scholarly journals Implications of Breast Cancer Chemotherapy-Induced Inflammation on the Gut, Liver, and Central Nervous System

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 189
Author(s):  
Taurean Brown ◽  
DeLawrence Sykes ◽  
Antiño R. Allen
Keyword(s):  
Breast Cancer ◽  
Nervous System ◽  
Processing Speed ◽  
Chemotherapy Treatment ◽  
Normal Organ ◽  
Breast Cancer Chemotherapy ◽  
Distress Symptoms ◽  
Organ Systems ◽  
Patients Experience

Breast Cancer is still one of the most common cancers today; however, with advancements in diagnostic and treatment methods, the mortality and survivorship of patients continues to decrease and increase, respectively. Commonly used treatments today consist of drug combinations, such as doxorubicin and cyclophosphamide; docetaxel, doxorubicin, and cyclophosphamide; or doxorubicin, cyclophosphamide, and paclitaxel. Although these combinations are effective at destroying cancer cells, there is still much to be understood about the effects that chemotherapy can have on normal organ systems such as the nervous system, gastrointestinal tract, and the liver. Patients can experience symptoms of cognitive impairments or “chemobrain”, such as difficulty in concentrating, memory recollection, and processing speed. They may also experience gastrointestinal (GI) distress symptoms such as diarrhea and vomiting, as well as hepatotoxicity and long term liver damage. Chemotherapy treatment has also been shown to induce peripheral neuropathy resulting in numbing, pain, and tingling sensations in the extremities of patients. Interestingly, researchers have discovered that this array of symptoms that cancer patients experience are interconnected and mediated by the inflammatory response.

scholarly journals Fatigue dan status nutrisi pada pasien dengan kanker payudara yang menjalani kemoterapi

2020 ◽  
Vol 13 (4) ◽  
pp. 278-283
Author(s):  
Sapti Ayubbana ◽  
Sari Narulita
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Nursing Intervention ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy

Fatigue and nutritional status in patients with breast cancer undergoing chemotherapyBackground: Breast cancer is one type of cancer and is one of the leading causes of death in the world. Cancer patients who receive chemotherapy are at risk of impaired nutritional status due to the disease and its treatment. Chemotherapy treatment can have side effects on the gastrointestinal system such as nausea, vomiting, stomatitis, anorexia, changes in taste. These side effects can cause the patient's nutritional intake to decrease. Cancer and its treatment can cause fatigue complaints.Purpose: to identify the relationship between fatigue and nutritional status in patients with breast cancer patients undergoing chemotherapyMethods: The design of this study was quantitative using a cross sectional approach. The population in this study were patients with breast cancer undergoing chemotherapy. This research was conducted at Dr.H. Abdul Moeloek Hospital of Lampung Province with 42 respondents.Results: Spearman correlation test results found that nutritional status variables have a significant relationship with fatigue (p value = 0.031) with moderate correlation strength (r = 0.471).Conclusion: The nursing intervention on the side effects of chemotherapy treatment which has a positive effect on nutritional conditions in an effort to overcome nutritional disorders and complaints of fatigue in cancer patients.Keywords: Breast Cancer; Chemotherapy; Fatigue; Nutritional StatusPendahuluan: Kanker payudara merupakan salah satu jenis kanker dan menjadi salah satu penyebab kematian di dunia. Pasien kanker yang menerima kemoterapi memiliki resiko gangguan status nutrisi akibat penyakit dan pengobatannya. Pengobatan kemoterapi dapat memberikan efek samping terhadap sistem ganstrointestinal seperti mual, muntah, stomatitis, anoreksia, perubahan rasa. Efek samping tersebut dapat menyebabkan asupan nutrisi pasien dapat mengalami penurunan. Kanker dan pengobatannya dapat menyebabkan keluhan fatigue.Tujuan: Mengetahui adanya hubungan antara status nutrisi terhadap fatigue pada pasien kanker payudara yang menjalani kemoterapi.Metode: Desain penelitian ini adalah kuantitatif dengan menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah pasien dengan kanker payudara yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Dr.H. Abdul Moeloek Provinsi Lampung dengan 42 responden.Hasil: Pada uji korelasi spearman didapatkan bahwa variabel status nutrisi mempunyai hubungan yang bermakna dengan fatigue ( p value = 0,031) dengan kekuatan korelasi sedang (r = 0,471).Simpulan: Kesimpulan diperlukan intervensi keperawatan terhadap efek samping pengobatan kemoterapi yang berdapak terhadap kondisi nutrisi dalam upaya mengatasigangguan nutrisi dan keluhan fatigue pada pasien kanker 

scholarly journals Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover

2016 ◽  
Vol 5 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Caroline Wilson ◽  
Fatma Gossiel ◽  
Robert Leonard ◽  
Richard A Anderson ◽  
Douglas J A Adamson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Turnover ◽  
Cancer Chemotherapy ◽  
Breast Cancer Chemotherapy ◽  
Adjuvant Breast Cancer

scholarly journals ‘A new normal with chemobrain’: Experiences of the impact of chemotherapy-related cognitive deficits in long-term breast cancer survivors

2019 ◽  
Vol 6 (1) ◽  
pp. 205510291983223 ◽  
Author(s):  
Fiona ME Henderson ◽  
Ainslea J Cross ◽  
Amy R Baraniak
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Lived Experience ◽  
Health Beliefs ◽  
Cognitive Deficits ◽  
Processing Speed ◽  
Interpretative Phenomenological Analysis ◽  
Breast Cancer Survivors ◽  
The Impact

Chemobrain is one of the most commonly reported side-effects of cancer treatment. However, there is limited research into its psychosocial concomitants. This study aimed to explore the long-term lived experience of chemobrain. Interpretative phenomenological analysis allowed an in-depth investigation of 12 breast cancer survivors suffering from perceived cognitive deficits at least 1-year post-treatment. Themes were organised around the illness representations framework. Commonly reported cognitive deficits related to memory, language and processing speed, which affected participants’ sense of identity and their interactions with others. Individual experiences were mediated by health beliefs regarding controllability, validation and impairment trajectory.

scholarly journals A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction

2021 ◽  
Vol 8 ◽  
Author(s):  
Christa Corley ◽  
Antiño R. Allen
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cognitive Dysfunction ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cancer Treatments ◽  
The Usa ◽  
Bibliometric Review ◽  
Long Term Survivors

Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades later, these patients still report experiencing cognitive side effects. In this present bibliometric review, we applied the VOSviewer tool to describe the existing landscape on literature concerning inflammation as it relates to CMF and cognitive dysfunctions. As time progressed, we saw an increase in interest in the topic. By the mid-2010s there were approximately 1,000 publications per year. Terms related to the brain and CNS did not appear until the later years, and terms related to inflammation and breast cancer were very prevalent throughout the three decades. Also, in more recent years, inflammatory markers and plant-derived compounds used to alleviate side effects of the inflammatory response appeared in the search results. The USA remained the most prolific producer of CMF-, inflammation-, and cognitive dysfunction-related papers throughout the three decades followed by Asia and Europe. As research of cognitive dysfunction caused by inflammation due to chemotherapy treatment progresses, more opportunities emerge for therapeutic methods to improve the quality of life for long-term survivors.

scholarly journals Long Term Complications Associated with Covid-19 : A Review

2020 ◽  
Vol 5 (9) ◽  
pp. 324-326
Author(s):  
Anushka Joshi
Keyword(s):  
Nervous System ◽  
Recovery Rate ◽  
The Body ◽  
Infected Person ◽  
Shortness Of Breath ◽  
Vital Functions ◽  
Close Proximity ◽  
Patients Experience ◽  
Transmissible Disease

The covid-19 has spread rapidly throughout the china and globally. This highly transmissible disease till date has infected around 17 million people worldwide. The infection spreads through the sputum or the droplets generated by the infected person by sneezing, coughing or talking. The droplets can settle down on the surfaces and floors or can remain in air where the viability of the virus varies from few minutes to several days. People can also get infected on coming in close proximity of the infected person. The patients experience mild to high fever, sore throat, headache, myalgia, tastelessness and shortness of breath along with pneumonia like symptoms in serious cases. A large number of asymptomatic cases were also reported making the detection difficult in early stages. The recovery rate as of now has reached to 78%, and fatality rates are low, still people are prone to various other long term symptoms after recovery which is a matter of concern. The researchers and scientists have found prominent effect on nervous system and other vital functions of the body, this article gives a brief review of such complications.

scholarly journals Occurrence of tinnitus and peripheral sensory neuropathy in women during chemotherapy treatment of breast cancer

2021 ◽  
Vol 11 (1) ◽  
pp. 69-79
Author(s):  
Simone Yuriko Kameo ◽  
Ricardo Barbosa-Lima ◽  
Josilene Luciene Andrade ◽  
Bruno Ferreira Amorim ◽  
Glebson Moura Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Medical Records ◽  
Analytical Study ◽  
Outpatient Service ◽  
Sensory Neuropathy ◽  
Inclusion Criteria ◽  
Chemotherapy Treatment ◽  
Peripheral Sensory Neuropathy ◽  
Breast Cancer Chemotherapy ◽  
Peripheral Sensory

Objective: To analyze the occurrence of tinnitus and peripheral sensory neuropathy in women during breast cancer chemotherapy. Methods: This is a retrospective analytical study with a quantitative approach, performed in medical records of an oncology outpatient service between February 2014 and February 2015, using the toxicities scores of Common Terminology Criteria for Adverse Events (CTCAE). Results: Considering 181 patients with breast cancer who met the inclusion criteria, 49.2% reported tinnitus at some point of the treatment, while 65.1% peripheral sensory neuropathy. In both conditions, the predominant severity score was grade 1, with frequencies of 23.8% and 33.1%, respectively. A significant, positive and weak correlation was observed between the severity of tinnitus and peripheral sensory neuropathy (ρ = 0.325 and p = 0.001), as well as very weak between the number of complete cycles of chemotherapy and tinnitus (ρ = 0.195 and p = 0.009) and neuropathy peripheral sensory (ρ = 0.237 and p = 0.002). Conclusions: Tinnitus and peripheral sensory neuropathy were frequent toxicities during chemotherapy treatment of breast cancer, and both manifested with low severity/functional impact in most participants.

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