Epidemiological Characteristics of COVID-19 Resurgence in Areas Initially Under Control

Objectives: To investigate the epidemiological characteristics and infection routes of new cases in order to provide information for preventing COVID-19 resurgence in areas initially under control.Methods: The information of new symptomatic and asymptomatic patients in Chinese mainland was collected. The location distribution, epidemic course, infection routes and patients' characteristics of outbreaks were described and analyzed.Results: There were 43 new outbreaks with 3,795 symptomatic patients in Chinese mainland from March 21, 2020 to June 13, 2021. These outbreaks mainly occurred in central, border and coastal port cities. The main infection route of first generation indigenous patients was contact with imported cases and contaminated goods or environments. The infection routes of secondary generation patients mainly included family transmission, indoor social gathering infection, nosocomial infection and other infection routes. Family transmission was the most common infection route, and indoor social gathering was the most important reason for the large-scale outbreaks.Conclusions: Strengthen the management of imported patients and staff in high-risk posts was the key point to avoid the first generation indigenous patients. Adequate family isolation, prompt management policies for indoor public place and monitor of population at risk of infection were key strategies for preventing COVID-19 resurgence in areas initially under control.

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High incidence of asymptomatic SARS-CoV-2 infection, Chongqing, China

10.1101/2020.03.16.20037259 ◽

2020 ◽

Cited By ~ 4

Author(s):

Yang Tao ◽

Panke Cheng ◽

Wen Chen ◽

Peng Wan ◽

Yaokai Chen ◽

...

Keyword(s):

Asymptomatic Patient ◽

Medical Center ◽

Age Groups ◽

The Elderly ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Asymptomatic Patients ◽

Imported Cases ◽

History Of ◽

Epidemiological Characteristics

SummaryBackgroundSARS-CoV-2 has been a global pandemic, but the emergence of asymptomatic patients has caused difficulties in the prevention of the epidemic. Therefore, it is significant to understand the epidemiological characteristics of asymptomatic patients with SARS-CoV-2 infection.MethodsIn this single-center, retrospective and observational study, we collected data from 167 patients with SARS-CoV-2 infection treated in Chongqing Public Health Medical Center (Chongqing, China) from January to March 2020. The epidemiological characteristics and variable of these patients were collected and analyzed.Findings82.04% of the SARS-CoV-2 infected patients had a travel history in Wuhan or a history of contact with returnees from Wuhan, showing typical characteristics of imported cases, and the proportion of severe Covid-19 patients was 13.2%, of which 59% were imported from Wuhan. For the patients who was returnees from Wuhan, 18.1% was asymptomatic patients. In different infection periods, compared with the proportion after 1/31/2020, the proportion of asymptomatic patient among SARS-CoV-2 infected patient was higher(19% VS 1.5%). In different age groups, the proportion of asymptomatic patient was the highest(28.6%) in children group under 14, next in elder group over 70 (27.3%). Compared with mild and common Covid-19 patients, the mean latency of asymptomatic was longer (11.25 days VS 8.86 days), but the hospital length of stay was shorter (14.3 days VS 16.96 days).ConclusionThe SARS-CoV-2 prevention needs to focus on the screening of asymptomatic patients in the community with a history of contact with the imported population, especially for children and the elderly population.

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High incidence of asymptomatic SARS-CoV-2 infection, Chongqing, China

10.21203/rs.3.rs-25603/v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Yang Tao ◽

Panke Cheng ◽

Wen Chen ◽

Peng Wan ◽

Yaokai Chen ◽

...

Keyword(s):

Asymptomatic Patient ◽

Medical Center ◽

Age Groups ◽

The Elderly ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Asymptomatic Patients ◽

Imported Cases ◽

History Of ◽

Epidemiological Characteristics

Abstract Background SARS-CoV-2 has been a global pandemic, but the emergence of asymptomatic patients has caused difficulties in the prevention of the epidemic. Therefore, it is significant to understand the epidemiological characteristics of asymptomatic patients with SARS-CoV-2 infection. Methods In this single-center, retrospective and observational study, we collected data from 167 patients with SARS-CoV-2 infection treated in Chongqing Public Health Medical Center (Chongqing, China) from January to March 2020. The epidemiological characteristics and variable of these patients were collected and analyzed. Findings 82.04% of the SARS-CoV-2 infected patients had a travel history in Wuhan or a history of contact with returnees from Wuhan, showing typical characteristics of imported cases, and the proportion of severe Covid-19 patients was 13.2%, of which 59% were imported from Wuhan. For the patients who was returnees from Wuhan, 18.1% was asymptomatic patients. In different infection periods, compared with the proportion after 1/31/2020, the proportion of asymptomatic patient among SARS-CoV-2 infected patient was higher(19% VS 1.5%). In different age groups, the proportion of asymptomatic patient was the highest(28.6%) in children group under 14, next in elder group over 70 (27.3%). Compared with mild and common Covid-19 patients, the mean latency of asymptomatic was longer (11.25 days VS 8.86 days), but the hospital length of stay was shorter (14.3 days VS 16.96 days). Conclusion The SARS-CoV-2 prevention needs to focus on the screening of asymptomatic patients in the community with a history of contact with the imported population, especially for children and the elderly population.

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Challenges Caused by Imported Cases Abroad for the Prevention and Control of COVID-19 in China

Frontiers in Medicine ◽

10.3389/fmed.2021.573726 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jianfei Zhu ◽

Qingqing Zhang ◽

Chenghui Jia ◽

Shuonan Xu ◽

Jie Lei ◽

...

Keyword(s):

Incubation Period ◽

Symptom Onset ◽

Onset Time ◽

Interquartile Range ◽

Categorical Variables ◽

Chinese Government ◽

Asymptomatic Patients ◽

Diagnostic Time ◽

Imported Cases ◽

Epidemiological Characteristics

Background: Overseas imported cases of COVID-19 continue to increase in China, so we conducted this study to review the epidemiological characteristics of these patients.Methods: From February 26 to April 4, 2020, the imported cases from abroad were enrolled in this study. The effect of prevention countermeasures in curbing the spread of COVID-19 was assessed in this study. Moreover, we defined incubation period and confirmed time as from the date of leaving the epicenter to date of symptom onset and date of final diagnosed, respectively, and the interval of symptom onset to final diagnosed time was defined as diagnostic time. Categorical variables were summarized as numbers and percentages, and the difference among the variables were analyzed.Results: For 670 cases imported from abroad, 555 were Chinese and 115 were foreigners. Apparently, confirmed cases had significantly decreased after China was compelled to temporarily suspend the entry of foreign passport holders with valid visas or residence permits; 6 days after implement of controlled measures, the daily new confirmed cases were reduced to 13 cases. Moreover, about 84.3% of patients (166/197) presented symptoms 1 week after leaving the epicenter, and notably seven patients (3.6%) had symptoms 2 weeks after leaving the epicenter. The median incubation period was 3.0 days (inter quartile range, 1.0 to 6.0), the 95th percentile was 11.6 days. Additionally, most of cases (92.9%) were detected positively of nucleic acid after symptom onset with 4 days, the median diagnostic time was 2.0 days (interquartile range, 1.0 to 3.0), and the 95th percentile of the distribution was 5.0 days. Finally, about 5.8% of patients were healthy carriers, and the median confirmed time of asymptomatic patients was 4.0 days (interquartile range, 2.0 to 9.0). The following variables might be associated with confirmed time: symptom type (P = 0.005), exported regions (P < 0.001), and symptom onset time (P < 0.001).Conclusions: The prevention countermeasures for imported cases implemented by the Chinese government played an indispensable role in curbing the spread of COVID-19; the time of departure from epicenter could provide an estimate of the incubation period; and a confirmed time, 2-week quarantine period might need to be prolonged, while asymptomatic patients should be closely monitored.

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Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old

10.31234/osf.io/tcdfb ◽

2020 ◽

Author(s):

Lungwani Muungo

Keyword(s):

Gene Expression ◽

Cancer Research ◽

Molecular Epidemiology ◽

Exposure Assessment ◽

Large Scale ◽

First Generation ◽

Cancer Epidemiology ◽

Policy Changes ◽

The Past ◽

New Generation

The purpose of this review is to evaluate progress inmolecular epidemiology over the past 24 years in canceretiology and prevention to draw lessons for futureresearch incorporating the new generation of biomarkers.Molecular epidemiology was introduced inthe study of cancer in the early 1980s, with theexpectation that it would help overcome some majorlimitations of epidemiology and facilitate cancerprevention. The expectation was that biomarkerswould improve exposure assessment, document earlychanges preceding disease, and identify subgroupsin the population with greater susceptibility to cancer,thereby increasing the ability of epidemiologic studiesto identify causes and elucidate mechanisms incarcinogenesis. The first generation of biomarkers hasindeed contributed to our understanding of riskandsusceptibility related largely to genotoxic carcinogens.Consequently, interventions and policy changes havebeen mounted to reduce riskfrom several importantenvironmental carcinogens. Several new and promisingbiomarkers are now becoming available for epidemiologicstudies, thanks to the development of highthroughputtechnologies and theoretical advances inbiology. These include toxicogenomics, alterations ingene methylation and gene expression, proteomics, andmetabonomics, which allow large-scale studies, includingdiscovery-oriented as well as hypothesis-testinginvestigations. However, most of these newer biomarkershave not been adequately validated, and theirrole in the causal paradigm is not clear. There is a needfor their systematic validation using principles andcriteria established over the past several decades inmolecular cancer epidemiology.

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Urban rejection of the vernacular: The SVS undone

Language Variation and Change ◽

10.1017/s0954394512000105 ◽

2012 ◽

Vol 24 (2) ◽

pp. 221-245 ◽

Cited By ~ 44

Author(s):

Robin Dodsworth ◽

Mary Kohn

Keyword(s):

Large Scale ◽

First Generation ◽

Acoustic Analysis ◽

Dialect Contact ◽

Economic Segregation ◽

Technology Sector ◽

Southern Vowel Shift ◽

Regional Dialect ◽

Vowel Shift ◽

Conversational Interviews

AbstractIn Raleigh, North Carolina, a Southern U.S. city, five decades of in-migration of technology-sector workers from outside the South has resulted in large-scale contact between the local Southern dialect and non-Southern dialects. This paper investigates the speed and magnitude of the reversal of the Southern Vowel Shift (SVS) with respect to the five front vowels, using Trudgill's (1998) model of dialect contact as a framework. The data consist of conversational interviews with 59 white-collar Raleigh natives representing three generations, the first generation having reached adulthood before large-scale contact. Acoustic analysis shows that all vowels shift away from their Southern variants across apparent time. The leveling of SVS variants begins within the first generation to grow up after large-scale contact began, and contrary to predictions, this generation does not show wide inter- or intraspeaker variability. Previous studies of dialect contact and new dialect formation suggest that leveling of regional dialect features and the establishment of stable linguistic norms occurs more quickly when children have regular contact with one another. Dialect contact in Raleigh has occurred primarily within the middle and upper classes, the members of which are densely connected by virtue of schools and heavy economic segregation in neighborhood residence.

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Socio-demographic and epidemiological characteristics associated with human immunodeficiency virus type I (HIV-1) infection in HIV-1-explosed but uninfected individuals, and in HIV-1-infected patients from a southern brasilian population

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652005000500001 ◽

2005 ◽

Vol 47 (5) ◽

pp. 239-246 ◽

Cited By ~ 3

Author(s):

Edna Maria Vissoci Reiche ◽

Ana Maria Bonametti ◽

Maria Angélica Ehara Watanabe ◽

Helena Kaminami Morimoto ◽

Arilson Akira Morimoto ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Screening Tests ◽

Type I ◽

Serological Tests ◽

Asymptomatic Patients ◽

Immunodeficiency Virus ◽

Epidemiological Characteristics ◽

Hiv 1

The ability to control human immunodeficiency virus type 1 (HIV-1) infection and progression of the disease is regulated by host and viral factors. This cross-sectional study describes the socio-demographic and epidemiological characteristics associated with HIV-1 infection in 1,061 subjects attended in Londrina and region, south of Brazil: 136 healthy individuals (Group 1), 147 HIV-1-exposed but uninfected individuals (Group 2), 161 HIV-1-infected asymptomatic patients (Group 3), and 617 patients with AIDS (Group 4). Data were obtained by a standardized questionnaire and serological tests. The age of the individuals ranged from 15.1 to 79.5 years, 54.0% and 56.1% of the Groups 3 and 4 patients, respectively, were men. The major features of groups 2, 3, and 4 were a predominance of education level up to secondary school (55.8%, 60.2% and 62.4%, respectively), sexual route of exposure (88.4%, 87.0% and 82.0%, respectively), heterosexual behavior (91.8%, 75.2% and 83.7%, respectively), and previous sexually transmitted diseases (20.4%, 32.5%, and 38.1%, respectively). The patients with AIDS showed the highest rates of seropositivity for syphilis (25.6%), of anti-HCV (22.3%), and anti-HTLV I/II obtained by two serological screening tests (6.2% and 6.8%, respectively). The results documenting the predominant characteristics for HIV-1 infection among residents of Londrina and region, could be useful for the improvement of current HIV-1 prevention, monitoring and therapeutic programs targeted at this population.

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Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the Plateau area

10.1101/2020.03.09.20033126 ◽

2020 ◽

Cited By ~ 3

Author(s):

Yu Lei ◽

Xiaobo Huang ◽

Bamu SiLang ◽

YunPing Lan ◽

Jianli Lu ◽

...

Keyword(s):

Clinical Laboratory ◽

Clinical Symptoms ◽

Asymptomatic Group ◽

Asymptomatic Patients ◽

Abnormal Chest ◽

Plateau Area ◽

Imported Cases ◽

High Altitude Area ◽

History Of ◽

The Mean

AbstractCoronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread throughout China, but the clinical characteristics of Tibetan patients living in the Qinghai-Tibetan plateau are unknown. We aimed to investigate the epidemiological, clinical, laboratory and radiological characteristics of these patients. We included 67 Tibetan patients with confirmed SARS-CoV-2 infection. The patients were divided into two groups based on the presence of clinical symptoms at admission, with 31 and 36 patients in the symptomatic and asymptomatic groups, respectively. The epidemiological, clinical, laboratory and radiological characteristics were extracted and analysed. No patient had a history of exposure to COVID-19 patients from Wuhan or had travelled to Wuhan. The mean age of Tibetan patients was 39.3 years and 59% of the patients were male. Seven patients presented with fever on admission and lymphocytopenia was present in 20 patients. 47 patients had abnormal chest CTs at admission instead of stating that 20 were unchanged. Lactate dehydrogenase levels were increased in 31 patients. Seven patients progressed to severe COVID-19; however, after treatment, their condition was stable. No patients died. Of the 36 asymptomatic patients, the mean age was younger than the symptomatic group (34.4±17.3vs 44.9±18.1 years, P=0.02). Lymphocyte count and prealbumin levels were higher in the asymptomatic group than the group with clinical symptoms (1.6±0.5 vs 1.3±0.6 and 241.8±68.2 vs 191.9±60.3, respectively; P<0.05). Imported cases of COVID-19 in Tibetan patients were generally mild in this high-altitude area. Absence of fever or radiologic abnormalities on initial presentation were common.

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Okinawa, 1972–1995: Life That Matters

Alegal ◽

10.5422/fordham/9780823282661.003.0006 ◽

2018 ◽

pp. 124-142

Author(s):

Annmaria M. Shimabuku

Keyword(s):

Large Scale ◽

First Generation ◽

Mixed Race ◽

The State ◽

Self Determination ◽

Sex Industry ◽

Philosophical Concept ◽

The Pacific ◽

Global World

This chapter examines the post-reversion era from 1972 to 1995. Along with reversion came the enforcement of the anti-prostitution law and the demise of Okinawa’s large-scale sex industry. The first generation of mixed-race individuals came of age and started speaking for themselves instead of allowing themselves to be spoken for. This was also a time when Okinawans started to look past the unfulfilled promises of the Japanese state for liberation and to conceptualize different forms of autonomy in the global world. This chapter reconsiders self-determination as a philosophical concept. In place of the imperative for a unified self and unified nation as the precondition for entry into selfhood and nationhood (i.e., the capacity for “self-determination”), this chapter revisits Matsushima Chōgi’s concept of the “Okinawan proletariat” to rethink the theoretical implications of Okinawa, as a borderland of the Pacific, where humans and non-human objects circulate. It appeals to Tosaka’s anti-idealist attempt to assign a different kind of agency to morphing matter and reads Tanaka Midori’s mixed-race memoir, My Distant Specter of a Father, for an example of a life that fails to unify before the state, but nonetheless continues to matter or be significant in the quality of its mutability.

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What is a good pattern of life model? Guidance for simulations

SIMULATION ◽

10.1177/0037549718795040 ◽

2018 ◽

Vol 95 (8) ◽

pp. 693-706

Author(s):

Barry G Silverman ◽

Gnana Bharathy ◽

Nathan Weyer

Keyword(s):

Large Scale ◽

First Generation ◽

Hybrid Approach ◽

Daily Activities ◽

Human Behaviors ◽

The World ◽

Life Model ◽

Good Pattern ◽

Definition Of

We have been modeling an ever-increasing scale of applications with agents that simulate the pattern of life (PoL) and real-world human behaviors in diverse regions of the world. The goal is to support sociocultural training and analysis. To measure progress, we propose the definition of a measure of goodness for such simulated agents, and review the issues and challenges associated with first-generation (1G) agents. Then we present a second generation (2G) agent hybrid approach that seeks to improve realism in terms of emergent daily activities, social awareness, and micro-decision making in simulations. We offer a PoL case study with a mix of 1G and 2G approaches that was able to replace the pucksters and avatar operators needed in large-scale immersion exercises. We conclude by observing that a 1G PoL simulation might still be best where large-scale, pre-scripted training scenarios will suffice, while the 2G approach will be important for analysis or if it is vital to learn about adaptive opponents or unexpected or emergent effects of actions. Lessons are shared about ways to blend 1G and 2G approaches to get the best of each.

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The increasing menace of dengue in Guangzhou, 2001–2016: the most important epicenter in mainland China

BMC Infectious Diseases ◽

10.1186/s12879-019-4504-3 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Zhoubin Zhang ◽

Qinlong Jing ◽

Zongqiu Chen ◽

Tiegang Li ◽

Liyun Jiang ◽

...

Keyword(s):

Incidence Rate ◽

Control Strategies ◽

Mainland China ◽

Time Period ◽

Dengue Transmission ◽

Infectious Disease Reporting ◽

Imported Cases ◽

System Data ◽

Using Data ◽

Epidemiological Characteristics

Abstract Background Dengue is the most prevalent mosquito-borne disease in the world, with China affected seriously in recent years. 65.8% of dengue cases identified in mainland China since 2005 were reported from the city of Guangzhou. Methods In this study, we described the incidence rate and distribution of dengue cases using data collected form National Notifiable Infectious Disease Reporting Information System data in Guangzhou for 2001 to 2016. All dengue cases were investigated using standardized questionnaire. Results A total of 42,469 dengue cases were reported, with an average annual incidence rate of 20.99 per 100,000 resident population. Over this time period, the incidence rate of indigenous cases increased. Dengue affected areas also expanded sharply geographically from 58.1% of communities affected during 2001–2005 to 96.4% of communities affected in 2011–2016. Overall 95.30% of the overseas imported cases were reported during March and December, while 99.79% of indigenous cases were reported during July and November. All four dengue virus serotypes were identified both in imported cases and indigenous cases. The Aedes albopictus mosquito was the only vector for dengue transmission in the area. Conclusions Guangzhou has become the dengue epicenter in mainland China. Control strategies for dengue should be adjusted to the epidemiological characteristics above and intensive study need to be conducted to explore the factors that driving the rapid increase of dengue.

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