scholarly journals Fatigue in Aviation: Safety Risks, Preventive Strategies and Pharmacological Interventions

2021 ◽  
Vol 12 ◽  
Author(s):  
Yara Q. Wingelaar-Jagt ◽  
Thijs T. Wingelaar ◽  
Wim J. Riedel ◽  
Johannes G. Ramaekers
Keyword(s):  
Work Load ◽  
Chronic Fatigue ◽  
Future Research ◽  
Preventive Strategies ◽  
Military Operations ◽  
Circadian Phase ◽  
Fatigue Management ◽  
Safety Risks ◽  
Military Aviation ◽  
Time Awake

Fatigue poses an important safety risk to civil and military aviation. In addition to decreasing performance in-flight (chronic) fatigue has negative long-term health effects. Possible causes of fatigue include sleep loss, extended time awake, circadian phase irregularities and work load. Despite regulations limiting flight time and enabling optimal rostering, fatigue cannot be prevented completely. Especially in military operations, where limits may be extended due to operational necessities, it is impossible to rely solely on regulations to prevent fatigue. Fatigue management, consisting of preventive strategies and operational countermeasures, such as pre-flight naps and pharmaceuticals that either promote adequate sleep (hypnotics or chronobiotics) or enhance performance (stimulants), may be required to mitigate fatigue in challenging (military) aviation operations. This review describes the pathophysiology, epidemiology and effects of fatigue and its impact on aviation, as well as several aspects of fatigue management and recommendations for future research in this field.

scholarly journals A review of Waste Tyre Rubber as an Alternative Concrete Consituent Material

2018 ◽  
Vol 199 ◽  
pp. 11003 ◽  
Author(s):  
Kudzai Mushunje ◽  
Mike Otieno ◽  
Yunus Ballim
Keyword(s):  
Health And Safety ◽  
Engineering Properties ◽  
Future Research ◽  
Rubber Material ◽  
Safety Risks ◽  
Concrete Production ◽  
Potential Benefits ◽  
Waste Tyre ◽  
Health And Safety Risks ◽  
Published Research

The current global waste tyre generation far exceeds its consumption in terms of recycling and re-use. The traditional recycling and re-use methods like thermal incineration have proven ineffective, costly and in some cases environmentally unsustainable. Particularly, in developing countries where some of the sophisticated techniques required to process tyres to allow them to be utilised are either too costly or have not yet been developed. The situation has resulted in accumulation of large waste tyre stockpiles that pose health and safety risks. To combat the problem, the use of waste tyre rubber in concrete construction has been proposed. Several studies have been conducted to assess the effects of the inclusion of waste tyre rubber in its different forms (fibres, particles), for concrete production and the results are promising. Although there are some apparent demerits to the inclusion of tyre rubber in concrete, the potential benefits seem to overshadow the negatives. This paper reviews published research on the scientific and technical viability of using waste tyre rubber in concrete production. It discusses the production and properties of waste tyre particles. It highlights advances made with regards to the incorporation of tyre rubber material in concrete, focusing on the engineering properties of the tyre rubber modified concrete. In conclusion, recommendations for future research and possible application for the material will be discussed.

scholarly journals Sex differences in the circadian regulation of sleep and waking cognition in humans

2016 ◽  
Vol 113 (19) ◽  
pp. E2730-E2739 ◽  
Author(s):  
Nayantara Santhi ◽  
Alpar S. Lazar ◽  
Patrick J. McCabe ◽  
June C. Lo ◽  
John A. Groeger ◽  
...  
Keyword(s):  
Sex Differences ◽  
Performance Measures ◽  
Brain Function ◽  
Early Morning ◽  
Circadian Rhythmicity ◽  
Men And Women ◽  
Circadian Phase ◽  
Time Awake ◽  
Everyday Performance ◽  
The Impact

The sleep–wake cycle and circadian rhythmicity both contribute to brain function, but whether this contribution differs between men and women and how it varies across cognitive domains and subjective dimensions has not been established. We examined the circadian and sleep–wake-dependent regulation of cognition in 16 men and 18 women in a forced desynchrony protocol and quantified the separate contributions of circadian phase, prior sleep, and elapsed time awake on cognition and sleep. The largest circadian effects were observed for reported sleepiness, mood, and reported effort; the effects on working memory and temporal processing were smaller. Although these effects were seen in both men and women, there were quantitative differences. The amplitude of the circadian modulation was larger in women in 11 of 39 performance measures so that their performance was more impaired in the early morning hours. Principal components analysis of the performance measures yielded three factors, accuracy, effort, and speed, which reflect core performance characteristics in a range of cognitive tasks and therefore are likely to be important for everyday performance. The largest circadian modulation was observed for effort, whereas accuracy exhibited the largest sex difference in circadian modulation. The sex differences in the circadian modulation of cognition could not be explained by sex differences in the circadian amplitude of plasma melatonin and electroencephalographic slow-wave activity. These data establish the impact of circadian rhythmicity and sex on waking cognition and have implications for understanding the regulation of brain function, cognition, and affect in shift-work, jetlag, and aging.

Introduction

2019 ◽  
pp. 1-10
Author(s):  
David J Ulbrich
Keyword(s):  
United States ◽  
World War Ii ◽  
East Asia ◽  
Culture Media ◽  
The United States ◽  
Future Research ◽  
Pacific Basin ◽  
Military Operations ◽  
World War ◽  
The Pacific

The introduction to this anthology connects a diverse collection of essays that examine the 1940s as the critical decade in the United States’ ascendance in the Pacific Rim. Following the end of World War II, the United States assumed the hegemonic role in the region when Japan’s defeat created military and political vacuums in the region. It is in this context that this anthology stands not only as a précis of current scholarship but also as a prospectus for future research. The contributors’ chapters eschew the traditional focus on military operations that has dominated the historiography of 1940s in the Pacific Basin and East Asia. Instead, the contributors venture into areas of race, gender, technology, culture, media, diplomacy, and institutions, all of which add nuance and clarity to the existing literature of World War II and the early Cold War.

scholarly journals A review of literature on substance abuse among anaesthesia providers

2019 ◽  
Vol 24 (8) ◽  
pp. 587-600
Author(s):  
Stephanie DeFord ◽  
Julie Bonom ◽  
Terri Durbin
Keyword(s):  
Substance Abuse ◽  
Literature Review ◽  
Registered Nurse ◽  
High Stress ◽  
Future Research ◽  
Educational Setting ◽  
Preventive Strategies ◽  
Nurse Anaesthetist ◽  
Anaesthetic Agents ◽  
American Society

Background Research has demonstrated that anaesthesia providers are susceptible to substance abuse. Several preventive measures are being implemented in certified registered nurse anaesthetist programmes to educate future providers about substance abuse. Given the continued prevalence and impact of the problem, more research is needed about the prevalence of substance abuse among student registered nurse anaesthetists and the implementation of preventive strategies in the educational setting. Aims The purpose of this narrative literature review was to examine the state of the science related to substance abuse among US certified anaesthesia providers. This literature review covered abuse of alcohol, tobacco, recreational drugs, opioids and anaesthetic agents. Methods This narrative review was conducted using the following search terms: anaesthesia, student, wellness, stress, substance abuse, satisfaction, personality, depression, nurse, nurse anaesthetist, propofol, isoflurane and fentanyl. References were identified using PubMed, CINAHL, Google Scholar, and the American Society of Anesthesiologists and American Association of Nurse Anesthetists websites. A total of 36 articles were identified as relevant to this literature review based on content and country of publication. This literature review was limited to articles published in the past 15 years. With one exception, our search was limited to manuscripts from the US. Results The literature underscored that various risk factors contribute to substance abuse. Board-certified anaesthesia providers fall prey to substance abuse due to ease of access, the high stress associated with administering anaesthesia, and the propensity to become addicted to opioids and other anaesthetics. A gap in the science exists about the prevalence of substance abuse among student registered nurse anaesthetists and the effectiveness of preventive strategies in the educational setting. Conclusions Anaesthesia providers are at high risk of abusing substances. To create a safer environment, future research should explore the prevalence of substance abuse among student registered nurse anaesthetists and emphasise the integration of effective preventive strategies in the educational setting.

Longitudinal outcomes associated with significant other responses to chronic fatigue and pain

2017 ◽  
Vol 25 (5) ◽  
pp. 692-702
Author(s):  
Karen B Schmaling ◽  
Jessica L Fales ◽  
Sterling McPherson
Keyword(s):  
Mental Health ◽  
Theoretical Models ◽  
Significant Others ◽  
Chronic Fatigue ◽  
Future Research ◽  
Significant Other ◽  
Physical And Mental Health ◽  
Longitudinal Outcomes ◽  
Over Time

This study investigated significant others’ behavior associated with fatigue, pain, and mental health outcomes among 68 individuals with chronic fatigue (43% also had fibromyalgia) over 18 months. More negative significant others’ responses were associated with more pain, poorer physical and mental health, and more fatigue-related symptoms over time. More fibromyalgia tender points covaried with more solicitous significant others’ responses over time. Better mental health covaried with more distracting significant others’ responses over time. The results are discussed in terms of theoretical models of the role of perceived significant others’ responses on patient outcomes and recommendations for future research.

scholarly journals CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities

2021 ◽  
Vol 12 ◽  
Author(s):  
Joseph W. Fischer ◽  
Nirjal Bhattarai
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Therapy ◽  
Future Research ◽  
T Cell Therapy ◽  
Cell Therapies ◽  
Car T Cell ◽  
Safety Risks ◽  
Car T Cell Therapy ◽  
Car T

Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current strategies for management and mitigation of these risks and highlights key areas of knowledge gap for future research.

scholarly journals A REVIEW STUDY OF FACTORS INFLUENCING SUICIDE AMONG SOUTH ASIANS IN THE UK

2021 ◽  
Vol 9 (2) ◽  
pp. 25-31
Author(s):  
Ubaid Rehman ◽  
Alamgeer Khan ◽  
Muhammad Jawad ◽  
Saima Sarir ◽  
Seema Zubair
Keyword(s):  
Family Relationships ◽  
South Asians ◽  
Future Research ◽  
Preventive Strategies ◽  
Health Issues ◽  
Class 1 ◽  
Culturally Sensitive Interventions ◽  
Review Study ◽  
The Uk ◽  
Family Contact

Purpose of the study: A systematic review of studies on factors in the suicide of South Asians in the UK was reviewed to enhance understanding by aggregating those factors contributing to suicide in this diverse group. Methodology: Digital databases PsycArticles, PsycINFO, PubMed, JSTOR, Science Direct, Web of sciences, and Google Scholar, were searched from 1990 to 2018 and, six studies were included for the review. Main Findings: Factors like cultural conflict, mental health issues, family relationships, and religious & other social aspects influence suicide in South Asians in the UK. Also, better family contact, culturally sensitive interventions & services, and educational pamphlets could support preventive strategies. Applications of this study: Future research needs to concentrate on the reasons behind high rates of suicide in social class 1 and disaggregation of factors in sub-groups of South Asians in the UK to support the development of sound preventive strategies. Novelty/Originality of this study: First study ever to aggregate factors in the suicide of South Asians in the UK.  

scholarly journals Social Co-Governance for Food Safety Risks

2018 ◽  
Vol 10 (11) ◽  
pp. 4246 ◽  
Author(s):  
Linhai Wu ◽  
Pingping Liu ◽  
Yuxin Lv ◽  
Xiujuan Chen ◽  
Fu-Sheng Tsai
Keyword(s):  
Food Safety ◽  
Social Innovation ◽  
Relevant Literature ◽  
Policy Implications ◽  
Future Research ◽  
Social Forces ◽  
Multiple Stakeholders ◽  
Safety Risks ◽  
Government Enterprise ◽  
Food Safety Risk

We review relevant literature to propose the connotation and operation logic of food safety co-governance, systematically constitute by roles, functions, as well as the boundaries of public government, enterprise, and social forces. The major thesis is that social co-governance is a kind of societal-wide innovation (i.e., social innovation) that integrates diverse resources and efforts from multiple stakeholders for better and sustainable development of an economy’s food institution and system. We then put forward a prospect of the future research on food safety risk co-governance. Theoretical, practical, and policy implications are discussed.

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