scholarly journals Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 300 ◽  
Author(s):  
Aiichiro Nagaki ◽  
Katsuyuki Hirose ◽  
Yuya Moriwaki ◽  
Masahiro Takumi ◽  
Yusuke Takahashi ◽  
...  
Keyword(s):  
Pressure Drop ◽  
Flow Rate ◽  
Flow Reactor ◽  
Scale Up ◽  
Good Method ◽  
Aryl Halides ◽  
Series Connection ◽  
Pore Sizes ◽  
Polymer Monolith ◽  
Increase In Productivity

The space integration of the lithiation of aryl halides, the borylation of aryllithiums, and Suzuki–Miyaura coupling using a Pd catalyst supported by a polymer monolith flow reactor without using an intentionally added base was achieved. To scale up the process, a series connection of the monolith Pd reactor was examined. To suppress the increase in the pressure drop caused by the series connection, a monolith reactor having larger pore sizes was developed by varying the temperature of the monolith preparation. The monolithic Pd reactor having larger pore sizes enabled Suzuki–Miyaura coupling at a higher flow rate because of a lower pressure drop and, therefore, an increase in productivity. The present study indicates that series connection of the reactors with a higher flow rate serves as a good method for increasing the productivity without decreasing the yields.

scholarly journals Continuous Diastereomeric Kinetic Resolution—Silybins A and B

Catalysts ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1106
Author(s):  
David Biedermann ◽  
Martina Hurtová ◽  
Oldřich Benada ◽  
Kateřina Valentová ◽  
Lada Biedermannová ◽  
...  
Keyword(s):  
Flow Rate ◽  
Kinetic Resolution ◽  
Flow Reactor ◽  
Scale Up ◽  
Acrylic Resin ◽  
Optimal Conditions ◽  
Continuous Flow Reactor ◽  
Resin Beads ◽  
Diastereomeric Mixture ◽  
Optically Pure

The natural diastereomeric mixture of silybins A and B is often used (and considered) as a single flavonolignan isolated from the fruit extract of milk thistle (Silybum marianum), silymarin. However, optically pure silybin diastereomers are required for the evaluation of their biological activity. The separation of silybin diastereomers by standard chromatographic methods is not trivial. Preparative chemoenzymatic resolution of silybin diastereomers has been published, but its optimization and scale-up are needed. Here we present a continuous flow reactor for the chemoenzymatic kinetic resolution of silybin diastereomers catalyzed by Candida antarctica lipase B (CALB) immobilized on acrylic resin beads (Novozym® 435). Temperature, flow rate, and starting material concentration were varied to determine optimal reaction conditions. The variables observed were conversion and diastereomeric ratio. Optimal conditions were chosen to allow kilogram-scale reactions and were determined to be −5 °C, 8 g/L silybin, and a flow rate of 16 mL/min. No significant carrier degradation was observed after approximately 30 cycles (30 days). Under optimal conditions and using a 1000 × 15 mm column, 20 g of silybin per day can be easily processed, yielding 6.7 and 5.6 g of silybin A and silybin B, respectively. Further scale-up depends only on the size of the reactor.

Study of fluid flow through a channel deformed by piezoelement

2018 ◽  
Vol 13 (3) ◽  
pp. 1-10 ◽  
Author(s):  
I.Sh. Nasibullayev ◽  
E.Sh Nasibullaeva ◽  
O.V. Darintsev
Keyword(s):  
Fluid Flow ◽  
Pressure Drop ◽  
Boundary Conditions ◽  
Flow Rate ◽  
Contact Surface ◽  
Piezoelectric Element ◽  
Neumann Boundary ◽  
Differential Pressure ◽  
Physical Parameters ◽  
Flow Through

The flow of a liquid through a tube deformed by a piezoelectric cell under a harmonic law is studied in this paper. Linear deformations are compared for the Dirichlet and Neumann boundary conditions on the contact surface of the tube and piezoelectric element. The flow of fluid through a deformed channel for two flow regimes is investigated: in a tube with one closed end due to deformation of the tube; for a tube with two open ends due to deformation of the tube and the differential pressure applied to the channel. The flow rate of the liquid is calculated as a function of the frequency of the deformations, the pressure drop and the physical parameters of the liquid.

scholarly journals Effect of Aspect Ratio on the Mixing Performance in the Kenics Static Mixer

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 464
Author(s):  
Xingren Jiang ◽  
Ning Yang ◽  
Rijie Wang
Keyword(s):  
Pharmaceutical Industry ◽  
Aspect Ratio ◽  
Flow Reactor ◽  
Mixing Time ◽  
Continuous Process ◽  
Scale Up ◽  
Influence Factors ◽  
Continuous Manufacturing ◽  
Static Mixer ◽  
Mixing Performance

Continuous manufacturing has received increasing interest because of the advantages of intrinsic safety and enhanced mass transfer in the pharmaceutical industry. However, the difficulty for scale-up has limited the application of continuous manufacturing for a long time. Recently, the tubular flow reactor equipped with the Kenics static mixer appears to be a solution for the continuous process scale-up. Although many influence factors on the mixing performance in the Kenics static mixer have been investigated, little research has been carried out on the aspect ratio. In this study, we used the coefficient of variation as the mixing evaluation index to investigate the effect of the aspect ratio (0.2–2) on the Kenics static mixer’s mixing performance. The results indicate that a low aspect ratio helps obtain a shorter mixing time and mixer length. This study suggests that adjusting the aspect ratio of the Kenics static mixer can be a new strategy for the scale-up of a continuous process in the pharmaceutical industry.

Pressure Drop Measurements for Air Flow Through Open-Cell Aluminum Foam

2004 ◽  
Author(s):  
Nihad Dukhan ◽  
Angel Alvarez
Keyword(s):  
Reynolds Number ◽  
Pressure Drop ◽  
Flow Rate ◽  
Aluminum Foam ◽  
Flow Direction ◽  
The Other ◽  
Turbulent Regime ◽  
Thick Sample ◽  
Open Cell ◽  
Two Samples

Wind-tunnel pressure drop measurements for airflow through two samples of forty-pore-per-inch commercially available open-cell aluminum foam were undertaken. Each sample’s cross-sectional area perpendicular to the flow direction measured 10.16 cm by 24.13 cm. The thickness in the flow direction was 10.16 cm for one sample and 5.08 cm for the other. The flow rate ranged from 0.016 to 0.101 m3/s for the thick sample and from 0.025 to 0.134 m3/s for the other. The data were all in the fully turbulent regime. The pressure drop for both samples increased with increasing flow rate and followed a quadratic behavior. The permeability and the inertia coefficient showed some scatter with average values of 4.6 × 10−8 m2 and 2.9 × 10−8 m2, and 0.086 and 0.066 for the thick and the thin samples, respectively. The friction factor decayed with the Reynolds number and was weakly dependent on the Reynolds number for Reynolds number greater than 35.

scholarly journals Scale-up of a photochemical flow reactor for the production of lignin-coated titanium dioxide as a sunscreen ingredient

2021 ◽  
pp. 100040
Author(s):  
Kelsey Fournier ◽  
Nancy Marina ◽  
Neeraj Joshi ◽  
Vincent R. Berthiaume ◽  
Sara Currie ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Flow Reactor ◽  
Scale Up

Simultaneous Measuring Method for Both Volumetric Flow Rates of Air-Water Mixture Using a Turbine Flowmeter

1996 ◽  
Vol 118 (1) ◽  
pp. 29-35 ◽  
Author(s):  
K. Minemura ◽  
K. Egashira ◽  
K. Ihara ◽  
H. Furuta ◽  
K. Yamamoto
Keyword(s):  
Pressure Drop ◽  
Flow Rate ◽  
Volumetric Flow Rate ◽  
Oil Field ◽  
Liquid Density ◽  
Water Mixture ◽  
Rotor Speed ◽  
Flow Rates ◽  
Field Development ◽  
Turbine Flowmeter

A turbine flowmeter is employed in this study in connection with offshore oil field development, in order to measure simultaneously both the volumetric flow rates of air-water two-phase mixture. Though a conventional turbine flowmeter is generally used to measure the single-phase volumetric flow rate by obtaining the rotational rotor speed, the method proposed additionally reads the pressure drop across the meter. After the pressure drop and rotor speed measured are correlated as functions of the volumetric flow ratio of the air to the whole fluid and the total volumetric flow rate, both the flow rates are iteratively evaluated with the functions on the premise that the liquid density is known. The evaluated flow rates are confirmed to have adequate accuracy, and thus the applicability of the method to oil fields.

Experimental Investigation of Effect of Tip Coolant Ejection on Internal Flow Characteristics Within a Realistic Blade Coolant Channel

2013 ◽  
Author(s):  
Jian Pu ◽  
Zhaoqing Ke ◽  
Jianhua Wang ◽  
Lei Wang ◽  
Hongde You
Keyword(s):  
Experimental Investigation ◽  
Reynolds Number ◽  
Pressure Drop ◽  
Turbine Blade ◽  
Flow Rate ◽  
Flow Characteristics ◽  
Reynolds Numbers ◽  
Flow Ratio ◽  
Lp Turbine ◽  
Mass Flow Ratio

This paper presents an experimental investigation on the characteristics of the fluid flow within an entire coolant channel of a low pressure (LP) turbine blade. The serpentine channel, which keeps realistic blade geometry, consists of three passes connected by a 180° sharp bend and a semi-round bend, 2 tip exits and 25 trailing edge exits. The mean velocity fields within several typical cross sections were captured using a particle image velocimetry (PIV) system. Pressure and flow rate at each exit were determined through the measurements of local static pressure and volume flow rate. To optimize the design of LP turbine blade coolant channels, the effect of tip ejection ratio (ER) from 180° sharp bend on the flow characteristics in the coolant channel were experimentally investigated at a series of inlet Reynolds numbers from 25,000 to 50,000. A complex flow pattern, which is different from the previous investigations conducted by a simplified square or rectangular two-pass U-channel, is exhibited from the PIV results. This experimental investigation indicated that: a) in the main flow direction, the regions of separation bubble and flow impingement increase in size with a decrease of the ER; b) the shape, intensity and position of the secondary vortices are changed by the ER; c) the mass flow ratio of each exit to inlet is not sensitive to the inlet Reynolds number; d) the increase of the ER reduces the mass flow ratio through each trailing edge exit to the extent of about 23–28% of the ER = 0 reference under the condition that the tip exit located at 180° bend is full open; e) the pressure drop through the entire coolant channel decreases with an increase in the ER and inlet Reynolds number, and a reduction about 35–40% of the non-dimensional pressure drop is observed at different inlet Reynolds numbers, under the condition that the tip exit located at 180° bend is full open.

Palladium nanoparticle loaded β-cyclodextrin monolith as a flow reactor for concentration enrichment and conversion of pollutants based on molecular recognition

2020 ◽  
Vol 56 (92) ◽  
pp. 14408-14411
Author(s):  
Shunsuke Mizuno ◽  
Taka-Aki Asoh ◽  
Yoshinori Takashima ◽  
Akira Harada ◽  
Hiroshi Uyama
Keyword(s):  
Molecular Recognition ◽  
Environmental Effect ◽  
Flow Reactor ◽  
Palladium Nanoparticle ◽  
Residual Concentration ◽  
Polymer Monolith

A palladium nanoparticle immobilized β-cyclodextrin cross-linked polymer monolith not only adsorbed pollutants to the residual concentration with no environmental effect, but also converted them into concentrated useful substances.

Heat Transfer and Pressure Drop in a Converging Pedestal Array With Exit Area Variation

2018 ◽  
Author(s):  
L. W. Soma ◽  
F. E. Ames ◽  
S. Acharya
Keyword(s):  
Heat Transfer ◽  
Pressure Drop ◽  
Flow Rate ◽  
Film Cooling ◽  
Reynolds Numbers ◽  
Flow Path ◽  
Internal Cooling ◽  
Channel Measurements ◽  
Trailing Edge ◽  
Cooling Air

The trailing edge of a vane is one of the most difficult areas to cool due to a narrowing flow path, high external heat transfer rates, and deteriorating external film cooling protection. Converging pedestal arrays are often used as a means to provide internal cooling in this region. The thermally induced stresses in the trailing edge region of these converging arrays have been known to cause failure in the pedestals of conventional solidity arrays. The present paper documents the heat transfer and pressure drop through two high solidity converging rounded diamond pedestal arrays. These arrays have a 45 percent pedestal solidity. One array which was tested has nine rows of pedestals with an exit area in the last row consistent with the convergence. The other array has eight rows with an expanded exit in the last row to enable a higher cooling air flow rate. The expanded exit of the eight row array allows a 30% increase in the coolant flow rate compared with the nine row array for the same pressure drop. Heat transfer levels correlate well based on local Reynolds numbers but fall slightly below non converging arrays. The pressure drop across the array naturally increases toward the trailing edge with the convergence of the flow passage. A portion of the cooling air pressure drop can be attributed to acceleration while a portion can be attributed to flow path losses. Detailed array static pressure measurements provide a means to develop a correlation for the prediction of pressure drop across the cooling channel. Measurements have been acquired over Reynolds numbers based on exit flow conditions and the characteristic pedestal length scale ranging from 5000 to over 70,000.

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