scholarly journals A Retrospective, Observational Study on Antimicrobial Drug Use in Beef Fattening Operations in Northwestern Italy and Evaluation of Risk Factors Associated with Increased Antimicrobial Usage

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1925
Author(s):  
Isabella Nicola ◽  
Giovanni Gallina ◽  
Giulia Cagnotti ◽  
Paola Gianella ◽  
Flaminia Valentini ◽  
...  
Keyword(s):  
Group Treatment ◽  
Human Medicine ◽  
Antimicrobial Usage ◽  
European Guidelines ◽  
Group Treatments ◽  
Potential Factor ◽  
The Mean ◽  
Antimicrobial Treatments ◽  
Batch Weight ◽  
Active Substances

The abuse or misuse of antimicrobials in animal production is thought to be a potential factor in the development of antimicrobial resistance in veterinary and human medicine. With this study, we wanted to quantify antimicrobial usage in beef fattening operations in northwestern Italy and to identify factors potentially influencing antimicrobial usage. The sample was composed of 26 beef fattening operations that import heifers and bulls from France. Data were extracted from the 2014 and 2015 treatment registers kept by the farmers. The mean (±SD) number of animal daily doses per animal (nADDa) per year for each farm was 3 (±2.1) during the study period (2014–2015). Group antimicrobial treatments (57.5% of all treatments) were often administered orally (70.5%) and consisted overwhelmingly of doxycycline (97%). Individual treatments (42.5% of all treatments) were administered parenterally (98.1%) and the most often used active substances were florfenicol (19.9%), marbofloxacin (19.5%), and tylosin (12.4%). There was a negative correlation between the nADDa for total and group treatments and average batch weight at arrival and between the amount of straw added per animal per day and the nADDa (p ≤ 0.05). Our data show that antimicrobials critical for human medicine were often used in beef fattening operations in northwestern Italy before the European guidelines for the prudent use of antimicrobials in veterinary medicine were issued. Additionally, the use of antimicrobials as a preventive group treatment was still widespread, mostly in lighter weight animals.

scholarly journals Association between antimicrobial usage and resistance in Salmonella from poultry farms in Nigeria

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Abdurrahman Hassan Jibril ◽  
Iruka N. Okeke ◽  
Anders Dalsgaard ◽  
John Elmerdahl Olsen
Keyword(s):  
Treatment Outcome ◽  
Antimicrobial Resistance ◽  
Global Health ◽  
Human Medicine ◽  
Antimicrobial Use ◽  
Resistance Development ◽  
Use Patterns ◽  
Antimicrobial Usage ◽  
Poultry Farms ◽  
Reduction Strategies

Abstract Background Antimicrobial resistance (AMR) is a global health threat affecting treatment outcome in animals and humans. A pre-requisite for development of AMR reduction strategies is knowledge of antimicrobial use patterns, and how these affect resistance development. The aim of this study was to determine antimicrobial usage (AMU) and whether such usage was associated with AMR in Salmonella from poultry farms in Northwest Nigeria. Results Fifteen (37%) of antimicrobial products observed contained compounds that are of highest priority and critically important for human medicine. Broilers chicken consumed higher (28 ± 14 mg/kg active ingredients) amounts of antimicrobials compared to layers (13 ± 8 mg/kg) per week (p = 0.0009). Surprisingly, chickens raised under backyard system consumed higher amounts of antimicrobials (34 ± 7 mg/kg) than poultry in other systems (p = 0.02). High levels of resistance to tetracycline (58%), sulphonamides (65%), ciprofloxacin (46%) and gentamicin (42%) correlated with high farm level usage of these antimicrobials, and there was a strong correlation (r = 0.9) between farm usage and resistance of isolates to the same antimicrobials (p = 0.03). Conclusion High AMU, including use of highest priority critically important antimicrobials was observed at poultry farms in Northwest Nigeria. AMU correlated with high levels of resistance. Communication of prudent use of antimicrobials to farmers and regulation to obtain reduction in AMU should be a priority.

Development of Adverse Sequelae in Children Born with Subclinical Congenital Toxoplasma Infection

PEDIATRICS ◽  
1980 ◽  
Vol 66 (5) ◽  
pp. 767-774 ◽  
Author(s):  
Christopher B. Wilson ◽  
Jack S. Remington ◽  
Sergio Stagno ◽  
David W. Reynolds
Keyword(s):  
Group Treatment ◽  
Toxoplasma Infection ◽  
Newborn Period ◽  
Group I ◽  
Neurologic Sequelae ◽  
The Mean ◽  
Iq Scores ◽  
Group Ii ◽  
Score Range

Most infants born with congenital Toxoplasma infection are asymptomatic in the newborn period, and therefore their infection is not recognized. We performed follow-up evaluations on 24 such children. The mean age of these children at last examination was 8.5 years. In group I (13 children), the diagnosis was made prospectively. In group II (11 children), no symptoms or signs were noted in the newborn period and the diagnosis was made only after the first sign developed. Eighty-five percent of the children in group I and all of the children in group II have developed chorioretinitis. In group I, three children (23%) have unilateral blindness; in group II, three children (27%) and five children (45%) have unilateral and bilateral blindness, respectively. One child (8%) in group I and two children (18%) in group II developed severe, permanent neurologic sequelae after they initially presented with eye disease. Two of the children in each group are now retarded (IQ score range, 36 to 62). Six of the children in group I who were tested sequentially have had lower IQ scores (mean change from 97 to 74) on repeat tests performed an average of 5.5 years later. Less severe neurologic, intellectual, and audiologic deficits were observed in other children in each group. Treatment of some children may have had a beneficial effect on their outcome.

Cataract surgery refractive outcomes: representative standards in a National Health Service setting

2018 ◽  
Vol 103 (4) ◽  
pp. 539-543 ◽  
Author(s):  
Kerr Brogan ◽  
Charles J M Diaper ◽  
Alan P Rotchford
Keyword(s):  
National Health Service ◽  
Health Service ◽  
Cataract Surgery ◽  
National Health ◽  
Postoperative Outcome ◽  
Absolute Error ◽  
European Guidelines ◽  
Refractive Outcomes ◽  
Service Setting ◽  
The Mean

Background/aimsTo report refractive outcomes from an National Health Service (NHS) cataract surgery service and assess if results meet suggested benchmark standard.MethodsDetails of all patients undergoing cataract surgery in the Southern General and New Victoria hospitals in Glasgow, UK, between November 2006 and December 2016 were prospectively entered into an electronic database. Patients were reviewed 4 weeks postoperatively in the eye clinic and underwent refraction at their local optometrist prior to this appointment. Surgically uncomplicated cases with in the bag’ non-toric intraocular lens implantation were included. Patients with previous laser refractive procedures or failing to achieve 6/12 acuity or better postoperatively were excluded. Proximity to targeted postoperative refraction was documented.ResultsOver this 10-year period, 11 083 eyes underwent cataract surgery. Of these, 8943 eyes of 6936 patients (80.69%) met the inclusion criteria and had both target and postoperative outcome refraction recorded. The mean difference between the targeted and outcome refraction was −0.07 D (SD 0.67). The mean absolute error was 0.50 D. Postoperative refraction was within 1 D of target refraction for 7938 eyes (88.76%) and within 0.50 D for 5577 eyes (62.36%).ConclusionRefractive outcomes following routine cataract surgery reported here are well within the targets recommended by the Royal College of Ophthalmologists and European guidelines, but suggest that higher cataract refractive outcome benchmark standards may not yet be a realistic expectation for all NHS units with current biometry practice.

scholarly journals Early Risk of Stroke in Patients Undergoing Acute Versus Elective Cardioversion for Atrial Fibrillation

2021 ◽  
Author(s):  
Tomas Forslund ◽  
Frieder Braunschweig ◽  
Martin J. Holzmann ◽  
Anwar J. Siddiqui
Keyword(s):  
Atrial Fibrillation ◽  
Lower Risk ◽  
Cox Regression ◽  
Oral Anticoagulants ◽  
Regression Analyses ◽  
Regional Health ◽  
European Guidelines ◽  
Regional Health Care ◽  
The Mean ◽  
First Time

Background Electrical cardioversion (ECV) is routinely used to restore sinus rhythm in patients with symptomatic atrial fibrillation. The European guidelines have been updated in recent years. Current information on differences in the risk for stroke after acute versus elective ECV is lacking. Methods And Results All patients with a first‐time acute or elective ECV in the Stockholm regional health care data warehouse from 2011 to 2018 were included. Cox regression analyses were performed evaluating ischemic or unspecified stroke within 30 days after ECV with adjustments for the CHA 2 DS 2 ‐VASc score, medical treatment, and year of inclusion. The study included 9139 patients, 3094 after acute and 6045 after elective ECV. The mean age was 65.9±11.3 years, 69.5% were men, and the mean CHA 2 DS 2 ‐VASc score was 2.4±1.7. Before the intervention, 49.6% of patients with an acute ECV and 96.4% of those with an elective ECV had claimed an oral anticoagulant prescription. Ischemic or unspecified stroke occurred in 26 (0.28%) patients within 30 days. The unadjusted risk was higher after acute compared with elective ECV (hazard ratio [HR], 2.29; 95% CI, 1.06–4.96), whereas there was no difference after multivariable adjustments (adjusted HR, 0.99; 95% CI, 0.36–2.72). Both non–vitamin K oral anticoagulants (adjusted HR, 0.28; 95% CI, 0.08–0.98) and warfarin (adjusted HR, 0.17; 95% CI, 0.05–0.53) were associated with a lower risk for stroke compared with no anticoagulation. Conclusions Acute ECV was associated with a higher unadjusted risk for stroke than elective ECV, but the risk was similar after adjustment for anticoagulant treatment. This study indicates the importance of anticoagulation before ECV according to recent European guidelines.

scholarly journals Analysis of Static Molecular Gradients in a High-Throughput Drug Screening Microfluidic Assay

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6385
Author(s):  
Roman G. Szafran ◽  
Benita Wiatrak
Keyword(s):  
High Throughput ◽  
Concentration Profile ◽  
Drug Screening ◽  
High Throughput Drug Screening ◽  
Analytical Protocol ◽  
The Mean ◽  
Gradient Generation ◽  
Mathematical Relationships ◽  
Mean Concentration ◽  
Active Substances

In this study, we thoroughly analyzed molecular gradient generation, its stability over time, and linearity in our high-throughput drug screening microfluidic assay (HTS). These parameters greatly affect the precision and accuracy of the device’s analytical protocol. As part of the research, we developed a mathematical model of dependence of the concentration profile on the initial concentrations of active substances in reservoirs and the number of tilts, as well as the dependence of the active substance concentration profiles in the culture chambers on the concentration profile of the reference dye in the indicator chamber. The mean concentration prediction error of the proposed equations ranged from 1.4% to 2.4% for the optimized parameters of the procedure and did not increase with the incubation time. The concentration profile linearity index, Pearson’s correlation coefficient reached −0.997 for 25 device tilts. The observed time stability of the profiles was very good. The mean difference between the concentration profile after 5 days of incubation and the baseline profile was only 7.0%. The newly created mathematical relationships became part of the new HTS biochip operating protocols, which are detailed in the article.

Sonographic characteristics of the placenta, uterine wall, and placentomes during pregnancy in cows

2019 ◽  
Vol 47 (06) ◽  
pp. 355-365
Author(s):  
Doreen Zoller ◽  
Susanne Peterson ◽  
Alois Boos ◽  
Michael Hässig ◽  
Ulrich Bleul
Keyword(s):  
Amniotic Fluid ◽  
Allantoic Fluid ◽  
Uterine Wall ◽  
Human Medicine ◽  
Close Monitoring ◽  
Sonographic Examination ◽  
Brown Swiss ◽  
Linear Transducer ◽  
Chorion Laeve ◽  
The Mean

Abstract Objective In human medicine, contrary to bovine medicine, close monitoring of risk pregnancies is an integral part of obstetrics. A prerequisite for this is the knowledge of the normal findings during pregnancy. Material and methods For this purpose serial transrectal sonographic examination of the placentomes, uterine wall, and fetal membranes were carried out in 24 healthy (mean age 8.1 ± 3.7 years, Brown Swiss [n = 21], Red Holstein [n = 2], Simmental [n = 1]) cows from week 6 to 43 of gestation. An 8-MHz linear transducer was used to assess the thickness and appearance of the endometrium and myometrium, the height and width of placentomes, the thickness of the uterine wall including the adjacent chorion laeve (combined thickness of uterus and placenta, CTUP), and the echogenicity of the fetal fluids. The uterine wall and the placentomes were measured in 4 different zones of both uterine sides including a zone near the cervix, at the corpus near to the bifurcation, at the middle, and near the tip of the uterine horn. Results Placentome height and width were closely correlated with gestational age (height: r = 0.78; width: r = 0.83; both p < 0.0001). Placentome size increased progressively in all uterine zones until week 27, after which time their growth slowed until week 31 and then plateaued until parturition. Placentomes in the fetus-bearing horn were larger than in the non-fetus-bearing horn (p < 0.01) and were significantly smaller (height and width) near the tip of the horn than in the other 3 zones (p < 0.001 to < 0.01). The mean thickness of endometrium and myometrium, myometrium at the base of the placentome, and the mean CTUP did not change significantly during gestation. The echogenicity of the allantoic fluid did not change, but the amniotic fluid became more echogenic during gestation (p < 0.0001). Conclusion and clinical relevance Sonographic examination of placentomes and amniotic fluid are a promising diagnostic tool for the estimation of the duration of bovine pregnancies and for diagnosing possible complications.

Can education and training improve the adoption of a psychosocial group treatment by dementia services?

2019 ◽  
Vol 27 (5) ◽  
pp. 496-500
Author(s):  
Gary Cheung ◽  
Kathy Peri
Keyword(s):  
Group Treatment ◽  
Online Survey ◽  
Cognitive Stimulation ◽  
Training Workshop ◽  
Self Evaluation ◽  
People With Dementia ◽  
Before And After ◽  
The Mean ◽  
The One ◽  
And Training

Objective: Cognitive stimulation therapy (CST) is a psychosocial group treatment for people with dementia. The aims of this project were to (a) evaluate the effectiveness of a one-day training workshop; (b) measure the uptake of CST following the workshops; and (c) explore the barriers of implementing CST. Method: Ten workshops were conducted. Attendees completed a self-evaluation at the end of the training day and were later invited to complete an online survey enquiring about implementation. Results: Two hundred and fourteen workshop attendees completed the self-evaluation. The mean self-rated knowledge and skills for conducting and facilitating CST (1 = No skills, 5 = Very good skills) was 2.3 (SD = 1.2) and 4.3 (SD = 0.7) before and after the workshop, respectively ( p = 0.000). The mean self-rated confidence for applying learning to conducting and facilitating CST was 4.2 (SD = 0.7) (1 = Not confident, 5 = Very confident). There were 11 CST programmes started after the workshops and another 10 sites were in the process of starting CST programmes. The main barriers of implementation were lack of staff time/funding and problems of finding suitable participants with dementia. Conclusions: The one-day training workshop is an effective method to disseminate CST. Addressing the barriers identified could improve the adoption of CST in practice.

Physiological responses in pigs on antioxidant supplementation during summer and winter

2017 ◽  
Author(s):  
Arindam Chakraborty ◽  
Anubha Baruah ◽  
B. C. Sarmah ◽  
J. Goswami ◽  
Arundhati Bora ◽  
...  
Keyword(s):  
Vitamin E ◽  
Pulse Rate ◽  
Rectal Temperature ◽  
Group Treatment ◽  
Physiological Responses ◽  
Growing Pigs ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
Vitamin E Supplementation

The objective of the study was to assess the variability in the physiological responses of growing pigs on melatonin and vitamin E supplementation during summer and winter seasons.36 nos. of weaned crossbred (Hampshire X Assam local) female pigs were selected for the study. Eighteen (18) animals were subjected to treatment separately during summer and winter. The selected animals were divided into three groups, with six pigs in each group, consisting of the control group (Treatment 1), a second group comprising of animals fed with melatonin (Meloset) @3 mg/animal (Treatment 2) and a third group in which the animals were fed Vitamin E (Evion) @100 mg (Treatment 3), for both the seasons. The rectal temperature, respiration and pulse rate differed significantly (P>0.01) between seasons. There was also significant difference (P>0.01) in the mean pulse rate between treatment.

P1949Changes in prevalence patients with arterial hypertension in Russia

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y Badin ◽  
I V Fomin ◽  
D S Polyakov ◽  
S S Yakushin ◽  
E A Smirnova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drug Treatment ◽  
Arterial Hypertension ◽  
Antihypertensive Drug ◽  
P Value ◽  
Antihypertensive Drug Treatment ◽  
European Guidelines ◽  
The Mean ◽  
Grade 3

Abstract Aim The present study shows the dynamics of the prevalence different grades of AH and treatment coverage over15 years of observation. Methods 8740 apartments were randomized in 2002 year in eight regions of Russia and 19449 individuals were included. Re-examination was carried out in 2017 year. The representative sample was separated in four groups: Grade 0 – individuals with systolic blood pressure (BP) <140 mm Hg and diastolic blood pressure <90 mm Hg; and three Grades of arterial hypertension (AH) in accordance with European guidelines. Also, we select patient with and without antihypertensive drug treatment (AHDT). Results The mean age individuals was 44.4±19.3 years in 2002 year. Grade 0 had 63.3% participants (mean age 36.5±17.1 y.), Grade 1 – 19.5% (mean age 55.2±15.4 y.), Grade 2 – 11.7% (mean age 60.6±13.5 y.) and Grade 3 – 5.6% (mean age 62.4±12.8 y.). 3.0% participants had AHDT and blood pressure meets Grade 0. Patients with AH Grade 1 used drugs in 25.5% cases, with Grade 2 – 49.4% and with Grade 3 – 60.8% patients respectively. The mean age of participants with AHTD was significantly higher than mean age group without AHTD in Grade 0, 1 and 2 (p<0.001). In group Grade 3 mean age was not difference (p=0.16). The mean age individuals (51.3±16.9 y.) in 2017 year was significantly higher on 6.9 years than mean age in 2002 year (p<0.001). The proportion of patients with AHDT in all grades groups in sample 2017 year were significantly higher than in sample 2002 year (Table). The prevalence of AH in 2002 y. amounted to 38.6%. In 2017 y. prevalence of AH was significantly higher – 41.4% (p<0.001). Structure of samples Grade 2002 2017 AHDT Mean age AHDT P value Mean age 0 63,3% No 35,8±16,8 70,1% 42,6±13,9 Yes 3,0% 57,4±14,5 16,3% <0,001 63,6±12,0 1 19,5% No 53,3±15,7 23,6% 57,3±13,3 Yes 25,5% 60,9±13,0 68,4% <0,001 66,3±11,3 2 11,7% No 58,5±14,2 5,4% 58,0±14,9 Yes 49,4% 62,7±12,3 80,6% <0,001 66,5±11,5 3 5,6% No 61,7±13,9 1,0% 63,6±17,6 Yes 60,8% 62,8±12,0 71,1% 0,03 66,0±12,8 ALL 100% 44,4±19,3 100% 51,3±16,9 AHDT: antihypertensive drug treatment. Conclusion Over 15 years follow up period the prevalence of hypertension in Russia increased to 41.4%, but the effectiveness of therapy remains low.

scholarly journals Effects of Bimax and Segmental Surgeries for Correction of Bimaxillary Dentoalveolar Protrusion Class I on Soft Tissue Parameters: Upper lip Thickness and Curvature, Nasolabial Angle and Nasal Prominence

2013 ◽  
Vol 14 (6) ◽  
pp. 1087-1093 ◽  
Author(s):  
Amin Rahpeyma ◽  
Saeedeh Khajehahmadi
Keyword(s):  
Soft Tissue ◽  
Group Treatment ◽  
Anterior Segment ◽  
Class I ◽  
Upper Lip ◽  
Perpendicular Line ◽  
Lower Jaw ◽  
Nasolabial Angle ◽  
Before And After ◽  
The Mean

ABSTRACT Aim Results of this study can show if bimax surgery for posterior repositioning of maxilla and correction of BPCLI has priority to the currently used segmental orthognathic surgery or not. Materials and methods This study was done on 40 whiteskinned Iranian patients with bimaxillary dentoalveolar protrusion class I (BPCLI) who sought treatment for their deformity. In the first group, treatment includes segmental surgery for backward replacement of anterior segment of the upper and lower jaw. In the second group, treatment was bimax surgery, in which whole upper and lower jaw moved backward. Twenty patients were included in each group. For this purpose, we measured upper lip thickness (ULT, distance between LS and IA), nose prominence (NP, distance between nasal tip and the perpendicular line from upper lip vermilion on FHP), subsulcus depth (SSD, distance of SLS from this perpendicular line), SN to H line distance and finally, nasolabial angle (NLA) before and after surgery. Results In our study, 65% of patients were female and the mean of age was 27 (17-39) years old. The mean of SNA, SNB, ANB and INA in our patients were 81.7 ± 2.9, 78.8 ± 2.8, 4.50 ± 1.4 and 120 ± 8.7, respectively. All variables except SSD were analyzed with t-test to compare the results of two methods of surgery. Differences in the values of NP, NLA, SN to H line distance and ULT before and after segmental and bimax surgeries between before and after surgery were significant. After surgeries, ULT and the SN to H line distance reduced significantly, and NLA became corrected to its normal range (90-110). Conclusion The results of this study showed that bimax and segmental surgeries can effectively correct BPCLI. Because of possible dental and periodontal complications of segmental surgery, we highly recommend bimax surgery for treatment of BPCLI. How to cite this article Rahpeyma A, Khajehahmadi S. Effects of Bimax and Segmental Surgeries for Correction of Bimaxillary Dentoalveolar Protrusion Class I on Soft Tissue Parameters: Upper lip Thickness and Curvature, Nasolabial Angle and Nasal Prominence. J Contemp Dent Pract 2013;14(6):1087-1093.

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