and the Cochrane Library were systematically investigated via searching clinical trials about Xiao’er Xiaoji Zhike oral liquid in treating MPP from the establishment of these databases to Jun 8, 2020, the valid data from which were entered meta-analysis. The quality of evidence was assessed by GRADE criteria. Results. Totally, 15 trials and 1500 patients were involved in this review. It showed that clinical efficacy of trial group was more superior than control group at the outcome measures of cough disappearance time, lung rale disappearance time, fever subsidence time, total effective rate, lung X-ray infiltrates disappearing time, reduction of hospital stay, immunological indexes, and some other measures. And the differences between groups were statistically significant. There was no statistical difference in the adverse effects between two groups. Lung X-ray infiltrates disappearing time and cough disappearance time were separately high- and moderate-quality evidences while lung rale disappearance time and fever subsidence time were all low in accordance with GRADE criteria. Conclusions. In accordance with trials with low methodological quality, Xiao’er Xiaoji Zhike oral liquid combined with azithromycin seems to be safe and superior to azithromycin alone for the treatment of MPP in children. However, further trials with rigorous methodology need to be implemented for these potential benefits.

TNF-α-308A>G and IL-10-819C>T polymorphisms as risk factors for cervical cancer: A case-control study, meta-analysis and trial sequential analysis

Meta Gene ◽  
2021 ◽  
pp. 100943
Author(s):  
EdilsonLeite de Moura ◽  
Denise Macedo da Silva ◽  
Ana CarolineMelo dos Santos ◽  
Adriely Ferreira da Silva ◽  
Abel Barbosa Lira Neto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Trial Sequential Analysis ◽  
Tnf Α ◽  
Control Study

scholarly journals Polymorphisms of Tumour necrosis factor-α-308 (rs 1800629) and gastric cancer susceptibility: A meta- analysis of associations studies with trial sequential analysis

2021 ◽  
Author(s):  
Norah Htet Htet ◽  
Cho Naing ◽  
Wong Siew Tung ◽  
Thin Thin Win ◽  
Joon Wah Mak
Keyword(s):  
Gastric Cancer ◽  
Sequential Analysis ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Trial Sequential Analysis ◽  
Tnf Α ◽  
Strength Of Association ◽  
Necrosis Factor

Abstract Background: Gastric cancer is globally the fifth most common cancer. Several studies have assessed the relationship between tumour necrosis factor-alpha (TNF-a- 308) and the risk of gastric cancer. These individual genetic association studies showed inconclusive results. The objective of the present study was to synthesis evidence on the association between TNF-a-308 polymorphisms and gastric cancer risk by meta-analysis of data from eligible studies.Methods: We performed a meta-analysis of genetic association studies, according to the PLOS One checklist. We searched relevant case-control studies in health-related electronic databases. The methodological quality of included studies was assessed by the Newcastle-Ottawa quality assessment scale. The strength of association was calculated as odds ratios (ORs) with 95% confidence intervals (CIs). Pooled ORs and 95 % CIs were estimated using random-effects model or fixed effect model, based on between-study heterogeneity. We analysed the strength of association under four genetic models (allele, dominant, recessive and additive models). Subgroup analyses on ethnic groups, Hardy-Weinberg equilibrium (HWE) status, status of Helicobacter pylori infection and study quality were done for robustness of the estimates. Publication bias was detected by inspection of funnel plot asymmetry. To estimate the required information size, we performed trial sequential analysis (TSA) that classified the effect estimates as ‘firm evidence of effect’ or ‘potentially spurious evidence of effect’.Results: A total of 35 studies, comprising 11353 cases and 12827 controls were identified. Based on 28 studies that met HWE, there was overall significant association between TNF-α-308 polymorphisms and gastric cancer risk under the dominant model (OR 1.19, 95%CI 1.1-1.29, I2:37%), as well as Asians (OR 1.2, 95%CI 1.05-1.38, I2:53%) and Cassian subgroups (OR 1.19, 95%CI 1.07-1.31, I2:28%). Based on 13 high quality studies under the dominant model, overall significant association was also found (OR 1.38, 95%CI 1.07, 1.77). The TSA plot indicated the analyses was with the required information size. There was no publication bias. In the subgroup analysis by ethnic groups, the quality of studies impacted on the estimates. Conclusions: The findings suggest that TNF-α-308 gene polymorphism plays an important predisposing role for gastric carcinogenesis, and can serve as a useful screening marker.

scholarly journals Laboratory abnormalities in children with refractory mycoplasma pneumoniae pneumonia: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Zhili Wang ◽  
Yu He ◽  
zhengxiu luo
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Clinical Chemistry ◽  
Meta Analysis ◽  
Inflammatory Biomarkers ◽  
Cochrane Library ◽  
Methodologic Quality ◽  
Tnf Α ◽  
Ifn Γ ◽  
Mycoplasma Pneumoniae Pneumonia ◽  
D Dimer

Abstract Objective: To evaluate the discriminative ability of laboratory abnormalities between general mycoplasma pneumoniae pneumonia (GMPP) and refractory MPP (RMPP) in children. Methods: An electronic search in PubMed, Web of Science, Embase, and Cochrane Library was performed to identify studies reporting on laboratory abnormalities in children with GMPP and RMPP. Data were independently extracted by two reviewers. Meta-analyses within the random-effects model were used to synthesize data. Effect sizes were calculated as standardized mean differences (SMD) or weighted mean difference (WMD). The Newcastle-Ottawa Scale (NOS) was used to assess the methodologic quality of included studies. Results: Twenty-one articles (3,877 patients) comparing laboratory findings between patients with GMPP and RMPP were eligible for this meta-analysis. Patients with RMPP had significantly increased neutrophils, CD8+ lymphocytes, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), D-dimer, total IgA, total IgM, as well as decreased lymphocytes, hemoglobin, and albumin. Multiple inflammatory biomarkers (C-reactive protein [CRP], procalcitonin [PCT], erythrocyte sedimentation rate [ESR], ferritin, interleukin [IL]-6, IL-10, IL-17, IL-18, interferon-γ [IFN-γ], and tumor necrosis factor-α [TNF-α]) were also markedly elevated in RMPP patients. Conclusions: Elevated levels of CD8+ lymphocytes, LDH, AST, D-dimer, total IgA, total IgM, inflammatory biomarkers (CRP, PCT, ESR, ferritin, IL-6, IL-10, IL-17, IL-18, IFN-γ, and TNF-α), and lower lymphocytes, hemoglobin, and albumin are associated with RMPP and thus may be used as early identification or even prediction of RMPP in children. Keywords: Child; Refractory Mycoplasma pneumoniae pneumonia; clinical chemistry; meta-analysis

scholarly journals Psychotherapy versus treatment as usual and other control interventions in children and adolescents with overweight and obesity: a protocol for systematic review with meta-analysis and Trial Sequential Analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e036058
Author(s):  
Rajeeb Rashid ◽  
Laura Condon ◽  
Christian Gluud ◽  
Janus C Jakobsen ◽  
Jane Lindschou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Children And Adolescents ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Overweight And Obesity ◽  
Trial Sequential Analysis ◽  
Serious Adverse Events ◽  
Treatment As Usual

IntroductionThe prevalence of children with overweight and obesity is increasing worldwide. Multicomponent interventions incorporating diet, physical activity and behavioural change have shown limited improvement to body mass index (BMI). However, the impact of psychotherapy is poorly explored. This systematic review aims to assess the effects of psychotherapeutic approaches for children with all degrees of overweight.Methods and analysisWe will include randomised clinical trials involving children and adolescents between 0 and 18 years with overweight and obesity, irrespective of publication type, year, status or language up to April 2020. Psychotherapy will be compared with no intervention; wait list control; treatment as usual; sham psychotherapy or pharmaceutical placebo. The following databases will be searched: Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, MEDLINE, Embase, PsycINFO, PubMed, Web of Science, CINAHL and LILACS. Primary outcomes will be BMI z-score, quality of life measured by a validated scale and proportion of patients with serious adverse events. Secondary outcomes will be body weight, self-esteem, anxiety, depression and proportion of patients with non-serious adverse events. Exploratory outcomes will be body fat, muscle mass and serious adverse events. Study inclusion, data extraction and bias risk assessments will be conducted independently by at least two authors. We will assess risk of bias according to Cochrane guidelines and the Cochrane Effective Practice and Organisation of Care guidance. We will use meta-analysis and control risks of random errors with Trial Sequential Analysis. The quality of the evidence will be assessed using Grading of Recommendations Assessment, Development and Evaluation Tool. The systematic review will be reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Cochrane guidelines.Ethics and disseminationAs individual patient data will not be included, we do not require ethics approval. This review will be published in a peer review journal.PROSPERO registration numberCRD42018086458.

Sign in / Sign up

Export Citation Format

Share Document