scholarly journals Hypolipidemic Effects and Preliminary Mechanism of Chrysanthemum Flavonoids, Its Main Components Luteolin and Luteoloside in Hyperlipidemia Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1309
Author(s):  
Jihan Sun ◽  
Zhaodan Wang ◽  
Lin Chen ◽  
Guiju Sun
Keyword(s):  
Antioxidant Activity ◽  
Lipid Metabolism ◽  
Liver Steatosis ◽  
Intervention Group ◽  
The Body ◽  
Control Group ◽  
Metabolism Regulation ◽  
Metabolism Enzymes ◽  
Model Control ◽  
Significant Difference

This study aimed to investigate the key constituents and preliminary mechanism for the hypolipidemic activity of chrysanthemum flavonoids. Hyperlipidemia (HPL) rats were divided into five groups: the model control group (MC); Chrysanthemum flavone intervention group (CF); luteolin intervention group; luteoloside intervention group and simvastatin intervention group. The body weight, organ coefficient, serum lipids, antioxidant activity, and lipid metabolism enzymes were detected. Hematoxylin and eosin (H&E) staining was used to observe the liver and adipose tissue. Chrysanthemum flavonoids, luteolin, and luteoloside can reduce the weight and levels of total cholesterol (TC), triglycerides (TG), and LDL-C, and increase the level of HDL-C in the blood and reduce liver steatosis. Indicators of liver function (AST, ALT, and ALP) improved. The antioxidant activity (GSH-Px, CAT, SOD) and enzymes associated with lipid catabolism (FAβO, CYP7A1, and HL) increased, while lipid peroxidation products (MDA) and enzymes associated with lipid synthesis (FAS, HMG-CoA, and DGAT) decreased. Chrysanthemum flavonoids had a better effect on the antioxidant level and lipid metabolism-related enzyme activity. There was no significant difference in the effects of the chrysanthemum flavonoids, luteolin, and Luteoloside on improving blood lipids and hepatic steatosis—mechanisms that may be related to antioxidant levels and regulating enzymes involved in the metabolism of fatty acids, cholesterol, and triglycerides in the liver. However, chrysanthemum flavonoids had a stronger antioxidant and lipid metabolism regulation ability, and the long-term effects may be better.

scholarly journals Optimalisasi Pertumbuhan Bayi dengan Baby Massage and Spa

2019 ◽  
Vol 10 (2) ◽  
pp. 276
Author(s):  
Yusari Asih ◽  
I Gusti Ayu Mirah WS
Keyword(s):  
Body Length ◽  
Head Circumference ◽  
Intervention Group ◽  
Sampling Technique ◽  
Holistic Approach ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference

<p><span>Baby Massage and Spa was a traditional effort that uses a holistic approach through comprehensive care using a combination of massage and water therapy methods that are carried out in an integrated manner to balance the body, mind, and feelings. Age 3-6 months is the right time for babies to do massage and spa. The purpose of this study was to determine the effect of baby massage and spa on the growth of infants aged 3-5 months in Pringsewu District in 2018. This study uses a quasi-experimental approach with research design pre and post-test with control group design. The purposive sampling technique was taken with a sample of 30 infants as the intervention group and 30 infants as the control group. Data were processed using computerization and analyzed using the T-Test. The results showed that there were significant differences between body weight, body length and baby head circumference in the pre and post-treatment. There was no significant difference in the average increase in infant weight between babies who were carried out by baby massage and spa with babies who were not carried out by baby massage and spa with p-value 0.116. There is a significant difference in the baby's body length and head circumference performed by baby massage and spa with those not carried out by baby massage and spa with p-value 0.000. Baby Massage and Spa has a significant effect on increasing the growth of babies aged 3-5 months.</span></p><p><span> </span></p>

scholarly journals Differences in Erythrocyte Magnesium Levels between Men with Schizophrenia Treated with Risperidone and Haloperidol in Prof. Dr. M Ildrem Psychiatric Hospital Medan

2021 ◽  
Vol 9 (T3) ◽  
pp. 186-192
Author(s):  
Ihsan Fadhilah ◽  
Bahagia Loebis ◽  
Muhammad Surya Husada ◽  
Nazli Mahdinasari Nasution ◽  
Elmeida Effendy
Keyword(s):  
Psychiatric Hospital ◽  
Glutamate Release ◽  
Intervention Group ◽  
Developed Countries ◽  
The Body ◽  
World Health ◽  
Control Group ◽  
Intracellular Magnesium ◽  
Significant Difference ◽  
The World

BACKGROUND: Schizophrenia according to the world health organization is one of the top ten causes of disability in developed countries around the world. Because of the severity, chronicity, and prevalence of schizophrenia, it has a very large economic burden. Magnesium is a micronutrient needed by the body which can affect mental health. Erythrocyte magnesium levels are considered more sensitive than serum magnesium levels to reflect intracellular magnesium status. AIM: The objective of the study was to determine the differences in erythrocyte magnesium levels between men with schizophrenia who received risperidone and haloperidol treatment at Prof. Dr. M Ildrem Psychiatric Hospital, Medan. METHODS: This study is an intention to treat and is an experimental pre-test and post-test that compares two groups, namely the intervention group and the control group. The sampling method is non-probability sampling with a consecutive sampling type. The research was conducted at Prof. Dr. M. Ildrem Psychiatric Hospital Medan between July and October 2019. The subjects of the study were 60 men with schizophrenia, namely, 30 who received risperidone and 30 who received haloperidol. RESULTS: There was a difference in the levels of male erythrocyte magnesium with schizophrenia who received risperidone and haloperidol between the initial week and the third week with a value of p = 0.007. Where there was a higher increase in the haloperidol group which showed a significant difference, namely, p < 0.05. CONCLUSION: The increase in magnesium levels will improve the symptoms of schizophrenia where magnesium activity decreases glutamate release associated with N-Methyl D-Aspartate receptors and results in the activity of the gamma-aminobutyric acid-ergic system.

Metabolic changes in hyperlipidemic rats after administration of Xuezhikang

2020 ◽  
Vol 16 ◽  
Author(s):  
Ke Su ◽  
Bingbao Chen ◽  
Xiaoting Tu ◽  
Luxin Ye ◽  
Xiaojie Lu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Glucuronic Acid ◽  
Intervention Group ◽  
Lipid Lowering ◽  
Control Group ◽  
High Fat ◽  
Glucose Content ◽  
Significant Difference ◽  
The Relationship

Background: Xuezhikang capsule, which contains cholesterol synthase inhibitors and a large number of natural statins, is put in the clinical application of lipid-lowering and so on. However, the specific use of dose, lipid-lowering effect and the relationship between metabolites are to be further studied. Introduction: Metabonomics is the study of the relationship between the change of quantity and physiological changes from metabolites. At present metabolomics has been widely used in drug development and testing. In this study, we developed a metabolomic method based on gas chromatography-mass spectrometry (GC-MS) to find out hyperlipemia-related substances, and study the lipid-lowering mechanism of Xuezhikang. Method: Fifty SD rats (220 ± 20 g) were given high-fat diet. After four-weeks modeling, they were randomly divided into semi-control group, high fat group, simvastatin intervention group and Xuezhikang intervention group (0.23, 0.69, 1.15 mg/kg, low, medium, high), each dosage in eight rats. The control group (rest eight rats) were given normal diet, and no specific treatment. The rats were sacrificed at the end of the experiment. Result: The biochemical and body weight indexes of the normal control group and the high fat group were significantly different (P <0.05), which indicated that the model of hyperlipidemia was established success. There was significant difference (P <0.05) between Xuezhikang intervention group and high fat control group (P <0.05), and hyperlipemia metabolomics related markers, oxalic acid, butyric acid, mannitol, glucose, glucuronic acid were found. Glucuronic acid and non-binding bilirubin combined with bilirubin, combined with some of the liver harmful substances, play a detoxification effect. Conclusion: The results of metabonomics showed that the high fat group and the control group were significant difference. Mannose, glucose content is relatively stable, lipid metabolism in high-fat group stearic acid, palmitic acid levels decreased, suggesting that high-fat diet disorders rat body lipid metabolism. It is worth mentioning that the experimental evaluation of rats such as biochemical indicators and pathological results are prompted to model success, Xuezhikang intervention effect is more significant, consistent with the expected.

scholarly journals Dragon Fruit (Hylocereus polyrhizus) Increases Hemoglobin Levels in Young Women

2018 ◽  
pp. 197-203
Author(s):  
Halida Thamrin ◽  
Budu Budu ◽  
Werna Nontji ◽  
Suchi Avnalurini Sharief
Keyword(s):  
Young Women ◽  
Intervention Group ◽  
Female Students ◽  
The Body ◽  
Female Adolescent ◽  
Control Group ◽  
Increased Risk ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Hylocereus Polyrhizus

Young women have a high risk of anemia, this is due to iron loss during menstruation. Female teenagers have an increased risk of anemia compared to young men because young women experience menstruation every month and the desire to reduce food so that the body lacks important nutrients such as iron. This study aims to determine the effect of dragon fruit (Hylocereus polyrhizus) on increasing hemoglobin levels in young women. This study used an experimental design with pretest-posttes with control group design. The sample in this research is student Prodi DIII Kebidanan. The total sample of 32 female students was divided into 2 groups, 16 female students were given dragon fruit (Hylocereus polyrhizus) as intervention group and 16 female students who were given nutrition education as control group. Measurements of hemoglobin levels were performed before and after treatment for 8 weeks, periodic measurements were performed every 2 weeks. Data analysis using Paired t-test. The results showed no effect but no significant difference of dragon fruit (Hylocereus polyrhizus) to increase hemoglobin level in female adolescent (P> 0,05).  

scholarly journals Perbedaan Tekanan Darah Sebelum dan Sesudah Exercise Intradialysis Pada Pasien Hemodialisis di Unit Hemodialisis Rumah Sakit Panti Rahayu Gunung Kidul

2021 ◽  
Vol 2 (2) ◽  
pp. 156-169
Author(s):  
Christina Murni Yuliastuti ◽  
Th.Tatik Pujiastuti ◽  
Sr. Lucilla Suparmi, CB
Keyword(s):  
Blood Pressure ◽  
Intervention Group ◽  
The Body ◽  
Control Group ◽  
Cardiovascular Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference ◽  
Intradialytic Exercise

ABSTRACT Background:Hemodialysis defines as a process of cleaning the blood from waste substances through a filtering process outside the body. Patients with chronic renal failure undergoing hemodialysis often experience complications including hypotension. Several references state an alternative intervention to prevent complications of hypotension in hemodialysis patients with an Intradialytic exercise. Intradialytic exercise is a planned and gradual form of exercise that includes various stages of flexibility exercise, strengthening exercise and cardiovascular exercise performed during hemodialysis. Intradialytic exercise is aimed to improve the work of the heart, respiration and improve hemodialysis regulation for the better. Objective:This study was aimed to determine the difference in blood pressure before and after intradialytic exercise in patients undergoing hemodialysis. Methods:This research design used a quasi-experimental design with pre-test and post-test with control design. The samples were 38 respondents who taken by total sampling at the Hemodialysis Unit of Panti Rahayu Hospital. The samples were divided into the intervention group who undertook intradialytic exercise for 4 weeks, each respondent experiences twice a week, while the control group who did routine hemodialysis and independent exercise. Results:The results showed that the distribution of the characteristics of the respondents was 51-54 years old (18.41%) the sex was mostly male (63.2%) Most of them (55.3%) underwent hemodialysis for less than 2 years. Statistically, it was known that there was no significant difference in blood pressure before and after intradialytic exercise inside patient’s body of the control and intervention groups. There was no significant difference in blood pressure between the intervention group compared to the control group, but there was a dynamic difference in blood pressure in patients who did intradialytic exercise. Conclusion:There was dynamics of differences in blood pressure in patients undergoing intradialytic exercise, it is recommended that hemodialysis nurses at Panti Rahayu Hospital take care patients during hemodialysis so that these interventions are routinely carried out.

scholarly journals The Effect Of Biofeedback On The Motor– Muscular Situation In Rehabilitation Of Stroke Patients

2017 ◽  
pp. 35 ◽  
Author(s):  
Zohre Najafi ◽  
Zahra sadat Manzari ◽  
Fariborz Rezaeitalab ◽  
Amin Azhari
Keyword(s):  
Muscle Strength ◽  
Intervention Group ◽  
Group Versus ◽  
Muscle Stiffness ◽  
The Body ◽  
Control Group ◽  
Check List ◽  
Post Intervention ◽  
Significant Difference ◽  
And Control

Background:Stroke is the most common debilitating neurological disease in adults. Therefore, rehabilitation is a major consideration to reduce costs and relief disabilities. Biofeedback, a newly recommended method is claimed to be able to improve the consequences following stroke by enhancement the understanding of the psychological functions of the body.  Objectives: The purpose of this study was to investigate the effect of biofeedback on the motor– muscular situation in rehabilitation of stroke patientsMethods:The present study was a randomized clinical trial that was started in May 2016 and completed in September 2016. The sample of this study included all the patients with stroke attending the physiotherapy center of Imam Raza hospital in Mashhad, Iran. The participants were randomly divided into 2 groups (case and control group) after considering the inclusion and exclusion criteria. In the intervention group, biofeedback (2 times a week for 15 sessions, each session lasting 20 minutes) was performed.Before the intervention demographic information questionnaire was complete by all participants. Then a check list of main variables such as hands muscle strength, muscle stiffness (spasticity), balance and ability to walk was complete by a physician. In the 7th session of the exercise and in the end of intervention (14th session), again, the main variables of the check list were reassessed by the researcher. The statistical analysis was done by Statistical Package for the Social Sciences (SPSS) software version 16.Results:the mean score of balance evaluation in pre-intervention had not any significant differences (p=0.503), but in post intervention evaluation, this score in intervention group versus control group showed significant differences (p=0.014).the mean score of muscle strength,Results showed that by eliminating the effects of muscular strength before the intervention, this variable in both intervention and control groups after the intervention, had improvement and significant difference (p=0.005).Comparison the average spasticity, showed that spasticity evaluation score before and after intervention had no significant difference between the two groups (p=1.00)Conclusion: Considering the findings of this study, the biofeedback therapy is a promising treatment modality in improvement the motor– muscular condition following stroke.  

scholarly journals Reduction of Fatigue and Musculoskeletal Complaints in Garment Sewing Operator through a Combination of Stretching Brain Gym® and Touch for Health

2021 ◽  
Vol 18 (17) ◽  
pp. 8931
Author(s):  
Lusi Ismayenti ◽  
Agus Suwandono ◽  
Hanifa Maher Denny ◽  
Bagoes Widjanarko
Keyword(s):  
Intervention Group ◽  
Left Knee ◽  
The Body ◽  
Control Group ◽  
Musculoskeletal Complaints ◽  
Brain Gym ◽  
Left Hand ◽  
Left Elbow ◽  
Significant Difference ◽  
Quasi Experimental

The purpose of this study was to assess the effect of using a combination of stretching and Brain Gym®(BG) + Touch for Health (TfH) movements to reduce fatigue and musculoskeletal complaints (MSCs) in garment-sewing operators. A quasi-experimental study was performed on 53 respondents with two sessions of stretching movements and BG + TfH movements of 5 min duration, three times a week for four weeks. Fatigue was measured using a reaction timer and MSCs were measured using a Nordic Body Map questionnaire. Wilcoxon and Mann–Whitney U tests were performed to examine the differences of pre/post and between the intervention group (IG) and control group (CG). A significant difference was found in IG for pre- and post-fatigue (p < 0.001) and MSCs (p < 0.001), while in CG there was no difference in fatigue (p = 0.200) and MSCs (p = 0.086). Significant differences were found between the IG and CG groups in terms of fatigue (p = 0.046), as well as in MSCs (p < 0.001). A significant decrease in MSCs per part body in IG was found on the left wrist, left hand, and left knee. The percentage of MSC severity decreased in all parts of the body, except the right shoulder, left elbow, and right thigh.

scholarly journals Reproductive Health Education in the Elderly

2019 ◽  
Vol 7 (5) ◽  
Author(s):  
Yuli Mulyanti Soenar ◽  
Deswani Kasim
Keyword(s):  
Health Education ◽  
Reproductive Health ◽  
Intervention Group ◽  
The Elderly ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
Reproductive Health Education ◽  
Quasi Experimental

An understanding of reproductive health in the elderly, especially women, becomes so important because there are so many changes that occur when women enter old age. Decreasing reproductive health in women occurs when women enter menopause. For this reason, it is necessary to provide appropriate information to the elderly regarding the health of their reproductive system, to avoid health problems that threaten the overall condition of the body. This study aims to determine the effect of reproductive health education in the elderly. The research method used was quasi-experimental with non-randomized pretest-posttest group control design. The number of samples in this study was 62 people consisting of 32 people in the intervention group and 30 people in the control group. Data analysis in this study with paired t-test and independent. The results showed that there was a significant difference in knowledge of the elderly between the intervention group and the control group after the intervention (p-value = 0,000), so there were significant differences in the attitudes of Keywords: reproductive health education, elderly, knowledge, attitudes the elderly between the intervention and control groups, after the intervention (p = 0.008). The conclusion is that there is an influence of reproductive health education in the elderly on the knowledge and attitudes.

Study on the Hypolipidemic Effect and Antioxidant Activity of Seabuckthorn Marc Flavonoids

2011 ◽  
Vol 345 ◽  
pp. 292-296 ◽  
Author(s):  
Yan Jiao ◽  
Xi Qun Zheng ◽  
Xiao Lan Liu ◽  
Ying Chang ◽  
Zhen Yu Wang
Keyword(s):  
Antioxidant Activity ◽  
Hepatic Lipase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Hypolipidemic Effect ◽  
Model Control ◽  
Model Control Group

The hypolipidemic effect and anti-oxidative activity of seabuckthorn marc flavonoids (SMF) on hyperlipidemic rats was investigated. The rats were divided into 5 groups, including normal control group, hyperlipidemic model control group and 3 different doses of SMF groups i.e. 3.0 mg/kg·bw, 30.0 mg/kg·bw, 90mg/kg·bw, respectively. The SMF was given orally for 35 days. After the treatment, the body, fat and liver weights of rats were weighed. The content of serum total triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and the activity of lipid metabolism and anti-oxidative enzyme were determined. The levels of serum lipids in hyperlipidemic rats fed with SMF were significantly lower than model control group. The activities of hepatic lipase (HL), lipoprotein lipase (LPL), lipidase (LPS), superoxide dismutase (SOD), glutathione (GSH) in liver were increased, while the contents of malondialdehyde (MDA) were decreased in SMF groups. The results indicate that SMF has significantly hypolipidemic effects and antioxidant activity.

scholarly journals The Eeffect of Swiss Ball Training on Core stability and Balance Functions in Students with Congenital deafness

2021 ◽  
Vol 5 (1) ◽  
pp. 6-9
Author(s):  
Zahra Noroz ◽  
◽  
Zohre Eskandar ◽  
Hadi Miri ◽  
◽  
...  
Keyword(s):  
Intervention Group ◽  
The Body ◽  
Core Stability ◽  
Control Group ◽  
Congenital Deafness ◽  
Strong Base ◽  
Statistical Population ◽  
Significant Difference ◽  
Balance Functions ◽  
Swiss Ball

Introduction: Based on past studies, it has been found that congenital deafness is weak in maintaining balance, strength, coordination, and endurance. So, the reinforcement of different aspects of physical fitness of these individuals should be considered in order to improve their quality of life. So, the purpose of present study was to assess the Effect of Swiss Ball Exercises on Trunk Endurance, and Balance Functions in Student with Congenital Deafness. Methods: The statistical population of the study consisted of students with congenital hearing loss in Qazvin, 24 of who were selected and were randomly divided into intervention and control groups. Functional tests were used to assess trunk endurance and balance. The intervention group performed the Swiss Ball training but control group continued their routine daily activities. Pre-test and post-test were performed by both groups before and after the training program. Independent ttest and covariance analysis were used to analyze the data. Result: According to the results of ANCOVA, there was a significant difference between the control and intervention groups in Trunk Endurance (p = 0.001), Static (p = 0.001) and Dynamic Balance (p = 0.001) tests after six weeks. Conclusion: Seems Swiss Ball training can provide a strong base for lower extremity movements by strengthening the core region of the body, thereby improving trunk endurance and balance functions in the deaf.

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