scholarly journals Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1962 ◽  
Author(s):  
Alexis Loiseau ◽  
Julien Boudon ◽  
Alexandra Oudot ◽  
Mathieu Moreau ◽  
Romain Boidot ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Radiation Effect ◽  
Hydrothermal Process ◽  
Therapeutic Agents ◽  
Titanate Nanotubes ◽  
Suspension Stability ◽  
Biodistribution Studies ◽  
Adenocarcinoma Cells

Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid to their step-by-step synthesis. TiONts were synthesized by a hydrothermal process. To develop the custom-engineered nanohybrids, the surface of TiONts was coated beforehand with a siloxane (APTES), and coupled with both dithiolated diethylenetriaminepentaacetic acid-modified gold nanoparticles (Au@DTDTPA NPs) and a heterobifunctional polymer (PEG3000) to significantly improve suspension stability and biocompatibility of TiONts for targeted biomedical applications. The pre-functionalized surface of this scaffold had reactive sites to graft therapeutic agents, such as docetaxel (DTX). This novel combination, aimed at retaining the AuNPs inside the tumor via TiONts, was able to enhance the radiation effect. Nanohybrids have been extensively characterized and were detectable by SPECT/CT imaging through grafted Au@DTDTPA NPs, radiolabeled with 111In. In vitro results showed that TiONts-AuNPs-PEG3000-DTX had a substantial cytotoxic activity on human PC-3 prostate adenocarcinoma cells, unlike initial nanohybrids without DTX (Au@DTDTPA NPs and TiONts-AuNPs-PEG3000). Biodistribution studies demonstrated that these novel nanocarriers, consisting of AuNP- and DTX-grafted TiONts, were retained within the tumor for at least 20 days on mice PC-3 xenografted tumors after IT injection, delaying tumor growth upon irradiation.

scholarly journals Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1094
Author(s):  
Allan Radaic ◽  
Nam E. Joo ◽  
Soo-Hwan Jeong ◽  
Seong-II Yoo ◽  
Nicholas Kotov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Therapeutic Potential ◽  
Control Treatment ◽  
Track Record ◽  
Males And Females ◽  
Breast And Prostate Cancer ◽  
First Time

Prostate and breast cancer are the current leading causes of new cancer cases in males and females, respectively. Phosphatidylserine (PS) is an essential lipid that mediates macrophage efferocytosis and is dysregulated in tumors. Therefore, developing therapies that selectively restore PS may be a potential therapeutic approach for carcinogenesis. Among the nanomedicine strategies for delivering PS, biocompatible gold nanoparticles (AuNPs) have an extensive track record in biomedical applications. In this study, we synthesized biomimetic phosphatidylserine-caped gold nanoparticles (PS-AuNPs) and tested their anticancer potential in breast and prostate cancer cells in vitro. We found that both cell lines exhibited changes in cell morphology indicative of apoptosis. After evaluating for histone-associated DNA fragments, a hallmark of apoptosis, we found significant increases in DNA fragmentation upon PS-AuNP treatment compared to the control treatment. These findings demonstrate the use of phosphatidylserine coupled with gold nanoparticles as a potential treatment for prostate and breast cancer. To the best of our knowledge, this is the first time that a phosphatidylserine-capped AuNP has been examined for its therapeutic potential in cancer therapy.

Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 735-744 ◽  
Author(s):  
Yamin Yang ◽  
Xiaochuan Yang ◽  
Jin Zou ◽  
Chao Jia ◽  
Yue Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Three Dimensional ◽  
Therapeutic Agents ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Tissue Model

A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.

scholarly journals Physicochemical properties and in vitro stability studies of green synthesized gold nanoparticles using pelargonium sidoides

2020 ◽  
Vol 39 (3) ◽  
Author(s):  
U.M. Badeggi ◽  
B.A. Lawal ◽  
A.O. Akinfenwa ◽  
Y.O. Ayipo ◽  
Y. Azeh ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Zeta Potential ◽  
Biomedical Applications ◽  
Capping Agent ◽  
Stability Studies ◽  
Hybrid Particles ◽  
Pelargonium Sidoides ◽  
In Vitro Stability ◽  
532 Nm

In the present study, Pelargonium sidoides (PS) extract was used in the green synthesis of AuNPs that was characterized by UV-Vis, TEM, SAED, EDS, XRD, FTIR, and DLS. UV-Vis showed a surface plasmon resonance (SPR) at λmax of 532 nm while TEM shows that the particles are predominantly spherical and monodispersed. DLS measurement indicated the particle size and the zeta potential to be 27.20 nm and -24.0 mV respectively. The in vitro stability of the hybrid particles in different solutions and buffers (pH 7 and 9) confirmed that the particles are stable over a given period. The method employed is simple, environmentally friendly, and inexpensive. Our studies suggest that the Pelargonium sidoides-gold nanoparticles (PS-AuNPs) may be safely used in biomedical applications such as drug delivery. Keywords: Pelargonium sidoides; biosynthesis; biomedicals; capping agent; zeta potential

scholarly journals Use of Gold Nanoparticles in Diagnostics, Surgery and Medicine: A Review

2013 ◽  
Vol 5 (2) ◽  
pp. 56-60 ◽  
Author(s):  
ASM Giasuddin ◽  
KA Jhuma ◽  
AM Mujibul Haq
Keyword(s):  
Gold Nanoparticles ◽  
Present Article ◽  
Critical Review ◽  
Biomedical Applications ◽  
Noble Metals ◽  
Therapeutic Agents ◽  
Tremendous Progress ◽  
Biological Interest ◽  
Low Toxicity

Noble metals and their compounds have a long and distinguished history as therapeutic agents in medicine. Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications. Particularly gold nanoparticles have attracted intensive interest, because they are easily prepared, have low toxicity and can be readily attached to molecules of biological interest. The gold nanoparticles have become more precious than pretty gold because of their wide use and applications. The present article gave a critical review of the wide applications and uses of gold nanoparticles in diagnostics, surgery and medicine. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13346 Bangladesh J Med Biochem 2012; 5(2): 56-60

In Vivo Biocompatibility and Immunogenicity of Metal-Phenolic Gelation

2019 ◽  
Author(s):  
Mattias Björnmalm ◽  
Lok Man Wong ◽  
Jonathan Wojciechowski ◽  
Jelle Penders ◽  
Conor Horgan ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Ease Of Use ◽  
Minimal Invasiveness ◽  
New Class ◽  
Biodistribution Studies ◽  
In Vivo Characterization

In vivo forming hydrogels are of interest for diverse biomedical applications due to their ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled using metal–phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. Ti<sup>IV </sup>or Zr<sup>IV</sup>) provide a versatile and robust platform for engineering such materials. However, the in situ formation and in vivo response to this new class of materials has not yet been reported. Here, we demonstrate that metal–phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. The Ti<sup>IV</sup>–tannic acid materials form stable gels that are well-tolerated following subcutaneous injection. Histology reveals a mild foreign body reaction, and titanium biodistribution studies show low accumulation in distal tissues. Compared to poloxamer-based hydrogels (commonly used for in vivo gelation), Ti<sup>IV</sup>–tannic acid materials show substantially improved in vitro drug loading and release profile for the corticosteroid dexamethasone (from <1 day to >10 days). These results provide essential in vivo characterization for this new class of metal–phenolic hydrogels, and highlight their potential suitability for biomedical applications in areas such as drug delivery and regenerative medicine.<br>

Gold Nanoparticles as Targeted Delivery Systems and Theranostic Agents in Cancer Therapy

2019 ◽  
Vol 26 (35) ◽  
pp. 6493-6513 ◽  
Author(s):  
Alexandra Mioc ◽  
Marius Mioc ◽  
Roxana Ghiulai ◽  
Mirela Voicu ◽  
Roxana Racoviceanu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Anticancer Agents ◽  
Targeted Delivery ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Theranostic Agents ◽  
Targeted Delivery Systems

Cancer is still a leading cause of death worldwide, while most chemotherapies induce nonselective toxicity and severe systemic side effects. To address these problems, targeted nanoscience is an emerging field that promises to benefit cancer patients. Gold nanoparticles are nowadays in the spotlight due to their many well-established advantages. Gold nanoparticles are easily synthesizable in various shapes and sizes by a continuously developing set of means, including chemical, physical or eco-friendly biological methods. This review presents gold nanoparticles as versatile therapeutic agents playing many roles, such as targeted delivery systems (anticancer agents, nucleic acids, biological proteins, vaccines), theranostics and agents in photothermal therapy. They have also been outlined to bring great contributions in the bioimaging field such as radiotherapy, magnetic resonance angiography and photoacoustic imaging. Nevertheless, gold nanoparticles are therapeutic agents demonstrating its in vitro anti-angiogenic, anti-proliferative and pro-apoptotic effects on various cell lines, such as human cervix, human breast, human lung, human prostate and murine melanoma cancer cells. In vivo studies have pointed out data regarding the bioaccumulation and cytotoxicity of gold nanoparticles, but it has been emphasized that size, dose, surface charge, sex and especially administration routes are very important variables.

Physico-Chemical Characteristics of TiO2 Derived Nanotube Synthesized by the Hydrothermal Process as a Bioceramic

2014 ◽  
Vol 631 ◽  
pp. 198-201 ◽  
Author(s):  
H. Eslami ◽  
F. Moztarzadeh ◽  
T.S. Jafarzadeh Kashi ◽  
M. Solati-Hashjin ◽  
K. Khoshroo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Cellular Response ◽  
Hydrothermal Process ◽  
In Vitro Study ◽  
High Specific Surface Area ◽  
Fesem Image ◽  
Physico Chemical ◽  
Different Temperatures ◽  
Main Factor

Titania (TiO2) nanotube gaining predominance as a bioceramic due to its excellent features such as high specific surface area and exhibiting appropriate cellular response. At present, we showed a conversion from titania nanoparticle to nanotube by hydrothermal treatment with 10M soduim hydroxide and 1M HCl solutions at 150°C over 48h. Then the sample annealed at various temperatures. Results indicate the reaction temperature is a main factor in determining the aspect ratio of the tubes. FESEM image conformed the synthesis of nanotube. In vitro study by using 150 °C-synthesized nanotube calcined at different temperatures are also presented establishing the potential of nanotubes in biomedical applications

Gold Nanoparticles for Biomedical Applications: Synthesis and In Vitro Evaluation

2016 ◽  
pp. 87-111 ◽  
Author(s):  
Peter Chhour ◽  
Pratap C. Naha ◽  
Rabee Cheheltani ◽  
Barbara Benardo ◽  
Shaameen Mian ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
In Vitro Evaluation
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