scholarly journals Cell and Cell Free Therapies in Osteoarthritis

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1726
Author(s):  
Pau Peláez ◽  
Elena Damiá ◽  
Marta Torres-Torrillas ◽  
Deborah Chicharro ◽  
Belén Cuervo ◽  
...  
Keyword(s):  
Negative Impact ◽  
Platelet Rich Plasma ◽  
Pharmacological Therapy ◽  
Invasive Treatment ◽  
Current Prevalence ◽  
Effective Option ◽  
Surgical Options ◽  
Threat To Life ◽  
A Current

Osteoarthritis (OA) is the most common articular disease in adults and has a current prevalence of 12% in the population over 65 years old. This chronic disease causes damage to articular cartilage and synovial joints, causing pain and leading to a negative impact on patients’ function, decreasing quality of life. There are many limitations regarding OA conventional therapies—pharmacological therapy can cause gastrointestinal, renal, and cardiac adverse effects, and some of them could even be a threat to life. On the other hand, surgical options, such as microfracture, have been used for the last 20 years, but hyaline cartilage has a limited regeneration capacity. In recent years, the interest in new therapies, such as cell-based and cell-free therapies, has been considerably increasing. The purpose of this review is to describe and compare bioregenerative therapies’ efficacy for OA, with particular emphasis on the use of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP). In OA, these therapies might be an alternative and less invasive treatment than surgery, and a more effective option than conventional therapies.

scholarly journals The prevalence of urinary incontinence and its impact on quality of life among the university female staff in South Africa

2011 ◽  
Vol 67 (2) ◽  
Author(s):  
L. Skaal ◽  
M.K. Mashola
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Negative Impact ◽  
Treatment Options ◽  
Cross Sectional Study ◽  
Invasive Treatment ◽  
Cross Sectional ◽  
University Women ◽  
The University

Background: Urinary incontinence (UI) is a common problem among females and has been associated with significant decreased quality of  life. Few  women  seek  help  for  this  condition  with  only  a  few  who consult physiotherapy treatment.Purpose: To determine the prevalence of urinary incontinence and its impact on quality of life among the university women in South Africa.Method:  A  quantitative  cross-sectional  study design  with  145  women  ran-domly selected from the university. A questionnaire was used to determine UI Diagnosis; Impact on Qol and treatment seeking tendencies. BMI was meas-ured objectively. ethical clearance was obtained from University. Data was analysed using SPSS 17.0Results:  Forty  six(32%)  women  reported  to  having  UI.  Risk  factors  associated  with  UI  included  age,  race,  and  obesity. UI had a significant negative impact on quality of life and only 4.4% of participants with UI consulted physio-therapy for this condition.Conclusion: There is a high prevalence of UI among the women at this university with a significant impact on quality of life.The role of Physiotherapy in management of UI has been demonstrated and there is therefore a need to empower women with non-invasive treatment options, like physiotherapy.

scholarly journals Organ-Preserving Surgery for Penile Carcinoma

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Francisco E. Martins ◽  
Raul N. Rodrigues ◽  
Tomé M. Lopes
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Psychological Impact ◽  
Surgical Techniques ◽  
Penile Carcinoma ◽  
Current Status ◽  
Radical Radiotherapy ◽  
Surgical Options ◽  
Cosmetic Outcomes

Introduction. Penile carcinoma has traditionally been treated by either surgical amputation or radical radiotherapy, both associated with devastating anatomical, functional, and psychological impact on the patient's life. Innovative surgical techniques have focused on penile preservation in well-selected patients to minimize physical disfigurement and consequently maximize quality of life. The objective of this article is to define the current status of these organ-preserving surgical options for penile carcinoma.Materials and Methods. An extensive review of the Pubmed literature was performed to find articles discussing only reconstructive surgery which have contributed significantly to change traditional, frequently mutilating treatments, to develop less disfiguring surgery, and to improve patients' quality of life over the last two decades.Results. Several articles were included in this analysis in which a major contribution to the change in therapy was thought to have occurred and was documented as beneficial. Some articles reported novel techniques of less-mutilating surgery involving different forms of glans reconstruction with the use of flaps or grafts. The issue of safe surgical margins was also addressed.Conclusion. The development of less-disfiguring techniques allowing phallus preservation has reduced the negative impact on functional and cosmetic outcomes of amputation without sacrificing oncological objectives in appropriately selected patients based on stage, grade, and location of the tumour. Until more prospective studies are available and solid evidence is documented, organ preservation should be offered with caution.

scholarly journals Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders

2006 ◽  
Vol 189 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Michael W. Otto ◽  
Naomi M. Simon ◽  
Stephen R. Wisniewski ◽  
David J. Miklowitz ◽  
Jane N. Kogan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Anxiety Disorders ◽  
Negative Impact ◽  
Mood State ◽  
Comorbid Anxiety ◽  
Depression Risk ◽  
The Impact ◽  
A Current

BackgroundThe impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder.AimsTo examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning.MethodA thousand out-patients with bipolar disorder were followed prospectively for 1 year.ResultsA current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life and diminished role function over 1 year of prospective study. The negative impact was greater with multiple anxiety disorders.ConclusionsAnxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course.

scholarly journals Vulvovaginal Candidiasis: A Current Understanding and Burning Questions

2020 ◽  
Vol 6 (1) ◽  
pp. 27 ◽  
Author(s):  
Hubertine M. E. Willems ◽  
Salman S. Ahmed ◽  
Junyan Liu ◽  
Zhenbo Xu ◽  
Brian M. Peters
Keyword(s):  
Reproductive Tract ◽  
Negative Impact ◽  
Vulvovaginal Candidiasis ◽  
Female Reproductive Tract ◽  
Current State ◽  
Child Bearing ◽  
Causative Agents ◽  
Insight Into ◽  
A Current

Candida albicans, along with other closely related Candida species, are the primary causative agents of vulvovaginal candidiasis (VVC)—a multifactorial infectious disease of the lower female reproductive tract resulting in pathologic inflammation. Unlike other forms of candidiasis, VVC is a disease of immunocompetent and otherwise healthy women, most predominant during their child-bearing years. While VVC is non-lethal, its high global incidence and profound negative impact on quality-of-life necessitates further understanding of the host and fungal factors that drive disease pathogenesis. In this review, we cover the current state of our understanding of the epidemiology, host response, fungal pathogenicity mechanisms, impact of the microbiome, and novel approaches to treatment of this most prevalent human candidal infection. We also offer insight into the latest advancements in the VVC field and identify important questions that still remain.

scholarly journals Non-invasive treatment in the management of Peyronie’s disease

2019 ◽  
Vol 11 ◽  
pp. 175628721882367 ◽  
Author(s):  
Karen Randhawa ◽  
C. J. Shukla
Keyword(s):  
Sexual Function ◽  
Surgical Management ◽  
Treatment Options ◽  
Invasive Treatment ◽  
Management Options ◽  
Non Invasive ◽  
Nonsurgical Management ◽  
Partner Satisfaction ◽  
Surgical Options

Peyronies disease (PD) is estimated to affect approximately 3–9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. Several non-surgical options are currently being employed in the treatment of PD that may reduce or stabilize both objective measures (e.g. penile length and deformity) and subjective measures (including sexual function, pain and partner satisfaction). Nonsurgical management can allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. In this article we explore the current non-surgical management options for PD including oral, mechanical therapies, intralesional and topical treatments. We also briefly discuss future treatment options in the form of stem cell therapy.

scholarly journals Ayurvedic Management of Mukhapaka w. s. r. To Stomatitis : A case Study

2021 ◽  
Vol 5 (03) ◽  
Author(s):  
Sulbha Kalme ◽  
Ashwini Gaikwad ◽  
Mansi Kulkarni ◽  
Noorjahan Mujawar
Keyword(s):  
Negative Impact ◽  
Modern Science ◽  
Daily Practice ◽  
Treatment Modalities ◽  
Significant Negative Impact ◽  
Present Case Study ◽  
Threat To Life ◽  
Overall Health Status

       Mukha ( mouth or oral cavity) is one of the important parts of our body. The digestive system starts from mukha so it is important to maintain proper oral hygiene for our overall health status. Mukhapaka is a commonest disease of oral mucosa found in India as well as all over the world. Mukhapaka can be correlated with stomatitis or mouth ulcers as per modern science. Oral ulceration is encountered frequently in our daily practice. Stomatitis is curable & not considered a threat to life but these ulcers have a significant negative impact on oral health, affecting the quality of life. It also affects normal activities like eating & swallowing. Sometimes brushing & talking also becomes painful. In Ayurveda  various treatment modalities are described for mukhapaka. I have selected one of them to establish the efficacy of Gandush on mukhapaka in my present case study.

Green Beans Cultivation Using Mice Pets Control to Improve the Quality of Bintaro Fruit Extract

2018 ◽  
Vol 1 (1) ◽  
pp. 38
Author(s):  
Ajeng Embri Legawati ◽  
Nur Azizah ◽  
Achmad Ramadhan
Keyword(s):  
Natural Resources ◽  
Negative Impact ◽  
Green Beans ◽  
Fruit Extract ◽  
Bean Plants ◽  
Cultivation Technology ◽  
Environmental Balance ◽  
The Impact ◽  
Chemical Pesticides

Green beans cultivation technology using mice pets control has been implemented in the Gluranploso village, Benjeng Gresik. The implementation of the technology performed for 2.5 months from August to October 2017. The purpose of the implementation is aimed to reduce the dependence of farmers on the use of chemical pesticides so that the farmers are aware of the negative impact of chemical pesticides. Assessing the impact of the utilization of Bintaro fruit and fruit extracts to explore ways of making Bintaro as a natural biopesticide to overcome rat attack on green bean plants in the Gluranploso village. Pest control mice can reduce the rate of loss of the crops more effectively and efficiently. Finally, with the use of those natural resources as a biopesticide material can also maintain the environmental balance

CHRONOBIOLOGICAL AND PSYCHOEMOTIONAL STATUS IN WOMEN WITH CHRONIC RECURRENT BACTERIAL CYSTITIS AND CARBOHYDRATE METABOLISM DISORDER

2020 ◽  
pp. 56-59
Author(s):  
Мария Николаевна Химичева ◽  
Андрей Владимирович Кузьменко ◽  
Владимир Васильевич Кузьменко ◽  
Тимур Асланбекович Гяургиев
Keyword(s):  
Chronic Disease ◽  
Carbohydrate Metabolism ◽  
Negative Impact ◽  
High Risk Group ◽  
Chronic Complications ◽  
Course Of Disease ◽  
Metabolism Disorder ◽  
Common Group ◽  
Tract Infections

Инфекции мочевых путей - наиболее распространённая группа заболеваний в практике врача уролога. Один из представителей является хронический рецидивирующий бактериальный цистит. Данное заболевание встречается во всех возрастных категориях и затрагивает все сферы жизни пациентов. Симптомы, возникающие при обострении хронического бактериального цистита, оказывают негативное влияние на качество жизни, что может приводить к нарушению психоэмоционального состояния больных. Отдельную группу высокого риска в отношении ИНМП составляют пациенты с нарушением углеводного обмена, у которых риск развития различных инфекций выше, чем у людей без подобных нарушений. К факторам, повышающим риск развития ИНМП у больных с нарушением углеводного обмена, относят возраст, компенсацию и наличие хронических осложнений, в первую очередь нефропатии и цистопатии. Человеческий организм функционирует циклически в соответствии с определенными индивидуальными ритмами. Любое хроническое заболевание приводит к рассогласованию процессов, протекающих в различных системах организма, вызывая развитие десинхроноза. Наличие у человека более 1 хронического заболевания утяжеляет течение болезни и приводит к снижению восстановительных способностей организма и сокращению его адаптационного потенциала Urinary tract Infections are the most common group of diseases in the practice of a urologist. One of the representatives is chronic recurrent bacterial cystitis. This disease occurs in all age categories and affects all areas of life of patients. Symptoms that occur with the exacerbation of chronic bacterial cystitis have a negative impact on the quality of life, which can lead to a violation of the psychoemotional state of patients. A separate high-risk group for INMP is patients with impaired carbohydrate metabolism, who have a higher risk of developing various infections than people without such disorders. Factors that increase the risk of developing INMP in patients with impaired carbohydrate metabolism include age, compensation, and the presence of chronic complications, primarily nephropathy and cystopathy. The human body functions cyclically in accordance with certain individual rhythms. Any chronic disease leads to misalignment of the processes occurring in various body systems, causing the development of DS, the Presence of more than 1 chronic disease complicates the course of disease and leads to a decrease in regenerative abilities of the organism and reduce its adaptive capacity

Modern challenges of border areas development in the context of decentralization reform

2019 ◽  
pp. 79-89
Author(s):  
Khrystyna Prytula ◽  
Yaroslava Kalat ◽  
Iryna Kyryk
Keyword(s):  
Ethnic Minorities ◽  
Negative Impact ◽  
Local Development ◽  
Economic Security ◽  
Uneven Development ◽  
Scientific Article ◽  
Border Regions ◽  
Border Areas ◽  
Decentralization Reform

An integral part of the implementation of any reform is the emergence of the risks of its negative impact on one or another area of region development. The decentralization reform in Ukraine is not an exception. In its the context the most probable occurrence of negative phenomena is in the border regions, which could be prevented by first detecting them. In the scientific article, the authors focus on the analysis of a number of challenges for the development of border regions in the context of decentralization reform. Given the territorial remoteness of the central regions of the country and the capital, which today serve as areas of concentration of investment and economic activity, the border regions traditionally (this is typical for the border areas of the EU member states) lag behind the rest of the regions by the main socio-economic indicators of development. Among the main challenges facing the border regions of Ukraine today are the following: the provision of competitiveness in the context of European integration processes and reduction of the border barrier function; low level of economic security; the outflow of human capital and the issue of ethnic minorities. Based on an expert survey of representatives of the fifteen united territorial communities (UTCs), the possibility of such risks of decentralization in the border regions were defined as following: groundless use of local budget funds; emergence of significant imbalances between delegated new authority and available financial resources of the community; increasing uneven development of territories within the community; increasing uneven development of communities within the country; deterioration of the availability and quality of providing educational and medical services; deterioration of the quality of local government; reducing of the state influence on the management of local development processes; radicalization of political unions representing the interests of ethnic minorities in places of their compact residence; further economic decline of the territory of communities and so on.

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