scholarly journals Biogenic Selenium Nanoparticles in Animal Nutrition: A Review

Agriculture ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1244
Author(s):  
Svetlana Malyugina ◽  
Sylvie Skalickova ◽  
Jiri Skladanka ◽  
Petr Slama ◽  
Pavel Horky
Keyword(s):  
Selenium Nanoparticles ◽  
Animal Nutrition ◽  
Anticancer Activities ◽  
Societal Pressure ◽  
Low Toxicity ◽  
New Space ◽  
New Perspective ◽  
Biogenic Selenium Nanoparticles

Selenium still represents a matter of debate in the scientific community. Bionanotechnology has introduced a whole new perspective on selenium use in animal nutrition. In recent years, attention has been focused on selenium nanoparticles prepared by chemical synthesis. Societal pressure directs research in a “greenway” that is more eco-friendly. Biogenic selenium nanoparticles thus represent a new space for research in the use of this new form of selenium in animal nutrition. Recent research shows that biogenic selenium nanoparticles have low toxicity, improve antioxidant status, and increase the body’s immune response. However, their benefits may be much greater, as numerous in vitro studies have shown. In addition, biogenic selenium nanoparticles possess antimicrobial, antifungal, and anticancer activities. Further research should answer questions on the use of biogenic selenium nanoparticles as a feed supplement in individual categories of livestock, and their safety in terms of long-term supplementation.

Efficacy of biogenic selenium nanoparticles against Leishmania major: In vitro and in vivo studies

2013 ◽  
Vol 27 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Nasibeh Beheshti ◽  
Saied Soflaei ◽  
Mojtaba Shakibaie ◽  
Mohammad Hossein Yazdi ◽  
Fatemeh Ghaffarifar ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Selenium Nanoparticles ◽  
In Vivo Studies ◽  
Biogenic Selenium Nanoparticles

scholarly journals Anticancer activities of cyclohexenone derivatives

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Soon Young Shin ◽  
Jihyun Park ◽  
Yearam Jung ◽  
Young Han Lee ◽  
Dongsoo Koh ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Binding Mode ◽  
Anticancer Activities ◽  
Cancer Cell Growth ◽  
Term Survival ◽  
In Silico Docking ◽  
Cyclohexenone Derivatives

AbstractWe designed 21 ethyl 3,5-diphenyl-2-cyclohexenone-6-carboxylate derivatives to identify compounds exhibiting anticancer activity. To measure the inhibitory effects of the compounds on cancer cell growth, a long-term survival clonogenic assay was performed. Since compounds containing a cyclohexenone moiety inhibit the enzyme acetylcholinesterase, an in vitro acetylcholinesterase assay was performed for all 21 cyclohexenone derivatives. To examine the effect of the derivative that exhibited the best cancer cell growth inhibition on the induction of apoptosis by demonstrating the activation of caspases and apoptosis regulatory proteins, immunoblotting and immunofluorescence microscopic analyses were performed. The binding mode between the cyclohexenone derivatives and acetylcholinesterase was elucidated at the molecular level using in silico docking. Druggability was evaluated based on ligand efficiency.

scholarly journals Biogenic selenium nanoparticles produced by Lactobacillus casei ATCC393 inhibit colon cancer cell growth in vitro and in vivo

2021 ◽  
Author(s):  
Katerina Spyridopoulou ◽  
Eleni Tryfonopoulou ◽  
Georgios Aindelis ◽  
Petros Ypsilantis ◽  
Charalampos Sarafidis ◽  
...  
Keyword(s):  
Lactobacillus Casei ◽  
Colon Cancer Cell ◽  
Selenium Nanoparticles ◽  
Therapeutic Window ◽  
Cancer Cell Growth ◽  
Selenium Compounds ◽  
Anticancer Properties ◽  
Biogenic Selenium Nanoparticles

Selenium compounds exhibit excellent anticancer properties but have a narrow therapeutic window. Selenium nanoparticles however, are less toxic compared to other selenium forms, and their biogenic production leads to improved...

scholarly journals Nanodiamonds and silicon quantum dots: ultrastable and biocompatible luminescent nanoprobes for long-term bioimaging

2015 ◽  
Vol 44 (14) ◽  
pp. 4853-4921 ◽  
Author(s):  
M. Montalti ◽  
A. Cantelli ◽  
G. Battistelli
Keyword(s):  
Quantum Dots ◽  
Silicon Quantum Dots ◽  
Low Toxicity ◽  
Fluorescent Nanodiamonds

Ultra-stability and low-toxicity of silicon quantum dots and fluorescent nanodiamonds for long-termin vitroandin vivobioimaging are demonstrated.

Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo

2019 ◽  
Vol 16 (11) ◽  
pp. 1296-1301
Author(s):  
Yu-Hui Zhang ◽  
Jie Wang ◽  
Siqintana Xin ◽  
Li-Juan Wang ◽  
Xianliang Sheng
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Cell Permeability ◽  
Mice Model ◽  
Tumor Treatment ◽  
Anticancer Activities ◽  
Ongoing Research ◽  
Low Toxicity

Background: Considering the limitations of cisplatin in clinical application, there is ongoing research to fabricate new platinum-containing prodrug which are highly effective to tumor cells and have low toxicity to normal cells. Methods: In this study, a cyclodextrin-based supramolecular platinum prodrug that is 6,6’-ophenylenediseleno- bridged bis (β-cyclodextrin)s (CD) and its potassium tetrachloroplatinate(II) complex was reported. The cytotoxicity experiments were performed to evaluate the anticancer activities of supramolecular prodrug in vitro by means of MTT assay. The practical application of supramolecular prodrug in tumor treatment in vivo were evaluated using BALB/c nude mice model bearing Hela cancer cells. Results: Compared with commercial anticancer drug cisplatin, the resultant cyclodextrin-based platinum prodrug exhibited comparative anticancer effect but with much lower toxicity side effects in vitro and in vivo. Conclusion: The cyclodextrin-based supramolecular platinum prodrug displayed antitumor activity comparable to the commercial antitumor drug cisplatin but with lower side effects both in vitro and in vivo, implying that the two adjacent cyclodextrin cavities not merely act as desired solubilizer, but also endowed the prodrug with cell permeability through the interaction of cyclodextrin with phospholipids and cholesterol on cell membrane.

Thermosensitive injectable decellularized nucleus pulposus hydrogel as an ideal biomaterial for nucleus pulposus regeneration

2020 ◽  
Vol 35 (2) ◽  
pp. 182-192 ◽  
Author(s):  
Lei Yu ◽  
Zi-Jie Sun ◽  
Quan-Chang Tan ◽  
Shuang Wang ◽  
Wei-Heng Wang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Three Dimensional ◽  
Uniform Grid ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Low Toxicity ◽  
Three Dimensional Culture

Extracellular matrix loss is one of the early manifestations of intervertebral disc degeneration. Stem cell-based tissue engineering creates an appropriate microenvironment for long term cell survival, promising for NP regeneration. We created a decellularized nucleus pulposus hydrogel (DNPH) from fresh bovine nucleus pulposus. Decellularization removed NP cells effectively, while highly preserving their structures and major biochemical components, such as glycosaminoglycan and collagen II. DNPH could be gelled as a uniform grid structure in situ at 37°C for 30 min. Adding adipose marrow-derived mesenchymal stem cells into the hydrogel for three-dimensional culture resulted in good bioactivity and biocompatibility in vitro. Meanwhile, NP-related gene expression significantly increased without the addition of exogenous biological factors. In summary, the thermosensitive and injectable hydrogel, which has low toxicity and inducible differentiation, could serve as a bio-scaffold, bio-carrier, and three-dimensional culture system. Therefore, DNPH has an outstanding potential for intervertebral disc regeneration.

scholarly journals Antiangiogenic Compound Axitinib Demonstrates Low Toxicity and Antitumoral Effects against Medulloblastoma

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 70
Author(s):  
Marina Pagnuzzi-Boncompagni ◽  
Vincent Picco ◽  
Valérie Vial ◽  
Victor Planas-Bielsa ◽  
Ashaina Vandenberghe ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Tumor Cells ◽  
Cell Lines ◽  
Single Agent ◽  
Normal Cells ◽  
Antiangiogenic Drugs ◽  
Low Toxicity

Background: Despite the improvement of medulloblastoma (MB) treatments, survivors face severe long-term adverse effects and associated morbidity following multimodal treatments. Moreover, relapses are fatal within a few months. Therefore, chemotherapies inducing fewer adverse effects and/or improving survival at relapse are key for MB patients. Our purpose was to evaluate the last-generation antiangiogenic drugs for their relevance in the therapeutic arsenal of MB. Methods: We screened three EMA- and FDA-approved antiangiogenic compounds (axitinib, cabozantinib and sunitinib) for their ability to reduce cell viability of five MB cell lines and their low toxicity towards two normal cell lines in vitro. Based on this screening, single-agent and combination therapies were designed for in vivo validation. Results: Axitinib, cabozantinib and sunitinib decreased viability of all the tested tumor cells. Although sunitinib was the most efficient in tumor cells, it also impacted normal cells. Therefore, axitinib showed the highest selectivity index for MB cells as compared to normal cells. The compound did not lead to acute toxicity in juvenile rats and crossed the blood–brain barrier. Moreover, axitinib efficiently reduced the growth rate of experimental brain tumors. Analysis of public databases showed that high expression of axitinib targets correlates with poor prognosis. Conclusion: Our results suggest that axitinib is a compelling candidate for MB treatment.

scholarly journals The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison

2020 ◽  
Vol 10 (1) ◽  
pp. 26851
Author(s):  
Shideh Khangholi ◽  
Mehdi Mahdavi ◽  
Mohammad Hossein Yazdi ◽  
Ahmad Reza Shahverdi
Keyword(s):  
Brain Tumors ◽  
Cell Line ◽  
Selenium Nanoparticles ◽  
Glioblastoma Cell ◽  
Significant Difference ◽  
Life Threatening ◽  
Selenium Supplements ◽  
Bax Gene ◽  
Biogenic Selenium Nanoparticles

Background: Brain tumors can be serious and life-threatening when they are treated effectively. Many therapeutic approaches, such as chemotherapy, radiotherapy, and surgery have been used to treat brain tumors. In this regard, selenium supplements have been reported effective.Methods: Selenium Nanoparticles (SeNPs) were produced in two forms of synthetic and biogenic to evaluate their cytotoxicity on brain glioblastoma cell lines. A-172 cell line was cultured in DMEM medium. The cytotoxicity of the synthetic and biogenic SeNP was assessed by MTT assay. Results: There was a significant difference between the group treated with biogenic and synthetic SeNP compared with non-treated cells after 24, 48, and 72 h. Both biogenic and synthetic SeNP increased Bax gene and decreased Bcl-2 gene expression. Conclusion: It seems that biogenic SeNP was more lethal than its synthetic form. Therefore, it should be considered that the method of NP construction may be an important parameter for its bioactivity.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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