scholarly journals Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

2021 ◽  
Vol 11 (18) ◽  
pp. 8702
Author(s):  
Naoual El Menyiy ◽  
Aya Khouchlaa ◽  
Nasreddine El Omari ◽  
Gokhan Zengin ◽  
Monica Gallo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Mechanisms Of Action ◽  
Bioactive Molecules ◽  
Multifactorial Disease ◽  
Scientific Databases ◽  
Starting Point

Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

scholarly journals Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Henok Kessete Afewerky ◽  
Ayeni Emmanuel Ayodeji ◽  
Bashir Bolaji Tiamiyu ◽  
Joshua Iseoluwa Orege ◽  
Emmanuel Sunday Okeke ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Critical Review ◽  
Economic Benefit ◽  
Withania Somnifera ◽  
Web Of Science ◽  
High Impact ◽  
Scientific Databases ◽  
Research Outcomes ◽  
Ethnomedicinal Uses ◽  
Comprehensive Compilation

Abstract Background Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documentation of medicinal plants, including W. somnifera, in Africa. There is, therefore, a need for a comprehensive compilation of research outcomes of this reviewed plant as used in traditional medicine in different regions of Africa. Methodology Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on W. somnifera. Scientific databases, including GBIF, PubMed, NCBI, Google Scholar, Research Gate, Science Direct, SciFinder, and Web of Science, were accessed to identify the most influential articles and recent breakthroughs published on the contexts of ethnography, ethnomedicinal uses, phytochemistry, pharmacology, and commercialization of W. somnifera. Results This critical review covers the W. somnifera ethnography, phytochemistry, and ethnomedicinal usage to demonstrate the use of the plant in Africa and elsewhere to prevent or alleviate several pathophysiological conditions, including cardiovascular, neurodegenerative, reproductive impotence, as well as other chronic diseases. Conclusion W. somnifera is reportedly safe for administration in ethnomedicine as several research outcomes confirmed its safety status. The significance of commercializing this plant in Africa for drug development is herein thoroughly covered to provide the much-needed highlights towards its cultivations economic benefit to Africa.

Review On Documented Medicinal Plants Used For The Treatment Of Cancer

2021 ◽  
Vol 07 ◽  
Author(s):  
Bhuwan Chandra Joshi ◽  
Vijay Juyal ◽  
Archana N. Sah ◽  
Piyush Verma ◽  
Minky Mukhija
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Anticancer Agents ◽  
Web Of Science ◽  
Review Paper ◽  
Molecular Level ◽  
Chemical Constituents ◽  
Experimental Studies ◽  
Chemical Compounds ◽  
Scientific Databases

Background: Cancer is a frightful disease and it is the second leading cause of death worldwide. Naturally derived compounds are gaining interest of research workers as they have less toxic side effects as compared to currently used treatments such as chemotherapy. Plants are the pool of chemical compounds which provides a promising future for research on cancer. Objective: This review paper provides updated information gathered on medicinal plants and isolated phytoconstituents used as anticancer agents and summarises the plant extracts and their isolated chemical constituents exhibiting anticancer potential on clinical trials. Methods: An extensive bibliographic investigation was carried out by analysing worldwide established scientific databases like SCOPUS, PUBMED, SCIELO, ScienceDirect, Springerlink, Web of Science, Wiley, SciFinder and Google Scholar etc. In next few decades, herbal medicine may become a new epoch of medical system. Results: Many researches are going on medicinal plants for the treatment of cancer but it is a time to increase further experimental studies on plant extracts and their chemical constituents to find out their mechanism of action at molecular level. Conclusion: The article may help many researchers to start off further experimentation that might lead to the drugs for the cancer treatment.

scholarly journals Plant-Based Bioactive Natural Products: Insights into Molecular Mechanisms of Action

2021 ◽  
Vol 11 (21) ◽  
pp. 10220
Author(s):  
Hari Prasad Devkota
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Human Health ◽  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Traditional Medicines ◽  
Bioactive Natural Products ◽  
Ancient Times

Medicinal plants have been used for the maintenance of human health since ancient times in the form of food, spices, and traditional medicines [...]

scholarly journals Drimia indica: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 255 ◽  
Author(s):  
Sonali Aswal ◽  
Ankit Kumar ◽  
Ruchi Badoni Semwal ◽  
Ashutosh Chauhan ◽  
Abhimanyu Kumar ◽  
...  
Keyword(s):  
Web Of Science ◽  
Mechanisms Of Action ◽  
Literature Survey ◽  
Ayurvedic Medicine ◽  
Cardiac Diseases ◽  
Bioactive Constituents ◽  
Scientific Databases ◽  
Therapeutic Benefits ◽  
Microbial Infections ◽  
Bioactive Potential

Drimia indica (Roxb.) Jessop (Asparagaceae) is a reputed Ayurvedic medicine for a number of therapeutic benefits, including for cardiac diseases, indigestion, asthma, dropsy, rheumatism, leprosy, and skin ailments. The present work aimed to critically and extensively review its traditional uses, phytochemistry, pharmacology, toxicology, and taxonomy together with the mechanisms of action of selected extracts of D. indica. A systematic literature survey from scientific databases such as PubMed, Scopus, and Web of Science as well as from some textbooks and classical texts was conducted. The plant, mainly its bulb, contains various bioactive constituents, such as alkylresorcinols, bufadienolides, phytosterols, and flavonoids. Various scientific studies have proven that the plant has anthelmintic, anticancer, antidiabetic, antimicrobial, antioxidant, and wound healing activities. The present work concludes that D. indica has the potential to treat various diseases, mainly microbial infections. This review also suggests that bufadienolides, flavonoids, and steroids might be responsible for its bioactive potential.

Plant-derived natural medicines for the management of depression: an overview of mechanisms of action

2015 ◽  
Vol 26 (3) ◽  
Author(s):  
Marzieh Sarbandi Farahani ◽  
Roodabeh Bahramsoltani ◽  
Mohammad Hosein Farzaei ◽  
Mohammad Abdollahi ◽  
Roja Rahimi
Keyword(s):  
Medicinal Plants ◽  
Psychiatric Disorder ◽  
Crucial Role ◽  
Molecular Mechanisms ◽  
Antidepressant Activity ◽  
Mechanisms Of Action ◽  
Cochrane Library ◽  
The World ◽  
Natural Drugs ◽  
Natural Medicines

AbstractDepression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents.

scholarly journals Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 20
Author(s):  
Mohammed Dalli ◽  
Oussama Bekkouch ◽  
Salah-eddine Azizi ◽  
Ali Azghar ◽  
Nadia Gseyra ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Pharmacological Effects ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Pharmacological Activities ◽  
Future Studies ◽  
Therapeutic Activities

Medicinal and aromatic plants are mainly characterized by the presence of different bioactive compounds which exhibit various therapeutic activities. In order to investigate the different pharmacological properties of different Nigella sativa extracts, a multitude of research articles published in the period between 2019 and 2021 were obtained from different databases (Scopus, Science Direct, PubMed, and Web of Science), and then explored and analyzed. The analysis of the collected articles allows us to classify the phytochemicals and the pharmacological activities through their underlying molecular mechanisms, as well as to explore the pharmacological activities exhibited by several identified compounds in Nigella sativa which allow a better understanding, and better elucidation, of the bioactive compounds responsible for the pharmacological effects. Also shown are the existence of other bioactive compounds that are still unexplored and could be of great interest. This review could be taken as a guide for future studies in the field.

scholarly journals Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3714
Author(s):  
Nasreddine El Omari ◽  
Saad Bakrim ◽  
Mohamed Bakha ◽  
José M. Lorenzo ◽  
Maksim Rebezov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Major Elements ◽  
Mechanisms Of Action ◽  
Systemic Diseases ◽  
Anticancer Effects ◽  
Tumor Transformation ◽  
The Subject

Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.

scholarly journals Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4030 ◽  
Author(s):  
Andreia S.P. Pereira ◽  
Antonio J. Banegas-Luna ◽  
Jorge Peña-García ◽  
Horacio Pérez-Sánchez ◽  
Zeno Apostolides
Keyword(s):  
Virtual Screening ◽  
Bioactive Compounds ◽  
Drug Targets ◽  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Retinol Binding Protein ◽  
Protein Targets ◽  
Treatment Of Diabetes ◽  
Culinary Herbs ◽  
Herbs And Spices

Culinary herbs and spices are widely used as a traditional medicine in the treatment of diabetes and its complications, and there are several scientific studies in the literature supporting the use of these medicinal plants. However, there is often a lack of knowledge on the bioactive compounds of these herbs and spices and their mechanisms of action. The aim of this study was to use inverse virtual screening to provide insights into the bioactive compounds of common herbs and spices, and their potential molecular mechanisms of action in the treatment of diabetes. In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasaponin I from fenugreek, bisdemethoxycurcumin from turmeric, carlinoside from lemongrass, cinnamtannin B1 from cinnamon, crocin from saffron and glabridin from liquorice. The major targets identified for the herbs and spices compounds were dipeptidyl peptidase-4 (DPP4), intestinal maltase-glucoamylase (MGAM), liver receptor homolog-1 (NR5A2), pancreatic alpha-amylase (AM2A), peroxisome proliferator-activated receptor alpha (PPARA), protein tyrosine phosphatase non-receptor type 9 (PTPN9), and retinol binding protein-4 (RBP4) with over 250 compounds observed to be potential inhibitors of these particular protein targets. Only bay leaves, liquorice and thyme were found to contain compounds that could potentially regulate all 18 protein targets followed by black pepper, cumin, dill, hops and marjoram with 17 protein targets. In most cases more than one compound within a given plant could potentially regulate a particular protein target. It was observed that through this multi-compound-multi target regulation of these specific protein targets that the major anti-diabetic effects of reduced hyperglycemia and hyperlipidemia of the herbs and spices could be explained. The results of this study, taken together with the known scientific literature, indicated that the anti-diabetic potential of common culinary herbs and spices was the result of the collective action of more than one bioactive compound regulating and restoring several dysregulated and interconnected diabetic biological processes.

Sign in / Sign up

Export Citation Format

Share Document