scholarly journals Natural Compounds as Antimicrobial Agents

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 217 ◽  
Author(s):  
Carlos Manuel Franco ◽  
Beatriz I. Vázquez
Keyword(s):  
Allium Sativum ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Extreme Environments ◽  
Natural Compounds ◽  
Animal Origin ◽  
Original Research ◽  
Protein Extract ◽  
Research Papers ◽  
Specific Effects

During the first two decades of this century, conventional antimicrobial compounds have been found out to have more bacterial resistance. What has also been worrying is the rediscovery of the so-called “natural compounds”, which in turn have a good name among the average citizen because of the former’s plant or animal origin. However, they do not form a well-classified group of substances. This Special Issue consists of five reviews focusing on clinical bacteria applications in food and their specific effects upon virulent bacterial factors. You will also find a research on much needed, new antimicrobials sourced in extreme environments, and secondary metabolites of Burkholderia. This issue includes 12 original research papers which will provide you with an in-depth coverage of the protein extract activity, as well as the activity of other plant extracts, on fighting bacteria, fungi or diarrhea. Their use in broilers or laying eggs for production purposes has also been focused on in order to improve gut microbiota. Last but not least, we should not forget about honey and its effect; Allium sativum-fermented extracts, as well as other “natural” compounds, have been studied in their fight against biofilms. Furthermore, we have also examined the use of essential oils, which are currently used in edibles such as fresh sausages. The present work also deals with other applications such as natural compound derivatives as well as compound mixtures.

scholarly journals Plant-Based Bioactive Molecules in Improving Health and Preventing Lifestyle Diseases

2021 ◽  
Vol 22 (6) ◽  
pp. 2991
Author(s):  
Rosaria Acquaviva ◽  
Giuseppe Antonio Malfa ◽  
Claudia Di Giacomo
Keyword(s):  
Human Health ◽  
Life Style ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Natural Compounds ◽  
Bioactive Molecules ◽  
Original Research ◽  
Special Issue ◽  
Research Papers ◽  
Lifestyle Diseases

The Special Issue, “Plant-Based Bioactive Molecules in Improving Health and Preventing Life-style Diseases”, includes original research papers and reviews, which aim to increase knowledge of the molecular mechanisms underlying multiple biological effects of natural compounds from plants, responsible for maintaining human health and improving many diseases caused by people’s daily lifestyles [...]

scholarly journals Mechanisms of antimicrobial resistance development in bacteria

2020 ◽  
Vol 8 (3) ◽  
pp. 226-236
Author(s):  
T. I. Stetsko ◽  
V. P. Muzyka ◽  
M. R. Kozak
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Agent ◽  
Resistance Genes ◽  
Target Genes ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Bacterial Species ◽  
Animal Health ◽  
Significant Risk ◽  
Animal Origin

Antimicrobial resistance poses a significant risk to animal health by reducing the effectiveness of the treatment and prevention of many infections caused by bacteria. Antibiotic resistance threatens human health by transmitting resistant strains of microorganisms or resistance genes from animals to humans through the food chain. Life-threatening infections that were previously manageable can become incurable through antimicrobial resistance. Antimicrobial resistance can be divided into two main types: natural and acquired. Natural bacterial resistance is associated with the absence or inaccessibility of target cites for the action of certain antimicrobial agents. The acquired resistance is specific and associated with the acquisition of extraneous resistance genes or mutational modification of chromosomal target genes. The resistance of bacteria to antimicrobial drugs varies depending on the antimicrobial agent, species or genus of bacteria, and the mechanism of resistance. Resistance to the same antimicrobial agent can be mediated by different resistance mechanisms. In some cases, the same resistance gene or mechanism are related to a wide variety of bacteria, whereas in other cases, resistance genes or mechanisms are restricted to certain bacterial species or genera. Bacterial resistance to different classes of antibiotics with common mechanisms often leads to the multidrug resistance. The data presented in this review focuses exclusively on the resistance genes and mechanisms found in bacteria of animal origin and on antimicrobials used in the veterinary medicine. For better coverage of the topic, information on the mechanisms of resistance is presented separately for each class of antimicrobial agents.

Journal of Technical and Natural Sciences 4(13), 2019/ OEAPS Inc.(Open European Academy of Public Sciences); Chief Editor Vitaly Yakovlev- Berlin, Germany. 26.05.2019: OEAPS Inc., 2019. - 74 P. ISBN: 9781075497858

2019 ◽  
Author(s):  
Inc. OEAPS
Keyword(s):  
Chief Editor ◽  
Natural Sciences ◽  
Theory And Practice ◽  
Original Research ◽  
Research Papers ◽  
European Academy ◽  
Constant Interest ◽  
Critical Reviews

Authoritative and critical reviews of the latest achievements of natural and technical disciplines are published by Journal of Technical and Natural Sciences. Journal of Technical and Natural Sciences, an international peerreviewed journal, publishes both theoretical and experimental highquality documents of constant interest, previously unpublished in journals, in the field of technical and natural sciences, whose purpose is to promote theory and practice. In addition to the peerreviewed original research papers, the Editorial Board welcomes original research reports, modern surveys and communications in a broadly defined field of technical and natural sciences.

Journal of Technical and Natural Sciences 9, 2018/ OEAPS Inc.(Open European Academy of Public Sciences); Chief Editor Vitaly Yakovlev- Berlin, Germany. 18.12.2018: OEAPS Inc., 2019. - 35 P.

2019 ◽  
Author(s):  
Inc. OEAPS ◽  
Михаил Владимирович Кармаза ◽  
Роман Владимирович Мотылев ◽  
Вероника Александровна Одрузова ◽  
Нишчхал ◽  
...  
Keyword(s):  
Chief Editor ◽  
Natural Sciences ◽  
Theory And Practice ◽  
Original Research ◽  
Research Papers ◽  
High Quality ◽  
European Academy ◽  
Constant Interest ◽  
Critical Reviews

Authoritative and critical reviews of the latest achievements of natural and technical disciplines are published by Journal of Technical and Natural Sciences.Journal of Technical and Natural Sciences, an international peer¬reviewed journal, publishes both theoretical and experimental high¬quality documents of constant interest, previously unpublished in journals, in the field of technical and natural sciences, whose purpose is to promote theory and practice. In addition to the peer¬reviewed original research papers, the Editorial Board welcomes original research reports, modern surveys and communications in a broadly defined field of technical and natural sciences.

Journal of Technical and Natural Sciences 2(11), 2019/ OEAPS Inc.(Open European Academy of Public Sciences); Chief Editor Vitaly Yakovlev- Berlin, Germany. 26.02.2019: OEAPS Inc., 2019. - 87 P.

2019 ◽  
Author(s):  
Саида Адиловна Низамова ◽  
Alina Evgenievna Averina ◽  
Руслан Сергеевич Решетов ◽  
Дмитрий Алексеевич Погожев ◽  
Мария Михайловна Кошелькова ◽  
...  
Keyword(s):  
Chief Editor ◽  
Natural Sciences ◽  
Theory And Practice ◽  
Original Research ◽  
Research Papers ◽  
European Academy ◽  
Constant Interest ◽  
Critical Reviews

Authoritative and critical reviews of the latest achievements of natural and technical disciplines are published by Journal of Technical and Natural Sciences. Journal of Technical and Natural Sciences, an international peerreviewed journal, publishes both theoretical and experimental highquality documents of constant interest, previously unpublished in journals, in the field of technical and natural sciences, whose purpose is to promote theory and practice. In addition to the peerreviewed original research papers, the Editorial Board welcomes original research reports, modern surveys and communications in a broadly defined field of technical and natural sciences

scholarly journals Advances in the Molecular Mechanisms of Abscisic Acid and Gibberellins Functions in Plants

2021 ◽  
Vol 22 (11) ◽  
pp. 6080
Author(s):  
Víctor Quesada
Keyword(s):  
Abscisic Acid ◽  
Molecular Mechanisms ◽  
Original Research ◽  
Special Issue ◽  
Research Papers

In this special issue entitled, “Advances in the Molecular Mechanisms of Abscisic Acid and Gibberellins Functions in Plants”, eight articles are collected, with five reviews and three original research papers, which broadly cover different topics on the abscisic acid (ABA) field and, to a lesser extent, on gibberellins (GAs) research [...]

scholarly journals The Lactococcal dgkB (yecE) and dxsA Genes for Lipid Metabolism Are Involved in the Resistance to Cell Envelope-Acting Antimicrobials

2021 ◽  
Vol 22 (3) ◽  
pp. 1014
Author(s):  
Aleksandra Tymoszewska ◽  
Tamara Aleksandrzak-Piekarczyk
Keyword(s):  
Antimicrobial Peptides ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Cytoplasmic Membrane ◽  
Cross Resistance ◽  
Resistant Bacteria ◽  
Membrane Targeting ◽  
Nucleotide Polymorphisms ◽  
Next Generation ◽  
Lipid Ii

The emergence of antibiotic-resistant bacteria led to an urgent need for next-generation antimicrobial agents with novel mechanisms of action. The use of positively charged antimicrobial peptides that target cytoplasmic membrane is an especially promising strategy since essential functions and the conserved structure of the membrane hinder the development of bacterial resistance. Aureocin A53- and enterocin L50-like bacteriocins are highly cationic, membrane-targeting antimicrobial peptides that have potential as next-generation antibiotics. However, the mechanisms of resistance to these bacteriocins and cross-resistance against antibiotics must be examined before application to ensure their safe use. Here, in the model bacterium Lactococcus lactis, we studied the development of resistance to selected aureocin A53- and enterocin L50-like bacteriocins and its correlation with antibiotics. First, to generate spontaneous resistant mutants, L.lactis was exposed to bacteriocin BHT-B. Sequencing of their genomes revealed single nucleotide polymorphisms (SNPs) in the dgkB (yecE) and dxsA genes encoding diacylglycerol kinase and 1-deoxy-D-xylulose 5-phosphate synthase, respectively. Then, selected mutants underwent susceptibility tests with a wide array of bacteriocins and antibiotics. The highest alterations in the sensitivity of studied mutants were seen in the presence of cytoplasmic membrane targeting bacteriocins (K411, Ent7, EntL50, WelM, SalC, nisin) and antibiotics (daptomycin and gramicidin) as well as lipid II cycle-blocking bacteriocins (nisin and Lcn972) and antibiotics (bacitracin). Interestingly, decreased via the SNPs accumulation sensitivity to membrane-active bacteriocins and antibiotics resulted in the concurrently increased vulnerability to bacitracin, carbenicillin, or chlortetracycline. It is suspected that SNPs may result in alterations to the efficiency of the nascent enzymes rather than a total loss of their function as neither deletion nor overexpression of dxsA restored the phenotype observed in spontaneous mutants.

Sign in / Sign up

Export Citation Format

Share Document