scholarly journals Effects of 7.5% Carbon Dioxide and Nicotine Administration on Latent Inhibition

2021 ◽  
Vol 12 ◽  
Author(s):  
Kiri T. Granger ◽  
Jennifer Ferrar ◽  
Sheryl Caswell ◽  
Mark Haselgrove ◽  
Paula M. Moran ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Latent Inhibition ◽  
Dopamine Release ◽  
Experimental Studies ◽  
Self Report ◽  
Differential Sensitivity ◽  
Placebo Control ◽  
Nicotine Administration ◽  
Direct Model ◽  
Medical Air

Stratified medicine approaches have potential to improve the efficacy of drug development for schizophrenia and other psychiatric conditions, as they have for oncology. Latent inhibition is a candidate biomarker as it demonstrates differential sensitivity to key symptoms and neurobiological abnormalities associated with schizophrenia. The aims of this research were to evaluate whether a novel latent inhibition task that is not confounded by alternative learning effects such as learned irrelevance, is sensitive to (1) an in-direct model relevant to psychosis [using 7.5% carbon dioxide (CO2) inhalations to induce dopamine release via somatic anxiety] and (2) a pro-cognitive pharmacological manipulation (via nicotine administration) for the treatment of cognitive impairment associated with schizophrenia. Experiment 1 used a 7.5% CO2 challenge as a model of anxiety-induced dopamine release to evaluate the sensitivity of latent inhibition during CO2 gas inhalation, compared to the inhalation of medical air. Experiment 2 examined the effect of 2 mg nicotine administration vs. placebo on latent inhibition to evaluate its sensitivity to a potential pro-cognitive drug treatment. Inhalation of 7.5% CO2 raised self-report and physiological measures of anxiety and impaired latent inhibition, relative to a medical air control; whereas administration of 2 mg nicotine, demonstrated increased latent inhibition relative to placebo control. Here, two complementary experimental studies suggest latent inhibition is modified by manipulations that are relevant to the detection and treatment of schizophrenia. These results suggest that this latent inhibition task merits further investigation in the context of neurobiological sub-groups suitable for novel treatment strategies.

scholarly journals The Influence of Alcohol Consumption on Fighting, Shoplifting and Vandalism in Young Adults

2021 ◽  
Vol 18 (7) ◽  
pp. 3509
Author(s):  
Ieuan Evans ◽  
Jon Heron ◽  
Joseph Murray ◽  
Matthew Hickman ◽  
Gemma Hammerton
Keyword(s):  
Young Adults ◽  
Longitudinal Study ◽  
Alcohol Consumption ◽  
Experimental Studies ◽  
Real Life ◽  
Self Report ◽  
Parents And Children ◽  
Experimental Findings ◽  
Avon Longitudinal Study ◽  
Causal Component

Experimental studies support the conventional belief that people behave more aggressively whilst under the influence of alcohol. To examine how these experimental findings manifest in real life situations, this study uses a method for estimating evidence for causality with observational data—‘situational decomposition’ to examine the association between alcohol consumption and crime in young adults from the Avon Longitudinal Study of Parents and Children. Self-report questionnaires were completed at age 24 years to assess typical alcohol consumption and frequency, participation in fighting, shoplifting and vandalism in the previous year, and whether these crimes were committed under the influence of alcohol. Situational decomposition compares the strength of two associations, (1) the total association between alcohol consumption and crime (sober or intoxicated) versus (2) the association between alcohol consumption and crime committed while sober. There was an association between typical alcohol consumption and total crime for fighting [OR (95% CI): 1.47 (1.29, 1.67)], shoplifting [OR (95% CI): 1.25 (1.12, 1.40)], and vandalism [OR (95% CI): 1.33 (1.12, 1.57)]. The associations for both fighting and shoplifting had a small causal component (with the association for sober crime slightly smaller than the association for total crime). However, the association for vandalism had a larger causal component.

Oral consumption of electrokinetically modified water attenuates muscle damage and improves postexercise recovery

2013 ◽  
Vol 114 (12) ◽  
pp. 1736-1742 ◽  
Author(s):  
Paul A. Borsa ◽  
Kelly L. Kaiser ◽  
Jeffrey S. Martin
Keyword(s):  
Muscle Damage ◽  
Functional Recovery ◽  
Biceps Brachii ◽  
Plasma Concentrations ◽  
High Sensitivity ◽  
Self Report ◽  
Placebo Control ◽  
Elbow Extension ◽  
Blood Draw ◽  
Oral Consumption

The purpose of this study was to assess the effects of consuming electrokinetically modified water (EMW) on attenuating muscle damage and improving functional recovery following a single bout of isokinetic resistance exercise. Subjects were randomly assigned to an EMW ( n = 20) or a placebo control ( n = 20) group. Subjects consumed EMW or placebo water daily for 23 days. On day 19 subjects completed an exercise protocol for the biceps brachii to induce muscle damage. The protocol consisted of three sets of 20 repetitions using concentric and eccentric contractions of the elbow flexors. Blood draw and clinical measurements were performed preexercise as well as 24, 48, and 96 h postexercise. Clinical measures included maximal isometric strength, muscle soreness, pain with elbow extension, relaxed elbow angle (RANG), and self-report arm disability. Plasma samples were analyzed to determine concentrations of creatine kinase (CK) and high-sensitivity C-reactive protein (hsCRP). Pain with elbow extension and self-report arm disability were significantly higher in the placebo group compared with the EMW group at 48 h ( P < 0.01) and 96 h ( P < 0.01) after exercise, while RANG was significantly higher in the EMW group compared with placebo at 48 h ( P < 0.01) and 96 h ( P < 0.01) after exercise. Similarly, plasma concentrations for hsCRP and CK were significantly lower in the EMW group compared with placebo at 48 h ( P < 0.05) and 96 h ( P < 0.01) after exercise. Oral consumption of EMW significantly reduced exercise-induced muscle damage and inflammation and improved functional recovery.

Sensitivity to financial rewards and impression management links to smartphone use and dependence

2021 ◽  
Vol 25 (2) ◽  
pp. 107-128
Author(s):  
Graham Pluck ◽  
◽  
Pablo Emilio Barrera Falconi ◽  
◽  
◽  
...  
Keyword(s):  
Impression Management ◽  
Technology Use ◽  
Experimental Studies ◽  
Negative Relationship ◽  
Reward Sensitivity ◽  
Self Report ◽  
Smartphone Addiction ◽  
Observational Measures ◽  
Instant Messenger ◽  
Smartphone Use

Computational modeling and brain imaging studies suggest that sensitivity to rewards and behaviorist learning principles partly explain smartphone engagement patterns and potentially smartphone dependence. Responses to a questionnaire, and observational measures of smartphone use were recorded for 121 university students. Each participant was also tested with a laboratory task of reward sensitivity and a test of verbal operant conditioning. Twenty-three percent of the sample had probable smartphone addiction. Using multivariate regression, smartphone use, particularly the number of instant messenger services employed, was shown to be significantly and independently predicted by reward sensitivity (a positive relationship), and by instrumental conditioning (a negative relationship). However, the latter association was driven by a subset of participants who developed declarative knowledge of the response-reinforcer contingency. This suggests a process of impression management driven by experimental demand characteristics, producing goal-directed instrumental behavior not habit-based learning. No other measures of smartphone use, including the self-report scale, were significantly associated with the experimental tasks. We conclude that stronger engagement with smartphones, in particular instant messenger services, may be linked to people being more sensitive to rewarding stimuli, suggestive of a motivational or learning mechanism. We propose that this mechanism could underly problem smartphone use and dependence. It also potentially explains why some aspects of smartphone use, such as habitual actions, appear to be poorly measured by technology-use questionnaires. A serendipitous secondary finding confirmed that smartphone use reflected active self-presentation. Our ‘conditioning’ task-induced this behavior in the laboratory and could be used in social-cognition experimental studies.

scholarly journals 35% Carbon Dioxide Reactivity In A Bulimia Nervosa Sample

2021 ◽  
Author(s):  
Andrea Woznica
Keyword(s):  
Carbon Dioxide ◽  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Vital Capacity ◽  
Distress Tolerance ◽  
Self Report ◽  
Discomfort Intolerance ◽  
State And Trait Anxiety ◽  
Carbon Dioxide Reactivity ◽  
Anxiety Depression

This study extended research on the specificity of the effects of the carbon dioxide (CO₂) challenge by examining panic reactivity in participants with bulimia nervosa (BN) (n=15) compared to those without bulimia nervosa (n=31). All participants completed self-report measures assessing state and trait anxiety, depression, anxiety sensitivity (AS), distress tolerance (DT), discomfort intolerance (DI), and eating disorder features. They subsequently breathed two vital capacity inhalations; room air and 35% CO₂-enriched air. Reactivity to room air was not different between groups. However, participants with BN displayed greater reactivity to CO₂ compared to the participants with BN. AS, DI, and DT could not be tested as potential mediators in the association between diagnostic group and reactivity because these constructs were not associated with reactivity. Eating disorder features and frequency of binges and purges were also not associated with reactivity. Detailed implications and suggestions for further research are discussed.

Rossenbeck. On the question of the ketogenic nature of physiological acidosis of pregnancy (Mtschs. Geburtsch. Gyn. 1936, 102, 3, 129-143)

1937 ◽  
Vol 33 (5) ◽  
pp. 649-649
Author(s):  
B. Ivanov
Keyword(s):  
Carbon Dioxide ◽  
Pregnant Women ◽  
Ketone Bodies ◽  
Experimental Studies

Based on his experimental studies in healthy non-pregnant and pregnant women, a. believes that the decrease in the ability of their blood to bind carbon dioxide cannot be explained by an increase in the level of ketone bodies in the blood during pregnancy, especially in her last 3 months.

Self-gasified biosystems for enhanced oil recovery

2021 ◽  
pp. 2150274
Author(s):  
B. A. Suleimanov ◽  
S. J. Rzayeva ◽  
U. T. Akhmedova
Keyword(s):  
Carbon Dioxide ◽  
Enhanced Oil Recovery ◽  
Oil Recovery ◽  
Experimental Studies ◽  
Microbial Enhanced Oil Recovery ◽  
Heterogeneous Porous Medium ◽  
Oil Displacement ◽  
Subcritical Region ◽  
Reservoir Conditions

Microbial enhanced oil recovery is considered to be one of the most promising methods of stimulating formation, contributing to a higher level of oil production from long-term fields. The injection of bioreagents into a reservoir results in the creation of oil-displacing agents along with a significant amount of gases, mainly carbon dioxide. Earlier, the authors failed to study the preparation of self-gasified biosystems and the implementation of the subcritical region (SR) under reservoir conditions. Gasified systems in the subcritical phase have better oil-displacing properties than nongasified systems. In a heterogeneous porous medium, the filtration profile of gasified liquids in the SR should be more uniform than for a degassed liquid. Based on experimental studies, the superior efficiency of oil displacement by gasified biosystems compared with degassed ones has been demonstrated. The possibility of efficient use of gasified hybrid biopolymer systems has been shown.

Interaction of dopamine and haloperidol with O2 and CO2 chemoreception in carotid body

1980 ◽  
Vol 49 (1) ◽  
pp. 45-51 ◽  
Author(s):  
S. Lahiri ◽  
T. Nishino ◽  
A. Mokashi ◽  
E. Mulligan
Keyword(s):  
Carbon Dioxide ◽  
Carotid Body ◽  
Intravenous Infusion ◽  
Dopamine Release ◽  
Carbon Dioxide Tension ◽  
Arterial Oxygen ◽  
Carotid Body Chemoreceptors

Effects of dopamine and of a dopaminergic blocker, haloperidol, on the responses of carotid body chemoreceptors to hypoxia and hypercapnia were investigated in 16 anesthetized cats. Intravenous infusion of dopamine (10-20 micrograms.min-1) decreased carotid body chemoreceptor responses to hypoxia and hypercapnia. The effect was greater at higher levels of arterial oxygen and carbon dioxide tension (PaO2 and PaCO2) stimulus. Thus, the magnitude of the dopamine effect depended on the degree of both PO2- and PCO2-mediated excitation of the receptors. Haloperidol potentiated responses to both hypoxia and hypercapnia but apparently did not stimulate the receptors in the absence of these stimuli. Potentiation by haloperidol and inhibition by dopamine of excitatory effects due to PaO2 decrease and PaCO2 increase are complementary. The data suggest that chemoreception of dopamine, O2, and CO2 converge at some site in the carotid body. Persistence of hypoxic and hypercapnic responses, following dopamine-blocking doses of haloperidol, does not support the theory that regulation of dopamine release is responsible for O2 and CO2 chemoreception in carotid body of the cat.

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