scholarly journals Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Maria Elena Ferrero
Keyword(s):  
Adverse Effects ◽  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Successful Management ◽  
Human Organs ◽  
Human Burden

Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.

scholarly journals EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update

Biomedicines ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 269
Author(s):  
Alessandro Fulgenzi ◽  
Daniele Vietti ◽  
Maria Elena Ferrero
Keyword(s):  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Human Subjects ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA2EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms.

scholarly journals EDTA Chelation Therapy for the Treatment of Neurotoxicity

2019 ◽  
Vol 20 (5) ◽  
pp. 1019 ◽  
Author(s):  
Fulgenzi Alessandro ◽  
Ferrero Maria Elena
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Agent ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Organophosphorus Pesticides ◽  
Chelating Agent ◽  
Oxygen Species ◽  
Anesthetic Drugs ◽  
Disodium Ethylenediaminetetraacetic Acid ◽  
Species Production

Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy. The development of neurodegenerative diseases has been associated with neurotoxicity. Which arms are useful to prevent or eliminate neurotoxicity? The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA)—previously used to treat cardiovascular diseases—is known to be useful for the treatment of neurodegenerative diseases. This review describes how EDTA functions as a therapeutic agent for these diseases. Some case studies are reported to confirm our findings.

scholarly journals Improvement of Oxidative and Metabolic Parameters by Cellfood Administration in Patients Affected by Neurodegenerative Diseases on Chelation Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Alessandro Fulgenzi ◽  
Rachele De Giuseppe ◽  
Fabrizia Bamonti ◽  
Maria Elena Ferrero
Keyword(s):  
Neurodegenerative Diseases ◽  
Ethylenediaminetetraacetic Acid ◽  
Oxidized Ldl ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Blood Parameters ◽  
Oxidative Status ◽  
Antioxidant Compounds ◽  
Before And After ◽  
Metabolic Conditions

Objective. This prospective pilot study aimed at evaluating the effects of therapy with antioxidant compounds (Cellfood, and other antioxidants) on patients affected by neurodegenerative diseases (ND), who displayed toxic metal burden and were subjected to chelation treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA or EDTA).Methods. Two groups of subjects were studied: (a) 39 patients affected by ND and (b) 11 subjects unaffected by ND (controls). The following blood parameters were analyzed before and after three months’ treatment with chelation + Cellfood or chelation + other antioxidants: oxidative status (reactive oxygen species, ROS; total antioxidant capacity, TAC; oxidized LDL, oxLDL; glutathione), homocysteine, vitamin B12, and folate.Results. After 3-months’ chelation + Cellfood administration oxLDL decreased, ROS levels were significantly lower, and TAC and glutathione levels were significantly higher than after chelation + other antioxidants treatment, both in ND patients and in controls. Moreover, homocysteine metabolism had also improved in both groups.Conclusions. Chelation + Cellfood treatment was more efficient than chelation + other antioxidants improving oxidative status and homocysteine metabolism significantly in ND patients and controls. Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects’ metabolic conditions.

scholarly journals Aluminium Involvement in Neurotoxicity

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Alessandro Fulgenzi ◽  
Daniele Vietti ◽  
Maria Elena Ferrero
Keyword(s):  
Multiple Sclerosis ◽  
Environmental Factors ◽  
Neurodegenerative Diseases ◽  
Ethylene Diamine Tetraacetic Acid ◽  
Toxic Metals ◽  
Healthy Subjects ◽  
Environmental Pollutants ◽  
Chelating Agent ◽  
Tetraacetic Acid ◽  
Intravenous Treatment

The aetiology of neurodegenerative diseases (ND) seems to involve susceptibility genes and environmental factors. Toxic metals are considered major environmental pollutants. Following our study of a case of multiple sclerosis (MS) improvement due to removal of aluminium (Al) and other toxic metals, we have examined the possible relationship between Al intoxication and ND. We used the slow intravenous treatment with the chelating agent EDTA (calcium disodium ethylene diamine tetraacetic acid) (chelation test) to remove Al and detected it in the urine collected from the patients for 12 hours. Patients affected by MS represented 85.6% of total ND. Al was present in 44.8% of cases comprehensive of ND and healthy patients. Al levels were significantly higher in ND patients than in healthy subjects. We here show that treatment of patients affected by Al burden with ten EDTA chelation therapies (EDTA intravenous administration once a week) was able to significantly reduce Al intoxication.

scholarly journals Spatial distribution and risk assessment of toxic metals in agricultural soils from endemic nasopharyngeal carcinoma region in South China

2020 ◽  
Vol 12 (1) ◽  
pp. 568-579
Author(s):  
Liping Mo ◽  
Yongzhang Zhou ◽  
Gnanachandrasamy Gopalakrishnana ◽  
Xingyuan Li
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
South China ◽  
Toxic Metals ◽  
Agricultural Soils ◽  
Hazard Index ◽  
Toxic Metal ◽  
Carcinogenic Risk ◽  
Pollution Indices ◽  
High Incidence ◽  
Low Incidence

AbstractSihui city (South China) is much affected by nasopharyngeal carcinoma (NPC). To investigate the relationships between the toxic metals in soil and NPC incidence in Sihui, 119 surface soil samples were collected from agricultural fields and analyzed. The soil As–Cr contents in Longjiang (high-incidence area) are significantly lower than those in Weizheng and Jianglin (low-incidence areas), whereas the soil Pb content in Longjiang is significantly higher than that in Weizheng. The Nemerow pollution indices (PIN) of soils decrease in the order of Jianglin > Weizheng > Longjiang. The enrichment factor (EF) of Cd indicates that the Cd enrichment is contributed by human activities. Potential toxic metal-related ecological risk values decrease in the order of Jianglin > Weizheng > Longjiang. The mean hazard index (HI) value of Longjiang was lower than those of Weizheng and Jianglin. There are no adverse noncarcinogenic health effects of soil toxic metals to adults in the study areas. Carcinogenic risks of As and Cr via ingestion and dermal contact and total carcinogenic risk are within the warning range, from 10−6 to 10−4. Hence, we suggest that toxic metals in the soil may not be major geochemical carcinogenic factors of high NPC incidence in Sihui.

scholarly journals Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication

2014 ◽  
Vol 7 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Juliana Ivanova ◽  
Yordanka Gluhcheva ◽  
Sonja Arpadjan ◽  
Mariana Mitewa
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Oral Treatment ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Treated Group ◽  
Epidemiological Studies ◽  
Organ Weight ◽  
Cardiac Functions ◽  
Icr Mouse

ABSTRACT Cadmium (Cd) is a well-known nephrotoxic agent. Cd-induced renal dysfunction has been considered as one of the causes leading to the development of hypertension. The correlation between Cd concentration in blood and urine and cardiovascular diseases has been discussed in many epidemiological studies. A therapy with chelating agents is utilized for the treatment of toxic metal intoxication. Herein we present novel information indicating that monensin (applied as tetraethylammonium salt) is a promising chelating agent for the treatment of Cd-induced renal and cardiac dysfunction. The study was performed using the ICR mouse model. Adult ICR male mice were divided into three groups with six animals in each group: control (received distilled water and food ad libitum for 28 days); Cd-intoxicated (treated orally with 20 mg/kg b.w. Cd(II) acetate from day 1 to day 14 of the experimental protocol), and monensin treated group (intoxicated with Cd(II) acetate as described for the Cd-intoxicated group followed by oral treatment with 16 mg/kg b.w. tetraethylammonium salt of monensic acid for 2 weeks). Cd intoxication of the animals resulted in an increase of the organ weight/body weight indexes. Cd elevated significantly creatinine and glucose level in serum. Monensin treatment improved the organ weight/body weight ratios. The therapy of the Cd-intoxicated animals with monensin ameliorated the creatinine and glucose level in serum and decreased the concentration of the toxic metal ions in the heart and kidneys by 54 % and 64 %, respectively

Effect of transfusional iron intake on response to chelation therapy in β-thalassemia major

Blood ◽  
2008 ◽  
Vol 111 (2) ◽  
pp. 583-587 ◽  
Author(s):  
Alan R. Cohen ◽  
Ekkehard Glimm ◽  
John B. Porter
Keyword(s):  
Chelation Therapy ◽  
Iron Concentration ◽  
Chelating Agent ◽  
Thalassemia Major ◽  
Phase Iii ◽  
Iron Loading ◽  
Iron Intake ◽  
Liver Iron ◽  
Iron Stores ◽  
Using Data

The success of chelation therapy in controlling iron overload in patients with thalassemia major is highly variable and may partly depend on the rate of transfusional iron loading. Using data from the 1-year phase III study of deferasirox, including volumes of transfused red blood cells and changes in liver iron concentration (LIC) in 541 patients, the effect of iron loading on achieving neutral or negative iron balance was assessed in patients receiving different doses of deferasirox and the comparator deferoxamine. After dose adjustment, reductions in LIC after 1 year of deferasirox or deferoxamine therapy correlated with transfusional iron intake. At a deferasirox dose of 20 mg/kg per day, neutral or negative iron balance was achieved in 46% and 75% of patients with the highest and lowest transfusional iron intake, respectively; 30 mg/kg per day produced successful control of iron stores in 96% of patients with a low rate of transfusional iron intake. Splenectomized patients had lower transfusional iron intake and greater reductions in iron stores than patients with intact spleens. Transfusional iron intake should be monitored on an ongoing basis in thalassemia major patients, and the rate of transfusional iron loading should be considered when choosing the appropriate dose of an iron-chelating agent. This study is registered at http://clinicaltrials.gov as NCT00061750.

Removal of Toxic Metal Ions from Solutions Using Industrial Solid Byproducts

1993 ◽  
Vol 27 (10) ◽  
pp. 83-93 ◽  
Author(s):  
A. I. Zouboulis ◽  
K. A. Kydros ◽  
K. A. Matis
Keyword(s):  
Toxic Metals ◽  
Toxic Metal ◽  
Industrial Wastes ◽  
Mineral Particles ◽  
Solid Adsorbent ◽  
Metals Removal ◽  
Environmental Considerations ◽  
Solid Liquid ◽  
Solid Liquid Separation ◽  
By Products

Nowadays the problem of industrial wastes handling and disposal is increasing continuously, as more strict environmental considerations have to be taken into account. In this paper, selected experimental results are presented from our current research in toxic metals removal (e.g. Cu, Pb, As), related to the applications of mineral particles as by-products (red mud, pyrite, dolomite, etc.) for the induced removal of toxic metals from aqueous solutions. These by-products, existing in finely divided form and considered rather as solid industrial wastes, have been used as a cheap solid adsorbent or substrate. Appropriate methods for the subsequent solid/liquid separation were examined, among them flotation. Different parameters were tested and high removals of toxic metals were achieved. In this way, a useful application may be realized for the waste mineral particles.

Cellulose powder functionalized with phenyl biguanide: Synthesis, cross-linking, metal adsorption, and molecular docking

BioResources ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. 7263-7282
Author(s):  
Othman Hamed ◽  
Majdi Qaisi ◽  
Ibrahim Abushqair ◽  
Avni Berisha ◽  
Omar Dagdag ◽  
...  
Keyword(s):  
Metal Ions ◽  
Adsorption Process ◽  
Polymer Surface ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Ion Concentration ◽  
Cellulose Powder ◽  
Dynamic Simulations ◽  
Promising Alternative ◽  
The Cross

A cellulose polymer functionalized with an amine chelating agent was designed and synthesized in a three-step process that involved oxidizing cellulose powder into dialdehyde cellulose, reacting cellulose dialdehyde with phenyl biguanide to create an imine linkage between the two reactants, and reducing the imine linkage to an amine. The cellulose amine polymer was cross-linked with glycerol digycidyl ether and evaluated as an adsorbent of toxic metal ions from wastewater. The adsorption efficiency of the cross-linked cellulose amine polymer toward Pb(II) and Cu(II) was evaluated as a function of the adsorbent dose, pH, time, temperature, and initial ion concentration. The cross-linked cellulose amine polymer showed an excellent efficiency toward over 15 metal ions present in a real sample of sewage. Thermodynamic analysis showed a spontaneous adsorption of metal ions on the polymer at room temperature. Monte Carlo and Molecular Dynamic simulations showed that the Cu(II) and Pb(II) ions adsorbed onto the cellulose amine polymer surface in a considerable amount, which agreed with the experimental and thermodynamic data. The negative free energy value confirmed the spontaneity of the adsorption process. As such, cross-linked cellulose amine polymers could be a promising alternative to current commercial adsorbents.

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