scholarly journals Amadis: A Comprehensive Database for Association Between Microbiota and Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Long Li ◽  
Qingxu Jing ◽  
Sen Yan ◽  
Xuxu Liu ◽  
Yuanyuan Sun ◽  
...  
Keyword(s):  
Dynamic Network ◽  
Human Diseases ◽  
Information Need ◽  
Current Version ◽  
Gastrointestinal Microbiota ◽  
Disease Associations ◽  
User Friendly ◽  
Short Time ◽  
The Relationship ◽  
Human Disease Network

The human gastrointestinal tract represents a symbiotic bioreactor that can mediate the interaction of the human host. The deployment and integration of multi-omics technologies have depicted a more complete image of the functions performed by microbial organisms. In addition, a large amount of data has been generated in a short time. However, researchers struggling to keep track of these mountains of information need a way to conveniently gain a comprehensive understanding of the relationship between microbiota and human diseases. To tackle this issue, we developed Amadis (http://gift2disease.net/GIFTED), a manually curated database that provides experimentally supported microbiota-disease associations and a dynamic network construction method. The current version of the Amadis database documents 20167 associations between 221 human diseases and 774 gut microbes across 17 species, curated from more than 1000 articles. By using the curated data, users can freely select and combine modules to obtain a specific microbe-based human disease network. Additionally, Amadis provides a user-friendly interface for browsing, searching and downloading. We hope it can serve as a useful and valuable resource for researchers exploring the associations between gastrointestinal microbiota and human diseases.

scholarly journals LncTarD: a manually-curated database of experimentally-supported functional lncRNA–target regulations in human diseases

2019 ◽  
Author(s):  
Hongying Zhao ◽  
Jian Shi ◽  
Yunpeng Zhang ◽  
Aimin Xie ◽  
Lei Yu ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Sequence Data ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Biological Functions ◽  
Functional Dynamics ◽  
Disease Associations ◽  
Non Coding Rnas ◽  
User Friendly ◽  
Pan Cancer

Abstract Long non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA–disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (http://biocc.hrbmu.edu.cn/LncTarD/ or http://bio-bigdata.hrbmu.edu.cn/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA–target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA–target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA–target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA–target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.

scholarly journals SRMDAP: SimRank and Density-Based Clustering Recommender Model for miRNA-Disease Association Prediction

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Xiaoying Li ◽  
Yaping Lin ◽  
Changlong Gu ◽  
Zejun Li
Keyword(s):  
Cross Validation ◽  
Computational Method ◽  
Human Diseases ◽  
Excellent Performance ◽  
Aberrant Expression ◽  
Experimental Identification ◽  
Density Based Clustering ◽  
Disease Associations ◽  
Leave One Out ◽  
The Relationship

Aberrant expression of microRNAs (miRNAs) can be applied for the diagnosis, prognosis, and treatment of human diseases. Identifying the relationship between miRNA and human disease is important to further investigate the pathogenesis of human diseases. However, experimental identification of the associations between diseases and miRNAs is time-consuming and expensive. Computational methods are efficient approaches to determine the potential associations between diseases and miRNAs. This paper presents a new computational method based on the SimRank and density-based clustering recommender model for miRNA-disease associations prediction (SRMDAP). The AUC of 0.8838 based on leave-one-out cross-validation and case studies suggested the excellent performance of the SRMDAP in predicting miRNA-disease associations. SRMDAP could also predict diseases without any related miRNAs and miRNAs without any related diseases.

Optimales Layout einer Walderschliessung

2016 ◽  
Vol 167 (5) ◽  
pp. 294-301
Author(s):  
Leo Bont
Keyword(s):  
Road Network ◽  
Spatial Arrangement ◽  
Problem Situation ◽  
Optimal Layout ◽  
Forest Road ◽  
The Road ◽  
Network Cost ◽  
User Friendly ◽  
Short Time

Optimal layout of a forest road network The road network is the backbone of forest management. When creating or redesigning a forest road network, one important question is how to shape the layout, this means to fix the spatial arrangement and the dimensioning standard of the roads. We consider two kinds of layout problems. First, new forest road network in an area without any such development yet, and second, redesign of existing road network for actual requirements. For each problem situation, we will present a method that allows to detect automatically the optimal road and harvesting layout. The method aims to identify a road network that concurrently minimizes the harvesting cost, the road network cost (construction and maintenance) and the hauling cost over the entire life cycle. Ecological issues can be considered as well. The method will be presented and discussed with the help of two case studies. The main benefit of the application of optimization tools consists in an objective-based planning, which allows to check and compare different scenarios and objectives within a short time. The responses coming from the case study regions were highly positive: practitioners suggest to make those methods a standard practice and to further develop the prototype to a user-friendly expert software.

scholarly journals Remedying the Mitochondria to Cure Human Diseases by Natural Products

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Jian-Kang Mu ◽  
Yan-Qin Li ◽  
Ting-Ting Shi ◽  
Li-Ping Yu ◽  
Ya-Qin Yang ◽  
...  
Keyword(s):  
Natural Products ◽  
Mitochondrial Dysfunction ◽  
Mechanism Of Action ◽  
Current Knowledge ◽  
Human Diseases ◽  
Mitochondrial Regulation ◽  
The Relationship

Mitochondria are the ‘engine’ of cells. Mitochondrial dysfunction is an important mechanism in many human diseases. Many natural products could remedy the mitochondria to alleviate mitochondria-involved diseases. In this review, we summarized the current knowledge of the relationship between the mitochondria and human diseases and the regulation of natural products to the mitochondria. We proposed that the development of mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represents an attractive strategy for a mitochondria-involved disorder therapy. Moreover, investigating the mitochondrial regulation of natural products can potentiate the in-depth comprehension of the mechanism of action of natural products.

scholarly journals Genetic and Environmental Structure of Altruism Characterized by Recipients in Relation to Personality

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 593
Author(s):  
Juko Ando ◽  
Tetsuya Kawamoto
Keyword(s):  
Genetic Factor ◽  
Common Factor ◽  
Dynamic Network ◽  
Self Report ◽  
Genetic Studies ◽  
Indirect Reciprocity ◽  
Environmental Structure ◽  
Additive Genetic Effects ◽  
The Relationship ◽  
Common Genetic Factor

Background and Objectives: Altruism is a form of prosocial behavior with the goal of increasing the fitness of another individual as a recipient while reducing the fitness of the actor. Although there are many studies on its heterogeneity, only a few behavioral genetic studies have been conducted to examine different recipient types: family members favored by kin selection, the dynamic network of friends and acquaintances as direct reciprocity, and strangers as indirect reciprocity. Materials and Methods: This study investigated the genetic and environmental structure of altruism with reference to recipient types measured by the self-report altruism scale distinguished by the recipient (the SRAS-DR) and examine the relationship to personality dimensions measured by the NEO-FFI with a sample of 461 adult Japanese twin pairs. Results: The present study shows that there is a single common factor of altruism: additive genetic effects explain 51% of altruism without a shared environmental contribution. The genetic contribution of this single common factor is explained by the genetic factors of neuroticism (N), extraversion (E), openness to experience (O), and conscientiousness (C), as well as a common genetic factor specific to altruism. Only altruism toward strangers is affected by shared environmental factors. Conclusions: Different types of altruistic personality are constructed by specific combinational profiles of general personality traits such as the Big Five as well as a genetic factor specific to altruism in each specific way.

Hypertension, Cerebrovascular Disease and Stomach Cancer: Is the Salt Hypothesis True?

1981 ◽  
Vol 61 (s7) ◽  
pp. 369s-371s ◽  
Author(s):  
Paul K. Whelton ◽  
Peter Goldblatt
Keyword(s):  
Stomach Cancer ◽  
Death Certificate ◽  
Positive Association ◽  
Special Relationship ◽  
Death Rates ◽  
Disease Associations ◽  
Strong Positive Association ◽  
Diagnostic Concordance ◽  
The Relationship ◽  
Unique Relationship

1. Analysis of age-adjusted death rates from 21 countries over a 20-year period identified the presence of a strong positive association between recorded mortality from stroke, hypertension and stomach cancer. However, the slopes of regression lines for secular trends analyses varied considerably from country to country, suggesting an inconsistency in the pattern of the relationship. 2. A death certificate study of diagnostic concordance correctly identified previously known disease associations but failed to recognise any special relationship between stroke and stomach cancer or hypertension and stomach cancer. 3. Our results fail to confirm the presence of a unique relationship between stroke and stomach cancer. On the basis of these observations, the hypothesis that exposure to salt increases an individual's risk of developing both stroke and stomach cancer seems unlikely.

The impact of Traditional Chinese Medicine on mitophagy in disease models

2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanisms ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Disease Models ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.

scholarly journals Combining Composition and Sonic Information Design in a New Electroacoustic Work

2018 ◽  
Vol 27 (1) ◽  
pp. 20-22
Author(s):  
James Cave ◽  
Ben Eyes
Keyword(s):  
Human Factors ◽  
International Community ◽  
Information Design ◽  
Auditory Display ◽  
Information Presentation ◽  
The Aesthetic ◽  
User Friendly ◽  
The Relationship

It might be suggested that composition and sonic information design are fundamentally different. However, some academic commentators and composers have explored the intersection between these disciplines. The authors presented one such work, Eonsounds: Fiamignano Gorge, at International Community of Auditory Display 2017. We argue that analysis of the aesthetic and informational choices in such hybrid works is essential to the development of sonic information design, with implications for the emergence of sonic information design as a subtype of human factors design. By acknowledging the relationship between aesthetics and information presentation, sound designers may develop designs that are safer and more user-friendly.

scholarly journals Current and Emerging Biomarkers of Cell Death in Human Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Kongning Li ◽  
Deng Wu ◽  
Xi Chen ◽  
Ting Zhang ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Molecular Mechanisms ◽  
Research Area ◽  
Human Diseases ◽  
Mitotic Catastrophe ◽  
Regulated Necrosis ◽  
Early Diagnose ◽  
Multicellular Organisms ◽  
The Relationship ◽  
Made In

Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases.

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