scholarly journals EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update

Biomedicines ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 269
Author(s):  
Alessandro Fulgenzi ◽  
Daniele Vietti ◽  
Maria Elena Ferrero
Keyword(s):  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Human Subjects ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA2EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms.

scholarly journals Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Maria Elena Ferrero
Keyword(s):  
Adverse Effects ◽  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Successful Management ◽  
Human Organs ◽  
Human Burden

Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.

scholarly journals Study on the Behavior and Removal of Cadmium and Zinc Using Taraxacum officinale and Gazania under the Application of Biodegradable Chelating Agents

2021 ◽  
Vol 11 (4) ◽  
pp. 1557
Author(s):  
Naoki Kano ◽  
Takumi Hori ◽  
Haixin Zhang ◽  
Naoto Miyamoto ◽  
David Eva Vanessa Anak ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Chelating Agents ◽  
Environmental Control ◽  
Chelating Agent ◽  
Taraxacum Officinale ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Experimental Treatments ◽  
The One

The removal of cadmium (Cd) and zinc (Zn) from soil by phytoremediation was investigated using Taraxacum officinale and Gazania. A plant environmental control system was used to cultivate the plants. The effects of different biodegradable chelating agents (i.e., EDDS, HIDS, and GLDA), relative humidity, and other competitive metals on the adsorption of Cd and Zn were also studied. In addition, the approach for metal recovery was explored by extraction of metals from plants after phytoremediation using Gazania. The concentrations of Cd and Zn were determined by inductively coupled plasma mass spectrometry (ICP-MS). In addition, one-way analysis of variance (ANOVA) tests were performed.to determine significant differences between the experimental treatments adopted in this work. Consequently, the following main conclusions were obtained: (1) In the case of Taraxacum officinale, Cd and Zn could be removed even under the presence of other heavy metals. (2) By adding a chelating agent, the amount absorbed by the shoot generally increased. (3) In the case of Gazania, the concentration of Cd was higher in root than that in shoot, whereas the concentration of Zn was higher in the shoot than that in the root. (4) Taraxacum officinale was more suitable for phytoremediation of Cd than Gazania. (5) Cd and Zn could be extracted from plants by adding a low concentration of nitric acid. (6) The one-way ANOVA tests showed no statistically significant differences among the experimental treatments.

scholarly journals Comparison of Selected Metals Content in Cambodian Striped Snakehead Fish (Channa striata) Using Solar Drying System and Open Sun Drying

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Dayang Fredalina Basri ◽  
Nur Faizah Abu Bakar ◽  
Ahmad Fudholi ◽  
Mohd Hafidz Ruslan ◽  
Im Saroeun
Keyword(s):  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Solar Drying ◽  
Conventional System ◽  
Skin Sample ◽  
Sun Drying ◽  
Inductively Coupled ◽  
Cu Content ◽  
Plasma Mass Spectrometry ◽  
Drying System

The content of 12 elements in Cambodian dried striped snakehead fish was determined using inductively coupled plasma mass spectrometry. The present study compares the level of the trace toxic metals and nutritional trace elements in the fish processed using solar drying system (SDS) and open sun drying (OSD). The skin of SDS fish has lower level of As, Pb, and Cd compared to the OSD sample. As such, the flesh of the fish accumulated higher amount of toxic metals during OSD compared to SDS. However, arsenic was detected in both samples within the safe limit. The nutritional elements (Fe, Mn, Mg, Se, Mo, Cu, Ni, and Cr) were higher in the skin sample SDS fish compared to OSD fish. These beneficial metals were not accumulated in the flesh sample SDS fish demonstrating lower level compared to drying under conventional system. The reddish coloration of the SDS fish was due to the presence of high Cu content in both the skin and flesh samples which possibly account for no mold formation 5 days after packaging. As conclusion, drying of CambodianC. striatausing solar-assisted system has proven higher content of the nutritious elements compared to using the conventional system despite only slight difference in the toxic metals level between the two systems.

Current views on the possible involvement of aluminum in the etiology of Alzheimer's disease

2021 ◽  
pp. 10-15
Author(s):  
N. B. Ivanenko ◽  
A. A. Ganeev ◽  
E. A. Zubakina ◽  
M. M. Bezruchko ◽  
A. R. Gubal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Inductively Coupled Plasma ◽  
Preventive Treatment ◽  
Absorption Spectrometry ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Literary Origins

The aim of the study was to investigate the possibility of using а concentration of aluminum as a marker of neurodegenerative diseases.Material and methods. To achieve this goal, there was carried out an analysis of literary origins from various databases, in particular Scopus and PubMed.Results. The analysis shows that by now there has been accumulated strong evidence that certain neurodegenerative diseases are associated with chronic exposure to low-dose of aluminum: in particular, Alzheimer's disease (AD); motor neuron disease or amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS) and a number of others.Conclusion. Thus, it can be assumed that the measurement of the concentration of Al in the blood plasma will make it possible to identify a group people with of high risk of AD, which will allow starting preventive treatment at the earliest stage of the disease. The capabilities of the existing methods of analysis: atomic absorption spectrometry with electrothermal atomization (GFAAS) and inductively coupled plasma mass spectrometry (ICP-MS) enable to solve this problem.

scholarly journals Profiling metals in Cordyceps sinensis by using inductively coupled plasma mass spectrometry

2017 ◽  
Vol 9 (4) ◽  
pp. 724-728 ◽  
Author(s):  
Xin Wei ◽  
Hankun Hu ◽  
Baogeng Zheng ◽  
Zikri Arslan ◽  
Hung-Chung Huang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Cordyceps Sinensis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
First Time ◽  
Assay Protocol

In this work an assay protocol based on the ICP-MS technique was developed and validated to simultaneously determine 24 essential, non-essential, and toxic metals for the first time in C. sinensis.

scholarly journals Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246748
Author(s):  
Roger Pamphlett ◽  
Philip A. Doble ◽  
David P. Bishop
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Thyroid Gland ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Human Thyroid ◽  
Follicular Cells ◽  
Inductively Coupled ◽  
Thyroid Follicular Cells ◽  
Plasma Mass Spectrometry

Objective Mercury and other toxic metals have been suggested to be involved in thyroid disorders, but the distribution and prevalence of mercury in the human thyroid gland is not known. We therefore used two elemental bio-imaging techniques to look at the distribution of mercury and other toxic metals in the thyroid glands of people over a wide range of ages. Materials and methods Formalin-fixed paraffin-embedded thyroid tissue blocks were obtained from 115 people aged 1–104 years old, with varied clinicopathological conditions, who had thyroid samples removed during forensic/coronial autopsies. Seven-micron sections from these tissue blocks were used to detect intracellular inorganic mercury using autometallography. The presence of mercury was confirmed using laser ablation-inductively coupled plasma-mass spectrometry which can detect multiple elements. Results Mercury was found on autometallography in the thyroid follicular cells of 4% of people aged 1–29 years, 9% aged 30–59 years, and 38% aged 60–104 years. Laser ablation-inductively coupled plasma-mass spectrometry confirmed the presence of mercury in samples staining with autometallography, and detected cadmium, lead, iron, nickel and silver in selected samples. Conclusions The proportion of people with mercury in their thyroid follicular cells increases with age, until it is present in over one-third of people aged 60 years and over. Other toxic metals in thyroid cells could enhance mercury toxicity. Mercury can trigger genotoxicity, autoimmune reactions, and oxidative damage, which raises the possibility that mercury could play a role in the pathogenesis of thyroid cancers, autoimmune thyroiditis, and hypothyroidism.

scholarly journals Analysis of Toxic Metals in Liquid from Electronic Cigarettes

2019 ◽  
Vol 16 (22) ◽  
pp. 4450 ◽  
Author(s):  
Naudia Gray ◽  
Mary Halstead ◽  
Nathalie Gonzalez-Jimenez ◽  
Liza Valentin-Blasini ◽  
Clifford Watson ◽  
...  
Keyword(s):  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Electronic Cigarettes ◽  
Metal Concentrations ◽  
Inductively Coupled ◽  
Nickel Copper ◽  
Zinc Cadmium ◽  
Plasma Mass Spectrometry ◽  
Copper Zinc ◽  
The Impact

As the technology of electronic nicotine delivery systems (ENDS), including e-cigarettes, evolves, assessing metal concentrations in liquids among brands over time becomes challenging. A method for quantification of chromium, nickel, copper, zinc, cadmium, tin, and lead in ENDS liquids using triple quadrupole inductively coupled plasma mass spectrometry was developed. The method’s limits of detection (LODs) were 0.031, 0.032, 3.15, 1.27, 0.108, 0.099, 0.066 µg/g for Cr, Ni, Cu, Zn, Cd, Sn, and Pb respectively. Liquids analyzed were from different brands and flavors of refill bottles or single-use, rechargeable, and pod devices from different years. Scanning electron microscopy with energy dispersive spectroscopy further evaluated the device components’ compositions. Refill liquids before contacting a device were below lowest reportable levels (LRL) for all metals. Copper and zinc were elevated in liquids from devices containing brass. Cadmium was <LRL in all liquids and was not observed in device components. Cr, Ni, Cu, Zn, Sn, and Pb, reported in µg/g, ranged from <LRL to 0.396, 4.04, 903, 454, 0.898, and 13.5 respectively. Elevated metal concentrations in the liquid were also elevated in aerosol from the corresponding device. The data demonstrates the impact of device design and materials on toxic metals in ENDS liquid.

scholarly journals Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1687 ◽  
Author(s):  
Alexa-Maria Croitoru ◽  
Anton Ficai ◽  
Denisa Ficai ◽  
Roxana Trusca ◽  
Georgiana Dolete ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Graphene Oxide ◽  
Aqueous Solutions ◽  
Metal Ions ◽  
Inductively Coupled Plasma ◽  
Heavy Metal Ions ◽  
Ethylenediaminetetraacetic Acid ◽  
Composite Membranes ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

The scope of this article is to develop composite membranes using chitosan (CS) and graphene oxide (GO) as adsorbents for the removal of inorganic pollutants such as heavy metal ions, particularly Pb2+, from aqueous solutions. GO was obtained by modified Hummers method and blended with CS solution. The introduction of ethylenediaminetetraacetic acid (EDTA) compound to CS/GO suspension lead to an increased adsorption capacity of CS/GO for the elimination of heavy metals by forming stable chelates with them. The synthesized membranes were examined by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), and the adsorption behaviour of Pb2+ from aqueous solutions using CS/EDTA/GO membranes was evaluated using inductively coupled plasma mass spectrometry (ICP-MS). The adsorption performance of Pb2+ ions was studied by monitoring the concentration of Pb2+ against the adsorption period at an initial content of the adsorbent. The maximum adsorption efficiency of Pb2+ metal ions reached 767 mg·g−1 for CS/EDTA/GO 0.1%, 889 mg·g−1 for CS/EDTA/GO 0.3%, 970 mg·g−1 for CS/EDTA, 853 mg·g−1 for CS and 1526 mg·g−1 for GO. These findings show promising potential for CS/EDTA/GO membranes as effective adsorbent materials for the removal of heavy metal ions in water.

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