Review On Documented Medicinal Plants Used For The Treatment Of Cancer

2021 ◽  
Vol 07 ◽  
Author(s):  
Bhuwan Chandra Joshi ◽  
Vijay Juyal ◽  
Archana N. Sah ◽  
Piyush Verma ◽  
Minky Mukhija
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Anticancer Agents ◽  
Web Of Science ◽  
Review Paper ◽  
Molecular Level ◽  
Chemical Constituents ◽  
Experimental Studies ◽  
Chemical Compounds ◽  
Scientific Databases

Background: Cancer is a frightful disease and it is the second leading cause of death worldwide. Naturally derived compounds are gaining interest of research workers as they have less toxic side effects as compared to currently used treatments such as chemotherapy. Plants are the pool of chemical compounds which provides a promising future for research on cancer. Objective: This review paper provides updated information gathered on medicinal plants and isolated phytoconstituents used as anticancer agents and summarises the plant extracts and their isolated chemical constituents exhibiting anticancer potential on clinical trials. Methods: An extensive bibliographic investigation was carried out by analysing worldwide established scientific databases like SCOPUS, PUBMED, SCIELO, ScienceDirect, Springerlink, Web of Science, Wiley, SciFinder and Google Scholar etc. In next few decades, herbal medicine may become a new epoch of medical system. Results: Many researches are going on medicinal plants for the treatment of cancer but it is a time to increase further experimental studies on plant extracts and their chemical constituents to find out their mechanism of action at molecular level. Conclusion: The article may help many researchers to start off further experimentation that might lead to the drugs for the cancer treatment.

scholarly journals Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Henok Kessete Afewerky ◽  
Ayeni Emmanuel Ayodeji ◽  
Bashir Bolaji Tiamiyu ◽  
Joshua Iseoluwa Orege ◽  
Emmanuel Sunday Okeke ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Critical Review ◽  
Economic Benefit ◽  
Withania Somnifera ◽  
Web Of Science ◽  
High Impact ◽  
Scientific Databases ◽  
Research Outcomes ◽  
Ethnomedicinal Uses ◽  
Comprehensive Compilation

Abstract Background Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documentation of medicinal plants, including W. somnifera, in Africa. There is, therefore, a need for a comprehensive compilation of research outcomes of this reviewed plant as used in traditional medicine in different regions of Africa. Methodology Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on W. somnifera. Scientific databases, including GBIF, PubMed, NCBI, Google Scholar, Research Gate, Science Direct, SciFinder, and Web of Science, were accessed to identify the most influential articles and recent breakthroughs published on the contexts of ethnography, ethnomedicinal uses, phytochemistry, pharmacology, and commercialization of W. somnifera. Results This critical review covers the W. somnifera ethnography, phytochemistry, and ethnomedicinal usage to demonstrate the use of the plant in Africa and elsewhere to prevent or alleviate several pathophysiological conditions, including cardiovascular, neurodegenerative, reproductive impotence, as well as other chronic diseases. Conclusion W. somnifera is reportedly safe for administration in ethnomedicine as several research outcomes confirmed its safety status. The significance of commercializing this plant in Africa for drug development is herein thoroughly covered to provide the much-needed highlights towards its cultivations economic benefit to Africa.

A Review on Himalayan Medicinal Plants against Cancer

2021 ◽  
Vol 07 ◽  
Author(s):  
Bhuwan Chandra Joshi ◽  
Piyush Verma ◽  
Vijay Juyal ◽  
Archana N. Sah
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Web Of Science ◽  
Chemical Constituents ◽  
Traditional Medicines ◽  
Natural Agents ◽  
Active Chemical ◽  
Anti Cancer ◽  
Synthetic Agents ◽  
Pharmaceutical Industries

Background: Plants contributed numerous novel compounds for prophylactic and curative medicine to modern science.They are the important source of natural agents used in various pharmaceutical industries. Himalayan plants are abundant in various secondary metabolites such as anthraquinones, flavonoids, tannins, alkaloids and terpenes. The Himalayan plants grown in high altitude and have around 6500 years old history as traditional medicines. Aim: This review article systematically presents information onHimalayan medicinal plants having anti-cancer potentials. Methodology: Around 160 articles were reviewed by using online search engines like PubMed, Scopus, Google Scholar, Web of Science, and floras of different Himalayan countries. Results: An attempt has been made to review anticancer plants and active constituents isolated from several anti-cancerous plants of Himalayan regions. Eighty three anticancer plants are reported in this review and total twenty two active chemical constituents including phenolic compounds, glycosides, terpenoidsand alkaloids from the plants were reported active against various cancer cell lines. Conclusion: Several synthetic agents are used to cure cancer but number of undesired side effects occurs during chemotherapy. Hence, the research is going on to investigate natural therapies, such as the use of the plant derived productsin cancer treatment. They may reduce adverse side effects.

scholarly journals A review on medicinal plants as potential sources of natural immunomodulatory action

2021 ◽  
Vol 11 (6) ◽  
pp. 324-331
Author(s):  
Omji Porwal ◽  
Mehmet Ozdemir ◽  
Duran Kala ◽  
Esra Tariq Anwer
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Plant Extracts ◽  
Review Paper ◽  
Polio Vaccine ◽  
Adaptive Immune ◽  
Therapeutic Consequences ◽  
Adaptive Immune Cells ◽  
Excellent Health ◽  
Immunomodulatory Action

The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. A brawny, fine-functioning immune system is the keystone of excellent health. Immune replies are the consequence of an effectual interaction among innate (natural and non-specific) and acquired (adaptive and specific) components of the immune system. Inequity or failure of the immune systems is connected with a variety of chronic illness counting allergies, autoimmune diseases, cancers and furthers. Diverse innate and adaptive immune cells that are incorporated in this multifaceted networking organization may symbolize talented targets for expanding immunotherapeutics for treating specific immune illness. An assorted array of natural, synthetic, and recombinant compounds is accessible with both advantages and demerits. A range of phytochemicals have been remote, differentiated and customized for expansion and employ as avoidance or cure of human diseases, but the request of customary or novel medicinal plants for employ as immunomodulators in indulgencing immune diseases is still comparatively limited. At present, there is much-growing interest in the use of medicinal plants as modulators of the complex immune system. Numerous therapeutic consequences of plant extracts have been recommended to be because of their extensive assortment of immunomodulatory effects and persuade on the immune system of the human body. In present review paper, various medicinal plants, their resultant crude or fractionated phyto extracts and the precise phytochemicals remote from them are conversed in terms of their immunomodulatory bioactivities. We also review their possible for future expansion as immunomodulatory or inflammation-regulatory therapeutics or agents. Keywords: Immunomodulation, Immune system, Phytochemicals, Medicinal plant, Plant extracts

scholarly journals Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

2021 ◽  
Vol 11 (18) ◽  
pp. 8702
Author(s):  
Naoual El Menyiy ◽  
Aya Khouchlaa ◽  
Nasreddine El Omari ◽  
Gokhan Zengin ◽  
Monica Gallo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Mechanisms Of Action ◽  
Bioactive Molecules ◽  
Multifactorial Disease ◽  
Scientific Databases ◽  
Starting Point

Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

scholarly journals Efek Sinergis Bahan Aktif Tanaman Obat Berbasiskan Jejaring Dengan Protein Target

2016 ◽  
Vol 1 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Nur Hilal A. Syahrir ◽  
Farit Mochamad Afendi ◽  
Budi Susetyo
Keyword(s):  
Medicinal Plants ◽  
Molecular Level ◽  
Synergistic Effects ◽  
Chemical Compounds ◽  
Zingiber Officinale ◽  
Momordica Charantia ◽  
Active Ingredients ◽  
Beneficial Effects ◽  
Synthetic Drugs

Medicinal plants contain inherently active ingredients. Such ingredients are beneficial to prevent and cure diseases, as well as to perform specific biological functions. In contrast to synthetic drugs, which is based on one single chemicals, medicinal plants exert their beneficial effects through the additive or synergistic action of several chemical compounds. Those chemical compound act on single or multiple targets (multicomponent therapeutic) associated with a physiological process. Active ingredients combinations show a synergistic effect. This means that the combinational effect of several active ingredients is greater than that of individual one acting separately. A network target can be used to identify synergistic effects of plants active ingredients. The method of NIMS (Network target-based Identification of Multicomponent Synergy) is a computational approach to identify the potential synergistics effect of active ingredients. It also assessess synergistic strength of any active ingradients at the molecular level by synergy scores. We investigate these synergistic on a Jamu formula for diabetes mellitus type 2.  The Jamu formula is composed of four medicinal plants, namely Tinospora crispa , Zingiber officinale, Momordica charantia, and Blumea balsamivera. Our work succesfully demonstrates that the highest synergy scores on medicinal plants synergy can be seen in pairs of several active ingredients in Zingiber officinale. On the other hand, the synergy of pairs of active ingredients in Momordica charantia and Zingiber officinale posseses a relatively high score. The same occurs in Tinospora crispa and Zingiber officinale.

scholarly journals The Effects of Herbs and Fruits on Leukaemia

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Tayebeh Azam Saedi ◽  
Sabariah Md Noor ◽  
Patimah Ismail ◽  
Fauziah Othman
Keyword(s):  
Developing Countries ◽  
Side Effects ◽  
Cancer Therapy ◽  
Plant Extracts ◽  
Anticancer Agents ◽  
Review Paper ◽  
Herbal Therapy ◽  
The Past ◽  
Major Treatment

In developing countries, herbal therapy is the first and basis form of treatment for most types of diseases. About 75–80% of the world’s population prefers herbal therapy as a major treatment due to its better adequacy and satisfactoriness, which enhance human body’s symmetry with minimal side effects. Fruits and plants have been presented from the past as promising tools in becoming a natural anticancer agents. Many of these plant extracts are currently used in cancer therapy and prevention. This review paper will particularly explore and emphasize on herbs and fruits used in the treatment of the leukaemia.

scholarly journals Phytochemical analysis and bioactivity screening of three medicinal plants of Saudi Arabia

2020 ◽  
Vol 19 (2) ◽  
pp. 371-376
Author(s):  
Lamya H. Al-Wahaibi ◽  
Adeem Mahmood ◽  
Merajuddin Khan ◽  
Hamad Z. Alkhathlan
Keyword(s):  
Antimicrobial Activity ◽  
Medicinal Plants ◽  
Plant Extracts ◽  
Inhibitory Concentration ◽  
Chemical Constituents ◽  
Phytochemical Analysis ◽  
Volatile Oils ◽  
Pentacyclic Triterpene ◽  
Plant Essential Oils ◽  
Solvent Extraction Method

Purpose: To investigate the phytochemical analysis and bioactivity screening of some Asteraceae medicinal plants. Methods: The chemical constituents were isolated by column chromatography and elucidated using chemical and extensive spectroscopic methodologies including gas chromatoraphy-mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FTIR), as well as 1D and 2D nuclear magnetic resonance (NMR). The plant extracts were obtained by solvent extraction method while hydrodistillation was used to isolate plant essential oils. Furthermore, cup-plate agar diffusion was applied for antimicrobial activity evaluation while minimum inhibitory concentration (MIC) was assessed by microdilution technique. Results: Centaurea pseudosinaica, Tripleurospermum auriculatum, and Koelpinia linearis afforded previously undescribed three coumarins (xanthotoxin, cirsimaritin, salvigenins) from C. pseudosinaica, one steroid (estradiol) and a pentacyclic triterpene (β-amyrin) from T. auriculatum and a coumarin (santin) from K. linearis in good yields. In addition, the plant extracts and oils exhibited remarkable bioactivities including antifungal, antibacterial and antipyretic etc. Conclusion: The results reveal the presence of bioactive phytomolecules from Asteraceae plant extracts and volatile oils from three Asteraceae plants. Keywords: C. pseudosinaica, T. auriculatum, K. linearis, Xanthotoxin, Salvigenin, Cirsimaritin, Santin, Estradiol, β-amyrin, Antimicrobial activity

Phytochemical Investigation and Spectrophotometric Studies of Piperine and Thymoquinone Compounds in Methanolic Extracts of Nigella sativa and Piper nigram spices

2021 ◽  
pp. 46-54
Author(s):  
Hamad. M. Adress. Hasan ◽  
Eman. I. Hassan. Eljadily
Keyword(s):  
Plant Extracts ◽  
Methanolic Extract ◽  
Nigella Sativa ◽  
Chemical Constituents ◽  
Chemical Compounds ◽  
Phytochemical Screening ◽  
Spectrophotometric Methods ◽  
Methanolic Extracts ◽  
Phytochemical Investigation ◽  
Major Chemical

This study was carried out on some spice samples including Nigella sativa and Piper nigram. Phytochemical screening was applied to the methanolic extraction of both the studied plants. The results showed that methanolic extract of Nigella sativa and Piper nigram revealed the presence of various chemical constituents, such as Alkaloide, Carbohydrates, Glycosides, Tannins, Flavones, Saponins. Piperine is characterizing compound present in fruits of piper nigram used as a bioavailability enhancer. Some spectrophotometric methods as (U.V) and I.R were applied to identify the major chemical compounds of the studied extracts. The results recorded that the Piperine and Thymoquinone compounds were found in the studied plant extracts. Keywords: Piper Nigram, Nigella sativa, Piperine Thymoquinone, Spectrophotometric

scholarly journals STRYCHNOS SPINOSA LAM: COMPREHENSIVE REVIEW ON ITS MEDICINAL AND NUTRITIONAL USES

2020 ◽  
Vol 17 (2) ◽  
pp. 8-28
Author(s):  
Nassifatou Koko Tittikpina ◽  
Wouyo Atakpama ◽  
Yao Hoekou ◽  
Yerim Mbagnick Diop ◽  
Komlan Batawila ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Chemical Compounds ◽  
Food Material ◽  
Traditional Medicines ◽  
Healthcare Needs ◽  
Microbial Infections ◽  
Ethnobotanical Uses ◽  
Strychnos Spinosa

Background: Most of the people living in developing countries rely on local remedies from traditional medicines to take care of their healthcare needs. In recent years, the use of medicinal plants increased considerably. Consequently, studies on medicinal plants are necessary to produce more effective drugs with fewer side-effects. This work aims to compile the dispersal data on Strychnos spinosa Lam., a medicinal plant with great therapeutic potential in traditional medicine, on its ethnobotanical uses, chemical compounds, as well as its pharmacological and nutritional effects. Material and Methods: To achieve the aforementioned aim, electronic databases such as Pubmed, Science Direct, Google scholar, Scopus and SciFinder were scanned. Results: Literature survey revealed that S. spinosa is used in the treatment of microbial infections, malaria, trypanosomiasis, intestinal worms, tuberculosis, infertility, gastrointestinal disorders, snake bite, hypertension, and diabetes mellitus among other ailments. The plant is also used as food material. S. spinosa contains many chemical compounds, such as alkaloids, terpenes, sterols, fatty acids, flavonoids, saponin, and others. The fruits are a source of important nutrients such as carbohydrates, sugars, proteins, vitamins and fibres. Experimental studies have shown numerous pharmacological properties, including antimicrobial, antiplasmodial, anti-trypanosomal, anti-leishmanial, anti-nematicidal, anti-inflammatory, anti-oxidant, antidiabetic and other activities. Conclusion: This review article provides comprehensive information on S. spinosa and its various extracts. Due to the promising effects of the plant extracts on various diseases and its nutritional values, there is a need for toxicity studies and clinical trials to assess the effects of its identified bioactive compounds.

scholarly journals Haemostatic Potential of Medicinal Plants and Their Phytochemicals

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mamta Baunthiyal ◽  
Preeti Semwal ◽  
Sushmita Dwivedi
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Traumatic Injury ◽  
The Body ◽  
Ethnobotanical Survey ◽  
Scientific Databases ◽  
Plant Parts ◽  
Hospital Deaths ◽  
Effective Remedy ◽  
Scientific Validation

Haemorrhage associated with traumatic injury is responsible for over 35% of pre-hospital deaths and over 40% of deaths within the first 24 hours.Some important pharmacological aspects of plants such as haemostatic potential remain underexplored due to lack of scientific validation for the medical use of plant extracts/active compounds in bleeding control. In this study, an ethnobotanical survey of medicinal plants, which are used to stop bleeding, was done. Information was gathered from local herbalists, elderly people, literature search through various books and previously reported research papers in scientific databases (Pubmed, Science Direct, Scopus, Chem Spider, PubChem). Information about plants used to treat bleeding, plant parts used, mode of preparation, possible compounds and mechanism of action and dosage was collected and recorded. The collected information revealed 92 medicinal plants belonging to 59 families which are used against bleeding. Members of the Asteraceae family (12%) were the most prominent, followed by Moraceae (6%), Poaceae (5%) and Euphorbiaceae (4%). Leaves and underground plant parts were reported to be the most commonly used plant parts. The most prominent methods of herbal administration used were intravenous and as an ointment on the body surface. These plant extracts can be used efficiently and in a managed proportion to develop an effective remedy for bleeding/haemorrhages.

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