scholarly journals Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 20
Author(s):  
Mohammed Dalli ◽  
Oussama Bekkouch ◽  
Salah-eddine Azizi ◽  
Ali Azghar ◽  
Nadia Gseyra ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Pharmacological Effects ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Pharmacological Activities ◽  
Future Studies ◽  
Therapeutic Activities

Medicinal and aromatic plants are mainly characterized by the presence of different bioactive compounds which exhibit various therapeutic activities. In order to investigate the different pharmacological properties of different Nigella sativa extracts, a multitude of research articles published in the period between 2019 and 2021 were obtained from different databases (Scopus, Science Direct, PubMed, and Web of Science), and then explored and analyzed. The analysis of the collected articles allows us to classify the phytochemicals and the pharmacological activities through their underlying molecular mechanisms, as well as to explore the pharmacological activities exhibited by several identified compounds in Nigella sativa which allow a better understanding, and better elucidation, of the bioactive compounds responsible for the pharmacological effects. Also shown are the existence of other bioactive compounds that are still unexplored and could be of great interest. This review could be taken as a guide for future studies in the field.

scholarly journals Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marjan Talebi ◽  
Mohsen Talebi ◽  
Tahereh Farkhondeh ◽  
Jesus Simal-Gandara ◽  
Dalia M. Kopustinskiene ◽  
...  
Keyword(s):  
Blood Cells ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Experimental Studies ◽  
Protective Effects ◽  
Pharmacological Activities ◽  
Current Review ◽  
Mesh Terms ◽  
Online Databases ◽  
Anti Cancer

AbstractChrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

A review on phytochemical and therapeutic potential of Iris germanica

2021 ◽  
Author(s):  
Bahareh Sadat Yousefsani ◽  
Motahareh Boozari ◽  
Kobra Shirani ◽  
Amirhossein Jamshidi ◽  
Majid Dadmehr
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Iris Germanica ◽  
Safety Studies ◽  
History Of ◽  
Therapeutic Activities

Abstract Objectives Iris germanica L. is a medicinal plant, which has a long history of uses, mainly in medieval Persia and many places worldwide for the management of a wide variety of diseases. In this study, we aimed to review ethnopharmacological applications in addition to phytochemical and pharmacological properties of I. germanica. Key findings Ethnomedical uses of I. germanica have been reported from many countries such as China, Pakistan, India, Iran and Turkey. The medicinal part of I. germanica is the rhizome and the roots. Based on phytochemical investigations, different bioactive compounds, including flavonoids, triterpenes, sterols, phenolics, ceramides and benzoquinones, have been identified in its medicinal parts. Current pharmacological studies represent that the plant possesses several biological and therapeutic effects, including neuroprotective, hypoglycaemic, hypolipidaemic, antimicrobial, antioxidant, antiproliferative, anti-inflammatory, antiplasmodial, antifungal, immunomodulatory, cytotoxic and antimutagenic effects. Summary Although the majority of preclinical studies reported various pharmacological activities of this plant, however, sufficient clinical trials are not currently available. Therefore, to draw a definitive conclusion about the efficacy and therapeutic activities of I. germanica and its bioactive compounds, further clinical and experimental studies are required. Moreover, it is necessary to focus on the pharmacokinetic and safety studies on the extracts of I. germanica.

scholarly journals A Review on the Medicinal and Aromatic Plants Growing in Libya and Their Therapeutic Properties.

2020 ◽  
pp. 327-334 ◽  
Author(s):  
Abdullah F Abogmaza ◽  
Kheri F Keer ◽  
Ayad A Takrizzah ◽  
Esam Bashir Yahya
Keyword(s):  
Medicinal Plants ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Therapeutic Option ◽  
Food Preservation ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Traditional Use ◽  
Therapeutic Properties ◽  
Therapeutic Activities

Plants are a rich source of diverse metabolites that have been traditionally used for thousands of years all over the world, providing safer and inexpensive therapeutic option for millions of people in developing countries including Libya. Many types of medicinal plants growing in Libya possess significantly important curative activities and have been traditionally used for treatment of chronic diseases such as diabetes and cancer, as well as their biological activities such as antibacterial, antifungal, antiparasitic and insecticidal properties, etc. Apart from the therapeutic activities, most of Libyan nation rather to use natural and plant-based materials for their daily activities such as food preservation, food flavoring as well as medicinal usages. This review presents the most important medicinal plants growing in Libya with their traditional usage, medical properties, and compare the reliability of using these plants as therapeutic agents. Presenting the latest works that have been done in term of justification of the traditional use and scientifically proving its ability as therapeutic agent

scholarly journals Pharmacological Properties of Geraniol – A Review

Planta Medica ◽  
2018 ◽  
Vol 85 (01) ◽  
pp. 48-55 ◽  
Author(s):  
Yu Lei ◽  
Peng Fu ◽  
Xie Jun ◽  
Peng Cheng
Keyword(s):  
Clinical Trial ◽  
Antimicrobial Activities ◽  
Drug Candidate ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Valeriana Officinalis ◽  
Aromatic Plants ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Further Development

AbstractGeraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of geraniol in the context of further development as a drug candidate in clinical application.

scholarly journals Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

2021 ◽  
Vol 11 (18) ◽  
pp. 8702
Author(s):  
Naoual El Menyiy ◽  
Aya Khouchlaa ◽  
Nasreddine El Omari ◽  
Gokhan Zengin ◽  
Monica Gallo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Mechanisms Of Action ◽  
Bioactive Molecules ◽  
Multifactorial Disease ◽  
Scientific Databases ◽  
Starting Point

Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

scholarly journals Theaflavin Chemistry and Its Health Benefits

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Zhiguo Shan ◽  
Muhammad Farrukh Nisar ◽  
Mingxi Li ◽  
Chunhua Zhang ◽  
Chunpeng (Craig) Wan
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Molecular Mechanisms ◽  
Antimicrobial Properties ◽  
Black Tea ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Health Lifestyle ◽  
Biological Potential ◽  
Health Promoting

Huge epidemiological and clinical studies have confirmed that black tea is a rich source of health-promoting ingredients, such as catechins and theaflavins (TFs). Furthermore, TF derivatives mainly include theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3 ′ -gallate (TF2B), and theaflavin-3,3 ′ -digallate (TF3). All of these TFs exhibit extensive usages in pharmaceutics, foods, and traditional medication systems. Various indepth studies reported that how TFs modulates health effects in cellular and molecular mechanisms. The available literature regarding the pharmacological activities of TFs has revealed that TF3 has remarkable anti-inflammatory, antioxidant, anticancer, antiobesity, antiosteoporotic, and antimicrobial properties, thus posing significant effects on human health. The current manuscript summarizes both the chemistry and various pharmacological effects of TFs on human health, lifestyle or aging associated diseases, and populations of gut microbiota. Furthermore, the biological potential of TFs has also been focused to provide a deeper understanding of its mechanism of action.

scholarly journals A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside

2022 ◽  
Vol 12 ◽  
Author(s):  
Cheng Wang ◽  
Shu Dai ◽  
Lihong Gong ◽  
Ke Fu ◽  
Cheng Ma ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Web Of Science ◽  
Inflammatory Diseases ◽  
Polygonum Multiflorum ◽  
Pharmacological Activities ◽  
Pharmacokinetic Properties ◽  
Pharmacological Studies ◽  
Botanical Drug ◽  
Further Development ◽  
Anti Inflammation

Polygonum multiflorum Thunb. (He-shou-wu in Chinese), a Chinese botanical drug with a long history, is widely used to treat a variety of chronic diseases in clinic, and has been given the reputation of “rejuvenating and prolonging life” in many places. 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside (TSG, C20H22O9) is the main and unique active ingredient isolated from Polygonum multiflorum Thunb., which has extensive pharmacological activities. Modern pharmacological studies have confirmed that TSG exhibits significant activities in treating various diseases, including inflammatory diseases, neurodegenerative diseases, cardiovascular diseases, hepatic steatosis, osteoporosis, depression and diabetic nephropathy. Therefore, this review comprehensively summarizes the pharmacological and pharmacokinetic properties of TSG up to 2021 by searching the databases of Web of Science, PubMed, ScienceDirect and CNKI. According to the data, TSG shows remarkable anti-inflammation, antioxidation, neuroprotection, cardiovascular protection, hepatoprotection, anti-osteoporosis, enhancement of memory and anti-aging activities through regulating multiple molecular mechanisms, such as NF-κB, AMPK, PI3K-AKT, JNK, ROS-NO, Bcl-2/Bax/Caspase-3, ERK1/2, TGF-β/Smad, Nrf2, eNOS/NO and SIRT1. In addition, the toxicity and pharmacokinetics of TSG are also discussed in this review, which provided direction and basis for the further development and clinical application of TSG.

scholarly journals Pharmacological Activities of Coumarin Compounds in Licorice: A Review

2020 ◽  
Vol 15 (9) ◽  
pp. 1934578X2095395
Author(s):  
Yimei Zang
Keyword(s):  
Web Of Science ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Future Research ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Current Trends ◽  
Coumarin Compounds ◽  
New Research ◽  
Research Frontiers

Licorice is a traditional medicine commonly used in China and many other countries. Over the last 50 years, the structure and pharmacological effects of coumarin compounds in licorice have been investigated. However, a comprehensive review of the literature summarizing current trends is currently lacking. Thus, the aim of the present review is to provide an up-to-date summary of the scientific literature regarding the pharmacological effects of coumarin compounds in licorice, thereby laying the foundation for further research and optimal utilization of licorice. We retrieved 111 articles on the coumarin components of licorice and their potential pharmacological effects, based on titles, keywords, and abstracts from databases (including PubMed and Web of Science). Glycycoumarin, isoglycycoumarin, licoarylcoumarin, licopyranocoumarin, glycyrin, isotrifoliol, glycyrol, and glycyrurol have been investigated for their anticancer, hepatoprotective, antispasmodic, immunosuppressive, anti-inflammatory, and antibacterial properties, and use as therapeutic agents in metabolic syndrome, thereby demonstrating their potential for clinical applications. Future research should further explore the pharmacological mechanisms of action of coumarin compounds, including their antibacterial activities. Investigations into the pharmacological activities of different glycycoumarin isomers might open new research frontiers.

scholarly journals The medicinal importance of Thyme plant (Thymus vulgaris)

Biomedicine ◽  
2021 ◽  
Vol 41 (3) ◽  
pp. 531-534
Author(s):  
Mohammed S. Taher ◽  
Yasamen F. Salloom ◽  
Ruaa Abd Ul Hussein Al-Asadi ◽  
Zainab J. Al-Mousswi ◽  
Hussein Aneed Alamrani
Keyword(s):  
Medicinal Plants ◽  
Nutritional Value ◽  
Health Conditions ◽  
Chemical Components ◽  
Thymus Vulgaris ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Different Types ◽  
Multiple Uses ◽  
Therapeutic Activities

Medicinal and aromatic plants are a group of the oldest plants known and used by man throughout the ages for different fields, as they are used as food and medicine, in the middle and modern ages. The importance of these plants has increased, and their uses varied. The term medicinal plants include different types of plants that have therapeutic activities. These medicinal plants are considered among the sources rich in chemical components that can be used for the treatment of a specific disease or to reduce it if they are used in pure extract or in the form of fresh, dried, or partially extracted vegetable herbs. In addition to its medicinal importance, some plants have great nutritional value. One of the important medicinal plants is the thyme plant which contains many benefits that treat many health conditions. So, this article aimed to explain the most important components of thyme, in addition to its extreme role as a medicinal plant and its multiple uses as food and medicine, as well as its importance in preventing viruses, especially Corona virus.

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